Cited by 361Vagus Nerve Stimulation ResearchGastrointestinal motility and disordersRegulation of Appetite and Obesity

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The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

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Browning, Kirsteen N., Verheijden, Simon, Boeckxstaens, Guy E.·2017·Gastroenterology

DOI 10.1053/j.gastro.2016.10.046PMC PMC5337130

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Abstract

Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant degree of independent control over gastrointestinal functions, the central nervous system provides extrinsic neural inputs that modulate, regulate, and integrate these functions. In particular, the vagus nerve provides the parasympathetic innervation to the gastrointestinal tract, coordinating the complex interactions between central and peripheral neural control mechanisms. This review discusses the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood, and the immune system, as well as the pathophysiological outcomes of vagus nerve dysfunction resulting in obesity, mood disorders, and inflammation. The therapeutic potential of vagus nerve modulation to attenuate or reverse these pathophysiological outcomes and restore autonomic homeostasis is also discussed.

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Authors: Browning, K. N., Verheijden, S., & Boeckxstaens, G. E.
Affiliations: Pennsylvania State University (US)
KU Leuven (BE)
Universitair Ziekenhuis Leuven (BE)
Corresponding author: Boeckxstaens, Guy E.
ORCID: Browning, Kirsteen N.
Verheijden, Simon
Boeckxstaens, Guy E.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2017-03
Volume: 152
Issue: 4
Pages: 730-744
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2016.10.046
PMC: PMC5337130
OpenAlex: W2561923085
Cited by: 361
References: 161
Citations by year: 2026: 40 · 2025: 65 · 2024: 42 · 2023: 41 · 2022: 36 · 2021: 49 · 2020: 36 · 2019: 23 · 2018: 22 · 2017: 7
FWCI: 1.52
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Gastroenterology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Lirias (KU Leuven) (submittedVersion, cc-by-nc-nd)
Funders: National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (078364)
National Science Foundation (IOS1148978)
European Research Council (ERC-2013-Adg, 340101)
FWO postdoctoral research fellowship
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: vagus nerve, appetite regulation, mood, intestinal inflammation, gut-brain axis, parasympathetic innervation, obesity, mood disorders, vagus nerve stimulation, autonomic homeostasis, immune system
MeSH terms: Gastrointestinal Microbiome, Affect, Afferent Pathways, Animals, Appetite Regulation, Colitis, Diet, Efferent Pathways, Enteritis, Humans, Neuronal Plasticity, Neurons, Afferent, Obesity, Vagus Nerve, Cytokines, Vagus Nerve Stimulation

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The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

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