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Cited by 260

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effect of pH on Muscle Glycolysis during Exercise

Sutton, J. R., Jones, N. L., Toews, C. J.·1981·Clinical Science
DOI 10.1042/cs0610331
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Abstract

1. Five males were studied on three occasions, after oral administration of CaCO3 (control), NH4Cl (acidosis) and NaHCO3 (alkalosis), in a dose of 0.3 g/kg, taken over a 3 h period at rest. The subjects then exercised on a cycle ergometer for 20 min at 33% maximal oxygen uptake (Vo2 max.), followed by 20 min at 66% and at 95% Vo2 max. until exhaustion. 2. Endurance at 95% Vo2 max. was longest with alkalosis (5.44 ± 1.05 min), shortest with acidosis (3.13 ± 0.97 min) and intermediate in the control study (4.56 ± 1.31 min); venous blood pH at exhaustion was 7.33 ± 0.02 (mean ±1 sem), 7.13 ± 0.02 and 7.26 ± 0.02 respectively. 3. Concentrations of plasma lactate at exhaustion were 7.10 ± 0.8 mmol/l 4.0 ± 0.5 and 7.9 ± 0.9 mmol/l in the control, acidosis and alkalosis studies respectively. 4. Muscle lactate increased most from rest to exhaustion with alkalosis to 17.1 ± 2.5 μmol/g and least with acidosis to 12.2 ± 1.4 μmol/g. Muscle glycogen depletion was comparable in control and alkalosis studies. 5. The lower plasma lactate concentration during exercise in acidosis compared with control and alkalosis appears to be due to an inhibition of muscle glycolysis combined with a reduction in lactate efflux from muscle.

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Metadata

Authors
Sutton, J. R., Jones, N. L., & Toews, C. J.
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
1981-09-01
Volume
61
Issue
3
Pages
331-338
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs0610331
OpenAlex
W137976010
Cited by
260
References
1
FWCI
7.20
Type
journal article
Language
en
Open access
closed

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