Cited by 1,974Inflammatory mediators and NSAID effectsImmune cells in cancerInflammatory Bowel Disease

The DOI matches its Crossref record; 243 of the 247 references it cites were found in a registry or an index.

Inflammation and Colon Cancer

Terzić, Janoš, Grivennikov, Sergei, Karin, Eliad, Karin, Michael·2010·Gastroenterology

DOI 10.1053/j.gastro.2010.01.058

Open this paper in CoChat — free account

Abstract

The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon cancer. The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and could differ between colitis-associated and other forms of colorectal cancer. Recent work has elucidated the role of distinct immune cells, cytokines, and other immune mediators in virtually all steps of colon tumorigenesis, including initiation, promotion, progression, and metastasis. These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2010.01.058

Cites

243 of 243 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Cancer-related inflammation
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Self-citation
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Flagged first, then by citations

Show all 247 references

4 of the 247 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 1,003

TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells
Straus, D. S. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-78 · Cited by 124
Interleukin-17: A Promoter in Colorectal Cancer Progression
Wu, D., Wu, P., Huang, Q., Liu, Y., Ye, J., & Huang, J. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/436307 · Cited by 123
The Role of Probiotics in Colorectal Cancer Management
Sivamaruthi, B. S., Kesika, P., & Chaiyasut, C. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3535982 · Cited by 123
Epithelial calcineurin controls microbiota-dependent intestinal tumor development
Peuker, K., Muff, S., Wang, J., Künzel, S., Bosse, E., Zeißig, Y., Luzzi, G., Basic, M., Strigli, A., Ulbricht, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4072 · Cited by 117
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo
Kim, H., Banerjee, N., Barnes, R. C., Pfent, C. M., Talcott, S. T., Dashwood, R. H., & Mertens‐Talcott, S. U. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22484 · Cited by 117
Estrogen Receptor β Induces Antiinflammatory and Antitumorigenic Networks in Colon Cancer Cells
Edvardsson, K., Ström, A., Jonsson, P., Gustafsson, J.-Α., & Williams, C. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0452 · Cited by 116
Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor-κB Signaling for Cancer Treatment
Zeligs, K., Neuman, M. K., & Annunziata, C. M. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1374 · Cited by 117
Fusobacterium nucleatum is associated with worse prognosis in Lauren’s diffuse type gastric cancer patients
Boehm, E. T., Thon, C., Kupčinskas, J., Steponaitienė, R., Skiecevičienė, J., Canbay, A. E., Malfertheiner, P., & Link, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-73448-8 · Cited by 117
Impact of food-derived bioactive peptides on gut function and health
Bao, X., & Wu, J. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110485 · Cited by 116
Tumor fibroblast–derived epiregulin promotes growth of colitis-associated neoplasms through ERK
Neufert, C. F., Becker, C., Türeci, Ö., Waldner, M. J., Backert, I., Floh, K., Atreya, I., Leppkes, M., Jefremow, A., Vieth, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63748 · Cited by 117
Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer
Vipperla, K., & O’Keefe, S. J. (2016) · Food & Function · doi:10.1039/c5fo01276g · Cited by 117
Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine
Zhang, Y., Lu, R., Wu, S., Chatterjee, I., Zhou, D., Xia, Y., & Sun, J. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.05.010 · Cited by 113
Targeting STAT3 Signaling Pathway in Colorectal Cancer
Gargalionis, A. N., Papavassiliou, K. A., & Papavassiliou, A. G. (2021) · Biomedicines · doi:10.3390/biomedicines9081016 · Cited by 115
Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome
Du, Q., Wang, Q., Fan, H., Wang, J., Liu, X., Wang, H., Wang, Y., & Hu, R. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.02.017 · Cited by 114
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer
Moody, T. W., Nuche‐Berenguer, B., & Jensen, R. T. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000218 · Cited by 112
A catch‐22: Interleukin‐22 and cancer
Hernández, P. P., Gronke, K., & Diefenbach, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201747183 · Cited by 117
Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?
Puré, E., & Lo, A. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0011 · Cited by 112
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar, A., Reschke, L. D., Kirschen, G. W., & Borahay, M. A. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab054 · Cited by 127
Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
Li, T., Fu, B., Zhang, X., Zhou, Y., Yang, M., Cao, M., Chen, Y., Tan, Y., & Hu, R. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-1043 · Cited by 113
A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies
Mao, Y., Han, M., Chen, C., Wang, X., Han, J., Gao, Y., & Wang, S. (2021) · Nanoscale · doi:10.1039/d1nr06015e · Cited by 111
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Zhang, J., Walker, M. E., Sanidad, K. Z., Zhang, H., Liang, Y., Zhao, E., Chacón-Vargas, K., Yeliseyev, V., Parsonnet, J., Haggerty, T. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27762-y · Cited by 113
EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis
Hardbower, D. M., Coburn, L. A., Asim, M., Singh, K., Sierra, J. C., Barry, D. P., Gobert, A. P., Piazuelo, M. B., Washington, M. K., & Wilson, K. T. (2017) · Oncogene · doi:10.1038/onc.2017.23 · Cited by 109
The Antioxidant Procyanidin Reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice
Chen, L., You, Q., Hu, L., Gao, J., Meng, Q., Liu, W., Wu, X., & Xu, Q. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01910 · Cited by 109
Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer
Xiao, B., Viennois, É., Chen, Q., Wang, L., Han, M. K., Zhang, Y., Zhang, Z., Kang, Y., Wan, Y., & Merlin, D. (2018) · ACS Nano · doi:10.1021/acsnano.7b08499 · Cited by 110
The Multifaceted S100A4 Protein in Cancer and Inflammation
Ambartsumian, N. S., Klingelhöfer, J., & Grigorian, M. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9030-6_22 · Cited by 116
Multiple Roles of Toll-Like Receptor 4 in Colorectal Cancer
Yesudhas, D., Gosu, V., Anwar, M. A., & Choi, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00334 · Cited by 112
Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis
Kalisperati, P., Spanou, E., Pateras, I. S., Korkolopoulou, P. A., Varvarigou, A. A., Karavokyros, I., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Sougioultzis, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00020 · Cited by 115
Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer
Brighenti, E., Calabrese, C., Liguori, G., Giannone, F. A., Treré, D., Montanaro, L., & Derenzini, M. (2014) · Oncogene · doi:10.1038/onc.2014.1 · Cited by 111
Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury
Zhan, Y., Chen, P.-J., Sadler, W. D., Wang, F., Poe, S., Núñez, G., Eaton, K. A., & Chen, G. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0827 · Cited by 113
New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin
Motilva, V., García‐Mauriño, S., Talero, E., & Illanes, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00915.x · Cited by 106
Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression
Lin, J., Wu, C., Lu, C., Hsia, S., & Yen, G. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500759 · Cited by 105
Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis
Constante, M., Fragoso, G., Lupien‐Meilleur, J., Calvé, A., & Santos, M. M. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001089 · Cited by 110
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Silva, V. R., Santos, L. D. S., Dias, R. B., Quadros, C. A., & Bezerra, D. P. (2021) · 癌症：英文版 · doi:10.1002/cac2.12235 · Cited by 106
Association between Appendectomy and Subsequent Colorectal Cancer Development: An Asian Population Study
Wu, S., Chen, W. T., Muo, C., Ke, T., Fang, C., & Sung, F.-C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118411 · Cited by 107
Anticancer Properties of Phenolic Acids in Colon Cancer – A Review
Rosa, L. S., & Silva, N. J. A. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000468 · Cited by 108
Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
Pedrazzani, C., Mantovani, G., Fernandes, E., Bagante, F., Salvagno, G. L., Surci, N., Campagnaro, T., Ruzzenente, A., Danese, E., Lippi, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01652-0 · Cited by 105
Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank
Morris, J. S., Bradbury, K. E., Cross, A. J., Gunter, M. J., & Murphy, N. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.496 · Cited by 105
Targeting the Microenvironment in Advanced Colorectal Cancer
Tauriello, D. V. F., & Batlle, E. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.08.001 · Cited by 106
Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer
Chen, J., Sun, H.-W., Yang, Y., Chen, H., Yu, X.-J., Wu, W., Xu, Y.-T., Jin, L.-L., Wu, X., Xu, J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00377-3 · Cited by 105
A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer.
Shibutani, M., Maeda, K., Nagahara, H., Noda, E., Ohtani, H., Nishiguchi, Y., & Hirakawa, K. (2013) · PubMed · Cited by 103
Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota
Wu, M., Wu, Y., Deng, B., Li, J., Cao, H., Qu, Y., Qian, X., & Zhong, G. (2016) · Oncotarget · doi:10.18632/oncotarget.13347 · Cited by 103
A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells
Kaltschmidt, C., Banz-Jansen, C., Benhidjeb, T., Beshay, M., Förster, C., Greiner, J., Hamelmann, E., Jorch, N., Mertzlufft, F., Pfitzenmaier, J., et al. (2019) · Cancers · doi:10.3390/cancers11050655 · Cited by 102
Obesity and Obese-related Chronic Low-grade Inflammation in Promotion of Colorectal Cancer Development
Pietrzyk, Ł., Torres, A., Maciejewski, R., & Torres, K. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.10.4161 · Cited by 102
Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles
Xiao, B., Zhang, M., Viennois, É., Zhang, Y., Wei, N., Baker, M. T., Jung, Y., & Merlin, D. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.014 · Cited by 101
The Dual Role of Inflammation in Colon Carcinogenesis
Monteleone, G., Pallone, F., & Stolfi, C. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911071 · Cited by 100
The metabolism-modulating activity of IL-17 signaling in health and disease
Bechara, R., McGeachy, M. J., & Gaffen, S. L. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202191 · Cited by 101
The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans
Gochman, E., Mahajna, J. A., Shenzer, P., Dahan, A., Blatt, A., Elyakim, R., & Reznick, A. Z. (2012) · Acta Histochemica · doi:10.1016/j.acthis.2012.02.004 · Cited by 100
The Role of Prostatitis in Prostate Cancer: Meta-Analysis
Jiang, J., Li, J., Yunxia, Z., Zhu, H. Y., Liu, J., & Pumill, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0085179 · Cited by 100
Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer
Vong, L. B., Yoshitomi, T., Matsui, H., & Nagasaki, Y. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.037 · Cited by 100
Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer
Viennois, É., Xiao, B., Ayyadurai, S., Wang, L., Wang, P. G., Zhang, Q., Chen, Y., & Merlin, D. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.89 · Cited by 99
Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4/Nuclear Factor-kappa B pathway
Song, Y., Han, M., & Zhang, X. (2016) · Pharmacognosy Magazine · doi:10.4103/0973-1296.182154 · Cited by 99
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer
Xie, L., Jiang, F., Zhang, L., He, W., Liu, J. J., Li, M., Zhang, X., Xing, S., Guo, H., & Zhou, P. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv364 · Cited by 102
Alternative Healthy Eating Index 2010, Dietary Inflammatory Index and risk of mortality: results from the Whitehall II cohort study and meta-analysis of previous Dietary Inflammatory Index and mortality studies
Shivappa, N., Hébert, J. R., Mika Kivimaki, B., & Akbaraly, T. N. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517001908 · Cited by 101
Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features
Cavestro, G. M., Mannucci, A., Zuppardo, R. A., Leo, M. D., Stoffel, E. M., & Tonon, G. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.02.009 · Cited by 102
Stromal Cell PD-L1 Inhibits CD8+ T-cell Antitumor Immune Responses and Promotes Colon Cancer
O’Malley, G., Treacy, O., Lynch, K., Naicker, S. D., Leonard, N. A., Lohan, P., Dunne, P. D., Ritter, T., Egan, L. J., & Ryan, A. E. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0443 · Cited by 100
Quercetin Suppresses AOM/DSS‐Induced Colon Carcinogenesis through Its Anti‐Inflammation Effects in Mice
Lin, R., Piao, M., Song, Y., & Liu, C. (2020) · Journal of Immunology Research · doi:10.1155/2020/9242601 · Cited by 101
Dietary Inflammatory Index and Site-Specific Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis
Jayedi, A., Emadi, A., & Shab‐Bidar, S. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy015 · Cited by 101
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer
Santhanam, S., Alvarado, D. M., & Ciorba, M. A. (2015) · Translational research · doi:10.1016/j.trsl.2015.07.003 · Cited by 99
Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas
Yoon, H. H., Orrock, J. M., Foster, N. R., Sargent, D. J., Smyrk, T. C., & Sinicrope, F. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042274 · Cited by 97
Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation
Cusimano, A., Balasus, D., Azzolina, A., Augello, G., Emma, M. R., Sano, C. D., Gramignoli, R., Strom, S. C., McCubrey, J. A., Montalto, G., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4049 · Cited by 97
Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome
Singh, K., Gobert, A. P., Coburn, L. A., Barry, D. P., Allaman, M. M., Asim, M., Luis, P. B., Schneider, C. G., Milne, G. L., Boone, H. H., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00066 · Cited by 96
Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function
Yuan, Z.-W., Yang, L., Zhang, X.-S., Ji, P., Hua, Y.-L., & Wei, Y.-M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01354 · Cited by 94
Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut
Wang, T., Pan, D., Zhou, Z., You, Y., Jiang, C., Zhao, X., & Lin, X. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005662 · Cited by 100
Subunit-Specific Role of NF-κB in Cancer
Kaltschmidt, B., Greiner, J. F. W., Kadhim, H. M., & Kaltschmidt, C. (2018) · Biomedicines · doi:10.3390/biomedicines6020044 · Cited by 97
Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis
Wu, X., Song, M., Wang, M., Zheng, J., Gao, Z., Xu, F., Zhang, G., & Xiao, H. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500378 · Cited by 96
Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis‐associated colorectal cancer acting on Notch signaling and gut microbiota
Piazzi, G., D’Argenio, G., Prossomariti, A., Lembo, V., Mazzone, G., Candela, M., Biagi, E., Brigidi, P., Vitaglione, P., Fogliano, V., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28853 · Cited by 96
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis
Ro, S., Xue, X., Ramakrishnan, S. K., Cho, C., Namkoong, S., Jang, I., Semple, I. A., Ho, A., Park, H., Shah, Y. M., et al. (2016) · eLife · doi:10.7554/elife.12204 · Cited by 97
EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
Srivatsa, S., Paul, M. C., Cardone, C., Holcmann, M., Amberg, N., Pathria, P., Diamanti, M. A., Linder, M., Timelthaler, G., Dienes, H. P., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.053 · Cited by 98
Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF‐κB nucleus translocation in macrophages and induce apoptosis by activating caspases‐8 and ‐3 in human colon cancer cells
Puangpraphant, S., Berhow, M. A., Vermillion, K. E., Potts, G., & de Mejı́a, E. G. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100128 · Cited by 96
The Chemokine CXCL8 in Carcinogenesis and Drug Response
Gales, D. N., Clark, C. E., Manne, U., & Samuel, T. (2013) · ISRN Oncology · doi:10.1155/2013/859154 · Cited by 97
YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis
Taniguchi, K., Moroishi, T., de Jong, P. R., Krawczyk, M., Grebbin, B. M., Luo, H., Xu, R., Golob‐Schwarzl, N., Schweiger, C., Wang, K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620290114 · Cited by 96
Self-citation
Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation
Fazolini, N. P. B., Cruz, A. L. S., Werneck, M. B. F., Viola, J. P. B., Maya‐Monteiro, C. M., & Bozza, P. T. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1041684 · Cited by 99
The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances
Arias, M. A., Martínez‐Lostao, L., Santiago, L., Ferrández, Á., Granville, D. J., & Pardo, J. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.04.001 · Cited by 97
Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice
Zhang, X., Wei, L., Wang, J., Qin, Z., Wang, J., Lu, Y., Zheng, X., Qiu, P., Ye, Q., Ai, F., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01774 · Cited by 92
Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases
Hosseini, A., Gharibi, T., Marofi, F., Javadian, M., Babaloo, Z., & Baradaran, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29593 · Cited by 94
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression
Quandt, J., Arnovitz, S., Haghi, L., Woehlk, J., Mohsin, A., Okoreeh, M. K., Mathur, P., Emmanuel, A. O., Osman, A., Krishnan, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00889-2 · Cited by 92
NF-κB in colorectal cancer
Vaiopoulos, G., Athanasoula, K. C., & Papavassiliou, A. G. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1045-x · Cited by 91
Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer
Shibutani, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i34.9966 · Cited by 91
miR-148a inhibits colitis and colitis-associated tumorigenesis in mice
Zhu, Y., Gu, L., Li, Y., Lin, X., Shen, H., Cui, K., Chen, L., Zhou, F., Zhao, Q., Zhang, J., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.151 · Cited by 91
Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage
Shen, P. F., Zhang, Z., He, Y. J., Gu, C., Zhu, K., Li, S., Li, Y., Lu, X., Liu, J., Zhang, N., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.016 · Cited by 91
Carcinogenesis as a Result of Multiple Inflammatory and Oxidative Hits: a Comprehensive Review from Tumor Microenvironment to Gut Microbiota
Morgillo, F., Dallio, M., Corte, C. M. D., Gravina, A. G., Viscardi, G., Loguercio, C., Ciardiello, F., & Federico, A. (2018) · Neoplasia · doi:10.1016/j.neo.2018.05.002 · Cited by 99
Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance
Ebrahimi, N., Afshinpour, M., Fakhr, S. S., Kalkhoran, P. G., Shadman-Manesh, V., Adelian, S., Beiranvand, S., Rezaei‐Tazangi, F., Khorram, R., Hamblin, M. R., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.103920 · Cited by 90
Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer
Yang, P., Li, Z., Li, H., Lu, Y., Wu, H., & Li, Z. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.02.032 · Cited by 91
Cancer secretome and inflammation: The bright and the dark sides of NF-κB
Capece, D., Verzella, D., Tessitore, A., Alesse, E., Capalbo, C., & Zazzeroni, F. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.004 · Cited by 94
Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer
Grill, M., Högenauer, C., Blesl, A., Haybaeck, J., Golob‐Schwarzl, N., Ferreirós, N., Thomas, D., Gurke, R., Trötzmüller, M., Köfeler, H. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38865-4 · Cited by 92
Colorectal carcinoma in the course of inflammatory bowel diseases
Hnatyszyn, A., Hryhorowicz, S., Kaczmarek-Ryś, M., Lis, E., Słomski, R., Scott, R. J., & Pławski, A. (2019) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-019-0118-4 · Cited by 90
Colorectal Cancer Survivorship: Movement Matters
Denlinger, C. S., & Engstrom, P. F. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0098 · Cited by 92
A colon targeted drug delivery system based on alginate modificated graphene oxide for colorectal liver metastasis
Zhang, B., Yan, Y., Shen, Q., Ma, D., Huang, L., Cai, X., & Tan, S. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.05.054 · Cited by 89
Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway
Chen, M., Ye, K., Zhang, B., Xin, Q., Li, P., Kong, A. T., Wen, X., & Yang, J. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.029 · Cited by 89
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2
Li, Z.-W., Sun, B., Gong, T., Guo, S., Zhang, J., Wang, J., Sugawara, A., Jiang, M., Yan, J., Gurary, A., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.040 · Cited by 89
Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer
Xiong, Y., Wang, Y., & Tiruthani, K. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102034 · Cited by 88
C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
Ding, P., Li, L., Li, L., Lv, X., Zhou, D., Wang, Q., Chen, J., Yang, C., Xu, E., Dai, W., et al. (2020) · Theranostics · doi:10.7150/thno.45058 · Cited by 89
The role of heme iron molecules derived from red and processed meat in the pathogenesis of colorectal carcinoma
Gamage, S. M. K., Dissabandara, L., Lam, A. K.-Y., & Gopalan, V. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.03.025 · Cited by 94
Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis
Bishehsari, F., Engen, P. A., Voigt, R. M., Swanson, G., Shaikh, M., Wilber, S., Naqib, A., Green, S. J., Shetuni, B., Forsyth, C. B., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.10.011 · Cited by 76
“matory processes in the colon compromise mucosal barrier function, resulting in increased intestinal permeability, which has been implicated in carcinogenesis.(29,30) Intestinal permeability also is promoted by alcohol and CRD.”
Background
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice
Qian, Z., Wu, Z., Huang, L., Qiu, H., Wang, L., Li, L., Yao, L., Kang, K., Qu, J., Wu, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep17348 · Cited by 88
Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages
Xu, H., Zhang, Y., Peña, M. M. O., Pirisi, L. A., & Creek, K. E. (2017) · Carcinogenesis · doi:10.1093/carcin/bgw121 · Cited by 88
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy
Maldonado, L. Y., Arsene, D., Mato, J. M., & Lu, S. C.-L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217740860 · Cited by 88
Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
Kotelevets, L., & Chastre, E. (2020) · Cancers · doi:10.3390/cancers12030665 · Cited by 92
Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
Jiang, R., & Lönnerdal, B. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0094 · Cited by 89
Distinct Clinicohistologic Features of Inflammatory Bowel Disease-associated Colorectal Adenocarcinoma
Liu, X., Goldblum, J. R., Zhao, Z., Landau, M. S., Heald, B., Pai, R. K., & Lin, J. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318253645a · Cited by 86

Authors: Terzić, J., Grivennikov, S., Karin, E., & Karin, M.
Affiliations: University of California San Diego (US)
Tel Aviv Sourasky Medical Center (IL)
Corresponding author: Karin, Michael
ORCID: Terzić, Janoš
Grivennikov, Sergei
Karin, Michael
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2010-05
Volume: 138
Issue: 6
Pages: 2101-2114.e5
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2010.01.058
OpenAlex: W2085852125
Cited by: 1,974
References: 247
Citations by year: 2026: 41 · 2025: 80 · 2024: 106 · 2023: 140 · 2022: 147 · 2021: 192 · 2020: 159 · 2019: 139 · 2018: 144 · 2017: 145 · 2016: 136 · 2015: 127 · 2014: 112 · 2013: 119 · 2012: 86
FWCI: 10.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Crohn's and Colitis Foundation of America (1762)
American Association for Cancer Research
American Cancer Society
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: inflammation, colon cancer, colorectal cancer, inflammatory bowel disease, colitis-associated colorectal cancer, carcinogenesis, immune cells, cytokines, cancer prevention, cancer therapy, metastasis
MeSH terms: Animals, Anti-Inflammatory Agents, Cell Transformation, Neoplastic, Colon, Colonic Neoplasms, Humans, Neoplasm Invasiveness, Risk Factors, Colorectal Neoplasms, Inflammatory Bowel Diseases, Signal Transduction, Gene Expression Regulation, Neoplastic, Cytokines, Anticarcinogenic Agents, Risk Assessment, Inflammation Mediators, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and Colon Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks