Inflammation and Colon Cancer

A genetic model for colorectal tumorigenesis

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Cancer-related inflammation

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Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196

Cancer Statistics, 2008

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Myeloid-derived-suppressor cells as regulators of the immune system

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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

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Metagenomic Analysis of the Human Distal Gut Microbiome

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STATs in cancer inflammation and immunity: a leading role for STAT3

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Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,922

Nuclear factor-κB in cancer development and progression

Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519

Gut flora in health and disease

Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241

The Three Es of Cancer Immunoediting

Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104803 · Cited by 3,235

The Immunobiology of Cancer Immunosurveillance and Immunoediting

Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.017 · Cited by 3,192

NF-κB: linking inflammation and immunity to cancer development and progression

Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

Yang, J., & Weinberg, R. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,079

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

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IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

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Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

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A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340

Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,232

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,210

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Willett, C. G., Boucher, Y., di Tomaso, E., Duda, D. G., Munn, L. L., Tong, R. T., Chung, D. C., Sahani, D. V., Kalva, S. P., Kozin, S. V., et al. (2004) · Nature Medicine · doi:10.1038/nm988 · Cited by 1,985

Tumour necrosis factor and cancer

Balkwill, F. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2628 · Cited by 1,976

A cytokine-mediated link between innate immunity, inflammation, and cancer

Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,841

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690

Linking Colorectal Cancer to Wnt Signaling

Bienz, M., & Clevers, H. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,518

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

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CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Gupta, R. A., & DuBois, R. N. (2001) · Nature reviews. Cancer · doi:10.1038/35094017 · Cited by 1,077

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A. K., Blumberg, R. S., Xavier, R. J., & Mizoguchi, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33194 · Cited by 1,059

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043

IL-1 is required for tumor invasiveness and angiogenesis

Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., & Apte, R. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437939100 · Cited by 1,033

IL-23 promotes tumour incidence and growth

Langowski, J. L., Zhang, X., Wu, L., Mattson, J. D., Chen, T., Smith, K., Basham, B., McClanahan, T., Kastelein, R. A., & Oft, M. (2006) · Nature · doi:10.1038/nature04808 · Cited by 1,018

Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

Grady, W. M., & Carethers, J. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.076 · Cited by 991

Celecoxib for the Prevention of Colorectal Adenomatous Polyps

Arber, N., Eagle, C. J., Špičák, J., Rácz, I. A., Dítě, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061652 · Cited by 971

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

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Toll-like receptors and cancer

Rakoff-Nahoum, S., & Medzhitov, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2541 · Cited by 925

Natalizumab Induction and Maintenance Therapy for Crohn's Disease

Sandborn, W. J., Colombel, J., Enns, R., Feagan, B. G., Hanauer, S. B., Lawrance, I. C., Panaccione, R., Sanders, M. E., Schreiber, S., Targan, S. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043335 · Cited by 925

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., Carbone, D. P., Matrisian, L. M., Richmond, A., Lin, P. C., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.004 · Cited by 918

Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis

Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 893

Risk of cardiovascular events and rofecoxib: cumulative meta-analysis

Jüni, P., Nartey, L., Reichenbach, S., Sterchi, R., Dieppe, P. A., & Egger, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17514-4 · Cited by 846

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., & Mukaida, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32453 · Cited by 845

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

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Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationPreprint

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Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

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Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

Wu, Y., Deng, J., Rychahou, P. G., Qiu, S., Evers, B. M., & Zhou, B. P. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.016 · Cited by 814

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

Tu, S., Bhagat, G., Cui, G., Takaishi, S., Kurt‐Jones, E. A., Rickman, B. H., Betz, K. S., Penz-Österreicher, M., Björkdahl, O., Fox, J. G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.011 · Cited by 812

NF‐κB in inflammatory bowel disease

Atreya, I., Atreya, R. N., & Neurath, M. F. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01953.x · Cited by 807

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., BLANK, M. A., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.014 · Cited by 772

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

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The colorectal microRNAome

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Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

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The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

Naugler, W. E., & Karin, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.007 · Cited by 730

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726

Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer 1 1The authors thank Professor T. K. Korhonen (Division of General Microbiology, University of Helsinki, Finland), who kindly donated Escherichia coli IH11165; Professor J.-F. Colombel (Laboratoire de Recherche sur les Maladies Inflammatoire de l’Intestine, Centre Hospitalier Universitaire, Lille, France) and Professor A. Darfeuille-Michaud (Faculte de Pharmacie, Clermont-Ferrand, France), who kindly donated the Crohn’s disease ileal isolates LF10 and LF82; and Dr. Keith Leiper (Gastroenterology Unit, Royal Liverpool & Broadgreen University Hospitals Trust, Liverpool, UK) for his cooperation in obtaining colorectal tissue specimens.As a consequence of the work described herein, a patent application has been filed by the University of Liverpool regarding the use of soluble plantain fiber in Crohn’s disease.

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Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

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Treatment of Ulcerative Colitis with a Humanized Antibody to the α 4 β 7 Integrin

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

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Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

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An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

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Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

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NF-κB and cancer — identifying targets and mechanisms

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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

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Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

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Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

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Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

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Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88

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CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

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