Maternal behavior regulates long‐term hippocampal expression of BAX and apoptosis in the offspring
Abstract
Naturally occurring variations in maternal care influence hippocampal development in the rat. In the present study we found that variations in maternal licking/grooming (LG) during the first week of life are associated with altered hippocampal expression of BAX (group‐1 tumor necrosis factor family mediated cell death effector) in 90‐day‐old male offspring. BAX‐like immunoreactivity on western blots is significantly increased in the adult offspring of low‐level LG mothers. There is no effect of maternal care on levels of either B‐cell lymphoma‐2 (BCL‐2) (group‐II mitochondria mediated cell death suppressor) or BAD (group‐III endoplasmic reticulum mediated cell death effector). The most striking biochemical event in apoptosis is DNA fragmentation. Terminal deoxynucleotidyl transerferase (Tdt)‐mediated dUTP‐biotin nick‐end labeling (TUNEL) and 4′,6′‐diamidino‐2‐phenylindole hydrochloride (DAPI) staining showed that the number of TUNEL‐positive cells in both the dentate gyrus and CA1 region of the hippocampus is significantly increased in the adult offspring of low‐level LG mothers. In conclusion, we propose that hippocampal neurons in the offspring of low‐level LG mothers may be more vulnerable to loss through apoptosis.
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Animal research suggests that infant-responsive maternal behavior is causally related to the offspring's long-term developmental outcome in domains including cognitive development, stress reactivity, and maternal behavior in adulthood.
“Animal research suggests that infant-responsive maternal behavior is causally related to the offspring’s long-term developmental outcome in a number of domains, including cognitive development (5;6) , stress reactivity (7–9) and maternal behavior in adulthood (7;10).”
From What’s in a smile? Maternal brain responses to infant facial cues (2008) · cites this paper as [6]
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Self-citationMaternal care is similar for rat pups subjected to birth hypoxia and for controls
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Long-Term Impact of Early-Life Stress on Hippocampal Apoptotic Gene Expression in BALB/c Mice
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Long-term Impact of Early-Life Stress on Hippocampal Apoptotic Gene Expression in MicePreprint
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Self-citation
- Authors
- Weaver, I. C. G., Grant, R. J., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
- Corresponding author
- Meaney, Michael J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 82
- Issue
- 4
- Pages
- 998-1002
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1550381749
- Cited by
- 73
- References
- 50
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- maternal care, hippocampus, Bax, apoptosis, Bcl-2, Bad, DNA fragmentation, TUNEL, dentate gyrus, CA1 region, offspring neurodevelopment
- MeSH terms
- Animals, Behavior, Animal, Carrier Proteins, Female, Hippocampus, Male, Maternal Behavior, Proto-Oncogene Proteins, Time, Blotting, Western, Apoptosis, Proto-Oncogene Proteins c-bcl-2, In Situ Nick-End Labeling, Rats, Long-Evans, bcl-Associated Death Protein, bcl-2-Associated X Protein, Rats
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