Cited by 977Hair Growth and Disordersdental development and anomaliesSkin and Cellular Biology Research

The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.

Molecular Mechanisms Regulating Hair Follicle Development

Open access

Millar, Sarah E.·2002·Journal of Investigative Dermatology

DOI 10.1046/j.0022-202x.2001.01670.x

Open this paper in CoChat — free account Open PDF

Abstract

Clinical conditions causing hair loss, such as androgenetic alopecia, alopecia areata, and scarring alopecia, can be psychologically devastating to individuals and are the target of a multimillion dollar pharmaceutical industry. The importance of the hair follicle in skin biology, however, does not rest solely with its ability to produce hair. Hair follicles are self-renewing and contain reservoirs of multipotent stem cells that are capable of regenerating the epidermis and are thought to be utilized in wound healing. Hair follicles are also the sites of origin of many neoplasias, including some basal cell carcinomas and pilomatricoma. These diseases result from inappropriate activation of signaling pathways that regulate hair follicle morphogenesis. Identification of the signaling molecules and pathways operating in developing and postnatal, cycling, hair follicles is therefore vital to our understanding of pathogenic states in the skin and may ultimately permit the development of novel therapies for skin tumors as well as for hair loss disease. The purpose of this review is to summarize recent progress in our understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.0022-202x.2001.01670.x

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vořechovský, I., Holmberg, E., Undén, A. B., Gillies, S. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,018
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
Johnson, R. L., Rothman, A., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A., Myers, R., Cox, D., Epstein, E. H., et al. (1996) · Science · doi:10.1126/science.272.5268.1668 · Cited by 1,856
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070
Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00208-2 · Cited by 1,043

Show all 131 references

Sorted by citations

Items 201–300 of 977

β-Catenin has sequential roles in the survival and specification of ventral dermis
Ohtola, J. A., Myers, J., Akhtar‐Zaidi, B., Zuzindlak, D., Sandesara, P. B., Yeh, K., Mackem, S., & Atit, R. P. (2008) · Development · doi:10.1242/dev.021170 · Cited by 75
Differential Expression of Cyclin D1 in the Human Hair Follicle
Xu, X., Lyle, S. R., Liu, Y., Solky, B. A., & Cotsarelis, G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63456-6 · Cited by 75
Neuropilins are positive regulators of Hedgehog signal transductionPreprint
Hillman, R. T., Feng, B. Y., Ni, J., Woo, W., Milenković, L., Gephart, M. H., Teruel, M. N., Oro, A. E., Chen, J., & Scott, M. P. (2011) · Genes & Development · doi:10.1101/gad.173054.111 · Cited by 82
Stem cells of the human epidermis and their niche: composition and function in epidermal regeneration and carcinogenesis
Boehnke, K., Falkowska-Hansen, B., Stark, H.-J., & Boukamp, P. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs136 · Cited by 79
Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways
Hwang, S. B., Park, H. J., & Lee, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911904 · Cited by 74
Does prostaglandin D2 hold the cure to male pattern baldness?
Nieves, A., & Garza, L. A. (2014) · Experimental Dermatology · doi:10.1111/exd.12348 · Cited by 75
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
Lee, J., Basak, J. M., Demehri, S., & Kopan, R. (2007) · Development · doi:10.1242/dev.02868 · Cited by 72
High-throughput reconstitution of epithelial–mesenchymal interaction in folliculoid microtissues by biomaterial-facilitated self-assembly of dissociated heterotypic adult cells
Yen, C.-M., Chan, C., & Lin, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.014 · Cited by 74
FGF signaling is required for initiation of feather placode development
Mandler, M., & Neubüser, A. (2004) · Development · doi:10.1242/dev.01203 · Cited by 74
Molecular Genetic and Endocrine Mechanisms of Hair Growth
Alonso, L. C., & Rosenfield, R. L. (2003) · Hormone Research in Paediatrics · doi:10.1159/000070821 · Cited by 74
Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction
Kageyama, T., Shimizu, A., Anakama, R., Nakajima, R., Suzuki, K., Okubo, Y., & Fukuda, J. (2022) · Science Advances · doi:10.1126/sciadv.add4603 · Cited by 73
SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice
Guo, L., Tang, X., Zhang, S., Jin, M., Wang, M., Deng, Z., Liu, Z., Qian, M., Shi, W., Wang, Z., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104365 · Cited by 76
Essential roles of BMPR‐IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis
Kwan, K. M., Li, A. G., Wang, X., Wurst, W., & Behringer, R. R. (2004) · genesis · doi:10.1002/gene.20021 · Cited by 73
Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin
Nie, Y., Li, S., Zheng, X., Chen, W., Li, X., Liu, Z., Hu, Y., Qiao, H., Qi, Q., Pei, Q., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00446 · Cited by 72
The biology of human hair: A multidisciplinary review
Koch, S. L., Tridico, S. R., Bernard, B. A., Shriver, M. D., & Jablonski, N. G. (2019) · American Journal of Human Biology · doi:10.1002/ajhb.23316 · Cited by 71
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development
Pispa, J., Pummila, M., Barker, P. A., Thesleff, I., & Mikkola, M. L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn232 · Cited by 71
Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex
Zouvelou, V., Luder, H., Mitsiadis, T. A., & Graf, D. (2009) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21262 · Cited by 71
Biology of the Hair Follicle
Vogt, A., McElwee, K. J., & Blume‐Peytavi, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-46911-7_1 · Cited by 70
A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis
Ali, G., Chishti, M. S., Raza, S. I., John, P. C. L., & Ahmad, W. (2007) · Human Genetics · doi:10.1007/s00439-007-0344-0 · Cited by 70
Physiological Functions and Underlying Mechanisms of Fibroblast Growth Factor (FGF) Family Members: Recent Findings and Implications for Their Pharmacological Application
Imamura, T. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00265 · Cited by 70
Impaired hair placode formation with reduced expression of hair follicle‐related genes in mice lacking Lgr4
Mohri, Y., Kato, S., Umezawa, A., Okuyama, R., & Nishimori, K. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21639 · Cited by 70
Spacing patterns on tongue surface-gustatory papilla.
Jung, H.-S., Akita, K., & Kim, J. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15272380 · Cited by 70
Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
Guha, U., Mecklenburg, L., Cowin, P., Kan, L., O'Guin, W. M., D'Vizio, D., Pestell, R. G., Paus, R., & Kessler, J. A. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63336-6 · Cited by 70
Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo
Peña-Jiménez, D., Fontenete, S., Megías, D., Torre, C. F., Graña‐Castro, O., Castellana, D., Loewe, R. P., & Pérez‐Moreno, M. (2019) · The EMBO Journal · doi:10.15252/embj.2019101688 · Cited by 70
Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
Zhang, R., Li, Y., Jia, K., Xu, X., Li, Y., Zhao, Y., Zhang, X., Zhang, J., Liu, G., Deng, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2622-x · Cited by 69
Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering
Ohyama, M., & Veraitch, O. K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.02.004 · Cited by 69
Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells
Veraitch, O. K., Mabuchi, Y., Matsuzaki, Y., Sasaki, T., Okuno, H., Tsukashima, A., Amagai, M., Okano, H., & Ohyama, M. (2017) · Scientific Reports · doi:10.1038/srep42777 · Cited by 69
Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle
Itami, S., & Inui, S. (2005) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1111/j.1087-0024.2005.10107.x · Cited by 69
Micro RNA s (mi RNA s) in the control of HF development and cycling: the next frontiers in hair research
Andl, T., & Botchkareva, N. V. (2015) · Experimental Dermatology · doi:10.1111/exd.12785 · Cited by 67
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
Brancaccio, A., Minichiello, A., Grachtchouk, M. A., Antonini, D., Sheng, H., Parlato, R., Dathan, N. A., Dlugosz, A. A., & Missero, C. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh292 · Cited by 68
A Single-Cell Transcriptome Atlas of Cashmere Goat Hair Follicle Morphogenesis
Ge, W., Zhang, W., Zhang, Y., Zheng, Y., Li, F., Wang, S., Liu, J., Tan, S., Yan, Z., Wang, L., et al. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2021.07.003 · Cited by 67
Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma
Gânier, C., Mazin, P., Herrera-Oropeza, G. E., Du-Harpur, X., Blakeley, M., Gabriel, J., Predeus, A. V., Çakır, B., Prete, M., Harun, N., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313326120 · Cited by 65
New investigational drugs for androgenetic alopecia
de Sousa, I. C. V. D., & Tosti, A. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.784743 · Cited by 67
Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients
Okamoto, M., Ogawa, Y., Watanabe, A., Sugiura, K., Shimomura, Y., Aoki, N., Nagasaka, T., Tomita, Y., & Muro, Y. (2004) · Journal of Autoimmunity · doi:10.1016/j.jaut.2004.07.004 · Cited by 67
Sox2 modulates the function of two distinct cell lineages in mouse skin
Lesko, M. H., Driskell, R. R., Kretzschmar, K., Goldie, S. J., & Watt, F. M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.08.004 · Cited by 66
Getting to the root of scales, feather and hair: As deep as odontodes?
Dhouailly, D., Godefroit, P., Martin, T., Nonchev, S., Caraguel, F., & Oftedal, O. T. (2017) · Experimental Dermatology · doi:10.1111/exd.13391 · Cited by 66
Hair regrowth through wound healing process after ablative fractional laser treatment in a murine model
Bae, J. M., Jung, H. M., Goo, B., & Park, Y. M. (2015) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22358 · Cited by 65
Derivation of Hair-Inducing Cell from Human Pluripotent Stem Cells
Gnedeva, K., Vorotelyak, E. A., Cimadamore, F., Cattarossi, G., Giusto, E., Terskikh, V. V., & Terskikh, A. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116892 · Cited by 65
Differentiation of the sebaceous gland
Niemann, C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.8486 · Cited by 65
Cellular Senescence: Ageing and Androgenetic Alopecia
Deng, Y., Wang, M., He, Y., Liu, F., Chen, L., & Xia, X. (2023) · Dermatology · doi:10.1159/000530681 · Cited by 68
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Perdigoto, C. N., Dauber, K. L., Bar, C., Tsai, P.-C., Valdés, V. J., Cohen, I., Santoriello, F. J., Zhao, D., Zheng, D., Hsu, Y., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006151 · Cited by 64
Functions of the Peroxisome Proliferator-Activated Receptor (PPAR) α and β in Skin Homeostasis, Epithelial Repair, and Morphogenesis
Icre, G., Wahli, W., & Michalik, L. (2006) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsymp.5650007 · Cited by 58
The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics
Carrasco, E., Soto‐Heredero, G., & Mittelbrunn, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112758 · Cited by 67
Model systems for regeneration: the spiny mouse, Acomys cahirinus
Maden, M., & Varholick, J. A. (2020) · Development · doi:10.1242/dev.167718 · Cited by 71
Managing the Prenatal Environment to Enhance Livestock Productivity
Greenwood, P. L., Bell, A. W., Vercoe, P. E., & Viljoen, G. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-3135-8 · Cited by 66
Cyclic Expression of Lhx2 Regulates Hair Formation
Törnqvist, G., Sandberg, A., Hägglund, A., & Carlsson, L. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000904 · Cited by 60
A review of adipocyte lineage cells and dermal papilla cells in hair follicle regeneration
Zhang, P., Kling, R. E., Ravuri, S. K., Kokai, L. E., Rubin, J. P., Chai, J., & Marra, K. G. (2014) · Journal of Tissue Engineering · doi:10.1177/2041731414556850 · Cited by 62
Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22
Yuan, S., Li, F., Meng, Q., Zhao, Y., Chen, L., Zhang, H., Xue, L., Zhang, X., Lengner, C. J., & Yu, Z. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005253 · Cited by 62
Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Castro, A. R., & Logarinho, E. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0301 · Cited by 63
Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/δ during Hair Follicle Development
Di‐Poï, N., Ng, C. Y., Tan, N. S., Yang, Z., Hemmings, B. A., Desvergne, B., Michalik, L., & Wahli, W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1696-1712.2005 · Cited by 61
β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid
Bejaoui, M., Villareal, M. O., & Isoda, H. (2019) · Aging · doi:10.18632/aging.102048 · Cited by 61
The Edar subfamily in feather placode formation.
Drew, C. F., Lin, C. M., Jiang, T. X., Blunt, G., Mou, C., Chuong, C. M., & Headon, D. J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.011 · Cited by 59
Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130
Ruiz, S., Segrelles, C., Bravo, A., Santos, M., Pérez, P., Leis, H., Jorcano, J. L., & Paramio, J. M. (2003) · Development · doi:10.1242/dev.00453 · Cited by 58
Electrochemically Triggered Assembly of Films: A One‐Pot Morphogen‐Driven Buildup
Rydzek, G., Jierry, L., Parat, A., Thomann, J., Voegel, J., Senger, B., Hemmerlé, J., Ponche, A., Frisch, B., Schaaf, P., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007436 · Cited by 58
Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling
Ahmed, N. S., Ghatak, S., Masry, M. S. E., Gnyawali, S. C., Roy, S., Amer, M., Everts, H. B., Sen, C. K., & Khanna, S. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.07.010 · Cited by 57
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat
Wang, S., Li, F., Liu, J., Zhang, Y., Zheng, Y., Ge, W., Qu, L., & Wang, X. (2020) · Cells · doi:10.3390/cells9040969 · Cited by 58
Valproic acid promotes human hair growth in in vitro culture model
Jo, S. J., Choi, S., Yoon, S., Lee, J. Y., Park, W.-S., Park, P. J., Kim, K. H., Eun, H. C., & Kwon, O. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.05.007 · Cited by 57
miRNAs, ‘stemness’ and skin
Aberdam, D., Candi, E., Knight, R. A., & Melino, G. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.09.002 · Cited by 59
Towards an integrated experimental–theoretical approach for assessing the mechanistic basis of hair and feather morphogenesis
Painter, K. J., Hunt, G. S., Wells, K. L., Johansson, J. A., & Headon, D. J. (2012) · Interface Focus · doi:10.1098/rsfs.2011.0122 · Cited by 60
Defining hair follicles in the age of stem cell bioengineering
Chuong, C.-M., Cotsarelis, G., & Stenn, K. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700947 · Cited by 56
Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling
Suzuki, K., Yamaguchi, Y., Villacorte-Tabelin, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M. M., Nakagata, N., Tsukiyama, T., Yamaguchi, T. P., et al. (2009) · Development · doi:10.1242/dev.021295 · Cited by 58
TGF‐β2 is specifically expressed in human dermal papilla cells and modulates hair folliculogenesis
Inoue, K., Aoi, N., Yamauchi, Y., Sato, T., Suga, H., Eto, H., D, H. K. M., Tabata, Y., & Yoshimura, K. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00739.x · Cited by 59
Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction
Huang, C.-F., Chang, Y., Hsueh, Y., Huang, C.-W., Wang, D.-H., Huang, T.-C., Wu, Y.-T., Su, F., Hughes, M. W., Chuong, C., et al. (2016) · Scientific Reports · doi:10.1038/srep26436 · Cited by 56
Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis
Lee, S.-H., Seo, S. H., Lee, D. H., Pi, L., Lee, W., & Choi, K. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.04.038 · Cited by 58
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells
CASTILHO, R. M., SQUARIZE, C. H., Patel, V., Millar, S. E., Zheng, Y., Molinolo, A., & Gutkind, J. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210322 · Cited by 56
Self-citation
Tbx18 Targets Dermal Condensates for Labeling, Isolation, and Gene Ablation during Embryonic Hair Follicle Formation
Grisanti, L., Clavel, C., Cai, X., Rezza, A., Tsai, S., Sennett, R., Mumau, M. D., Cai, C., & Rendl, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.329 · Cited by 55
Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis
Jo, S. J., Shin, H., Park, Y. W., Paik, S. H., Park, W. S., Jeong, Y. S., Shin, H. J., & Kwon, O. (2014) · The Journal of Dermatology · doi:10.1111/1346-8138.12422 · Cited by 57
Reprograming the immune niche for skin tissue regeneration – From cellular mechanisms to biomaterials applications
Mu, R., de Souza, S. C., Liao, Z., Dong, L., & Wang, C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114298 · Cited by 57
Versican gene: Regulation by the β-catenin signaling pathway plays a significant role in dermal papilla cell aggregative growth
Yang, Y., Li, Y., Wang, Y., Wu, J., Yang, G., Yang, T., Gao, Y., & Lu, Y. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.09.011 · Cited by 54
Redefining the structure of the hair follicle by 3D clonal analysis
Sequeira, I., & Nicolas, J.-F. (2012) · Development · doi:10.1242/dev.081091 · Cited by 54
Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin
Riche, A. L., Aberdam, É., Marchand, L., Frank, E., Jahoda, C. A. B., Petit, I., Bordes, S., Closs, B., & Aberdam, D. (2019) · Stem Cells · doi:10.1002/stem.3043 · Cited by 56
The cellular basis of mechanosensory Merkel-cell innervation during development
Jenkins, B. A., Fontecilla, N. M., Lu, C. P.-J., Fuchs, E. V., & Lumpkin, E. A. (2019) · eLife · doi:10.7554/elife.42633 · Cited by 53
The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles.
Gai, Z., Gui, T., & Muragaki, Y. (2011) · PubMed · doi:10.14670/hh-26.915 · Cited by 53
Epithelioma of Malherbe: new ultrasound patterns
Solivetti, F. M., Elia, F., Drusco, A., Panetta, C., Amantea, A., & Carlo, A. D. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-42 · Cited by 53
A Small Deletion Hotspot in the Type II Keratin GenemK6irs1/Krt2-6gon Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation
Kikkawa, Y., Oyama, A., Ishii, R., Miura, I., Amano, T., Ishii, Y., Yoshikawa, Y., Masuya, H., Wakana, S., Shiroishi, T., et al. (2003) · Genetics · doi:10.1093/genetics/165.2.721 · Cited by 53
Sculpting Skin Appendages Out of Epidermal Layers Via Temporally and Spatially Regulated Apoptotic Events
Chang, C., Yu, M., Wu, P., Jiang, T., Yu, H., Widelitz, R. B., & Chuong, C. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22611.x · Cited by 53
An overview on congenital alopecia in domestic animals
Mecklenburg, L. (2006) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2006.00544.x · Cited by 52
Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality
Qiu, W., Li, X., Tang, H., Huang, A. S., Panteleyev, A. A., Owens, D. M., & Su, G. H. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.400 · Cited by 52
Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls
Abreu, C. M., & Marques, A. P. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10235 · Cited by 50
Expression and localization of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 in human epidermal appendages: a comparison study by immunofluorescence
Man, X., Yang, X., Cai, S., Bu, Z., Wu, X., Lu, Z., & Zheng, M. (2009) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2008.03104.x · Cited by 51
Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers
Lim, T. C., Leong, M. F., Lu, H., Du, C., Gao, S., Wan, A. C. A., & Ying, J. Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.068 · Cited by 51
Fibroblast morphogenesis on 3D collagen matrices: The balance between cell clustering and cell migration
da Rocha-Azevedo, B., & Grinnell, F. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.003 · Cited by 51
Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing ΔNp63α
Romano, R., Smalley, K., Liu, S., & Sinha, S. (2010) · Development · doi:10.1242/dev.045427 · Cited by 51
Bottom‐up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration
Wang, J., Miao, Y., Huang, Y., Lin, B., Liu, X., Xiao, S., Du, L., Hu, Z., & Xing, M. M. Q. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700447 · Cited by 51
Repair and regeneration: opportunities for carcinogenesis from tissue stem cells
Perryman, S. V., & Sylvester, K. G. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00400.x · Cited by 51
Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration
Derman, İ. D., Rivera, T., Garriga-Cerda, L., Singh, Y. P., Saini, S., Abaci, H. E., & Ozbolat, I. T. (2024) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ad878c · Cited by 55
Congenital hair loss disorders: Rare, but not too rare
Shimomura, Y. (2011) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2011.01395.x · Cited by 50
Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures
Casale, C., Imparato, G., Urciuolo, F., & Netti, P. A. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.047 · Cited by 50
Scientific foundations and current state of trace evidence—A review
Trejos, T., Koch, S. L., & Mehltretter, A. H. (2020) · Forensic Chemistry · doi:10.1016/j.forc.2020.100223 · Cited by 60
Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
Kageyama, T., Chun, Y., & Fukuda, J. (2021) · Scientific Reports · doi:10.1038/s41598-020-79722-z · Cited by 51
Tissue engineering for the oncologic urinary bladder
Drewa, T. A., Adamowicz, J., & Sharma, A. K. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.158 · Cited by 50
Review of the Hair Follicle Origin Hypothesis for Basal Cell Carcinoma
Donovan, J. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01236.x · Cited by 49
As a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells
Xiao, S., Miao, Y., Wang, J., Jiang, W., Fan, Z., Liu, X., & Hu, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-01105-8 · Cited by 49
Engineering the niche for hair regeneration — A critical review
Nilforoushzadeh, M. A., Zare, M., Zarrintaj, P., Alizadeh, E., Taghiabadi, E., Heidari‐Kharaji, M., Amirkhani, M. A., Saeb, M. R., & Mozafari, M. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.08.012 · Cited by 52
The role of activins and follistatins in skin and hair follicle development and function
McDowall, M., Edwards, N. M., Jahoda, C. A. B., & Hynd, P. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.005 · Cited by 49
Fullerene nanomaterials potentiate hair growth
Zhou, Z., Lenk, R., Dellinger, A. L., MacFarland, D. K., Kumar, K., Wilson, S. R., & Kepley, C. L. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.09.005 · Cited by 48
Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
Fessing, M. Y., Sharova, T. Y., Sharov, A. A., Atoyan, R., & Botchkarev, V. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060227 · Cited by 47
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice
Xing, F., Yi, W., Fang, M., Su, M., & Lei, T. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3391 · Cited by 47
An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities
Daszczuk, P., Mazurek, P., Pieczonka, T. D., Olczak, A., Boryń, Ł. M., & Kobielak, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.595178 · Cited by 46
Ras signaling is essential for skin development
Drosten, M., Lechuga, C. G., & Barbacid, M. (2014) · Oncogene · doi:10.1038/onc.2013.254 · Cited by 46

Authors: Millar, S. E.
Affiliations: University of Pennsylvania (US)
Corresponding author: Millar, Sarah E.
ORCID: Millar, Sarah E.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2002-02
Volume: 118
Issue: 2
Pages: 216-225
ISSN: 0022-202X (ISSN-L)
DOI: 10.1046/j.0022-202x.2001.01670.x
OpenAlex: W2034432190
Cited by: 967
References: 131
Citations by year: 2026: 27 · 2025: 39 · 2024: 45 · 2023: 51 · 2022: 56 · 2021: 46 · 2020: 57 · 2019: 43 · 2018: 45 · 2017: 40 · 2016: 32 · 2015: 41 · 2014: 43 · 2013: 41 · 2012: 51
FWCI: 8.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5052 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alopecia Areata Foundation
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Health Sciences › Dentistry › General Dentistry › dental development and anomalies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: hair follicle development, hair follicle morphogenesis, hair loss, androgenetic alopecia, alopecia areata, scarring alopecia, hair follicle stem cells, signaling pathways, basal cell carcinoma, pilomatrixoma, skin tumors, epidermal regeneration, wound healing
MeSH terms: Animals, Cell Communication, Cell Division, Embryo, Mammalian, Embryo, Nonmammalian, Embryonic and Fetal Development, Humans, Skin, Signal Transduction, Hair Follicle

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Mechanisms Regulating Hair Follicle Development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks