Cited by 73Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolNeuroendocrine regulation and behavior

Maternal behavior regulates long‐term hippocampal expression of BAX and apoptosis in the offspring

Weaver, Ian C. G., Grant, Rebecca J., Meaney, Michael J.·2002·Journal of Neurochemistry

Abstract

Naturally occurring variations in maternal care influence hippocampal development in the rat. In the present study we found that variations in maternal licking/grooming (LG) during the first week of life are associated with altered hippocampal expression of BAX (group‐1 tumor necrosis factor family mediated cell death effector) in 90‐day‐old male offspring. BAX‐like immunoreactivity on western blots is significantly increased in the adult offspring of low‐level LG mothers. There is no effect of maternal care on levels of either B‐cell lymphoma‐2 (BCL‐2) (group‐II mitochondria mediated cell death suppressor) or BAD (group‐III endoplasmic reticulum mediated cell death effector). The most striking biochemical event in apoptosis is DNA fragmentation. Terminal deoxynucleotidyl transerferase (Tdt)‐mediated dUTP‐biotin nick‐end labeling (TUNEL) and 4′,6′‐diamidino‐2‐phenylindole hydrochloride (DAPI) staining showed that the number of TUNEL‐positive cells in both the dentate gyrus and CA1 region of the hippocampus is significantly increased in the adult offspring of low‐level LG mothers. In conclusion, we propose that hippocampal neurons in the offspring of low‐level LG mothers may be more vulnerable to loss through apoptosis.

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Crossref · 10.1046/j.1471-4159.2002.01054.x

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  • Animal research suggests that infant-responsive maternal behavior is causally related to the offspring's long-term developmental outcome in domains including cognitive development, stress reactivity, and maternal behavior in adulthood.

    “Animal research suggests that infant-responsive maternal behavior is causally related to the offspring’s long-term developmental outcome in a number of domains, including cognitive development (5;6) , stress reactivity (7–9) and maternal behavior in adulthood (7;10).”

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Authors
Weaver, I. C. G., Grant, R. J., & Meaney, M. J.
Affiliations
  • Douglas Mental Health University Institute (CA)
  • McGill University (CA)
Corresponding author
Meaney, Michael J.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2002-08
Volume
82
Issue
4
Pages
998-1002
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W1550381749
Cited by
73
References
50
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
maternal care, hippocampus, Bax, apoptosis, Bcl-2, Bad, DNA fragmentation, TUNEL, dentate gyrus, CA1 region, offspring neurodevelopment
MeSH terms
Animals, Behavior, Animal, Carrier Proteins, Female, Hippocampus, Male, Maternal Behavior, Proto-Oncogene Proteins, Time, Blotting, Western, Apoptosis, Proto-Oncogene Proteins c-bcl-2, In Situ Nick-End Labeling, Rats, Long-Evans, bcl-Associated Death Protein, bcl-2-Associated X Protein, Rats

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