The DOI matches its Crossref record; 243 of the 247 references it cites were found in a registry or an index.
Inflammation and Colon Cancer
Abstract
The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Inflammation is also likely to be involved with other forms of sporadic as well as heritable colon cancer. The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and could differ between colitis-associated and other forms of colorectal cancer. Recent work has elucidated the role of distinct immune cells, cytokines, and other immune mediators in virtually all steps of colon tumorigenesis, including initiation, promotion, progression, and metastasis. These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review.
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In the citing paper
“There is evidence that a link between inflammation and colorectal cancer exists.”
From Hyaluronic a cid–doxorubicin nanoparticles for targeted treatment of colorectal cancer (2021) · cites this paper as [98]
In the citing paper
“Chronic intestinal inflammation has been associated with the development of CRC and it can result from an aberrant ratio of protective (tolerogenic) to aggressive (proinflammatory, pro-tumorigenic) microbiota [45] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [45]
In the citing paper
“Many bacterial species were found to be enriched in colorectal tumour samples and adjacent tissue: B. fragilis, Bacteroides vulgatus, Bifidobacterium longum, Clostridium butyricum, Mitsuokella multiacida, E. coli, Enterococcus faecalis, and S. bovis [45] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [45]
Citations
Cites
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Immunity, Inflammation, and Cancer
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Self-citationThe basics of epithelial-mesenchymal transition
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Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
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Chung, K.-S., Choi, H.-E., Shin, J.-S., Cho, E.-J., Cho, Y.-W., Choi, J.-H., Baek, N.-I., & Lee, K.-T. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.11.007 · Cited by 14
HypoxaMIRs: Key Regulators of Hallmarks of Colorectal Cancer
Coronel-Hernández, J., Delgado-Waldo, I., Cantú de León, D., López-Camarillo, C., Jacobo-Herrera, N., Ramos-Payán, R., & Pérez-Plasencia, C. (2022) · Cells · doi:10.3390/cells11121895 · Cited by 13
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Metadata
- Authors
- Terzić, J., Grivennikov, S., Karin, E., & Karin, M.
- Affiliations
- University of California San Diego (US)
- Tel Aviv Sourasky Medical Center (IL)
- Corresponding author
- Karin, Michael
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 138
- Issue
- 6
- Pages
- 2101-2114.e5
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2085852125
- Cited by
- 1,974
- References
- 247
- Citations by year
- 2026: 41 · 2025: 80 · 2024: 106 · 2023: 140 · 2022: 147 · 2021: 192 · 2020: 159 · 2019: 139 · 2018: 144 · 2017: 145 · 2016: 136 · 2015: 127 · 2014: 112 · 2013: 119 · 2012: 86
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Crohn's and Colitis Foundation of America (1762)
- American Association for Cancer Research
- American Cancer Society
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- inflammation, colon cancer, colorectal cancer, inflammatory bowel disease, colitis-associated colorectal cancer, carcinogenesis, immune cells, cytokines, cancer prevention, cancer therapy, metastasis
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Transformation, Neoplastic, Colon, Colonic Neoplasms, Humans, Neoplasm Invasiveness, Risk Factors, Colorectal Neoplasms, Inflammatory Bowel Diseases, Signal Transduction, Gene Expression Regulation, Neoplastic, Cytokines, Anticarcinogenic Agents, Risk Assessment, Inflammation Mediators, Genetic Predisposition to Disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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