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Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy
Open accessAbstract
The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups. We take stock of the evidence from these studies to explore potentials and limitations of pharmacotherapeutic applications. In healthy participants, intranasally administered OT leads to better emotion recognition and more trust in conspecifics, but the effects appear to be moderated by context (perceived threat of the 'out-group'), personality and childhood experiences. In individuals with untoward childhood experiences, positive behavioral or neurobiological effects seem lowered or absent. In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of OT administration were tested, with doses ranging from 15 IU to more than 7000 IU. The combined effect size was d=0.32 (N=304; 95% confidence interval (CI): 0.18-0.47; P<0.01). However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size (d=0.57; N=68; 95% CI: 0.15-0.99; P<0.01). We hypothesize that for some of the other disorders, etiological factors rooted in negative childhood experiences may also have a role in the diminished effectiveness of treatment with OT.
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“These studies yielded summarized effect sizes ranging from d=0.21 to d=0.48.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
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“The meta-analyses mentioned in this paper all tested for evidence of publication bias in the IN-OT literature, with mixed results (9–11).”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Finally, in the meta-analysis by Bakermans-Kranenburg and Van IJzendoorn (11) IN-OT seems to have the largest effect size in individuals with autism. Only four studies of autism were included in the analysis and should therefore be interpreted cautiously. However, the larger effect size for autism (d=0.57) compared to all clinical studies (d=0.32)”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
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“Bakermans-Kranenburg and Van IJzendoorn studied the effect of IN-OT in clinical trials (19 effect sizes, total N=304)(11).”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
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“To date three meta-analyses of the effects of IN-OT on human behavior have been published.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
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“Only four studies of autism were included in the analysis and should therefore be interpreted cautiously.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
In the citing paper
“Several clinical studies have also investigated the potential of intranasal oxytocin as a treatment for socio-cognitive, behavioral, and socio-affective symptoms of ASD. So far, these studies cannot provide a certain conclusion about oxytocin’s therapeutic potential43–47.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [46]
In the citing paper
“In typically developing individuals, OT has been linked to interpersonal bonding, parental care, and the ability to establish trust and form social attachments [2, 3].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [2]
In the citing paper
“the genetic background of oxytocin system might influence efficacy of oxytocin administration.19, 20”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [19]
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“oxytocin is emerging as a pharmacological target for social dysfunction in clinical trials (29, 30).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [30]
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Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
(1969) · Cited by 18,340
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
(2000) · Cited by 9,198
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005653411471 · Cited by 6,450
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
The precuneus: a review of its functional anatomy and behavioural correlates
Cavanna, A. E., & Trimble, M. R. (2006) · Brain · doi:10.1093/brain/awl004 · Cited by 5,128
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635
Flagged first, then by citations
Research works printed but not linked: 1
- Borenstein M, Hedges LV, Higgins JPT, Rothstein HR . Comprehensive Meta-Analysis, Version 2. Biostat: Englewood, NJ, USA, 2005.
Cited by
Sorted by citations
Assessing human mirror activity with EEG mu rhythm: A meta-analysis.
Fox, N. A., Bakermans‐Kranenburg, M. J., Yoo, K. H., Bowman, L. C., Cannon, E. N., Vanderwert, R. E., Ferrari, P. F., & van IJzendoorn, M. H. (2015) · Psychological Bulletin · doi:10.1037/bul0000031 · Cited by 466
The adaptive human parental brain: implications for children's social development
Feldman, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.004 · Cited by 419
Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies
Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 347
“Finally, in the meta-analysis by BakermansKranenburg and Van IJzendoorn (11) IN-OT seems to have the largest effect size in individuals with autism.”
BackgroundMethodInfluentialRole of neuropeptides in anxiety, stress, and depression: From animals to humans
Kormos, V., & Gaszner, B. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.014 · Cited by 333
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 316
Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299
De Dreu, C. K. W., & Kret, M. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.020 · Cited by 297
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223
“revealed that autism was the candidate psychiatric disorder with most potential to benefit (80).”
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229
Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism
Watanabe, T., Kuroda, M., Kuwabara, H., Aoki, Y., Iwashiro, N., Tatsunobu, N., Takao, H., Nippashi, Y., Kawakubo, Y., Kunimatsu, A., et al. (2015) · Brain · doi:10.1093/brain/awv249 · Cited by 222
An update on pharmacotherapy for autism spectrum disorder in children and adolescents
Ji, N. Y., & Findling, R. L. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000132 · Cited by 217
Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice
Ferretti, V., Maltese, F., Contarini, G., Nigro, M., Bonavia, A., Huang, H., Gigliucci, V., Morelli, G., Scheggia, D., Managò, F., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.070 · Cited by 212
The neurobiology of mammalian parenting and the biosocial context of human caregiving
Feldman, R. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.001 · Cited by 219
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187
King, L. B., Walum, H., Inoue, K., Eyrich, N. W., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.008 · Cited by 191
“In humans, intranasal OXT reportedly enhances many aspects of social cognition, including trust, emotion recognition, and eye gaze (1, 10).”
Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193
Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions
Leppanen, J., Ng, K. W., Tchanturia, K., & Treasure, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.010 · Cited by 188
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187
An update on pharmacotherapy of autism spectrum disorder in children and adolescents
Goel, R., Hong, J. S., Findling, R. L., & Ji, N. Y. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1458706 · Cited by 194
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179
Nose-to-brain peptide delivery – The potential of nanotechnology
Samaridou, E., & Alonso, M. J. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.11.001 · Cited by 183
Oxytocin, testosterone, and human social cognition
Crespi, B. J. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12175 · Cited by 183
“…restricted to individuals with reduced social interest or abilities prior to administration (Guastella et al., 2010; Luminet et al., 2011; Rosenfeld, Lieberman & Jarskog, 2011; Fischer-Shofty, Shamay-Tsoory & Levkovitz, 2013; Leknes et al., 2013; Bakermans-Kranenburg & van IJzendoorn, 2013).”
BackgroundAnxiety in Patients with Schizophrenia: Epidemiology and Management
Temmingh, H., & Stein, D. J. (2015) · CNS Drugs · doi:10.1007/s40263-015-0282-7 · Cited by 173
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171
Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum
Debbané, M., Salaminios, G., Luyten, P., Badoud, D., Armando, M., Solida-Tozzi, A., Fonagy, P., & Brent, B. K. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00406 · Cited by 177
Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis
Keech, B., Crowe, S., & Hocking, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.022 · Cited by 145
Feldman, R., & Bakermans-Kranenburg, M. J. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.011 · Cited by 160
“Unfortunately, however, a number of studies suggest that the positive effects on behavior or neurobiology may be minimal or absent in individuals with negative childhood experiences or insecure attachment styles [59-61].”
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Fan, Y., Herrera-Meléndez, A. L., Pestke, K., Feeser, M., Aust, S., Otte, C., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22553 · Cited by 142
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131
“Here, we mainly review OT effects on brain activity in SAD and ASD (two types of psychological disorder typically characterized by social dysfunction), given that IN-OT fMRI studies of clinical populations have mainly examined OT effects in patients with these conditions (see [33–35] for systematic reviews of IN-OT be…”
BackgroundMethodLong-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131
A Multilevel Perspective on the Development of Borderline Personality Disorder
Fonagy, P., & Luyten, P. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy317 · Cited by 136
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129
Epigenetics of Autism Spectrum Disorder
Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121
Grace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Oxytocin and postpartum depression: Delivering on what's known and what's not
Kim, S., Soeken, T. A., CROMER, S. J., Martinez, S. R., Hardy, L. R., & Strathearn, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.11.009 · Cited by 121
Kosaka, H., Okamoto, Y., Munesue, T., Yamasue, H., Inohara, K., Fujioka, T., Anme, T., Orisaka, M., Ishitobi, M., Jung, M., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.152 · Cited by 117
Agile delivery of protein therapeutics to CNS
Yi, X., Manickam, D. S., Brynskikh, A. M., & Kabanov, A. V. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.017 · Cited by 116
Oxytocin pathways in the intergenerational transmission of maternal early life stress
Töpfer, P., Heim, C. C., Entringer, S., Binder, E. B., Wadhwa, P. D., & Buß, C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.026 · Cited by 118
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107
Quintana, D. S., Westlye, L. T., Hope, S., Nærland, T., Elvsåshagen, T., Dørum, E., Rustan, Ø., Valstad, M., Rezvaya, L., Lishaugen, H., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.103 · Cited by 111
Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes
Altirriba, J., Poher, A.-L., Caillon, A., Arsenijevic, D., Veyrat‐Durebex, C., Lyautey, J., Dulloo, A. G., & Rohner‐Jeanrenaud, F. (2014) · Endocrinology · doi:10.1210/en.2014-1466 · Cited by 113
Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers
Li, T., Chen, X., Mascaro, J., Haroon, E., & Rilling, J. K. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.01.006 · Cited by 105
Social Decision-Making and the Brain: A Comparative Perspective
Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 116
Ellis, B. J., Horn, A. J., Carter, C. S., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101985 · Cited by 103
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103
Bernaerts, S., Boets, B., Bosmans, G., Steyaert, J., & Alaerts, K. (2020) · Molecular Autism · doi:10.1186/s13229-020-0313-1 · Cited by 102
“In typically developing individuals, OT has been linked to interpersonal bonding, parental care, and the ability to establish trust and form social attachments [2, 3].”
BackgroundOxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
Serine-Selective Bioconjugation
Vantourout, J. C., Adusumalli, S. R., Knouse, K. W., Flood, D. T., Ramı́rez, A., Padial, N. M., Istrate, A., Maziarz, K., deGruyter, J. N., Merchant, R. R., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c05595 · Cited by 99
Insular function in autism: Update and future directions in neuroimaging and interventions
Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 98
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95
Mah, B. L., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., & Smith, R. (2014) · Depression and Anxiety · doi:10.1002/da.22245 · Cited by 93
Wang, D., Yan, X., Li, M., & Ma, Y. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx085 · Cited by 86
Long-term oxytocin administration enhances the experience of attachment
Bernaerts, S., Prinsen, J., Berra, E., Bosmans, G., Steyaert, J., & Alaerts, K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.010 · Cited by 90
Oxytocin and the modulation of pain experience: Implications for chronic pain management
Tracy, L. M., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.013 · Cited by 93
Disentangling the molecular genetic basis of personality: From monoamines to neuropeptides
Montag, C., & Reuter, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.006 · Cited by 93
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 92
Does oxytocin affect mind-reading? A replication study
Radke, S., & de Bruijn, E. R. A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.006 · Cited by 82
Learning About Oxytocin: Pharmacologic and Behavioral Issues
Chini, B., Leonzino, M., Braida, D., & Sala, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.029 · Cited by 91
Munesue, T., Nakamura, H., Kikuchi, M., Miura, Y., Takeuchi, N., Anme, T., Nanba, E., Adachi, K., Tsubouchi, K., Sai, Y., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00002 · Cited by 84
Social neuroscience: undoing the schism between neurology and psychiatry
Ibáñez, A. M., García, A. M., Esteves, S., Yoris, A., Muñoz, É., Reynaldo, L., Pietto, M. L., Adolfi, F., & Manes, F. F. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1245214 · Cited by 86
Reiner, I., Van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Bleich, S., Beutel, M., & Frieling, H. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.012 · Cited by 83
Self-citationInhaled oxytocin increases positive social behaviors in newborn macaques
Simpson, E. A., Sclafani, V., Paukner, A., Hamel, A. F., Novak, M. A., Meyer, J. S., Suomi, S. J., & Ferrari, P. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402471111 · Cited by 82
Kim, Y., Kim, C., Cardi, V., Eom, J., Seong, Y., & Treasure, J. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.019 · Cited by 82
Oxytocin reduces neural activity in the pain circuitry when seeing pain in others
Bos, P. A., Montoya, E. R., Hermans, E. J., Keysers, C., & van Honk, J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.049 · Cited by 72
Oxytocin and socioemotional aging: current knowledge and future trends
Ebner, N. C., Maura, G. M., MacDonald, K., Westberg, L., & Fischer, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00487 · Cited by 78
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Hurlemann, R., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00512 · Cited by 78
Passoni, I. P., Leonzino, M., Gigliucci, V., Chini, B., & Busnelli, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12363 · Cited by 76
Fan, Y., Pestke, K., Feeser, M., Aust, S., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.123 · Cited by 75
Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment
Goh, K. K., Chen, C.-H., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042146 · Cited by 84
“Childhood adversities also moderate the effect of oxytocin on social cognition although the findings are inconsistent [20,27].”
ResultRussell, J. D., Maguire, S., Hunt, G. E., Kesby, A., Suraev, A. S., Stuart, J. M., Booth, J., & McGregor, I. S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.10.014 · Cited by 79
Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72
The effects of DNA methylation on human psychology
Kader, F., Ghai, M., & Maharaj, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.004 · Cited by 75
Hormones, Stress, and Cognition: The Effects of Glucocorticoids and Oxytocin on Memory
Wirth, M. M. (2014) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-014-0010-4 · Cited by 77
DeMayo, M. M., Song, Y. J. C., Hickie, I. B., & Guastella, A. J. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0248-y · Cited by 71
“A recent meta-analysis of studies in participants with ASD found that oxytocin administration resulted in significant improvements on social cognition tasks [58].”
BackgroundThe endocrinology of human caregiving and its intergenerational transmission
Bos, P. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000973 · Cited by 71
Cognition as a target in major depression: new developments.
Solé, B., Jiménez, E., Martinez-Aran, A., & Vieta, E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.12.004 · Cited by 68
Oxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits
Aspé-Sánchez, M., Moreno, M., Rivera, M. I., Rossi, A., & Ewer, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00510 · Cited by 71
Face individual identity recognition: a potential endophenotype in autism
Minio-Paluello, I., Porciello, G., Pascual‐Leone, Á., & Baron‐Cohen, S. (2020) · Molecular Autism · doi:10.1186/s13229-020-00371-0 · Cited by 73
A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia
Guastella, A. J., Ward, P. B., Hickie, I. B., Shahrestani, S., Hodge, M. A., Scott, E. M., & Langdon, R. A. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.005 · Cited by 69
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Endogenous Oxytocin Levels in Autism—A Meta-Analysis
Moerkerke, M., Peeters, M., de Vries, L. M., Daniëls, N., Steyaert, J. G., Alaerts, K., & Boets, B. (2021) · Brain Sciences · doi:10.3390/brainsci11111545 · Cited by 68
Attachment style and oxytocin receptor gene variation interact in influencing social anxiety
Notzon, S., Domschke, K., Holitschke, K., Ziegler, C., Arolt, V., Pauli, P., Reif, A., Deckert, J., & Zwanzger, P. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1091502 · Cited by 65
A Guide for Calculating Study-Level Statistical Power for Meta-Analyses
Quintana, D. S. (2023) · Advances in Methods and Practices in Psychological Science · doi:10.1177/25152459221147260 · Cited by 95
Intranasal administration of oxytocin promotes social play in domestic dogs
Romero, T., Nagasawa, M., Mogi, K., Hasegawa, T., & Kikusui, T. (2015) · Communicative & Integrative Biology · doi:10.1080/19420889.2015.1017157 · Cited by 61
“autism spectrum disorder, social anxiety disorder, and borderline personality disorder; for reviews see refs.(6,7)).”
BackgroundOxytocin as Treatment for Social Cognition, Not There Yet
Erdozain, A. M., & Peñagarikano, O. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00930 · Cited by 62
Is crying a self-soothing behavior?
Gračanin, A., Bylsma, L. M., & Vingerhoets, A. J. J. M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00502 · Cited by 75
Ebert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 66
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Hammen, C. L., Bower, J. E., & Cole, S. W. (2014) · Journal of Personality Disorders · doi:10.1521/pedi_2014_28_152 · Cited by 59
Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O., & Hoekstra, P. J. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.025 · Cited by 57
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Ma, Y., Liu, Y., Rand, D. G., Heatherton, T. F., & Han, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.87 · Cited by 55
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Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
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Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57
“Seventeen years later, another study, published hitherto as a poster abstract only, revealed more promising results because the authors reported a significant effect of a single dose of 24 IU oxytocin on non-provoked PTSD symptoms, in particular on the intensity of recurrent thoughts about the traumatic event and on t…”
Riem, M. M. E., Kunst, L. E., Bekker, M. H. J., Fallon, M., & Kupper, N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104482 · Cited by 61
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Rich, M. E., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00090 · Cited by 60
Mah, B. L., van IJzendoorn, M. H., Out, D., Smith, R., & Bakermans‐Kranenburg, M. J. (2016) · Child Psychiatry & Human Development · doi:10.1007/s10578-016-0642-7 · Cited by 55
“The absence of a significant effect on sensitivity in our sample adds some weight to the current trend found in two recent meta-analytic studies that OT effects are often diminished or absent in clinical samples [38, 49].”
BackgroundResultInfluential
Metadata
- Authors
- Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H.
- Venue
- Translational Psychiatry
- Published
- 2013-05-21
- Volume
- 3
- Issue
- 5
- Pages
- e258-e258
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3669921
- OpenAlex
- W1966317054
- Cited by
- 383
- References
- 142
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 11 · 2021: 24 · 2020: 22 · 2019: 29 · 2018: 41 · 2017: 55 · 2016: 43 · 2015: 59 · 2014: 40 · 2013: 9
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, intranasal administration, pharmacotherapy, autism spectrum disorder, social anxiety, postpartum depression, obsessive-compulsive disorder, schizophrenia, borderline personality disorder, post-traumatic stress disorder, emotion recognition, trust, child abuse, personality moderators, treatment effect size
- MeSH terms
- Administration, Intranasal, Anxiety, Mental Disorders, Child, Child Development Disorders, Pervasive, Depression, Humans, Oxytocin, Personality Disorders, Phobic Disorders, Schizophrenia, Stress Disorders, Post-Traumatic, Anti-Anxiety Agents, Trust
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