C. elegans: des neurones et des gènes

The structure of the nervous system of the nematode Caenorhabditis elegans

White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589

A circuit for navigation in Caenorhabditis elegans

Gray, J. M., Hill, J. J., & Bargmann, C. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409009101 · Cited by 811

Genetic Analysis of Tissue Aging in Caenorhabditis elegans : A Role for Heat-Shock Factor and Bacterial Proliferation

Garigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803

Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish

Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., et al. (2011) · Science · doi:10.1126/science.1213210 · Cited by 379

UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans

Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1466-07.2007 · Cited by 333

Teratozoospermia: spotlight on the main genetic actors in the human

Coutton, C., Escoffier, J., Martinez, G., Arnoult, C., & Ray, P. F. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv020 · Cited by 352

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation

Kang, C., You, Y.-J., & Avery, L. (2007) · Genes & Development · doi:10.1101/gad.1573107 · Cited by 294

Parallel Use of Two Behavioral Mechanisms for Chemotaxis in Caenorhabditis elegans

Iino, Y., & Yoshida, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3633-08.2009 · Cited by 264

Glycolytic enzymes localize to synapses under energy stress to support synaptic function

Jang, S., Nelson, J. C., Bend, E. G., Rodríguez-Laureano, L., Tueros, F. G., Cartagenova, L., Underwood, K., Jorgensen, E. M., & Colón-Ramos, D. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.011 · Cited by 270

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

Hamamichi, S., Rivas, R. N., Knight, A. L., Cao, S., Caldwell, K. A., & Caldwell, G. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711018105 · Cited by 268

Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Dickey, C. A., Yue, M., Lin, W.-L., Dickson, D. W., Dunmore, J. H., Lee, W. C., Zehr, C., West, G., Cao, S., Clark, A. M. K., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0746-06.2006 · Cited by 248

Dock180 and ELMO1 Proteins Cooperate to Promote Evolutionarily Conserved Rac-dependent Cell Migration

Grimsley, C. M., Kinchen, J. M., Tosello-Trampont, A.-C., Brugnera, E., Haney, L. B., Lu, M., Chen, Q., Klingele, D., Hengartner, M. O., & Ravichandran, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307087200 · Cited by 224

Indoles from commensal bacteria extend healthspan

Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., Bhingarde, J. A., Ejzak, E. A., Ranawade, A., Qadota, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706464114 · Cited by 197

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

Zhou, Q., Li, H., Li, H., Nakagawa, A., Lin, J. L. J., Lee, E.-S., Harry, B. L., Skeen-Gaar, R. R., Suehiro, Y., William, D., et al. (2016) · Science · doi:10.1126/science.aaf4777 · Cited by 198

Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME‐4, a coated‐pit protein

Sato, M., Sato, K., Liou, W., Pant, S., Harada, A., & Grant, B. D. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.54 · Cited by 177

A dynamic network simulation of the nematode tap withdrawal circuit: predictions concerning synaptic function using behavioral criteria

Wicks, S. R., Roehrig, C. J., & Rankin, C. H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-12-04017.1996 · Cited by 156

POP-1 controls axis formation during early gonadogenesis in C. elegans

Siegfried, K. R., & Kimble, J. (2002) · Development · doi:10.1242/dev.129.2.443 · Cited by 136

The Two Isoforms of the Caenorhabditis elegans Leukocyte-Common Antigen Related Receptor Tyrosine Phosphatase PTP-3 Function Independently in Axon Guidance and Synapse Formation

Ackley, B. D., Harrington, R. J., Hudson, M. L., Williams, L., Kenyon, C. J., Chisholm, A. D., & Jin, Y. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2010-05.2005 · Cited by 113

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans

Sumakovic, M., Hegermann, J., Luo, L., Husson, S. J., Schwarze, K., Olendrowitz, C., Schoofs, L., Richmond, J., & Eimer, S. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902096 · Cited by 97

Caenorhabditis elegans Gαq Regulates Egg-Laying Behavior via a PLCβ-Independent and Serotonin-Dependent Signaling Pathway and Likely Functions Both in the Nervous System and in Muscle

Bastiani, C. A., Gharib, S., Simon, M. I., & Sternberg, P. W. (2003) · Genetics · doi:10.1093/genetics/165.4.1805 · Cited by 99

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Martínez-Mármol, R., Giordano-Santini, R., Kaulich, E., Cho, A.-N., Przybyla, M., Riyadh, M. A., Robinson, E., Chew, K. Y., Amor, R., Meunier, F. A., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg2248 · Cited by 94

Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans

Russell, J., Vidal-Gadea, A. G., Makay, A., Lanam, C., & Pierce-Shimomura, J. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322512111 · Cited by 91

Viscoelastic properties of the nematode Caenorhabditis elegans , a self-similar, shear-thinning worm

Backholm, M., Ryu, W. S., & Dalnoki-Veress, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219965110 · Cited by 94

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

Morsci, N. S., Hall, D. H., Driscoll, M., & Sheng, Z.-H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2799-15.2016 · Cited by 92

Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2

Edwards, S. L., Charlie, N. K., Richmond, J. E., Hegermann, J., Eimer, S., & Miller, K. G. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902095 · Cited by 83

SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes

Norris, A., Tammineni, P., Wang, S., Gerdes, J., Murr, A., Kwan, K. Y., Cai, Q., & Grant, B. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612730114 · Cited by 90

An Epidermal MicroRNA Regulates Neuronal Migration Through Control of the Cellular Glycosylation State

Pedersen, M. E., Snieckute, G., Kagias, K., Nehammer, C., Multhaupt, H. A. B., Couchman, J. R., & Pocock, R. (2013) · Science · doi:10.1126/science.1242528 · Cited by 80

An Organelle Gatekeeper Function for Caenorhabditis elegans UNC-16 (JIP3) at the Axon Initial Segment

Edwards, S. L., Yu, S.-C., Hoover, C. M., Phillips, B. C., Richmond, J. E., & Miller, K. G. (2013) · Genetics · doi:10.1534/genetics.112.147348 · Cited by 76

TDP‐1, the Caenorhabditis elegans ortholog of TDP‐43, limits the accumulation of double‐stranded RNA

Saldi, T. K., Ash, P. E., Wilson, G., Gonzales, P., Garrido‐Lecca, A., Roberts, C. M., Dostal, V., Gendron, T. F., Stein, L. D., Blumenthal, T., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488740 · Cited by 71

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes

Welker, N. C., Habig, J. W., & Bass, B. L. (2007) · RNA · doi:10.1261/rna.542107 · Cited by 63

C. elegans midbodies are released, phagocytosed and undergo LC3-dependent degradation independent of macroautophagy

Fazeli, G., Trinkwalder, M., Irmisch, L., & Wehman, A. M. (2016) · Journal of Cell Science · doi:10.1242/jcs.190223 · Cited by 50

A consistent muscle activation strategy underlies crawling and swimming in Caenorhabditis elegans

Butler, V. J., Branicky, R., Yemini, E., Liewald, J. F., Gottschalk, A., Kerr, R. A., Chklovskii, D. B., & Schafer, W. R. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0963 · Cited by 50

The beginning of connectomics: a commentary on White et al. (1986) ‘The structure of the nervous system of the nematode Caenorhabditis elegans ’

Emmons, S. W. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0309 · Cited by 47

Stimulation of Movement in a Quiescent, Hibernation-Like Form of Caenorhabditis elegans by Dopamine Signaling

Gaglia, M. M., & Kenyon, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3429-08.2009 · Cited by 49

Sperm-inherited organelle clearance in C. elegans relies on LC3-dependent autophagosome targeting to the pericentrosomal area

Djeddi, A., Al Rawi, S., Deuve, J. L., Perrois, C., Liu, Y.-Y., Russeau, M., Sachse, M., & Galy, V. (2015) · Development · doi:10.1242/dev.117879 · Cited by 47

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

Tezil, T., Chamoli, M., Ng, C.-P., Simon, R. P., Butler, V. J., Jung, M., Andersen, J., Kao, A. W., & Verdin, E. (2019) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-019-0037-7 · Cited by 40

LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling

Liu, H., Wang, S., Hang, W., Gao, J., Zhang, W., Cheng, Z., Yang, C., He, J., Zhou, J., Chen, J., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201705136 · Cited by 38

A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na+Chemotaxis

Wang, L., Sato, H., Satoh, Y., Tomioka, M., Kunitomo, H., & Iino, Y. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1774-16.2017 · Cited by 37

Stem cells: the new “model organism”

Drubin, D. G., & Hyman, A. A. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-03-0183 · Cited by 34

Caenorhabditis elegans VEM-1, a Novel Membrane Protein, Regulates the Guidance of Ventral Nerve Cord-Associated Axons

Runko, E., & Kaprielian, Z. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2385-04.2004 · Cited by 36

UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons

Edwards, S. L., Morrison, L. M., Yorks, R. M., Hoover, C. M., Boominathan, S., & Miller, K. G. (2015) · Genetics · doi:10.1534/genetics.115.177345 · Cited by 34

Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

Guo, H., Stamper, E. L., Sato-Carlton, A., Shimazoe, M. A., Li, X., Zhang, L., Stevens, L., Tam, K. J., Dernburg, A. F., & Carlton, P. M. (2022) · eLife · doi:10.7554/elife.77956 · Cited by 32

Identification of Residues of the Caenorhabditis elegans LIN-1 ETS Domain That Are Necessary for DNA Binding and Regulation of Vulval Cell Fates

Miley, G. R., Fantz, D., Glossip, D., Lu, X., Saito, R. M., Palmer, R. E., Inoue, T., van den Heuvel, S., Sternberg, P. W., & Kornfeld, K. (2004) · Genetics · doi:10.1534/genetics.104.029017 · Cited by 28

Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal

Zinovyeva, A. Y., Veksler-Lublinsky, I., Vashisht, A. A., Wohlschlegel, J. A., & Ambros, V. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506576112 · Cited by 29

The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans

Fujiwara, M., Hino, T., Miyamoto, R., Inada, H., Mori, I., Koga, M., Miyahara, K., Ohshima, Y., & Ishihara, T. (2015) · Genetics · doi:10.1534/genetics.115.177543 · Cited by 23

Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points

Norris, A., McManus, C. T., Wang, S., Ying, R., & Grant, B. D. (2022) · PLOS Genetics · doi:10.1371/journal.pgen.1010296 · Cited by 13

Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex

Birklbauer, M. J., Müller, F., Geetha, S. S., Matzinger, M., Mechtler, K., & Dorfer, V. (2024) · Communications Chemistry · doi:10.1038/s42004-024-01386-x · Cited by 11

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans

Williams, A. B., Heider, F., Messling, J.-E., Rieckher, M., Bloch, W., & Schumacher, B. (2019) · Genetics · doi:10.1534/genetics.119.302422 · Cited by 10

Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans

Jonk, S. M., Nicol, A., Chrysostomou, V., Lardner, E., Yu, S.-C., Stålhammar, G., Crowston, J. G., Tribble, J. R., Swoboda, P., & Williams, P. A. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103732 · Cited by 6

Dynamic Birth and Death of Argonaute Gene Family Functional Repertoire Across Caenorhabditis Nematodes

(2025) · doi:10.1093/gbe/evaf106 · Cited by 5

RG motifs promote piRNA-mediated gene silencing in C. elegans

Wallis, D. C., & Phillips, C. M. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1331 · Cited by 3

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

(2022) · doi:10.12688/wellcomeopenres.17893.1 · Cited by 3

Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda

Song, H., Kim, S., Lim, D. S., Choi, H.-J., & Lee, J. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf085 · Cited by 2

Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

(2021) · doi:10.1101/2021.10.05.463267 · Cited by 2

Functional classification of GNAI1 disorder variants in Caenorhabditis elegans uncovers conserved and cell-specific mechanisms of dysfunction

Salama, R., Peet, E., Morrione, T. L., Durant, S., Seager, M., Rennie, M., Scarlata, S., & Nechipurenko, I. (2025) · GENETICS · doi:10.1093/genetics/iyaf216 · Cited by 2

Genome-wide analysis reveals pathways important for the development and maturation of excitatory synaptic connections to GABAergic neurons

Oliver, D. B., Ramachandran, S., Biswas, K., Bénard, C. Y., Doitsidou, M., McKillop, H., Genao, N., Lemons, M. L., & Francis, M. M. (2025) · doi:10.1101/2025.07.05.663213 · Cited by 1

TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles

Rudnik, S., Li, C. H., Gottschling, D.-C., Veh, A., Barbosa, D. J., Richter, J., Stroobants, S., Schuster, B., Beck, I. M., Sedlack, R., et al. (2026) · doi:10.64898/2026.10.27.762112

A pilot study for whole proteome tagging in C. elegans

Eroglu, M., & Hobert, O. (2026) · doi:10.64898/2026.02.09.704846