Cited by 176RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Biomaterials for mRNA delivery

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Islam, Mohammad Ariful, Reesor, Emma K. G., Xu, Yingjie, Zope, Harshal R., Zetter, Bruce R., Shi, Jinjun·2015·Biomaterials Science

DOI 10.1039/c5bm00198fPMC PMC4641793

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Abstract

Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective alternative to DNA-based therapies because of several unique advantages. mRNA does not require nuclear entry for transfection activity and has a negligible chance of integrating into the host genome which excludes the possibility of potentially detrimental genomic alternations. Chemical modification of mRNA has further enhanced its stability and decreased its activation of innate immune responses. Additionally, mRNA has been found to have rapid expression and predictable kinetics. Nevertheless, the ubiquitous application of mRNA remains challenging given its unfavorable attributes, such as large size, negative charge and susceptibility to enzymatic degradation. Further refinement of mRNA delivery modalities is therefore essential for its development as a therapeutic tool. This review provides an exclusive overview of current state-of-the-art biomaterials and nanotechnology platforms for mRNA delivery, and discusses future prospects to bring these exciting technologies into clinical practice.

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Authors: Islam, M. A., Reesor, E. K. G., Xu, Y., Zope, H. R., Zetter, B. R., & Shi, J.
Affiliations: Brigham and Women's Hospital (US)
Boston Children's Hospital (US)
Corresponding author: Zetter, Bruce R.
Shi, Jinjun
ORCID: Islam, Mohammad Ariful
Reesor, Emma K. G.
Xu, Yingjie
Zetter, Bruce R.
Shi, Jinjun
Venue: Biomaterials Science
Publisher: Royal Society of Chemistry (RSC)
Published: 2015
Volume: 3
Issue: 12
Pages: 1519-1533
ISSN: 2047-4830 (ISSN-L)
2047-4849
DOI: 10.1039/c5bm00198f
PMC: PMC4641793
OpenAlex: W1945220000
Cited by: 176
References: 123
Citations by year: 2026: 9 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 27 · 2019: 16 · 2018: 24 · 2017: 13 · 2016: 11
FWCI: 6.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biomaterials Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
National Institutes of Health
National Cancer Institute (R01 CA37393, R01CA037393, R00CA160350)
DOD Prostate Cancer Research Program
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: mRNA delivery, biomaterials, nanotechnology, mRNA therapeutics, mRNA stability, innate immune response, mRNA degradation, nucleic acid delivery systems
MeSH terms: Biocompatible Materials, Biological Transport, Genetic Vectors, Humans, RNA, Messenger, Transfection, Gene Transfer Techniques, Nanotechnology

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