Cited by 1,974Inflammatory mediators and NSAID effectsImmune cells in cancerInflammatory Bowel Disease

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Inflammation and Colon Cancer

Terzić, Janoš, Grivennikov, Sergei, Karin, Eliad, Karin, Michael·2010·Gastroenterology

DOI 10.1053/j.gastro.2010.01.058

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Abstract

The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon cancer. The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and could differ between colitis-associated and other forms of colorectal cancer. Recent work has elucidated the role of distinct immune cells, cytokines, and other immune mediators in virtually all steps of colon tumorigenesis, including initiation, promotion, progression, and metastasis. These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review.

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Authors: Terzić, J., Grivennikov, S., Karin, E., & Karin, M.
Affiliations: University of California San Diego (US)
Tel Aviv Sourasky Medical Center (IL)
Corresponding author: Karin, Michael
ORCID: Terzić, Janoš
Grivennikov, Sergei
Karin, Michael
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2010-05
Volume: 138
Issue: 6
Pages: 2101-2114.e5
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2010.01.058
OpenAlex: W2085852125
Cited by: 1,974
References: 247
Citations by year: 2026: 41 · 2025: 80 · 2024: 106 · 2023: 140 · 2022: 147 · 2021: 192 · 2020: 159 · 2019: 139 · 2018: 144 · 2017: 145 · 2016: 136 · 2015: 127 · 2014: 112 · 2013: 119 · 2012: 86
FWCI: 10.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Crohn's and Colitis Foundation of America (1762)
American Association for Cancer Research
American Cancer Society
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: inflammation, colon cancer, colorectal cancer, inflammatory bowel disease, colitis-associated colorectal cancer, carcinogenesis, immune cells, cytokines, cancer prevention, cancer therapy, metastasis
MeSH terms: Animals, Anti-Inflammatory Agents, Cell Transformation, Neoplastic, Colon, Colonic Neoplasms, Humans, Neoplasm Invasiveness, Risk Factors, Colorectal Neoplasms, Inflammatory Bowel Diseases, Signal Transduction, Gene Expression Regulation, Neoplastic, Cytokines, Anticarcinogenic Agents, Risk Assessment, Inflammation Mediators, Genetic Predisposition to Disease

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