The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation
Open accessAbstract
Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant degree of independent control over gastrointestinal functions, the central nervous system provides extrinsic neural inputs that modulate, regulate, and integrate these functions. In particular, the vagus nerve provides the parasympathetic innervation to the gastrointestinal tract, coordinating the complex interactions between central and peripheral neural control mechanisms. This review discusses the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood, and the immune system, as well as the pathophysiological outcomes of vagus nerve dysfunction resulting in obesity, mood disorders, and inflammation. The therapeutic potential of vagus nerve modulation to attenuate or reverse these pathophysiological outcomes and restore autonomic homeostasis is also discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Changes in enteric neuron activity perceived by the vagus nerve are essential for mediating satiety, stress, and mood (12, 58, 59).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [59]
Experimental — accuracy not yet measuredIn the citing paper
“Compared to the HPA axis, the CAIP has some unique properties, such as a high speed of neural conductance, which enables an immediate modulatory input to the affected region of inflammation (70).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Zhu, J., Wu, X., Owyang, C., & Li, Y. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0431k.x · Cited by 226
RetractedRetracted: KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin
Grabauskas, G., Wu, X., Lu, Y., Heldsinger, A. A., Song, I., Zhou, S.-Y., & Owyang, C. (2015) · The Journal of Physiology · doi:10.1113/jp270788 · Cited by 25
RetractedBeckett, A. H., Rowland, M., & TURNER, P. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91037-8 · Cited by 16,917
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551
Functional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., Kangawa, K., & Nakazato, M. (2002) · Gastroenterology · doi:10.1053/gast.2002.35954 · Cited by 1,099
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074
Self-citationKoopman, F. A., Chavan, S. S., Miljko, S., Grazio, S., Sokolovic, S., Schuurman, P. R., Mehta, A. D., Levine, Y. A., Faltys, M., Zitnik, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605635113 · Cited by 1,024
Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018
Autonomic innervation and regulation of the immune system (1987–2007)
Nance, D. M., & Sanders, V. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.008 · Cited by 855
Altschuler, S. M., Bao, X., Bieger, D., Hopkins, D. A., & Miselis, R. R. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902830207 · Cited by 754
Liddle, R. A., Goldfine, I. D., Rosen, M. S., Taplitz, R. A., & Williams, J. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111809 · Cited by 744
Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages
Gabanyi, I., Muller, P. A., Feighery, L. M., Oliveira, T. Y., Costa‐Pinto, F. A., & Mucida, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.023 · Cited by 675
Dopamine mediates vagal modulation of the immune system by electroacupuncture
Rosas, R. T., Yehia, G., Peña, G., Mishra, P., Thompson-Bonilla, M. D. R., Moreno‐Eutímio, M. A., Arriaga‐Pizano, L., Isibasi, A., & Ulloa, L. (2014) · Nature Medicine · doi:10.1038/nm.3479 · Cited by 633
Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation
Krahl, S. E., Clark, K. B., Smith, D. C., & Browning, R. A. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01155.x · Cited by 556
Browning, K. N., & Travagli, R. A. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130055 · Cited by 541
Self-citationVagal immune-to-brain communication: a visceral chemosensory pathway
Goehler, L. E., Gaykema, R. P. A., Hansen, M. K., Anderson, K., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00219-8 · Cited by 525
The central organization of the vagus nerve innervating the stomach of the rat
Shapiro, R. E., & Miselis, R. R. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380411 · Cited by 492
Chronic vagus nerve stimulation in Crohn's disease: a 6‐month follow‐up pilot study
Bonaz, B., Sinniger, V., Hoffmann, D., Clarençon, D., Mathieu, N., Dantzer, C., Vercueil, L., Picq, C., Trocmé, C., Faure, P., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12792 · Cited by 492
Matteoli, G., Gomez‐Pinilla, P. J., Némethova, A., Giovangiulio, M. D., Cailotto, C., van Bree, S. H., Michel, K., Tracey, K. J., Schemann, M., Boesmans, W., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-304676 · Cited by 448
Self-citationGoehler, L. E., Gaykema, R. P. A., Opitz, N., Reddaway, R., Badr, N., & Lyte, M. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.09.002 · Cited by 442
Melancholic microbes: a link between gut microbiota and depression
Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12198 · Cited by 424
Microbes and the gut‐brain axis
Bercik, P., Collins, S. M., & Verdu, E. F. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01906.x · Cited by 417
Ghia, J., Blennerhassett, P. A., Kumar–Ondiveeran, H., Verdu, E. F., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.016 · Cited by 412
Rethinking inflammation: neural circuits in the regulation of immunity
Olofsson, P. S., Rosas‐Ballina, M., Levine, Y. A., & Tracey, K. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01138.x · Cited by 393
Neural reflexes in inflammation and immunity
Andersson, U., & Tracey, K. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120571 · Cited by 388
Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III
Yuan, H., & Silberstein, S. D. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12649 · Cited by 381
Ben‐Menachem, E., Hamberger, A., Hedner, T., Hammond, E. J., Uthman, B. M., Slater, J. D., Treig, T., Stefan, H., Ramsay, R. E., Wernicke, J. F., et al. (1995) · Epilepsy Research · doi:10.1016/0920-1211(94)00083-9 · Cited by 377
Mechanisms of postoperative ileus
Bauer, A. J., & Boeckxstaens, G. E. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00558.x · Cited by 377
Self-citationTopography of efferent vagal innervation of the rat gastrointestinal tract
Berthoud, H., Carlson, N. R., & Powley, T. L. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r200 · Cited by 366
Neuroimmune mechanisms in postoperative ileus
Boeckxstaens, G. E., & de Jonge, W. J. (2009) · Gut · doi:10.1136/gut.2008.169250 · Cited by 356
Self-citationHuston, J. M., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02321.x · Cited by 345
The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential
Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329
The vagus nerve, food intake and obesity
Berthoud, H.-R. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.024 · Cited by 316
Inoue, T., Abe, C., Sung, S. J., Moscalu, S., Jankowski, J., Huang, L., Ye, H., Rosin, D. L., Guyenet, P. G., & Okusa, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83658 · Cited by 316
Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease
Meregnani, J., Clarençon, D., Vivier, M., Peinnequin, A., Mouret, C., Sinniger, V., Picq, C., Job, A., Canini, F., Jacquier-Sarlin, M., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.10.007 · Cited by 310
Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part II
Yuan, H., & Silberstein, S. D. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12650 · Cited by 304
Extrinsic primary afferent signalling in the gut
Brookes, S. J., Spencer, N. J., Costa, M., & Zagorodnyuk, V. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.29 · Cited by 300
Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
Luyer, M. D., Greve, J. W. M., Hadfoune, M., Jacobs, J. A., Dejong, C. H., & Buurman, W. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042397 · Cited by 295
Rinaman, L., Card, J. P., Schwaber, J. S., & Miselis, R. R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-01985.1989 · Cited by 263
α7-Cholinergic Receptor Mediates Vagal Induction of Splenic Norepinephrine
Vida, G., Peña, G., Deitch, E. A., & Ulloa, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003722 · Cited by 262
Communication between gastrointestinal bacteria and the nervous system
Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.010 · Cited by 261
Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254
Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current
Kilgore, K. L., & Bhadra, N. (2013) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12100 · Cited by 252
Glucose‐sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea‐pig.
Niijima, A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014415 · Cited by 237
Cano, G., Sved, A. F., Rinaman, L., Rabin, B. S., & Card, J. P. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1331 · Cited by 237
Choi, K. M., Kashyap, P. C., Dutta, N., Stoltz, G. J., Ordog, T., Shea Donohue, T., Bauer, A. J., Linden, D. R., Szurszewski, J. H., Gibbons, S. J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.02.014 · Cited by 233
Ghia, J.-E., Blennerhassett, P., & Collins, S. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32849 · Cited by 233
Overview of the Clinical Applications of Vagus Nerve Stimulation
Beekwilder, J. P., & Beems, T. (2010) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e3181d64d8a · Cited by 215
Travagli, R. A., Gillis, R. A., Rossiter, C. D., & Vicini, S. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.260.3.g531 · Cited by 213
Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
Ji, H. L., Rabbi, M. F., Labis, B., Pavlov, V. A., Tracey, K. J., & Ghia, J. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.52 · Cited by 212
Sensory circumventricular organs: central roles in integrated autonomic regulation
Cottrell, G. T., & Ferguson, A. V. (2003) · Regulatory Peptides · doi:10.1016/j.regpep.2003.09.004 · Cited by 210
Sun, P., Zhou, K., Wang, S., Li, P., Chen, S., Lin, G., Zhao, Y., & Wang, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069424 · Cited by 209
Fox, E. A., & Powley, T. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91066-2 · Cited by 208
Bratton, B. O., Martelli, D., McKinley, M. J., Trevaks, D., Anderson, C. R., & McAllen, R. M. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.061531 · Cited by 207
Marrosu, F., Serra, A., Maleci, A., Puligheddu, M., Biggio, G., & Piga, M. (2003) · Epilepsy Research · doi:10.1016/s0920-1211(03)00107-4 · Cited by 206
Andresen, M. C., & Yang, M. Y. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.4.h1307 · Cited by 202
NEUROCHEMISTRY OF THE NODOSE GANGLION
ZHUO, H. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00003-8 · Cited by 195
Boelens, P. G., Heesakkers, F. F. B. M., Luyer, M. D. P., van Barneveld, K. W. Y., de Hingh, I. H. J. T., Nieuwenhuijzen, G. A. P., Roos, A. N., & Rutten, H. J. T. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000288 · Cited by 192
Gastrointestinal hormones and the dialogue between gut and brain
Dockray, G. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.270850 · Cited by 189
Daly, D., Park, S. J., Valinsky, W. C., & Beyak, M. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.204594 · Cited by 188
Yang, R., Han, X., Uchiyama, T., Watkins, S. C., Yaguchi, A., Delude, R. L., & Fink, M. P. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00177.2003 · Cited by 186
Little, T. J., Horowitz, M., & Feinle‐Bisset, C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.531 · Cited by 184
The central organization of the vagus nerve innervating the colon of the rat
Altschuler, S. M., Escardo, J., Lynn, R. B., & Miselis, R. R. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90419-d · Cited by 183
Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression
Ghia, J., Blennerhassett, P. A., Deng, Y., Verdu, E. F., Khan, W. I., & Collins, S. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.069 · Cited by 182
Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons
de Lartigue, G., Barbier de la Serre, C., Espero, E., Lee, J., & Raybould, H. E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00056.2011 · Cited by 179
Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation
Schwartz, E. S., Christianson, J. A., Chen, X., La, J., Davis, B. M., Albers, K. M., & Gebhart, G. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.033 · Cited by 178
Houghton, L. A., Atkinson, W., Whitaker, R. P., Whorwell, P. J., & Rimmer, M. J. (2003) · Gut · doi:10.1136/gut.52.5.663 · Cited by 176
Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia
Berthoud, H., & Powley, T. L. (1993) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(93)90046-w · Cited by 173
The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose
Hansen, M. K., O'Connor, K. A., Goehler, L. E., Watkins, L. R., & Maier, S. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.4.r929 · Cited by 169
The EMPOWER Study Group, Sarr, M. G., Billington, C. J., Brancatisano, R., Brancatisano, A., Toouli, J., Kow, L., Nguyen, N. T., Blackstone, R., Maher, J. W., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0751-8 · Cited by 162
Regulation of Limbic Motor Seizures by GABA and Glutamate Transmission in Nucleus Tractus Solitarius
Walker, B. R., Easton, A. E., & Gale, K. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00818.x · Cited by 161
Costantini, T. W., Bansal, V., Krzyżaniak, M., Putnam, J. G., Peterson, C. Y., Loomis, W. H., Wolf, P. L., Baird, A., Eliceiri, B. P., & Coimbra, R. S. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00156.2010 · Cited by 153
Mechanisms of CCK signaling from gut to brain
Raybould, H. E. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.09.006 · Cited by 151
Vagal tone: effects on sensitivity, motility, and inflammation
Bonaz, B. L., Sinniger, V., & Sonia Pellissier, A. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12817 · Cited by 150
Powley, T. L., Spaulding, R. A., & Haglof, S. A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22541 · Cited by 146
Tsuchida, Y., Hatao, F., Fujisawa, M., Murata, T., Kaminishi, M., Seto, Y., Hori, M., & Ozaki, H. (2010) · Gut · doi:10.1136/gut.2010.227546 · Cited by 140
Serre, C. B. D. L., de Lartigue, G., & Raybould, H. E. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.032 · Cited by 136
Diet‐induced adaptation of vagal afferent function
Kentish, S. J., Li, H., Philp, L., O’Donnell, T. A., Isaacs, N. J., Young, R. L., Wittert, G., Blackshaw, L. A., & Page, A. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.222158 · Cited by 136
One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
Waise, T. M. Z., Toshinai, K., Naznin, F., NamKoong, C., Moin, A. S. M., Sakoda, H., & Nakazato, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.097 · Cited by 134
Davis, S. F., Derbenev, A. V., Williams, K. W., Glatzer, N. R., & Smith, B. N. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.049 · Cited by 128
Cailotto, C., Gomez‐Pinilla, P. J., Costes, L. M. M., van der Vliet, J., Giovangiulio, M. D., Némethova, A., Matteoli, G., & Boeckxstaens, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087785 · Cited by 126
Self-citationVal‐Laillet, D., Biraben, A., Randuineau, G., & Malbert, C. (2010) · Appetite · doi:10.1016/j.appet.2010.06.008 · Cited by 124
Rescigno, M. (2010) · Advances in immunology · doi:10.1016/b978-0-12-381300-8.00004-6 · Cited by 123
Neuronal and Nonneuronal Cholinergic Structures in the Mouse Gastrointestinal Tract and Spleen
Gautron, L., Rutkowski, J. M., Burton, M. D., Wei, W., Wan, Y., & Elmquist, J. (2013) · The Journal of comparative neurology · doi:10.1002/cne.23376 · Cited by 123
Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Speelmans, G., Knol, J., Jacobs, J. A., Dejong, C. H. C., Vriesema, A. J. M., & Greve, J. W. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.6.3686-3692.2005 · Cited by 119
Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
Naznin, F., Toshinai, K., Waise, T. M. Z., NamKoong, C., Moin, A. S. M., Sakoda, H., & Nakazato, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0139 · Cited by 118
Vagus nerve integrity and experimental colitis
Ghia, J., Blennerhassett, P. A., & Collins, S. M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2007 · Cited by 113
Galitovskiy, V., Qian, J., Chernyavsky, A. I., Marchenko, S. A., Gindi, V., Edwards, R. A., & Grando, S. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002711 · Cited by 110
Role of GABAA receptors in rat hindbrain nuclei controlling gastric motor function
SIVARAO, KROWICKI, & HORNBY (1998) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1998.00110.x · Cited by 105
Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer
O’Mahony, C., van der Kleij, H. P. M., Bienenstock, J., Shanahan, F., & O’Mahony, L. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90904.2008 · Cited by 103
Steinert, R. E., & Beglinger, C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.039 · Cited by 101
Majoie, M., Rijkers, K., Berfelo, M. W., Hulsman, J. A. R. J., Myint, A.-M., Schwarz, M., & Vles, J. S. H. (2010) · NeuroImmunoModulation · doi:10.1159/000315530 · Cited by 100
Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons
Bielefeldt, K., Ozaki, N., & Gebhart, G. F. (2002) · Gastroenterology · doi:10.1053/gast.2002.31026 · Cited by 99
High fat maintenance diet attenuates hindbrain neuronal response to CCK
Covașă, M., Grahn, J. C., & Ritter, R. C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00084-1 · Cited by 97
Gastric vagal afferent modulation by leptin is influenced by food intake status
Kentish, S. J., O’Donnell, T. A., Isaacs, N. J., Young, R. L., Li, H., Harrington, A. M., Brierley, S. M., Wittert, G., Blackshaw, L. A., & Page, A. J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.247577 · Cited by 95
Dorsal motor nucleus of the vagus nerve: A cyto‐ and chemoarchitectonic study in the human
Huang, X., Törk, I., & Paxinos, G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903300203 · Cited by 95
Guiraud, D., Andreu, D., Bonnet, S., Carrault, G., Couderc, P., Hagège, A. A., Henry, C., Hernandez, A. I., Karam, N., Rolle, V. L., et al. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/4/041002 · Cited by 93
Wu, R., Dong, W., Ji, Y., Zhou, M., Marini, C. P., Ravikumar, T. S., & Wang, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002026 · Cited by 92
Orts-Del’Immagine, A., Wanaverbecq, N., Tardivel, C., Tillement, V., Dallaporta, M., & Trouslard, J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.227959 · Cited by 91
Herdt, V. D., Bogaert, S., Bracke, K. R., Raedt, R., Vos, M. D., Vonck, K. E. J., & Boon, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.008 · Cited by 91
Cailotto, C., Costes, L. M. M., van der Vliet, J., van Bree, S. H. W., van Heerikhuize, J. J., Buijs, R. M., & Boeckxstaens, G. E. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01824.x · Cited by 91
Self-citationThe, F., Cailotto, C., van der Vliet, J., de Jonge, W. J., Bennink, R. J., Buijs, R. M., & Boeckxstaens, G. E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01296.x · Cited by 89
Self-citationPhysiological mechanisms of cholecystokinin action on pancreatic secretion
Owyang, C. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.1.g1 · Cited by 88
Browning, K. N., Fortna, S. R., & Hajnal, A. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.249268 · Cited by 84
Self-citationLubbers, T., Luyer, M. D. P., de Haan, J. J., Hadfoune, M., Buurman, W. A., & Greve, J. W. M. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e318194d187 · Cited by 78
Circadian Variation in Gastric Vagal Afferent Mechanosensitivity
Kentish, S. J., Frisby, C. L., Kennaway, D. J., Wittert, G., & Page, A. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3846-13.2013 · Cited by 73
VAGOTOMY FOR TREATMENT OF SEVERE OBESITY
Kral, J. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90074-0 · Cited by 71
Marquette, C., Linard, C., Galonnier, M., Uye, A. V., Mathieu, J., Gourmelon, P., & Clarençon, D. (2003) · International Journal of Radiation Biology · doi:10.1080/09553000310001610998 · Cited by 70
van der Kleij, H. P. M., O’Mahony, C., Shanahan, F., O’Mahony, L., & Bienenstock, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90434.2008 · Cited by 69
High-Fat Diet-Induced Obesity Ablates Gastric Vagal Afferent Circadian Rhythms
Kentish, S. J., Vincent, A. D., Kennaway, D. J., Wittert, G., & Page, A. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2710-15.2016 · Cited by 68
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni0905-954b · Cited by 68
Self-citationElectrophysiological identification of glucose-sensing neurons in rat nodose ganglia
Grabauskas, G., Song, I., Zhou, S.-Y., & Owyang, C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.182147 · Cited by 67
Effects of cholecystokinin-8s in the nucleus tractus solitarius of vagally deafferented rats
Baptista, V., Browning, K. N., & Travagli, R. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00517.2006 · Cited by 64
Self-citationAn Electrophysiological Study on Amino Acid Sensors in the Hepato‐Portal System in the Rat
Niijima, A., & Meguid, M. M. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00494.x · Cited by 63
Obesity, innate immunity and gut inflammation
Karagiannides, I., & Pothoulakis, C. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282c8c8d3 · Cited by 63
Browning, K. N., & Travagli, R. A. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702908 · Cited by 63
Self-citationRole of oxidative stress in the pathogenesis of septic ileus in mice
Winter, B. Y. D., Nassauw, L. V., Man, J. G. D., Jonge, F. D., Bredenoord, A. J., Seerden, T. C. J., Herman, A. G., Timmermans, J., & Pelckmans, P. A. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00618.x · Cited by 63
Date, Y. (2012) · Methods in Enzymology · doi:10.1016/b978-0-12-381272-8.00016-7 · Cited by 61
Neuronal connections of the area postrema.
Leslie, R. A., & Gwyn, D. G. (1984) · PubMed · Cited by 61
Advances in vagal afferent neurobiology
Undem, B. J. (2005) · Cited by 59
Mechanism of cholecystokinin-induced relaxation of the rat stomach
Takahashi, T., & Owyang, C. (1999) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00181-7 · Cited by 54
Role of satellite glial cells in gastrointestinal pain
Menachem Hanani, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00412 · Cited by 54
Atkinson, C., Penfold, C. M., Ness, A., Longman, R. J., Thomas, S. J., Hollingworth, W., Kandiyali, R., Leary, S. D., & Lewis, S. J. (2016) · British journal of surgery · doi:10.1002/bjs.10194 · Cited by 52
Food allergy and eosinophilic gastroenteritis and colitis
Bischoff, S. C. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32833982c3 · Cited by 51
Morton, J. M., Shah, S. N., Wolfe, B. M., Apovian, C. M., Miller, C. J., Tweden, K. S., Billington, C. J., & Shikora, S. A. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2143-y · Cited by 51
Giovangiulio, M. D., Bosmans, G., Meroni, E., Stakenborg, N., Florens, M. V., Farro, G., Gomez‐Pinilla, P. J., Matteoli, G., & Boeckxstaens, G. E. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00062 · Cited by 51
Self-citationKang, Y., Bielefeldt, K., & Gebhart, G. F. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01097.2003 · Cited by 46
Satellite cells as blood-ganglion cell barrier in autonomic ganglia
ten Tusscher, M. P. M., Klooster, J., & Vrensen, G. F. J. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)90434-4 · Cited by 43
Nikfar, S., Ehteshami‐Afshar, S., Rahimi, R., & Abdollahi, M. R. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.01.004 · Cited by 40
Glucagon-like peptide-1 inhibits voltage-gated potassium currents in mouse nodose ganglion neurons
Gaisano, G., park, S. J., Daly, D., & Beyak, M. J. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01430.x · Cited by 40
Troy, A. E., Simmonds, S., Stocker, S. D., & Browning, K. N. (2015) · The Journal of Physiology · doi:10.1113/jp271558 · Cited by 38
Self-citationTumor Necrosis Factor Potentiates Central Vagal Afferent Signaling by Modulating Ryanodine Channels
Rogers, R. C., Meter, M. J. V., & Hermann, G. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3530-06.2006 · Cited by 37
Truncal vagotomy in morbid obesity.
Kral, J. G., & Gortz, L. (1981) · PubMed · Cited by 36
Aalbers, M. W., Klinkenberg, S., Rijkers, K., Verschuure, P., Kessels, A. G. H., Aldenkamp, A. P., Vles, J. S. H., & Majoie, M. (2012) · NeuroImmunoModulation · doi:10.1159/000341402 · Cited by 35
Ghia, J., Park, A. J., Blennerhassett, P., Khan, W., & Collins, S. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21531 · Cited by 35
Melanocortins and the Cholinergic Anti-Inflammatory Pathway
Giuliani, D., Ottani, A., Altavilla, D., Bazzani, C., Squadrito, F., & Guarini, S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6354-3_6 · Cited by 34
Vagal modulation of intestinal afferent sensitivity to systemic LPS in the rat
Liu, C. Y., Mueller, M. H., Grundy, D., & Kreis, M. E. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00267.2006 · Cited by 33
Downs, A. M., Bond, C. E., & Hoover, D. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.011 · Cited by 30
Lacolley, P. J., Owen, J. R., Sandock, K., Lewis, T. H. J., Bates, J. N., Robertson, T. P., & Lewis, S. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.047 · Cited by 27
Mechanisms and State of the Art of Vagus Nerve Stimulation
Kosel, M., & Schlaepfer, T. E. (2002) · Journal of Ect · doi:10.1097/00124509-200212000-00004 · Cited by 27
Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion
Viard, E., Zheng, Z., Wan, S., & Travagli, R. A. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00118.2007 · Cited by 26
Bischoff, S. C. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0022-8 · Cited by 26
Effects of IL-1β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices
Mo, Z., Katafuchi, T., & Hori, T. (1996) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00196-7 · Cited by 25
Browning, K. N., Wan, S., Baptista, V., & Travagli, R. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00054.2011 · Cited by 24
Self-citationFunctional protease-activated receptors in the dorsal motor nucleus of the vagus
Wang, H., Wu, X., Li, J.-Y., Chai, B., Wang, J., Mulholland, M. W., & Zhang, W. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01391.x · Cited by 23
Vagus Nerve and Postinjury Inflammatory Response
Peterson, C. Y. (2011) · Archives of Surgery · doi:10.1001/archsurg.2011.237 · Cited by 23
Regulation of GH secretagogue receptor gene expression in the rat nodose ganglion
Sato, M., Nakahara, K., Miyazato, M., Kangawa, K., & Murakami, N. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0078 · Cited by 20
Bischoff, S. C. (2007) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-007-0055-6 · Cited by 13
Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury
Langness, S. M., Coimbra, R. S. M., Eliceiri, B. P., & Costantini, T. W. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.05.015 · Cited by 11
Gomez‐Pinilla, P. J., Giovangiulio, M. D., Némethova, A., Stakenborg, N., Farro, G., Bosmans, G., Matteoli, G., & Boeckxstaens, G. E. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)60324-3 · Cited by 10
Self-citationTNFα Causes Thrombin-Dependent Vagal Neuron Apoptosis in Inflammatory Bowel Disease
Fritze, D. M., Zhang, W., Li, J.-Y., Chai, B., & Mulholland, M. W. (2014) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-014-2573-6 · Cited by 9
[The brain-gut axis: insights from the obese pig model].
Malbert, C. (2013) · PubMed · Cited by 4
Stakenborg, N., Gomez‐Pinilla, P. J., Farro, G., Wolthuis, A. M., Bosmans, G., Labeeuw, E., Giovangiulio, M. D., D’Hoore, A. J. L., Matteoli, G., & Boeckxstaens, G. E. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31816-9 · Cited by 3
Self-citationTroy, A. E., & Browning, K. N. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.1158.3 · Cited by 2
Self-citationSu1564 Improvement of Oxazolone-Induced Colitis by Vagus Nerve Stimulation
Meroni, E., Verheijden, S., Stakenborg, N., Schepper, S. D., Goverse, G., Gomez‐Pinilla, P. J., Matteoli, G., & Boeckxstaens, G. E. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)31817-0 · Cited by 2
Self-citation
Research works printed but not linked: 1
- Gray’s anatomy. The anatomical basis of clinical practice. Cambridge, MA: Elsevier, 2008.
Cited by
Sorted by citations
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043
“by the vagus nerve are essential for mediating satiety, stress, and mood (12, 58, 59).”
BackgroundVagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189
“Compared to the HPA axis, the CAIP has some unique properties, such as a high speed of neural conductance, which enables an immediate modulatory input to the affected region of inflammation (70).”
BackgroundMechanisms and Therapeutic Relevance of Neuro-immune Communication
Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 678
Alzheimer’s disease hypothesis and related therapies
Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 623
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494
Metadata
- Authors
- Browning, K. N., Verheijden, S., & Boeckxstaens, G. E.
- Affiliations
- Pennsylvania State University (US)
- KU Leuven (BE)
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Boeckxstaens, Guy E.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 152
- Issue
- 4
- Pages
- 730-744
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC5337130
- OpenAlex
- W2561923085
- Cited by
- 361
- References
- 161
- Citations by year
- 2026: 40 · 2025: 65 · 2024: 42 · 2023: 41 · 2022: 36 · 2021: 49 · 2020: 36 · 2019: 23 · 2018: 22 · 2017: 7
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lirias (KU Leuven) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (078364)
- National Science Foundation (IOS1148978)
- European Research Council (ERC-2013-Adg, 340101)
- FWO postdoctoral research fellowship
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- vagus nerve, appetite regulation, mood, intestinal inflammation, gut-brain axis, parasympathetic innervation, obesity, mood disorders, vagus nerve stimulation, autonomic homeostasis, immune system
- MeSH terms
- Gastrointestinal Microbiome, Affect, Afferent Pathways, Animals, Appetite Regulation, Colitis, Diet, Efferent Pathways, Enteritis, Humans, Neuronal Plasticity, Neurons, Afferent, Obesity, Vagus Nerve, Cytokines, Vagus Nerve Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
