The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011

Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance

Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873

Inflammation in atherosclerosis

Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.

(1998) · PubMed · Cited by 4,290

The anti-inflammatory effect of exercise

Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100

Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials

Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., Skidmore, B., Stone, J. A., Thompson, D. R., & Oldridge, N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.009 · Cited by 2,239

Inflammation: the link between insulin resistance, obesity and diabetes

Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388

Exercise builds brain health: key roles of growth factor cascades and inflammation

Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268

Muscle–Organ Crosstalk: The Emerging Roles of Myokines

Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098

Muscles and their myokines

Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Chen, C.-D., Podvin, S., Gillespie, E., Leeman, S. E., & Abraham, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709805104 · Cited by 563

Muscle as a secretory organ

Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516

Exercise as a Mean to Control Low‐Grade Systemic Inflammation

Mathur, N., & Pedersen, B. K. (2008) · Mediators of Inflammation · doi:10.1155/2008/109502 · Cited by 514

Serum irisin levels in new-onset type 2 diabetes

Choi, Y., Kim, M. K., Bae, K.-H., Seo, H.-A., Jeong, J.-Y., Lee, W.-K., Kim, J., Lee, I., & Park, K. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.007 · Cited by 432

The role of intratumoral and systemic IL-6 in breast cancer

Dethlefsen, C., Højfeldt, G. W., & Højman, P. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2488-z · Cited by 372

A review of physical and cognitive interventions in aging

Bamidis, P. D., Vivas, A. B., Styliadis, C., Frantzidis, C., Klados, M. A., Schlee, W., Σιούντας, Α., & Papageorgiou, S. G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.019 · Cited by 397

Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives

Rolland, Y., Abellan van Kan, G., & Vellas, B. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.02.007 · Cited by 312

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 270

Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus

Hajj, N. E., Pliushch, G., Schneider, E., Dittrich, M. T., Müller, T., Korenkov, M., Aretz, M., Zechner, U., Lehnen, H., & Haaf, T. (2012) · Diabetes · doi:10.2337/db12-0289 · Cited by 263

Beyond Obesity and Lifestyle: A Review of 21st Century Chronic Disease Determinants

Egger, G. J., & Dixon, J. B. (2014) · BioMed Research International · doi:10.1155/2014/731685 · Cited by 264

Reproducible Isolation of Lymph Node Stromal Cells Reveals Site-Dependent Differences in Fibroblastic Reticular Cells

Fletcher, A. L., Malhotra, D., Acton, S. E., Lukacs‐Kornek, V., Bellemare‐Pelletier, A., Curry, M. S., Armant, M. A., & Turley, S. J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00035 · Cited by 244

Physiological roles of muscle-derived interleukin-6 in response to exercise

Pedersen, B. K., & Fischer, C. P. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3280ebb5b3 · Cited by 227

Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines

Pedersen, B. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00734.2009 · Cited by 221

Physical Activity and Diet Shape the Immune System during Aging

Weyh, C., Krüger, K., & Strasser, B. (2020) · Nutrients · doi:10.3390/nu12030622 · Cited by 217

Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice

Vieira‐Potter, V. J., Valentine, R. J., Wilund, K. R., Antao, N. N., Baynard, T., & Woods, J. A. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00054.2009 · Cited by 194

IL-6 signalling in exercise and disease

Pedersen, B. K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351295 · Cited by 193

Exercise Intensity and Recovery

de Oliveira, A. L. B., de Oliveira, V. N., de Agostini, G. G., Oliveira, R. J. D. S., de Oliveira, A. C. S., White, G. E., Wells, G. D., Teixeira, D. N. S., & Espíndola, F. S. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828f1ee9 · Cited by 189

Physical Activity Plays an Important Role in Body Weight Regulation

Chaput, J., Klingenberg, L., Rosenkilde, M., Gilbert, J., Tremblay, A., & Sjödin, A. M. (2010) · Journal of Obesity · doi:10.1155/2011/360257 · Cited by 186

Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna‐Romano, G., Lio, D., Carlo, D., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883840 · Cited by 168

Physical Activity and Cancer

Clague, J., & Bernstein, L. (2012) · Current Oncology Reports · doi:10.1007/s11912-012-0265-5 · Cited by 153

High intensity interval training improves liver and adipose tissue insulin sensitivity

Marcinko, K., Sikkema, S. R., Samaan, M. C., Kemp, B. E., Fullerton, M. D., & Steinberg, G. R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.006 · Cited by 146

Myokines and Resistance Training: A Narrative Review

Zunner, B. E. M., Wachsmuth, N. B., Eckstein, M. L., Scherl, L., Schierbauer, J., Haupt, S., Stumpf, C., Reusch, L., & Moser, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073501 · Cited by 146

A New Venue of TNF Targeting

Steeland, S., Libert, C., & Vandenbroucke, R. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051442 · Cited by 145

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman, L. J., Little, J. P., & Klegeris, A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.012 · Cited by 142

Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity

Rios, J. L., Bomhof, M. R., Reimer, R. A., Hart, D. A., Collins, K. H., & Herzog, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-40601-x · Cited by 136

Prostaglandin E2: From Clinical Applications to Its Potential Role in Bone- Muscle Crosstalk and Myogenic Differentiation

Mo, C., Romero‐Suarez, S., Bonewald, L. F., Johnson, M. L., & Brotto, M. (2012) · Recent Patents on Biotechnology · doi:10.2174/1872208311206030223 · Cited by 134

Exercise therapy in Type 2 diabetes

Praet, S., & van Loon, L. J. C. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0129-0 · Cited by 135

Resistance Training at Eight-Repetition Maximum Reduces the Inflammatory Milieu in Elderly Women

Phillips, M. D., Flynn, M. G., McFarlin, B. K., Stewart, L. K., & Timmerman, K. L. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181b11ab7 · Cited by 116

Skeletal muscle as an immunogenic organ

Nielsen, S. J., & Pedersen, B. K. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.02.005 · Cited by 115

Cytokine response to strenuous exercise in athletes and non-athletes—an adaptive response

Gokhale, R., Chandrashekara, S., & Vasanthakumar, K. (2007) · Cytokine · doi:10.1016/j.cyto.2007.08.006 · Cited by 113

Effects of mode and intensity on the acute exercise-induced IL-6 and CRP responses in a sedentary, overweight population

Mendham, A. E., Donges, C. E., Liberts, E. A., & Duffield, R. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1724-z · Cited by 117

Muscle-Organ Crosstalk: Focus on Immunometabolism

Bay, M. L., & Pedersen, B. K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567881 · Cited by 117

Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects

Accattato, F., Greco, M., Pullano, S. A., Carè, I., Fiorillo, A. S., Pujia, A., Montalcini, T., FOTI, D. P., Brunetti, A., & Gulletta, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178900 · Cited by 109

Physical activity, exercise and low-grade systemic inflammation

Wärnberǵ, J., Cunningham, K., Romeo, J., & Marcos, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001928 · Cited by 111

Exercise: it's the real thing!

Hawley, J. A., & Holloszy, J. O. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00185.x · Cited by 112

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

Staiger, H., Böhm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F. E., Fritsche, A., Stefan, N., Weigert, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061903 · Cited by 107

Oxidative stress in exercise training: the involvement of inflammation and peripheral signals

Magherini, F., Fiaschi, T., Marzocchini, R., Mannelli, M., Gamberi, T., Modesti, P. A., & Modesti, A. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1697438 · Cited by 104

Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice

Groover, A. L., Ryals, J. M., Guilford, B. L., Wilson, N. M., Christianson, J. A., & Wright, D. E. (2013) · Pain · doi:10.1016/j.pain.2013.07.052 · Cited by 102

The Beneficial Role of Intensive Exercise on Parkinson Disease Progression

Frazzitta, G., Balbi, P., Maestri, R., Bertotti, G., Boveri, N., & Pezzoli, G. (2013) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31828cd254 · Cited by 99

Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines

Puglisi, M. J., Vaishnav, U., Shrestha, S., Torres‐Gonzalez, M., Wood, R. J., Volek, J. S., & Fernández, M. L. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-14 · Cited by 101

Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training

Mavros, Y., Kay, S., Simpson, K. A., Baker, M. K., Wang, Y., Zhao, R. R., Meiklejohn, J., Climstein, M., O'Sullivan, A. J., de Vos, N., et al. (2014) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-014-0134-1 · Cited by 91

Influence of Physical Exercise on Traumatic Brain Injury Deficits: Scaffolding Effect

Archer, T. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9297-0 · Cited by 95

Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats

Donatto, F. F., das Neves, R. X., Rosa, F. O., Camargo, R. G., Ribeiro, H., de Matos‐Neto, E. M., & Seelaender, M. C. L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.10.021 · Cited by 88

Plasma MicroRNA Levels Differ between Endurance and Strength Athletes

Wardle, S. L., Bailey, M. E. S., Kilikevičius, A., Malkova, D., Wilson, R. H., Venckūnas, T., & Moran, C. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122107 · Cited by 86

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

Garcia, C., Karri, J. V., Zacharias, N. A., & Abd-Elsayed, A. A. (2020) · Pain and Therapy · doi:10.1007/s40122-020-00225-w · Cited by 94

The Role of Systemic Inflammation in Cancer‐Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention

Cole, C. L., Kleckner, I. R., Jatoi, A., Schwarz, E. M., & Dunne, R. F. (2018) · JCSM Clinical Reports · doi:10.17987/jcsm-cr.v3i2.65 · Cited by 84

Depressive symptoms and cognitive decline: A longitudinal analysis of potentially modifiable risk factors in community dwelling older adults

Gallagher, D., Kiss, A., Lanctôt, K. L., & Herrmann, N. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.046 · Cited by 88

The effects of exercise modalities on adiposity in obese rats

Speretta, G. F. F., Rosante, M. C., Duarte, F. O., Leite, R. D., Lino, A. D. D. S., Andre, R. A., Silvestre, J. G., Selistre-de-Araújo, H. S., & Duarte, A. C. G. D. O. (2012) · Clinics · doi:10.6061/clinics/2012(12)19 · Cited by 83

Myokines, physical activity, insulin resistance and autoimmune diseases

Díaz, B. B., González, D. A., Gannar, F., Pérez, M. C. R., & de León, A. C. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.09.002 · Cited by 82

Do sessions of cryostimulation have influence on white blood cell count, level of IL6 and total oxidative and antioxidative status in healthy men?

Lubkowska, A., Szyguła, Z., Klimek, A., & Torii, M. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1207-2 · Cited by 82

Convergence of Hormones, Inflammation, and Energy-Related Factors: A Novel Pathway of Cancer Etiology

Slattery, M. L., & Fitzpatrick, F. A. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0191 · Cited by 82

Long-standing, insulin-treated type 2 diabetes patients with complications respond well to short-term resistance and interval exercise training

Praet, S. F. E., Jonkers, R. A. M., Schep, G., Stehouwer, C. D. A., Kuipers, H., Keizer, H. A., & van Loon, L. J. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0169 · Cited by 80

Relationship between Inflammatory Cytokines and Indices of Cardiac Dysfunction following Intense Endurance Exercise

La Gerche, A., Inder, W. J., Roberts, T. J., Brosnan, M. J., Heidbuchel, H., & Prior, D. L. (2015) · PLOS ONE · doi:10.1371/journal.pone.0130031 · Cited by 80

Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect

Markovitch, D., Tyrrell, R. M., & Thompson, D. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00096.2008 · Cited by 79

Anti-Inflammatory Effect of Exercise Mediated by Toll-Like Receptor Regulation in Innate Immune Cells – A Review

Collao, N., Rada, I., Francaux, M., Deldicque, L., & Zbinden‐Foncea, H. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1682569 · Cited by 79

Exercise increases pancreatic β‐cell viability in a model of type 1 diabetes through IL‐6 signaling

de Paula, F. M. M., Leite, N. C., Vanzela, E. C., Kurauti, M. A., Dias, R. D. F., Carneiro, E. M., Boschero, A. C., & Zoppi, C. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-264820 · Cited by 78

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

Pimentel, G. D., Lira, F. S., Neto, J. C. R., Caris, A. V., Pinheiro, F., Ribeiro, E. B., do Nascimento, C. M. O., & Oyama, L. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.016 · Cited by 78

Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study

Vandercappellen, E. J., Koster, A., Savelberg, H. H. C. M., Eussen, S. J. P. M., Dagnelie, P. C., Schaper, N. C., Schram, M. T., Kallen, C., van Greevenbroek, M. M. J., Wesselius, A., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05651-3 · Cited by 76

Effects of resistance training at different loads on inflammatory markers in young adults

Forti, L. N., Roie, E. V., Njemini, R., Coudyzer, W., Beyer, I., Delecluse, C., & Bautmans, I. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3548-6 · Cited by 72

The interleukin-6 and noradrenaline mediated inflammation-stress feedback mechanism is dysregulated in metabolic syndrome: Effect of exercise

Martín-Cordero, L., García, J. J., Hinchado, M. D., & Ortega, E. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-42 · Cited by 67

Moderate exercise improves leucocyte function and decreases inflammation in diabetes

Belotto, M., Magdalon, J., Rodrigues, H. G., Vinolo, M. A. R., Curi, R., Pithon‐Curi, T. C., & Hatanaka, E. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04240.x · Cited by 66

Exercise Leads to Better Clinical Outcomes in Those Receiving Medication Plus Cognitive Behavioral Therapy for Major Depressive Disorder

Gourgouvelis, J., Yielder, P. C., Clarke, S. T., Behbahani, H., & Murphy, B. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00037 · Cited by 66

Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate-induced arthritis

Nam, J., Perera, P., Liu, J., Wu, L., Rath, B., Butterfield, T. A., & Agarwal, S. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30311 · Cited by 62

Interactions between Ambient Air Particles and Greenness on Cause-specific Mortality in Seven Korean Metropolitan Cities, 2008–2016

Kim, S., Kim, H., & Lee, J.-T. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16101866 · Cited by 63

A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals' models with mild cognitive impairment or dementia

Ayari, S., Abellard, A., Carayol, M., Guedj, É., & Gavarry, O. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112141 · Cited by 65

Effects of Treadmill Exercise on Cell Proliferation and Differentiation in the Subgranular Zone of the Dentate Gyrus in a Rat Model of Type II Diabetes

Yi, S. S., Hwang, I. K., Yoo, K., Park, O. K., Yu, J., Yan, B., Kim, I. Y., Kim, Y. N., Pai, T.-K., Song, W. J., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9870-y · Cited by 66

A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children

Izadpanah, A., Barnard, R. J., Almeda, A. J. E., Baldwin, G. C., Bridges, S. A., Shellman, E. R., Burant, C., & Roberts, C. K. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2012 · Cited by 59

Non‐nutrient causes of low‐grade, systemic inflammation: support for a ‘canary in the mineshaft’ view of obesity in chronic disease

Egger, G. J., & Dixon, J. B. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00795.x · Cited by 60

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo

Neschen, S., Katterle, Y., Richter, J., Augustin, R., Scherneck, S., Mirhashemi, F., Schürmann, A., Joost, H.-G., & Klaus, S. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00226.2007 · Cited by 58

Whole-body cryostimulation as an effective way of reducing exercise-induced inflammation and blood cholesterol in young men-->

Ziemann, E., Olek, R. A., Grzywacz, T., Kaczor, J. J., Antosiewicz, J., Skrobot, W. R., Kujach, S., & Laskowski, R. (2014) · European Cytokine Network · doi:10.1684/ecn.2014.0349 · Cited by 56

Influence of Commonly Employed Resistance Exercise Protocols on Circulating IL-6 and Indices of Insulin Sensitivity

Phillips, M. D., Mitchell, J. B., Currie-Elolf, L. M., Yellott, R. C., & Hubing, K. A. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181cc2212 · Cited by 59

The Role of Exercise in Amyotrophic Lateral Sclerosis

Chen, A., Montes, J., & Mitsumoto, H. (2008) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2008.02.003 · Cited by 56

Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men

Ziemann, E., Olek, R. A., Grzywacz, T., Antosiewicz, J., Kujach, S., Łuszczyk, M., Smaruj, M., Śledziewska, E., & Laskowski, R. (2013) · The Journal of Physiological Sciences · doi:10.1007/s12576-013-0269-4 · Cited by 56

Effect of biosynthesized gold nanoparticles by Sargassum swartzii in alloxan induced diabetic rats

Dhas, T. S., Kumar, V. G., Karthick, V., Vasanth, K., Singaravelu, G., & Govindaraju, K. (2016) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2016.09.003 · Cited by 55

ENDURANCE TRAINING ACTIVATES PANCREATIC ISLETS AMP-ACTIVATED KINASE-UNCOUPLING PROTEIN 2 PATHWAY AND REDUCES INSULIN SECRETION

Calegari, V. C., Zoppi, C. C., Rezende, L., Silveira, L. R., Carneiro, E. M., & Boschero, A. C. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0450 · Cited by 54

Exercise Physiologists Emerge as Allied Healthcare Professionals in the Era of Non-Communicable Disease Pandemics: A Report from Australia, 2006–2012

Cheema, B. S., Robergs, R. A., & Askew, C. D. (2014) · Sports Medicine · doi:10.1007/s40279-014-0173-y · Cited by 53

Effect of Yoga Module on Pro- Inflammatory and Anti-Inflammatory Cytokines in Industrial Workers of Lonavla: A Randomized Controlled Trial

Rajbhoj, P. H., Shete, S. U., Verma, A., & Bhogal, R. S. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/11426.5551 · Cited by 53

Exercise Training Modulates Adipokine Dysregulations in Metabolic Syndrome

Babaei, P., & Hoseini, R. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.01.001 · Cited by 52

Central sympatholytic therapy has anti-inflammatory properties in hypertensive postmenopausal women

Pöyhönen‐Alho, M., Manhem, K., Katzman, P., Kibarskis, A., Antikaínen, R., Erkkola, R. U., Tuomilehto, J. O., Ebeling, P. E., & Kaaja, R. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328311cf37 · Cited by 51

Should obesity be the main game? Or do we need an environmental makeover to combat the inflammatory and chronic disease epidemics?

Egger, G. J., & Dixon, J. B. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00542.x · Cited by 51

The Effect of Physical Activity on Cardiometabolic Health and Inflammation in Treated HIV Infection

Dirajlal‐Fargo, S., Webel, A. R., Longenecker, C. T., Kinley, B., Labbato, D. E., Sattar, A., & McComsey, G. A. (2015) · Antiviral Therapy · doi:10.3851/imp2998 · Cited by 55

The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review

Saeidi, A., Haghighi, M. M., Kolahdouzi, S., Daraei, A., Abderrahman, A. B., Essop, M. F., Laher, I., Hackney, A. C., & Zouhal, H. (2020) · Obesity Reviews · doi:10.1111/obr.13090 · Cited by 50

Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

Lira, F. S., Yamashita, A. S., Neto, J. C. R., Tavares, F. L., Caperuto, É. C., Carnevali, L. C., Pimentel, G. D., dos Santos, R. V. T., Júnior, M. L. B., Laviano, A., et al. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-60 · Cited by 46

The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine Expression in Young Racehorses During Training

Horohov, D. W., Sinatra, S. T., Chopra, R. K., Jankowitz, S., Betancourt, A., & Bloomer, R. J. (2012) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2012.03.017 · Cited by 46

The Effect of Aerobic Exercise on Neuroplasticity within the Motor Cortex following Stroke

Murdoch, K., Buckley, J. D., & McDonnell, M. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152377 · Cited by 45

In humans IL‐6 is released from the brain during and after exercise and paralleled by enhanced IL‐6 mRNA expression in the hippocampus of mice

Rasmussen, P., Vedel, J. ‐., Olesen, J., Adser, H., Pedersen, M. V., Hart, E. C., Secher, N. H., & Pilegaard, H. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02223.x · Cited by 44

Inflammation and the Silent Sequelae of Stroke

Becker, K. J. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0451-5 · Cited by 46

Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – A randomised controlled trial

Witham, M. D., Adams, F., McSwiggan, S., Kennedy, G., Kabir, G., Belch, J. J. F., & Khan, F. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.007 · Cited by 43

Prescription of physical exercise in Crohn's disease

Pérez, C. A. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.08.006 · Cited by 41

Clinical relevance of serum vascular endothelial growth factor and Interleukin-6 in patients with colorectal cancer

Eldesoky, A., Shoma, A. M., Mosaad, Y. M., & El-Hawary, A. K. (2011) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.80378 · Cited by 41

Effect of Nordic Walking training on iron metabolism in elderly women

Antosiewicz, J., Kortas, J. A., Prusik, K., Flis, D. J., Leaver, N., Ziemann, E., & Prusik, K. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s90413 · Cited by 40

Does 20-min arm crank ergometer exercise increase plasma interleukin-6 in individuals with cervical spinal cord injury?

Kouda, K., Furusawa, K., Sugiyama, H., Sumiya, T., Ito, T., Tajima, F., & Shimizu, K. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2004-2 · Cited by 40

Lipids in health and disease

Finkelstein, J. M., Heemels, M.-T., Shadan, S., & Weiss, U. K. (2014) · Nature · doi:10.1038/510047a · Cited by 41

The effect of water-based intervention on sleep habits and two sleep-related cytokines in children with autism

Ansari, S., AdibSaber, F., Elmieh, A., & Gholamrezaei, S. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.03.045 · Cited by 39

The anti-inflammatory effect of exercise

Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100

The role of IL-6 in mediating the anti-inflammatory effects of exercise.

Petersen, A. M. W., & Pedersen, B. K. (2006) · PubMed · Cited by 354

Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease

Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617

State of the Art Reviews: Health Benefits Related to Exercise in Patients With Chronic Low-Grade Systemic Inflammation

Pedersen, B. K. (2007) · American Journal of Lifestyle Medicine · doi:10.1177/1559827607301410 · Cited by 14

Exercise as a Mean to Control Low‐Grade Systemic Inflammation

Mathur, N., & Pedersen, B. K. (2008) · Mediators of Inflammation · doi:10.1155/2008/109502 · Cited by 514