Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works

Inflammation in atherosclerosis

Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey

Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works

Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works

Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome

Festa, A., D’Agostino, R., Howard, G., Mykkänen, L. M., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,363 · see citing works

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1

Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012 · see citing works

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

Hansson, L., Lindholm, L. H., NISKANEN, L. K., Lanke, J., Hedner, T., Niklason, A., LUOMANMÄKI, K., Dahlöf, B., Fairé, U. D., Mörlin, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05012-0 · Cited by 1,991 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735 · see citing works

Hyperinsulinemia as an independent risk factor for ischemic heart disease

Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699 · see citing works

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474 · see citing works

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,344 · see citing works

Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

Festa, A., D’Agostino, R., Tracy, R. P., & Haffner, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1131 · Cited by 1,057 · see citing works

Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342:145-53.

Yusuf, S., & Jha, P. (2000) · Cited by 898 · see citing works

Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty

Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890 · see citing works

Interleukin-6 induces cellular insulin resistance in hepatocytes.

Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · see citing works

Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease

Kohler, H. P., & Grant, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422406 · Cited by 805 · see citing works

Adipose tissue as a buffer for daily lipid flux

Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752 · see citing works

Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis

Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.4.369 · Cited by 739 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease

Alessi, M., Peiretti, F., Morange, P., Henry, M., Nalbone, G., & Juhan-Vague, I. (1997) · Diabetes · doi:10.2337/diab.46.5.860 · Cited by 614 · see citing works

High Plasminogen Activator Inhibitor and Tissue Plasminogen Activator Levels in Plasma Precede a First Acute Myocardial Infarction in Both Men and Women: Evidence for the Fibrinolytic System as an Independent Primary Risk Factor

Thögersen, A. M., Jansson, J.-H., Boman, K., Nilsson, T. K., Weinehall, L., Huhtasaari, F., & Hallmans, G. (1998) · Circulation · doi:10.1161/01.cir.98.21.2241 · Cited by 602 · see citing works

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

Juhan-Vague, I., Alessi, M., & Vague, P. (1991) · Diabetologia · doi:10.1007/bf00403280 · Cited by 566 · see citing works

High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

Vozarova, B., Weyer, C., Lindsay, R. S., Pratley, R. E., Bogardus, C., & Tataranni, P. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.455 · Cited by 564 · see citing works

Fibrinolytic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients With Angina Pectoris

Juhan-Vague, I., Pyke, S., Alessi, M., Jespersen, J., Haverkate, F., & Thompson, S. G. (1996) · Circulation · doi:10.1161/01.cir.94.9.2057 · Cited by 551 · see citing works

Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study.

Meigs, J. B., Mittleman, M. A., Nathan, D. M., Tofler, G. H., Singer, D. E., Murphy-Sheehy, P., Lipinska, I., D’Agostino, R. B., & Wilson, P. W. F. (2000) · PubMed · doi:10.1001/jama.283.2.221 · Cited by 536 · see citing works

Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes

Ruan, H., Hacohen, N., Golub, T. R., Parijs, L. V., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1319 · Cited by 531 · see citing works

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

Unger, R. H., & Zhou, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s118 · Cited by 476 · see citing works

Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes Mellitus

Ravussin, É., & Smith, S. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04292.x · Cited by 461 · see citing works

Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects

Vague, P., Juhan-Vague, I., Aillaud, M. F., Badier, C., Viard, R., Alessi, M., & Collen, D. (1986) · Metabolism · doi:10.1016/0026-0495(86)90209-x · Cited by 443 · see citing works

Inflammatory status and insulin resistance

Grimble, R. F. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200209000-00015 · Cited by 410 · see citing works

Effects of Metformin on Insulin Resistance, Risk Factors for Cardiovascular Disease, and Plasminogen Activator Inhibitor in NIDDM Subjects: A study of two ethnic groups

Nagi, D. K., & Yudkin, J. S. (1993) · Diabetes Care · doi:10.2337/diacare.16.4.621 · Cited by 353 · see citing works

Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

Alessi, M. C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., & Juhan-Vague, I. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1374 · Cited by 344 · see citing works

Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein.

Stiko, A., Wiman, B., Hamsten, A., & Nilsson, J. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.6.1067 · Cited by 297 · see citing works

Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients – Relationship with Plasma Insulin

Juhan-Vague, I., Roul, C., Alessi, M., Ardissone, J. P., Heim, M., & Vague, P. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646598 · Cited by 289 · see citing works

Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2

Alessi, M., Juhan-Vague, I., Kooistra, T., Declerck, P. J., & Collen, D. (1988) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646997 · Cited by 289 · see citing works

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus.

Auwerx, J. H., Bouillon, R., Collen, D., & Geboers, J. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.1.68 · Cited by 276 · see citing works

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275 · see citing works

Increased Plasminogen Activator Inhibitor Type 1 in Coronary Artery Atherectomy Specimens From Type 2 Diabetic Compared With Nondiabetic Patients

Sobel, B. E., Woodcock‐Mitchell, J., Schneider, D. J., Holt, R. E., Marutsuka, K., & Gold, H. K. (1998) · Circulation · doi:10.1161/01.cir.97.22.2213 · Cited by 270 · see citing works

Insulin Inhibits the Pro-Inflammatory Transcription Factor Early Growth Response Gene-1 (Egr)-1 Expression in Mononuclear Cells (MNC) and Reduces Plasma Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) Concentrations

Aljada, A., Ghanim, H., Mohanty, P., Kapur, N., & Dandona, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8462 · Cited by 267 · see citing works

Effects of Ramipril on Plasma Fibrinolytic Balance in Patients With Acute Anterior Myocardial Infarction

Vaughan, D. E., Rouleau, J. L., Ridker, P. M., Arnold, J. M. O., Menapace, F. J., & Pfeffer, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.442 · Cited by 264 · see citing works

Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals

Eriksson, P. O., Reynisdottir, S., Lönnqvist, F., Stemme, V., Hamsten, A., & Arner, P. (1998) · Diabetologia · doi:10.1007/s001250050868 · Cited by 227 · see citing works

Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., & Loskutoff, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6902 · Cited by 226 · see citing works

The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance

van Loon, B. J. P., Kluft, C., Radder, J. K., Blankenstein, M. A., & Meinders, A. E. (1993) · Metabolism · doi:10.1016/0026-0495(93)90005-9 · Cited by 225 · see citing works

Stromal Cells Are the Main Plasminogen Activator Inhibitor-1-Producing Cells in Human Fat

Bastelica, D., Morange, P., Berthet, B., Borghi, H., Paulmyer‐Lacroix, O., Grino, M., Juhan-Vague, I., & Alessi, M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101552 · Cited by 190 · see citing works

Induction of Plasminogen Activator Inhibitor Type-1 (PAI-1) by Proinsulin and Insulin In Vivo

Nordt, T. K., Sawa, H., Fujii, S., & Sobel, B. E. (1995) · Circulation · doi:10.1161/01.cir.91.3.764 · Cited by 185 · see citing works

Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects.

Kruszynska, Y. T., Yu, J., Olefsky, J. M., & Sobel, B. E. (2000) · Diabetes · doi:10.2337/diabetes.49.4.633 · Cited by 184 · see citing works

Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation

Alessi, M., Bastelica, D., Mavri, A., Morange, P., Berthet, B., Grino, M., & Juhan-Vague, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000077401.36885.bb · Cited by 178 · see citing works

Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice

Schäfer, K., Fujisawa, K., Konstantinides, S., & Loskutoff, D. J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0750fje · Cited by 174 · see citing works

Age-Dependent Spontaneous Coronary Arterial Thrombosis in Transgenic Mice That Express a Stable Form of Human Plasminogen Activator Inhibitor-1

Eren, M., Painter, C., Atkinson, J. B., Declerck, P. J., & Vaughan, D. E. (2002) · Circulation · doi:10.1161/01.cir.0000023186.60090.fb · Cited by 170 · see citing works

Plasminogen Activator Inhibitor Type 1 Is Increased in the Arterial Wall of Type II Diabetic Subjects

Pandolfi, A., Cetrullo, D., Polishuck, R. S., Alberta, M. M., Calafiore, A., Pellegrini, G., Vitacolonna, E., Capani, F., & Consoli, A. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0801.093667 · Cited by 156 · see citing works

Visceral Fat Accumulation and Its Relation to Plasma Hemostatic Factors in Healthy Men

CIGOLINI, M., Targher, G., Andreis, I. A. B., Tonoli, M., Agostino, G., & Sandre, G. D. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.3.368 · Cited by 141 · see citing works

Influence of PAI-1 on Adipose Tissue Growth and Metabolic Parameters in a Murine Model of Diet-Induced Obesity

Morange, P., LIJNEN, H. R., Alessi, M., Kopp, F., Collen, D., & Juhan-Vague, I. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1150 · Cited by 130 · see citing works

Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis.

Nordt, T., Klassen, K. J., Schneider, D. J., & Sobel, B. E. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.12.1822 · Cited by 129 · see citing works

Lack of Plasminogen Activator Inhibitor-1 Promotes Growth and Abnormal Matrix Remodeling of Advanced Atherosclerotic Plaques in Apolipoprotein E–Deficient Mice

Luttun, A., Lupu, F., Storkebaum, E., Hoylaerts, M., Moons, L., Crawley, J. T. B., Bono, F., Poole, A. R., Tipping, P. G., Herbert, J., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.104529 · Cited by 123 · see citing works

Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss

Mavri, A., Alessi, M., Georgelin, O., Fina, F., Sentočnik, J. T., Bastelica, D., Stegnar, M., & Juhan-Vague, I. (2001) · Diabetologia · doi:10.1007/s001250100007 · Cited by 121 · see citing works

A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis

Dandona, P., & Aljada, A. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02556-0 · Cited by 121 · see citing works

Metabolic Determinants Are Much More Important Than Genetic Polymorphisms in Determining the PAI-1 Activity and Antigen Plasma Concentrations

Henry, M., Trégouët, D., Alessi, M., Aillaud, M. F., Visvikis‐Siest, S., Siest, G., Tiret, L., & Juhan-Vague, I. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.84 · Cited by 121 · see citing works

Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue.

Morange, P., Aubert, J., Peiretti, F., LIJNEN, H. R., Vague, P., Verdier, M., Négrel, R., Juhan-Vague, I., & Alessi, M. (1999) · Diabetes · doi:10.2337/diabetes.48.4.890 · Cited by 115 · see citing works

Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes

Kietzmann, T., Samoylenko, A., Roth, U., & Jungermann, K. A. (2003) · Blood · doi:10.1182/blood-2002-06-1693 · Cited by 103 · see citing works

Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women

Janand-Delenne, B., Chagnaud, C., Raccah, D., Alessi, M., Juhan-Vague, I., & Vague, P. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800585 · Cited by 103 · see citing works

Relationship of Proinsulin and Insulin to Cardiovascular Risk Factors in Nondiabetic Subjects

Haffner, S. M., Mykkänen, L. M., D, M. P. S. M., Valdez, R. A., Heisserman, J. A., & Bowsher, R. R. (1993) · Diabetes · doi:10.2337/diab.42.9.1297 · Cited by 100 · see citing works

Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-α?

CIGOLINI, M., Tonoli, M., Borgato, L., Frigotto, L., Manzato, F., Zeminian, S., Cardinale, C. J., Camin, M., Chiaramonte, E., Sandre, G. D., et al. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00281-0 · Cited by 95 · see citing works

Nutritionally Induced Obesity Is Attenuated in Transgenic Mice Overexpressing Plasminogen Activator Inhibitor-1

LIJNEN, H. R., Maquoi, E., Morange, P., Vörös, G., HOEF, B. V., Kopp, F., Collen, D., Juhan-Vague, I., & Alessi, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000044457.60665.dd · Cited by 94 · see citing works

Unsaturated Fatty Acids Increase Plasminogen Activator Inhibitor-1 Expression in Endothelial Cells

Nilsson, L., Banfi, C., Diczfalusy, U., Tremoli, E., Hamsten, A., & Eriksson, P. O. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.11.1679 · Cited by 94 · see citing works

Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNFα-induced PAI-1 expression

Грубер, Ф., Hufnagl, P., Hofer-Warbinek, R., Schmid, J. A., Breuss, J. M., Huber-Beckmann, R., Lucerna, M., Papac-Miličević, N., Harant, H., Lindley, I. J. D., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2331 · Cited by 93 · see citing works

Exclusive Action of Transmembrane TNF in Adipose Tissue Leads to Reduced Adipose Mass and Local But Not Systemic Insulin Resistance

Xu, H., Hirosumi, J., Uysal, K. T., Güler, A. D., & Hotamışlıgil, G. S. (2002) · Endocrinology · doi:10.1210/endo.143.4.8715 · Cited by 92 · see citing works

Liver Steatosis and Its Relation to Plasma Haemostatic Factors in Apparently Healthy Men - Role of the Metabolic Syndrome

CIGOLINI, M., Targher, G., Agostino, G., Tonoli, M., Muggeo, M., & Sandre, G. D. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650524 · Cited by 85 · see citing works

Proinsulin and Insulin Concentrations in Relation to Carotid Wall Thickness

Haffner, S. M., D’Agostino, R., Mykkänen, L. M., Hales, C. N., Savage, P. J., Bergman, R. N., O’Leary, D., Rewers, M., Selby, J. V., Tracy, R. P., et al. (1998) · Stroke · doi:10.1161/01.str.29.8.1498 · Cited by 83 · see citing works

Angiotensin and vascular fibrinolytic balance

Vaughan, D. A. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02273-7 · Cited by 80 · see citing works

Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries

DeYoung, M. B., Tom, C., & Dichek, D. A. (2001) · Circulation · doi:10.1161/hc4101.097110 · Cited by 79 · see citing works

Endogenous Vitronectin and Plasminogen Activator Inhibitor-1 Promote Neointima Formation in Murine Carotid Arteries

Peng, L., Bhatia, N., Parker, A. C., Zhu, Y., & Fay, W. P. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000019360.14554.53 · Cited by 74 · see citing works

Plasminogen Activator Inhibitor 1 and Vitronectin Protect Against Stenosis in a Murine Carotid Artery Ligation Model

de Waard, V., Arkenbout, E. K., Carmeliet, P., Lindner, V., & Pannekoek, H. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000042231.04318.e6 · Cited by 66 · see citing works

Effect of tumor necrosis factor alpha and transforming growth factor beta 1 on plasminogen activator inhibitor-1 secretion from subcutaneous and omental human fat cells in suspension culture

Gottschling-Zeller, H., Birgel, M., Röhrig, K., & Hauner, H. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80046-3 · Cited by 65 · see citing works

Plasma PAI-1 Levels in Obese Children – Effect of Weight Loss and Influence of PAI-1 Promoter 4G/5G Genotype

Dalmau, J., Falcó, C., Berbel, O., Castelló, R., España, F., Aznar, J., & Estellés, A. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616100 · Cited by 56 · see citing works

Low-Density Lipoprotein Particle Size Is Inversely Related to Plasminogen Activator Inhibitor-1 Levels

Festa, A., Agostino, R. B. D., Mykkänen, L. M., Tracy, R. P., Howard, B. V., & Haffner, S. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.605 · Cited by 53 · see citing works

Orexin-A Augments Voltage-Gated Ca2+ Currents and Synergistically Increases Growth Hormone (GH) Secretion with GH-Releasing Hormone in Primary Cultured Ovine Somatotropes

Xu, R., Wang, Q., Yan, M., Hernández, M. I., Gong, C., Boon, W. C., Murata, Y., Ueta, Y., & Chen, C. (2002) · Endocrinology · doi:10.1210/en.2002-220506 · Cited by 53 · see citing works

Syndrome X

Reaven, G. (1999) · Drugs · doi:10.2165/00003495-199958001-00006 · Cited by 49 · see citing works

Proinsulin-like molecules and plasminogen activator inhibitor type 1 (PAI-1) activity in diabetic and non-diabetic subjects with and without myocardial infarction

Gray, R. P. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06070-4 · Cited by 41 · see citing works

In Vivo Plasminogen Deficiency Reduces Fat Accumulation

Ellis, J. R., Yuen, L., & Hoover-Plow, J. L. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613126 · Cited by 39 · see citing works

Do PAI-1 and Vitronectin Promote or Inhibit Neointima Formation?

Konstantinides, S., Schäfer, K., & Loskutoff, D. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000047462.65341.22 · Cited by 39 · see citing works

The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM.

Samad, F., & Loskutoff, D. J. (1997) · PubMed · Cited by 38 · see citing works

Relationships between fibrinolytic and inflammatory parameters in human adipose tissue: strong contribution of TNFalpha receptors to PAI-1 levels.

Bastelica, D., Mavri, A., Verdier, M., Berthet, B., Juhan-Vague, I., & Alessi, M. (2002) · PubMed · Cited by 38 · see citing works

The Fat Mouse: A Powerful Genetic Model to Study Elevated Plasminogen Activator Inhibitor 1 in Obesity/NIDDM

David, J. L., & Samad, F. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657606 · Cited by 33 · see citing works

Plasminogen Activator Inhibitor Type 1 in Ischemic Cardiomyopathy

Cesari, M., & Rossi, G. P. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1378 · Cited by 32 · see citing works

Relationships between Fibrinolytic and Inflammatory Parameters in Human Adipose Tissue: Strong Contribution of TNFα Receptors to PAI-1 Levels

Bastelica, D., Mavri, A., Verdier, M., Berthet, B., Juhan-Vague, I., & Alessi, M. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613241 · Cited by 31 · see citing works

A Forkhead/Winged Helix-related Transcription Factor Mediates Insulin-increased Plasminogen Activator Inhibitor-1 Gene Transcription

Vulin, A. I., & Stanley, F. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112073200 · Cited by 22 · see citing works

Relation between Plasminogen Activator Inhibitor-1 and Hepatic Enzyme Concentrations in Hyperlipidemic Patients

Bruckert, É., Ankri, A., Glral, P., & Turpin, G. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648885 · Cited by 19 · see citing works

Hormonal Control of Haemostasis During Hypoglycaemia in Diabetes Mellitus

Grant, P. J., Stickland, M. H., Wiles, P. G., Davies, J. A., Wales, J. K., & Prentice, C. R. M. (1987) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651130 · Cited by 18 · see citing works

10 YEARS AFTER

Richards, D. (2004) · Evidence-Based Dentistry · doi:10.1038/sj.ebd.6400294 · Cited by 15 · see citing works

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works

Inflammation: the link between insulin resistance, obesity and diabetes

Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

Jung, U. J., & Choi, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,898 · see citing works

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441 · see citing works

The Metabolic Syndrome

Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,225 · see citing works

Metabolic syndrome: pathophysiology, management, and modulation by natural compounds

Rochlani, Y. M., Pothineni, N. V. K., Kovelamudi, S., & Mehta, J. L. (2017) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944717711379 · Cited by 1,103 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint

Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works

Cross Talk Pathways Between Coagulation and Inflammation

Foley, J. H., & Conway, E. M. (2016) · Circulation Research · doi:10.1161/circresaha.116.306853 · Cited by 585 · see citing works

Obesity as a risk factor in venous thromboembolism

Stein, P. D., Beemath, A., & Olson, R. E. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.03.012 · Cited by 588 · see citing works

Biology of Stem Cells in Human Umbilical Cord Stroma: In Situ and In Vitro Surveys

Karahüseyinoğlu, S., Çınar, Ö., Kılıç, E., Kara, F., Akay, G. G., Demiralp, D. Ö., Tükün, A., Uçkan, D., & Can, A. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0286 · Cited by 515 · see citing works

REVIEW: Plasminogen Activator Inhibitor‐1 (PAI‐1): A Key Factor Linking Fibrinolysis and Age‐Related Subclinical and Clinical Conditions

Cesari, M., Pahor, M., & Incalzi, R. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00171.x · Cited by 451 · see citing works

Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J. I., & Sodhi, K. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.13800 · Cited by 443 · see citing works

Diagnosis and management of the metabolic syndrome

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 434 · see citing works

Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study

Cesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 422 · see citing works

PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

Alessi, M.-C., & Juhan-Vague, I. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000242905.41404.68 · Cited by 390 · see citing works

Insulin resistance and cardiovascular disease

Kosmas, C. E., Bousvarou, M. D., Kostara, C. E., Papakonstantinou, E. J., Salamou, E., & Guzman, E. (2023) · Journal of International Medical Research · doi:10.1177/03000605231164548 · Cited by 413 · see citing works

Blood Coagulation: Hemostasis and Thrombin Regulation

Tanaka, K. A., Key, N. S., & Levy, J. H. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31819bcc9c · Cited by 343 · see citing works

The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review

Hughes, R., Alvarado, D. A., Swanson, K. S., & Holscher, H. D. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab119 · Cited by 301 · see citing works

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295 · see citing works

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice

Sasaki, R., Nishimura, N., Hoshino, H., Isa, Y., Kadowaki, M., Ichi, T., Tanaka, A., Nishiumi, S., Fukuda, I., Ashida, H., et al. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.008 · Cited by 300 · see citing works

The Placenta Cytokine Network and Inflammatory Signals

Mouzon, S. H., & Guerre-Millo, M. (2005) · Placenta · doi:10.1016/j.placenta.2005.08.009 · Cited by 294 · see citing works

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease

Dellas, C., & Loskutoff, D. J. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-01-0033 · Cited by 285 · see citing works

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity

Samad, F., Hester, K. D., Yang, G., Hannun, Y. A., & Bielawski, J. (2006) · Diabetes · doi:10.2337/db06-0330 · Cited by 276 · see citing works

Adipokines: New potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261 · see citing works

Role of macrophage tissue infiltration in metabolic diseases

Bouloumié, A., Curat, C. A., Sengenès, C., Lolmède, K., Miranville, A., & Busse, R. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172571.41149.52 · Cited by 262 · see citing works

Plasma leptin: Associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease

Wannamethee, S. G., Tchernova, J., Whincup, P. H., Lowe, G. D. O., Kelly, A., Rumley, A., Wallace, A. M., & Sattar, N. A. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.012 · Cited by 210 · see citing works

Circulating inflammatory markers and risks of cardiovascular and non‐cardiovascular disease

Lowe, G. D. O. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01416.x · Cited by 208 · see citing works

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)

Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 215 · see citing works

Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes

Kahn, S. E., Zinman, B., Haffner, S. M., O’Neill, M., Kravitz, B. G., Yu, D., Freed, M. I., Herman, W. H., Holman, R. R., Jones, N. P., et al. (2006) · Diabetes · doi:10.2337/db06-0116 · Cited by 188 · see citing works

Metabolic syndrome and cardiovascular risk

Alshehri, A. (2010) · Journal of Family and Community Medicine · doi:10.4103/1319-1683.71987 · Cited by 184 · see citing works

Microarray profiling of gene expression in human adipocytes in response to anthocyanins

Tsuda, T., Ueno, Y., Yoshikawa, T., Kojo, H., & Osawa, T. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.042 · Cited by 164 · see citing works

The clinical biochemistry of obesity.

Sikaris, K. A. (2004) · PubMed Central · Cited by 158 · see citing works

Fat poetry: a kingdom for PPARγ

Anghel, S. I., & Wahli, W. (2007) · Cell Research · doi:10.1038/cr.2007.48 · Cited by 156 · see citing works

Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1

Shah, C., Yang, G., Lee, I., Bielawski, J., Hannun, Y. A., & Samad, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709950200 · Cited by 155 · see citing works

Progression of Plasminogen Activator Inhibitor-1 and Fibrinogen Levels in Relation to Incident Type 2 Diabetes

Festa, A., Williams, K., Tracy, R. P., Wagenknecht, L. E., & Haffner, S. M. (2006) · Circulation · doi:10.1161/circulationaha.106.616177 · Cited by 150 · see citing works

Hemostasis and aging

Franchini, M. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.06.004 · Cited by 145 · see citing works

Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis

Aso, Y. (2007) · Frontiers in bioscience · doi:10.2741/2285 · Cited by 147 · see citing works

Obesity, hypertension and insulin resistance

Sharma, A. M., & Chetty, V. T. (2005) · Acta Diabetologica · doi:10.1007/s00592-005-0175-1 · Cited by 148 · see citing works

Metabolic Actions of Adipocyte Hormones: Focus on Adiponectin

Ahima, R. S. (2006) · Obesity · doi:10.1038/oby.2006.276 · Cited by 145 · see citing works

Regulation of plasminogen activation on cell surfaces and fibrin

Urano, T., Castellino, F., & Suzuki, Y. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14157 · Cited by 140 · see citing works

Regulation and interactions in the activation of cell-associated plasminogen

My�h�nen, H., & Vaheri, A. I. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4230-9 · Cited by 137 · see citing works

The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men

Wannamethee, S. G., Lowe, G. D. O., Shaper, A. G., Rumley, A., LENNON, L. T., & Whincup, P. H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.12.031 · Cited by 135 · see citing works

Nanoformulations of natural products for management of metabolic syndrome

Taghipour, Y. D., Hajialyani, M., Naseri, R., Hesari, M., Mohammadi, P., Stefanucci, A., Mollica, A., Farzaei, M. H., & Abdollahi, M. R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s213831 · Cited by 134 · see citing works

Adipose Tissue and Adipokines: The Association with and Application of Adipokines in Obesity

Khan, M. A., & Joseph, F. (2014) · Scientifica · doi:10.1155/2014/328592 · Cited by 115 · see citing works

Blood coagulation and the risk of atherothrombosis: a complex relationship.

Spronk, H. M. H., van der Voort, D., & Cate, H. T. (2004) · Thrombosis Journal · doi:10.1186/1477-9560-2-12 · Cited by 116 · see citing works

A Diet Rich in High-Oleic-Acid Sunflower Oil Favorably Alters Low-Density Lipoprotein Cholesterol, Triglycerides, and Factor VII Coagulant Activity

Allman-Farinelli, M. A., Gomes, K. E. P., Favaloro, E. J., & Petocz, P. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.04.008 · Cited by 115 · see citing works

Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER Study

Canonico, M., Oger, E., Conard, J., Meyer, G., Levesque, H., Trillot, N., Barrellier, M. ‐., Wahl, D. G., Emmerich, J., & Scarabin, P. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01933.x · Cited by 113 · see citing works

Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events

Feinbloom, D. B., & Bauer, K. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000181762.31694.da · Cited by 112 · see citing works

Association between the A?2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus

Simeoni, E., Hoffmann, M. M., Winkelmann, B. R., Ruiz, J., Fleury, S., Boehm, B. O., M�rz, W., & Vassalli, G. (2004) · Diabetologia · doi:10.1007/s00125-004-1494-4 · Cited by 109 · see citing works

Nicotinic acid in the management of dyslipidaemia associated with diabetes and metabolic syndrome: a position paper developed by a European Consensus Panel

Shepherd, J., Betteridge, J. D., Gaal, L. V., & Panel, O. B. O. A. E. C. (2005) · Current Medical Research and Opinion · doi:10.1185/030079905x43677 · Cited by 100 · see citing works

Circulating procoagulant microparticles in obesity

Goichot, B., Grunebaum, L., Desprez, D., Vinzio, S., Meyer, L., Schlienger, J.-L., Lessard, M., & Simon, C. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70251-3 · Cited by 99 · see citing works

Type 2 diabetes – An autoinflammatory disease driven by metabolic stress

Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 98 · see citing works

Brain Endothelial Hemostasis Regulation by Pericytes

Kim, J. A., Tran, N., Li, Z., Yang, F., Zhou, W., & Fisher, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600181 · Cited by 97 · see citing works

What is the contribution of obesity to the metabolic syndrome?

Grundy, S. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.001 · Cited by 96 · see citing works

Mixed Dyslipidemia, Metabolic Syndrome, Diabetes Mellitus, and Cardiovascular Disease: Clinical Implications

Cannon, C. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.09.067 · Cited by 96 · see citing works

Inflammatory Cytokines Interleukin-6 and Oncostatin M Induce Plasminogen Activator Inhibitor-1 in Human Adipose Tissue

Rega‐Kaun, G., Kaun, C., Weiss, T. W., Demyanets, S., Zorn, G., Kastl, S., Steiner, S., Seidinger, D., Kopp, C. W., Frey, M., et al. (2005) · Circulation · doi:10.1161/01.cir.0000161823.55935.be · Cited by 91 · see citing works

Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes

Ahn, J., Lee, H., Kim, S., & Ha, T. Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.109 · Cited by 89 · see citing works

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

Urano, T., Suzuki, Y., Iwaki, T., Sano, H., Honkura, N., & Castellino, F. (2019) · Current Drug Targets · doi:10.2174/1389450120666190715102510 · Cited by 89 · see citing works

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and Sepsis

Hermans, P. W. M., & Hazelzet, J. A. (2005) · Clinical Infectious Diseases · doi:10.1086/431996 · Cited by 87 · see citing works

Anti-inflammatory and antioxidant effects of polyphenols extracted from Antirhea borbonica medicinal plant on adipocytes exposed to Porphyromonas gingivalis and Escherichia coli lipopolysaccharides

Sage, F. L., Meilhac, O., & Gonthier, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.02.020 · Cited by 87 · see citing works

Effects of Polyphenolic Compounds on Tumor Necrosis Factor-α (TNF-α)-Induced Changes of Adipokines and Oxidative Stress in 3T3-L1 Adipocytes

Yen, G., Chen, Y., Chang, W.-T., & Hsu, C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1036992 · Cited by 84 · see citing works

Epidemiology and Incidence: The Scope of the Problem and Risk Factors for Development of Venous Thromboembolism

Stein, P. D., & Matta, F. (2010) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2010.07.001 · Cited by 82 · see citing works

CCAAT/Enhancer Binding Proteinβin relation to ER Stress, Inflammation, and Metabolic Disturbances

van der Krieken, S. E., Popeijus, H. E., Mensink, R. P., & Plat, J. (2015) · BioMed Research International · doi:10.1155/2015/324815 · Cited by 81 · see citing works

Molecular mechanisms of tumor necrosis factor‐α‐mediated plasminogen activator inhibitor‐1 expression in adipocytes

Pandey, M., Loskutoff, D. J., & Samad, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-3459fje · Cited by 80 · see citing works

Obesity and pulmonary embolism: The mounting evidence of risk and the mortality paradox

Stein, P. D., Matta, F., & Goldman, J. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.10.019 · Cited by 81 · see citing works

Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue

Yu, I.-C. I., Lin, H., Liu, N.-C., Wang, R.-S., Sparks, J. D., Yeh, S., & Chang, C. (2008) · Endocrinology · doi:10.1210/en.2007-0516 · Cited by 80 · see citing works

Endothelial Dysfunction, Inflammation and Diabetes

Dandona, P., Aljada, A., Chaudhuri, A., & Mohanty, P. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000032407.88070.0a · Cited by 77 · see citing works

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study

Madách, K., Aladzsity, I., Szilágyi, Á., Füst, G., Gál, J., Pénzes, I., & Prohászka, Z. (2010) · Critical Care · doi:10.1186/cc8992 · Cited by 75 · see citing works

Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children

Martos, R., Valle, M., Morales, R. M., Cañete, R., Gavilan, M. I., & Sánchez‐Margalet, V. (2005) · Metabolism · doi:10.1016/j.metabol.2005.07.008 · Cited by 74 · see citing works

Mediterranean diet and the metabolic syndrome

Esposito, K., Ciotola, M., & Giugliano, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600297 · Cited by 74 · see citing works

Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer

Rajesh, Y., & Sarkar, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042163 · Cited by 72 · see citing works

Adipose tissue inflammation and liver pathology in human obesity

Tordjman, J., Guerre-Millo, M., & Clément, K. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74601-9 · Cited by 68 · see citing works

Obesity is strongly and independently associated with a higher prevalence of pulmonary embolism

Movahed, M. R., Khoubyari, R., Hashemzadeh, M., & Hashemzadeh, M. (2019) · Respiratory Investigation · doi:10.1016/j.resinv.2019.01.003 · Cited by 70 · see citing works

Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese

Qi, Q., Wang, J., Li, H., Yu, Z., Ye, X., Hu, F. B., Franco, O. H., Pan, A., Liu, Y., & Xu, L. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0427 · Cited by 68 · see citing works

Obesity and Thromboembolic Disease

Stein, P. D., & Goldman, J. (2009) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2009.05.006 · Cited by 67 · see citing works

Pharmacokinetics and pharmacodynamics of single doses of rivaroxaban in obese patients prior to and after bariatric surgery

Kröll, D., Stirnimann, G., Vogt, A. P., Lai, D. L. L., Borbély, Y., Altmeier, J., Schädelin, S., Candinas, D., Alberio, L., & Nett, P. C. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13243 · Cited by 65 · see citing works

Aucubin, a naturally occurring iridoid glycoside inhibits TNF-α-induced inflammatory responses through suppression of NF-κB activation in 3T3-L1 adipocytes

Park, K. S. (2013) · Cytokine · doi:10.1016/j.cyto.2013.04.005 · Cited by 64 · see citing works

Adipokines from white adipose tissue in regulation of whole body energy homeostasis

Sahu, B., & Bal, N. C. (2022) · Biochimie · doi:10.1016/j.biochi.2022.09.003 · Cited by 69 · see citing works

Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients

Nagy, B., Fülöp, T., Varga, Z., Karányi, Z., Magyar, M. T., Oláh, L., Papp, M., Facskó, A., Kappelmayer, J., Paragh, G., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-01-0030 · Cited by 62 · see citing works

Adipose Tissue and Atherothrombosis

Alessi, M., LIJNEN, H. R., Bastelica, D., & Juhan-Vague, I. (2003) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000083816 · Cited by 62 · see citing works

The ameliorating effect of carotenoid rich fraction extracted from Dunaliella salina microalga against inflammation- associated cardiac dysfunction in obese rats

El-Baz, F. K., Aly, H. F., & Abd-Alla, H. I. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.12.008 · Cited by 61 · see citing works

Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity

Samad, F., Badeanlou, L., Shah, C., & Yang, G. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1_5 · Cited by 60 · see citing works

Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation

Mastinu, A., Premoli, M., Ferrari‐Toninelli, G., Tambaro, S., Maccarinelli, G., Memo, M., & Bonini, S. A. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0013 · Cited by 60 · see citing works

Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity

Darmon, P., Dadoun, F., Boullu-Ciocca, S., Grino, M., Alessi, M.-C., & Dutour, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00654.2005 · Cited by 59 · see citing works

Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity

Kwon, E., Lee, J., Kim, Y.-S., Do, A., Choi, J., Cho, S.-J., Jung, U. J., Lee, M., Park, Y., & Choi, M. (2017) · Nutrients · doi:10.3390/nu9060569 · Cited by 59 · see citing works

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

de la Monte, S. M., Tong, M., Daiello, L. A., & Ott, B. R. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180906 · Cited by 57 · see citing works

Growth hormone, menopause and ageing: no definite evidence for 'rejuvenation' with growth hormone

Fanciulli, G., Delitala, A., & Delitala, G. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp005 · Cited by 56 · see citing works

Markers of Hemostasis and Systemic Inflammation in Heart Disease and Atherosclerosis in Smokers

MacCallum, P. K. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200406-036ms · Cited by 55 · see citing works

Metaflammatory responses during obesity: Pathomechanism and treatment

Debnath, M., Agrawal, S., Agrawal, A., & Dubey, G. P. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.10.012 · Cited by 55 · see citing works

Adipokines and Cardiovascular Risk in Cushing’s Syndrome

Valassi, E., Biller, B. M. K., Klibanski, A., & Misra, M. (2011) · Neuroendocrinology · doi:10.1159/000330416 · Cited by 53 · see citing works

Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects

Al-Hamodi, Z. H., Ismail, I. S., Saif-Ali, R., Ahmed, K. A., & Muniandy, S. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-23 · Cited by 54 · see citing works

Posterior Reversible Encephalopathy Syndrome After Transplantation: a Review

Chen, S., Hu, J., Xu, L., Brandon, D., Yu, J., & Zhang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9560-0 · Cited by 52 · see citing works

Obesity‐Associated Diseases Biomarkers Are Differently Modulated in Lean and Obese Individuals and Inversely Correlated to Plasma Polyphenolic Metabolites After 6 Weeks of Mango (Mangifera indica L.) Consumption

Fang, C., Kim, H., Barnes, R. C., Talcott, S. T., & Mertens‐Talcott, S. U. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800129 · Cited by 52 · see citing works

Metabolic Syndrome: The Constellation of Co-morbidities, A Global Threat

Madan, K., Paliwal, S., Sharma, S. K., Kesar, S., Chauhan, N., & Madan, M. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230309144825 · Cited by 55 · see citing works

Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children

Valle, M., Martos, R., Cañete, M. D., Valle, R., van Donkelaar, E. L., Bermudo, F., & Cañete, R. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12199 · Cited by 49 · see citing works

The Ternary Complex Factor Net Regulates Cell Migration through Inhibition of PAI-1 Expression

Buchwalter, G., Gross, C., & Wasylyk, B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10853-10862.2005 · Cited by 48 · see citing works

Plasminogen activator inhibitor 1 (PAI‐1): in vitro activities and clinical relevance

Horrevoets, A. J. G. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04844.x · Cited by 48 · see citing works

Plasminogen Activator Inhibitor-1 in Obstructive Sleep Apnea Patients with and without Hypertension

Zamarrón, C., Ricoy, J., Riveiro, A., & Gudé, F. (2008) · Lung · doi:10.1007/s00408-008-9076-8 · Cited by 45 · see citing works

Hypofibrinolysis in the insulin resistance syndrome: implication in cardiovascular diseases

Mavri, A., Alessi, M., & Juhan-Vague, I. (2004) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01288.x · Cited by 52 · see citing works

Hypofibrinolysis and increased PAI-1 are linked to atherothrombosis via insulin resistance and obesity.

Juhan-Vague, I., Alessi, M., & Morange, P. (2000) · PubMed · Cited by 157 · see citing works

PAI-1, Obesity, and Insulin Resistance

Juhan-Vague, I., Alessi, M., & Morange, P. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_17 · Cited by 10 · see citing works

Pathophysiology of impaired pulsatile insulin release

Bergsten, P. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200005/06)16:3 · Cited by 69 · see citing works

Regulation of Fibrinolysis in the Development of Atherothrombosis: Role of Adipose Tissue

Alessi, M., & Juhan-Vague, I. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615919 · Cited by 54 · see citing works