Cited by 977Hair Growth and Disordersdental development and anomaliesSkin and Cellular Biology Research

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Molecular Mechanisms Regulating Hair Follicle Development

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Millar, Sarah E.·2002·Journal of Investigative Dermatology

DOI 10.1046/j.0022-202x.2001.01670.x

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Abstract

Clinical conditions causing hair loss, such as androgenetic alopecia, alopecia areata, and scarring alopecia, can be psychologically devastating to individuals and are the target of a multimillion dollar pharmaceutical industry. The importance of the hair follicle in skin biology, however, does not rest solely with its ability to produce hair. Hair follicles are self-renewing and contain reservoirs of multipotent stem cells that are capable of regenerating the epidermis and are thought to be utilized in wound healing. Hair follicles are also the sites of origin of many neoplasias, including some basal cell carcinomas and pilomatricoma. These diseases result from inappropriate activation of signaling pathways that regulate hair follicle morphogenesis. Identification of the signaling molecules and pathways operating in developing and postnatal, cycling, hair follicles is therefore vital to our understanding of pathogenic states in the skin and may ultimately permit the development of novel therapies for skin tumors as well as for hair loss disease. The purpose of this review is to summarize recent progress in our understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic.

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Self-citation

Authors: Millar, S. E.
Affiliations: University of Pennsylvania (US)
Corresponding author: Millar, Sarah E.
ORCID: Millar, Sarah E.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2002-02
Volume: 118
Issue: 2
Pages: 216-225
ISSN: 0022-202X (ISSN-L)
DOI: 10.1046/j.0022-202x.2001.01670.x
OpenAlex: W2034432190
Cited by: 967
References: 131
Citations by year: 2026: 27 · 2025: 39 · 2024: 45 · 2023: 51 · 2022: 56 · 2021: 46 · 2020: 57 · 2019: 43 · 2018: 45 · 2017: 40 · 2016: 32 · 2015: 41 · 2014: 43 · 2013: 41 · 2012: 51
FWCI: 8.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5052 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alopecia Areata Foundation
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Health Sciences › Dentistry › General Dentistry › dental development and anomalies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: hair follicle development, hair follicle morphogenesis, hair loss, androgenetic alopecia, alopecia areata, scarring alopecia, hair follicle stem cells, signaling pathways, basal cell carcinoma, pilomatrixoma, skin tumors, epidermal regeneration, wound healing
MeSH terms: Animals, Cell Communication, Cell Division, Embryo, Mammalian, Embryo, Nonmammalian, Embryonic and Fetal Development, Humans, Skin, Signal Transduction, Hair Follicle

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Molecular Mechanisms Regulating Hair Follicle Development

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