Cited by 176RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Biomaterials for mRNA delivery

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Islam, Mohammad Ariful, Reesor, Emma K. G., Xu, Yingjie, Zope, Harshal R., Zetter, Bruce R., Shi, Jinjun·2015·Biomaterials Science

DOI 10.1039/c5bm00198fPMC PMC4641793

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Abstract

Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective alternative to DNA-based therapies because of several unique advantages. mRNA does not require nuclear entry for transfection activity and has a negligible chance of integrating into the host genome which excludes the possibility of potentially detrimental genomic alternations. Chemical modification of mRNA has further enhanced its stability and decreased its activation of innate immune responses. Additionally, mRNA has been found to have rapid expression and predictable kinetics. Nevertheless, the ubiquitous application of mRNA remains challenging given its unfavorable attributes, such as large size, negative charge and susceptibility to enzymatic degradation. Further refinement of mRNA delivery modalities is therefore essential for its development as a therapeutic tool. This review provides an exclusive overview of current state-of-the-art biomaterials and nanotechnology platforms for mRNA delivery, and discusses future prospects to bring these exciting technologies into clinical practice.

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Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Progress and problems with the use of viral vectors for gene therapy
Thomas, C. E., Ehrhardt, A., & Kay, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1066 · Cited by 2,501
mRNA-based therapeutics--developing a new class of drugs
Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474
Gold Nanoparticles for Biology and Medicine
Giljohann, D. A., Seferos, D. S., Daniel, W. L., Massich, M. D., Patel, P. C., & Mirkin, C. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904359 · Cited by 2,389
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton‐Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Delivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
Regulating the fate of mRNA: the control of cellular iron metabolism
Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210
Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform
Zhang, L., Chan, J. M., Gu, F., Rhee, J., Wang, A. Z., Radovic‐Moreno, A. F., Alexis, F., Langer, R., & Farokhzad, O. C. (2008) · ACS Nano · doi:10.1021/nn800275r · Cited by 1,042
Cationic liposome-mediated RNA transfection.
Malone, R. W., Felgner, P. L., & Verma, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6077 · Cited by 911
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
Farhood, H., Serbina, N. V., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 799
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625
Cationic lipids, lipoplexes and intracellular delivery of genes
Wasungu, L., & Hoekstra, D. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.024 · Cited by 616
Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif
D’Souza, S. E., Ginsberg, M. H., & Plow, E. F. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90096-e · Cited by 609
Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles
Giljohann, D. A., Seferos, D. S., Patel, P. C., Millstone, J. E., Rosi, N. L., & Mirkin, C. A. (2007) · Nano Letters · doi:10.1021/nl072471q · Cited by 553
5'-terminal cap structure in eucaryotic messenger ribonucleic acids
Banerjee, A. K. (1980) · Microbiological Reviews · doi:10.1128/mr.44.2.175-205.1980 · Cited by 477
Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform
Mandal, B., Bhattacharjee, H., Mittal, N. K., Sah, H., Balabathula, P., Thoma, L. A., & Wood, G. C. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.010 · Cited by 468
Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells
Van Tendeloo, V. F. I., Ponsaerts, P., Lardon, F., Nijs, G., Lenjou, M., Van Broeckhoven, C., Van Bockstaele, D. R., & Berneman, Z. N. (2001) · Blood · doi:10.1182/blood.v98.1.49 · Cited by 468
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
Chen, M., Sonaje, K., Chen, K., & Sung, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.087 · Cited by 427
Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery
Elbakry, A. M., Zaky, A. A., Liebl, R., Rachel, R., Göpferich, A. M., & Breunig, M. (2009) · Nano Letters · doi:10.1021/nl9003865 · Cited by 424
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
Hatakeyama, H., Akita, H., Kogure, K., Oishi, M., Nagasaki, Y., Kihira, Y., Ueno, M., Kobayashi, H., Kikuchi, H., & Harashima, H. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302843 · Cited by 400
Cytoplasmic regulation of mRNA function: The importance of the 3′ untranslated region
Jackson, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)90290-7 · Cited by 388
Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients
Weide, B., Pascolo, S., Scheel, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. K., Pawelec, G., Hoerr, I., Rammensee, H.-G., & Garbe, C. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181a00068 · Cited by 378
Scavenger Receptors Mediate Cellular Uptake of Polyvalent Oligonucleotide-Functionalized Gold Nanoparticles
Patel, P. C., Giljohann, D. A., Daniel, W. L., Zheng, D., Prigodich, A. E., & Mirkin, C. A. (2010) · Bioconjugate Chemistry · doi:10.1021/bc1002423 · Cited by 366
Untitled work
(2001) · PubMed Central · Cited by 342
Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity
Fotin-Mleczek, M., Duchardt, K. M., Lorenz, C., Pfeiffer, R., Ojkić-Zrna, S., Probst, J., & Kallen, K.-J. (2011) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181f7dbe8 · Cited by 335
Untitled work
(1995) · PubMed · Cited by 330
Translational control by changes in poly(A) tail length: recycling mRNAs
Weill, L., Belloc, E., Bava, F.-A., & Méndez, R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2311 · Cited by 328
In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287
A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids
Read, M. L., Singh, S., Ahmed, Z., Stevenson, M., Briggs, S. S., Oupický, D., Barrett, L. B., Spice, R., Kendall, M. A. F., Berry, M., et al. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni085 · Cited by 279
Novel “anti-reverse” cap analogs with superior translational properties
Jemielity, J., Fowler, T. E., Zuberek, J., Stȩpiński, J., Lewdorowicz, M., Niedźwiecka-Kornaś, A., Stolarski, R., Darżynkiewicz, E., & Rhoads, R. E. (2003) · RNA · doi:10.1261/rna.5430403 · Cited by 263
Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA
Weide, B., Carralot, J.-P., Reese, A., Scheel, B., Eigentler, T. K., Hoerr, I., Rammensee, H.-G., Garbe, C., & Pascolo, S. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31815ce501 · Cited by 261
Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups
Salvador-Morales, C., Zhang, L., Langer, R., & Farokhzad, O. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.005 · Cited by 251
Controlling liposome blood clearance by surface-grafted polymers
Woodle, M. C. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00136-1 · Cited by 246
The regulation of mRNA stability in mammalian cells: 2.0
Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239
Characterization of the inhibitory effect of PEG-lipid conjugates on the intracellular delivery of plasmid and antisense DNA mediated by cationic lipid liposomes
Song, L. Y., AHKONG, Q. F., Rong, Q., Wang, Z., Ansell, S. M., Hope, M. J., & Mui, B. L. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00399-6 · Cited by 233
mRNA as gene therapeutic: How to control protein expression
Tavernier, G., Andries, O., Demeester, J., Sanders, N. N., De Smedt, S. C., & Rejman, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.020 · Cited by 232
Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA
Perche, F., Benvegnu, T. J., Berchel, M., Lebegue, L., Pichon, C., Jaffrès, P., & Midoux, P. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.12.010 · Cited by 228
Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients
Rittig, S. M., Haentschel, M., Weimer, K. J., Heine, A., Muller, M. R., Brugger, W., Horger, M. S., Maksimovic, O., Stenzl, A., Hoerr, I., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2010.289 · Cited by 226
Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
Bettinger, T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3882 · Cited by 224
Lipid-based mRNA vaccine delivery systems
Midoux, P., & Pichon, C. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2015.986104 · Cited by 213
Current prospects for mRNA gene delivery
Yamamoto, A., Kormann, M., Rosenecker, J., & Rudolph, C. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.016 · Cited by 200
Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA
Scheel, B., Teufel, R., Probst, J., Carralot, J., Geginat, J., Radsak, M. P., Jarrossay, D., Wagner, H., Jung, G., Rammensee, H., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200425656 · Cited by 198
Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
Shi, J., Xiao, Z., Votruba, A. R., Vilos, C., & Farokhzad, O. C. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201101554 · Cited by 195
Self-citation
Identification of the gene for an Escherichia coli poly(A) polymerase.
Cao, G. J., & Sarkar, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10380 · Cited by 193
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.
Wang, Y.-H., Su, H.-H., Yang, Y., Hu, Y.-X., Zhang, L., Blancafort, P., & Huang, L. (2013) · Molecular Therapy · doi:10.1038/mt.2012.250 · Cited by 189
5'-terminal cap structure in eucaryotic messenger ribonucleic acids.
Banerjee, A. K. (1980) · Microbiological Reviews · doi:10.1128/mmbr.44.2.175-205.1980 · Cited by 188
Lipid-coated polymeric nanoparticles for cancer drug delivery
Krishnamurthy, S., Vaiyapuri, R., Zhang, L., & Chan, J. M. (2015) · Biomaterials Science · doi:10.1039/c4bm00427b · Cited by 183
Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines
Deering, R. P., Kommareddy, S., Ulmer, J. B., Brito, L. A., & Geall, A. J. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.901308 · Cited by 180
Polymeric nanoparticles for pulmonary protein and DNA delivery
Menon, J. U., Ravikumar, P., Pise, A., Gyawali, D., Hsia, C. C. W., & Nguyen, K. T. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.01.033 · Cited by 174
Transfection and intracellular trafficking properties of carbon dot-gold nanoparticle molecular assembly conjugated with PEI-pDNA
Kim, J., Park, J., Kim, H., Singha, K., & Kim, W. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.072 · Cited by 168
mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes
Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 167
mRNA transfection of dendritic cells: Synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level
Mockey, M., Gonçalves, C., Dupuy, F. P., Lemoine, F. M., Pichon, C., & Midoux, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.105 · Cited by 165
Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells
Zou, S., Scarfo, K. A., Nantz, M. H., & Hecker, J. G. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.019 · Cited by 161
Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format
Phua, K. K. L., Leong, K. W., & Nair, S. K. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.029 · Cited by 159
Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells
Grudzien‐Nogalska, E., Jemielity, J., Kowalska, J., Darżynkiewicz, E., & Rhoads, R. E. (2007) · RNA · doi:10.1261/rna.701307 · Cited by 152
Reverse 5' caps in RNAs made in vitro by phage RNA polymerases.
Pasquinelli, A. E., Dahlberg, J. E., & Lund, E. (1995) · PubMed · Cited by 148
Lipid- and Polymer-Based Nanostructures for Cancer Theranostics
Luk, B. T., Fang, R. H., & Zhang, L. (2012) · Theranostics · doi:10.7150/thno.4381 · Cited by 147
Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer
Sebastian, M., Papachristofilou, A., Weiß, C., Früh, M., Cathomas, R. L., Hilbe, W., Wehler, T., Rippin, G., Koch, S. D., Scheel, B., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-748 · Cited by 143
Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers
Wu, J., Kamaly, N., Shi, J., Zhao, L., Xiao, Z., Hollett, G., John, R. A., Ray, S., Xu, X., Zhang, X., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404766 · Cited by 141
Self-citation
Immunostimulating capacities of stabilized RNA molecules
Scheel, B., Braedel, S., Probst, J., Carralot, J., Wagner, H., Schild, H., Jung, G., Rammensee, H., & Pascolo, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200324198 · Cited by 138
mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers
Rejman, J., Tavernier, G., Bavarsad, N., Demeester, J., & Smedt, S. C. D. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.124 · Cited by 133
Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release
Kong, S. D., Sartor, M., Hu, C. J., Zhang, W., Zhang, L., & Jin, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.11.006 · Cited by 125
Quantitative Assessment of mRNA Cap Analogues as Inhibitors of in Vitro Translation
Cai, A., Jankowska‐Anyszka, M., Centers, A., Chlebicka, L., Stȩpiński, J., Stolarski, R., Darżynkiewicz, E., & Rhoads, R. E. (1999) · Biochemistry · doi:10.1021/bi9830213 · Cited by 123
Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery
Heyes, J. A., Hall, K., Tailor, V., Lenz, R., & MacLachlan, I. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.012 · Cited by 123
Multifunctional triblock copolymers for intracellular messenger RNA delivery
Cheng, C., Convertine, A. J., Stayton, P. S., & Bryers, J. D. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.020 · Cited by 123
A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs
Kallen, K., & Theß, A. (2013) · Therapeutic Advances in Vaccines · doi:10.1177/2051013613508729 · Cited by 122
Cellular Uptake of Gold Nanoparticles Passivated with BSA−SV40 Large T Antigen Conjugates
Ryan, J. A., Overton, K. W., Speight, M. E., Oldenburg, C. N., Loo, L., Robarge, W. P., Franzen, S., & Feldheim, D. L. (2007) · Analytical Chemistry · doi:10.1021/ac0715524 · Cited by 120
Effect of “helper lipid” on lipoplex electrostatics
Hirsch‐Lerner, D., Zhang, M., Eliyahu, H., Ferrari, M. E., Wheeler, C. J., & Barenholz, Y. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.04.008 · Cited by 119
Efficient genetic modification of murine dendritic cells by electroporation with mRNA
Meirvenne, S. V., Straetman, L., Heirman, C., Dullaers, M., Greef, C. D., Tendeloo, V. F. V., & Thielemans, K. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700499 · Cited by 118
The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy
Dewitte, H., Lint, S. V., Heirman, C., Thielemans, K., Smedt, S. C. D., Breckpot, K., & Lentacker, I. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.011 · Cited by 118
Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers
Leonhardt, C., Schwake, G., Stögbauer, T. R., Rappl, S., Kuhr, J.-T., Ligon, T. S., & Rädler, J. O. (2014) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2013.11.008 · Cited by 117
mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer
Rausch, S., Schwentner, C., Stenzl, A., & Bedke, J. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.29553 · Cited by 117
mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells
Temmerman, M. D., Dewitte, H., Vandenbroucke, R. E., Lucas, B., Libert, C., Demeester, J., Smedt, S. C. D., Lentacker, I., & Rejman, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.024 · Cited by 116
Poly(A) Tail Length-dependent Stabilization of GAP-43 mRNA by the RNA-binding Protein HuD
Beckel-Mitchener, A. C., Miera, A., Keller, R., & Perrone-Bizzozero, N. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201982200 · Cited by 113
Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes
Bao, Y., Jin, Y., Chivukula, P., Zhang, J., Liu, Y., Liu, J., Clamme, J., Mahato, R. I., Ng, D., Ying, W., et al. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0874-6 · Cited by 107
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect
Fotin‐Mleczek, M., Zanzinger, K., Heidenreich, R., Lorenz, C., Thess, A., Duchardt, K. M., & Kallen, K. (2012) · The Journal of Gene Medicine · doi:10.1002/jgm.2605 · Cited by 103
Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing
Shi, J., Xu, Y., Xu, X., Zhu, X. D., Pridgen, E. M., Wu, J., Votruba, A. R., Swami, A., Zetter, B. R., & Farokhzad, O. C. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.03.006 · Cited by 102
Self-citation
Synthesis and Characterization of Lipid–Polymer Hybrid Nanoparticles with pH-Triggered Poly(ethylene glycol) Shedding
Clawson, C., Ton, L., Aryal, S., Fu, V., Esener, S. C., & Zhang, L. (2011) · Langmuir · doi:10.1021/la202123e · Cited by 93
Single Emulsion-Solvent Evaporation Technique and Modifications for the Preparation of Pharmaceutical Polymeric Nanoparticles
Nava-Arzaluz, M. G., Piñón‐Segundo, E., Ganem‐Rondero, A., & Lechuga‐Ballesteros, D. (2012) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221112802652633 · Cited by 89
Overexpression of urokinase receptor in mammalian cells following administration of the in vitro transcribed encoding mRNA
Karikó, K., Kuo, A., & Barnathan, E. S. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300930 · Cited by 89
The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme
SCHWARTZ, D., Decker, C. J., & Parker, R. (2003) · RNA · doi:10.1261/rna.2171203 · Cited by 86
Surface engineering of gold nanoparticles for in vitro siRNA delivery
Zhao, E.-Y., Zhao, Z.-X., Wang, J., Yang, C., Chen, C., Gao, L., Feng, Q., Hou, W., Gao, M., & Zhang, Q. (2012) · Nanoscale · doi:10.1039/c2nr31290e · Cited by 85
Induction of Anti-Tumor Immunity with Epidermal Cells Pulsed with Tumor-Derived RNA or Intradermal Administration of RNA
Granstein, R. D., Ding, W., & Ozawa, H. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00929.x · Cited by 81
A brilliant disguise for self RNA: 5’-end and internal modifications of primary transcripts suppress elements of innate immunity
Nallagatla, S. R., Toroney, R., & Bevilacqua, P. C. (2008) · RNA Biology · doi:10.4161/rna.5.3.6839 · Cited by 79
Effective delivery with enhanced translational activity synergistically accelerates mRNA-based transfection
Zohra, F. T., Chowdhury, E. H., Tada, S., Hoshiba, T., & Akaike, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.059 · Cited by 71
Messenger RNA (mRNA) nanoparticle tumour vaccination
Phua, K. K. L., Nair, S. K., & Leong, K. W. (2014) · Nanoscale · doi:10.1039/c4nr01346h · Cited by 70
Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles
Kim, J., Yeom, J., Ko, J., Han, M. S., Lee, K., Na, S.-Y., & Bae, J. (2011) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.07.014 · Cited by 69
Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebrospinal Fluid: Methods and Evidence for Nonviral mRNA Gene Delivery to the Central Nervous System
Anderson, D. M., Hall, L. L., Ayyalapu, A. R., Irion, V. R., Nantz, M. H., & Hecker, J. G. (2003) · Human Gene Therapy · doi:10.1089/10430340360535751 · Cited by 66
Novel cationic liposomes provide highly efficient delivery of DNA and RNA into dendritic cell progenitors and their immature offsets
Markov, O. V., Mironova, N. L., Maslov, M. A., Petukhov, I. A., Morozova, N. G., Vlassov, V. V., & Аркадьевна, З. М. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.034 · Cited by 63
Lipoplexes formed from sugar-based gemini surfactants undergo a lamellar-to-micellar phase transition at acidic pH. Evidence for a non-inverted membrane-destabilizing hexagonal phase of lipoplexes
Wasungu, L., Stuart, M. C. A., Scarzello, M., Engberts, J. B. F. N., & Hoekstra, D. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.019 · Cited by 62
Synthetic mRNAs with Superior Translation and Stability Properties
Grudzien‐Nogalska, E., Kowalska, J., Su, W., Kuhn, A. N., Slepenkov, S. V., Darżynkiewicz, E., Şahin, U., Jemielity, J., & Rhoads, R. E. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_4 · Cited by 59
High performance mRNA transfection through carbonate apatite–cationic liposome conjugates
Zohra, F. T., Chowdhury, E. H., & Akaike, T. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.050 · Cited by 58
Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34+ acute myeloid leukemia cells
Gül-Uludağ, H., Valencia‐Serna, J., Kucharski, C., Marquez‐Curtis, L. A., Jiang, X., Larratt, L. M., Janowska‐Wieczorek, A., & Uludağ, H. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.08.008 · Cited by 52
PEGylation Improves Nanoparticle Formation and Transfection Efficiency of Messenger RNA
Üzgün, S., Nica, G., Pfeifer, C., Bosinco, M., Michaelis, K., Lutz, J., Schneider, M., Rosenecker, J., & Rudolph, C. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0464-z · Cited by 51
Inhibition of Xenograft Tumor Growth by Gold Nanoparticle-DNA Oligonucleotide Conjugates-Assisted Delivery of BAX mRNA
Yeom, J., Ryou, S.-M., Won, M., Park, M., Bae, J., & Lee, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075369 · Cited by 51
Synthetic mRNAs for manipulating cellular phenotypes: an overview
Quabius, E. S., & Krupp, G. (2014) · New Biotechnology · doi:10.1016/j.nbt.2014.04.008 · Cited by 47
Delivery of shRNA using gold nanoparticle–DNA oligonucleotide conjugates as a universal carrier
Ryou, S.-M., Kim, S., Jang, H. H., Kim, J., Yeom, J., Eom, M. S., Bae, J., Han, M. S., & Lee, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.115 · Cited by 45
Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications
Strenkowska, M., Kowalska, J., Łukaszewicz, M., Zuberek, J., Su, W., Rhoads, R. E., Darżynkiewicz, E., & Jemielity, J. (2010) · New Journal of Chemistry · doi:10.1039/b9nj00644c · Cited by 42
Pharmaceutical Polymeric Nanoparticles Prepared by the Double Emulsion- Solvent Evaporation Technique
Piñón‐Segundo, E., Nava-Arzaluz, M. G., & Lechuga‐Ballesteros, D. (2012) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221112802652606 · Cited by 42
Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
Shi, J., Xiao, Z., Votruba, A. R., Vilos, C., & Farokhzad, O. C. (2011) · Angewandte Chemie · doi:10.1002/ange.201101554 · Cited by 41
Self-citation
Multi-Level Kinetic Model of mRNA Delivery via Transfection of Lipoplexes
Ligon, T. S., Leonhardt, C., & Rädler, J. O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107148 · Cited by 36
mRNA Transfection of Mouse and Human Neural Stem Cell Cultures
McLenachan, S., Zhang, D., Palomo, A. B. A., Edel, M. J., & Chen, F. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083596 · Cited by 33
Interaction of Poliovirus-Specific RNAs with HeLa Cells and E. coli
Koch, G. (1973) · Modern aspects of electrochemistry · doi:10.1007/978-3-642-65772-6_4 · Cited by 32
Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self-adjuvanted mRNA.
Kübler, H. R., Maurer, T., Stenzl, A., Feyerabend, S., Steiner, U., Schostak, M., Schultze‐Seemann, W., Dorp, F. V., Pilla, L., Viatali, G., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.29.15_suppl.4535 · Cited by 31
Programming Human Dendritic Cells with mRNA
Lee, J. W., Boczkowski, D., & Nair, S. K. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_8 · Cited by 31
Drastic effect of nanoapatite particles on liposome-mediated mRNA delivery to mammalian cells
Zohra, F. T., Chowdhury, E. H., Nagaoka, M., & Akaike, T. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.06.031 · Cited by 26
In Vivo and In Vitro Analysis of Poly(A) Length Effects on mRNA Translation
Peng, J., Murray, E. L., & Schoenberg, D. R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-033-1_15 · Cited by 23
A multicenter phase II randomized study of Cremophor‐free polymeric nanoparticle formulation of paclitaxel in women with locally advanced and/or metastatic breast cancer after failure of anthracycline
Ranade, A. A., Bapsy, P. P., Nag, S. M., Digumarti, R., Raina, V., Advani, S. H., Patil, S., Maru, A., Gangadharan, V. P., Goswami, C., et al. (2012) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.12035 · Cited by 21
mRNA Delivery through Fibronectin Associated Liposome-Apatite Particles: A New Approach for Enhanced mRNA Transfection to Mammalian Cell
Zohra, F. T., Maitani, Y., & Akaike, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.111 · Cited by 21
Nature Biotechnology's academic spinouts of 2013
Bouchie, A. J., Allison, M., Webb, S., & DeFrancesco, L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2846 · Cited by 14
Transient Gene Expression in Tobacco using Gibson Assembly and the Gene Gun
Mattozzi, M. D., Voges, M. J. E. E. E., Silver, P. A., & Way, J. C. (2014) · Journal of Visualized Experiments · doi:10.3791/51234 · Cited by 8
A phase I/IIa study of the mRNA based cancer vaccine CV9103 prepared with the RNActive technology results in distinctly longer survival than predicted by the Halabi Nomogram which correlates with the induction of antigen-specific immune responses
Kallen, K., Gnad-Vogt, U., Scheel, B., Rippin, G., & Stenzl, A. (2013) · Journal for ImmunoTherapy of Cancer · doi:10.1186/2051-1426-1-s1-p219 · Cited by 6
7046 POSTER Final Analysis of a Phase l/lla Study With CV9103, an Intradermally Administered Prostate Cancer Immunotherapy Based on Self Adjuvanted mRNA
Kübier, H., Stenzl, A., Schultze‐Seemann, W., Dorp, F. V., Pilla, L., Hampel, C., Jocham, D., Center for Cancer Research and Therapeutic Development, & Miller, K. (2011) · European Journal of Cancer · doi:10.1016/s0959-8049(11)71997-9 · Cited by 4
Untitled work
Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1
Untitled work
Harvie (2000) · doi:10.1002/(sici)1520-6017(200005)89:5

Flagged first, then by citations

Research works printed but not linked: 13

Quabius, 2015, Nat. Biotechnol., 32, 229
Stepinski, 2001, RNA, 7, 1486
Mattozzi, 2014, J. Vis. Exp., 86, e51234
Dewitte, 2014, J. Controlled Release, 194c, 28, 10.1016/j.jconrel.2014.08.011 · DOI
Koch, 1973, Curr. Top. Microbiol. Immunol., 62, 89
Pasquinelli, 1995, RNA, 1, 957
K. J. Kallen and A.Thess, Therapeutic Advances in Vaccines, 2014, vol. 2, pp. 10–31
Sebastian, 2012, J. Clin. Oncol., 2012, 30
Zhang, 2008, ACS Nano, 2, 1696, 10.1021/nn800275r · DOI
Salvador-Morales, 2009, Biomaterials, 30, 2231, 10.1016/j.biomaterials.2009.01.005 · DOI
Su, 2011, Mol. Pharm., 8, 774, 10.1021/mp100390w · DOI · Paper page
Conry, 1995, Cancer Res., 55, 1397
Anderson, 2003, Hum. Gene Ther., 14, 191, 10.1089/10430340360535751 · DOI · Paper page

Sorted by citations

Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873
Self-citation
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 767
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636
Opportunities and Challenges in the Delivery of mRNA-Based Vaccines
Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020102 · Cited by 584
The challenge and prospect of mRNA therapeutics landscape
Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107534 · Cited by 417

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Authors: Islam, M. A., Reesor, E. K. G., Xu, Y., Zope, H. R., Zetter, B. R., & Shi, J.
Affiliations: Brigham and Women's Hospital (US)
Boston Children's Hospital (US)
Corresponding author: Zetter, Bruce R.
Shi, Jinjun
ORCID: Islam, Mohammad Ariful
Reesor, Emma K. G.
Xu, Yingjie
Zetter, Bruce R.
Shi, Jinjun
Venue: Biomaterials Science
Publisher: Royal Society of Chemistry (RSC)
Published: 2015
Volume: 3
Issue: 12
Pages: 1519-1533
ISSN: 2047-4830 (ISSN-L)
2047-4849
DOI: 10.1039/c5bm00198f
PMC: PMC4641793
OpenAlex: W1945220000
Cited by: 176
References: 123
Citations by year: 2026: 9 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 16 · 2021: 22 · 2020: 27 · 2019: 16 · 2018: 24 · 2017: 13 · 2016: 11
FWCI: 6.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biomaterials Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
National Institutes of Health
National Cancer Institute (R01 CA37393, R01CA037393, R00CA160350)
DOD Prostate Cancer Research Program
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: mRNA delivery, biomaterials, nanotechnology, mRNA therapeutics, mRNA stability, innate immune response, mRNA degradation, nucleic acid delivery systems
MeSH terms: Biocompatible Materials, Biological Transport, Genetic Vectors, Humans, RNA, Messenger, Transfection, Gene Transfer Techniques, Nanotechnology

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