Cited by 311Tuberculosis Research and EpidemiologyGenomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

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Analysis of the proteome of Mycobacterium tuberculosis in silico

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Tekaia, F., Gordon, S.V., Garnier, T., Brosch, R., Barrell, B.G., Cole, S.T.·1999·Tubercle and Lung Disease

DOI 10.1054/tuld.1999.0220

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Abstract

Novel bioinformatics routines have been used to provide a more detailed definition of the proteome of Mycobacterium tuberculosis H37Rv. Over half of the current proteins result from gene duplication or domain shuffling events while one-sixth show no similarity to polypeptides described in other organisms. Prominent among the genes that appear to have been duplicated on numerous occasions are those involved in fatty acid metabolism, regulation of gene expression, and the unusually glycine-rich PE and PPE proteins. Protein similarity analysis, coupled with inspection of the genetic neighbourhood, was used to explore possible functional relatedness. This uncovered four large mce operons whose proteins may mediate initial interactions between the tubercle bacillus and host cells, together with a cluster of genes that might encode components of a structure required for secretion of ESAT-6 like proteins. Close linkage of the mmpL genes, encoding large membrane proteins, with those required for fatty acid metabolism suggests involvement in lipid transport. Compared to free-living bacteria, M. tuberculosis has a significantly smaller transport protein repertoire and this may reflect its intracellular lifestyle.

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Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617
PHYLIP-Phylogeny inference package (Version 3.2)
Felsenstein, J. (1989) · Cladistics · Cited by 17,682
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citation
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
Nielsen, H., Engelbrecht, J., Brunak, S., & von HEIJNE, G. (1997) · Protein Engineering Design and Selection · doi:10.1093/protein/10.1.1 · Cited by 5,343
Fitting a mixture model by expectation maximization to discover motifs in biopolymers.
Bailey, T. L., & Elkan, C. (1994) · PubMed · Cited by 4,982
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Theory and Applications of Correspondence Analysis.
Jolliffe, I. T., & Greenacre, M. J. (1986) · Biometrics · doi:10.2307/2531266 · Cited by 3,026

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Banerji, S., & Flieger, A. (2004) · Microbiology · doi:10.1099/mic.0.26957-0 · Cited by 120
Microbial genome analysis: insights into virulence, host adaptation and evolution
Wren, B. W. (2000) · Nature Reviews Genetics · doi:10.1038/35049551 · Cited by 121
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Sayes, F., Sun, L., Luca, M. D., Siméone, R., Degaiffier, N., Fiette, L., Esin, S., Brosch, R., Bottai, D., Leclerc, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.003 · Cited by 125
Self-citation
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Okkels, L. M., Brock, I., Follmann, F., Agger, E. M., Arend, S. M., Ottenhoff, T. H. M., Oftung, F., Rosenkrands, I., & Andersen, P. L. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6116-6123.2003 · Cited by 118
Yeast Two-Hybrid Systems and Protein Interaction Mapping Projects for Yeast and Worm
Walhout, A. J. M., Boulton, S. J., & Vidal, M. (2000) · Yeast · doi:10.1002/1097-0061(20000630)17:2 · Cited by 149
Self-citation
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Melly, G. C., & Purdy, G. E. (2019) · Microorganisms · doi:10.3390/microorganisms7030070 · Cited by 112
The Enigmatic Esx Proteins: Looking Beyond Mycobacteria
Unnikrishnan, M., Constantinidou, C., Palmer, T., & Pallen, M. J. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.11.004 · Cited by 117
Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems
Dumas, E., Christina Boritsch, E., Vandenbogaert, M., Rodríguez de la Vega, R. C., Thiberge, J.-M., Caro, V., Gaillard, J.-L., Heym, B., Girard-Misguich, F., Brosch, R., et al. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw001 · Cited by 112
Self-citation
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Sinha, S. K., Kosalai, K., Arora, S., Namane, A., Sharma, P., Gaikwad, A. N., Brodin, P. M., & Cole, S. T. (2005) · Microbiology · doi:10.1099/mic.0.27799-0 · Cited by 112
Self-citation
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Niazi, A., Manzoor, S., Asari, S., Bejai, S., Meijer, J., & Bongcam‐Rudloff, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104651 · Cited by 112
Assessing the Serodiagnostic Potential of 35 Mycobacterium tuberculosis Proteins and Identification of Four Novel Serological Antigens
Weldingh, K. N., Rosenkrands, I., Okkels, L. M., Doherty, T. M., & Andersen, P. L. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.1.57-65.2005 · Cited by 109
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
Bottai, D., Frigui, W., Sayes, F., Luca, M. D., Spadoni, D., Pawlik, A., Zoppo, M., Orgeur, M., Khanna, V., Hardy, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14508-5 · Cited by 112
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Type VII secretion systems: structure, functions and transport models
Rivera-Calzada, Á., Famelis, N., Llorca, Ó., & Geibel, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00560-5 · Cited by 113
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Betts, J. C., Dodson, P., Quan, S., Lewis, A. P., Thomas, P. J., Duncan, K., & McAdam, R. A. (2000) · Microbiology · doi:10.1099/00221287-146-12-3205 · Cited by 104
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Singh, K. K., Zhang, X., Patibandla, A. S., Chien, P., & Laal, S. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.4185-4191.2001 · Cited by 103
Comparative genomics of metabolic pathways inMycobacteriumspecies: gene duplication, gene decay and lateral gene transfer
Marri, P. R., Bannantine, J. P., & Golding, G. B. (2006) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2006.00041.x · Cited by 107
CFP10 discriminates between nonacetylated and acetylated ESAT‐6 of Mycobacterium tuberculosis by differential interaction
Okkels, L. M., Müller, E., Schmid, M., Rosenkrands, I., Kaufmann, S. H. E., Andersen, P. L., & Jungblut, P. R. (2004) · PROTEOMICS · doi:10.1002/pmic.200400906 · Cited by 100
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Korepanova, A. V., Gao, F. P., Hua, Y., Qin, H., Nakamoto, R. K., & Cross, T. A. (2004) · Protein Science · doi:10.1110/ps.041022305 · Cited by 98
Fatty acid biosynthesis in Mycobacterium tuberculosis : Lateral gene transfer, adaptive evolution, and gene duplication
Kinsella, R. J., Fitzpatrick, D. A., Creevey, C. J., & McInerney, J. O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1737230100 · Cited by 102
Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs
Viveiros, M., Martins, M., Rodrigues, L., Machado, D., Couto, I., Aínsa, J. A., & Amaral, L. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.89 · Cited by 96
Regulation of the Mycobacterium tuberculosis mce1 Operon
Casali, N., White, A. M., & Riley, L. W. (2005) · Journal of Bacteriology · doi:10.1128/jb.188.2.441-449.2006 · Cited by 96
Release of mycobacterial antigens
Majlessi, L., Prados‐Rosales, R., Casadevall, A., & Brosch, R. (2015) · Immunological Reviews · doi:10.1111/imr.12251 · Cited by 93
Self-citation
Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets
Pal, R., Bisht, M. K., & Mukhopadhyay, S. (2022) · FEBS Journal · doi:10.1111/febs.16369 · Cited by 100
Genomics of Mycobacterium bovis
Gordon, S. V., Eiglmeier, K., Garnier, T., Brosch, R., Parkhill, J., Barrell, B. G., Cole, S. T., & Hewinson, R. G. (2001) · Tuberculosis · doi:10.1054/tube.2000.0269 · Cited by 93
Self-citation
Tubercle bacilli rely on a type VII army for pathogenicity
Stoop, E. J. M., Bitter, W., & van der Sar, A. M. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.07.001 · Cited by 90
Clusters of PE and PPE genes of Mycobacterium tuberculosis are organized in operons: Evidence that PE Rv2431c is co‐transcribed with PPE Rv2430c and their gene products interact with each other
Tundup, S., Akhter, Y., Thiagarajan, D., & Hasnain, S. E. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.042 · Cited by 89
Use of Bioinformatics Tools in Different Spheres of Life Sciences
Mehmood, M. A. (2014) · Journal of Data Mining in Genomics & Proteomics · doi:10.4172/2153-0602.1000158 · Cited by 90
Evolution and emergence ofMycobacterium tuberculosis
Orgeur, M., Sous, C., Madacki, J., & Brosch, R. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae006 · Cited by 97
Self-citation

Authors: Tekaia, F., Gordon, S. V., Garnier, T., Brosch, R., Barrell, B. G., & Cole, S. T.
Affiliations: Institut Pasteur (FR)
Wellcome Sanger Institute (GB)
ORCID: Tekaia, F.
Gordon, S.V.
Brosch, R.
Cole, S.T.
Venue: Tubercle and Lung Disease
Publisher: Elsevier BV
Published: 1999-12
Volume: 79
Issue: 6
Pages: 329-342
ISSN: 0962-8479 (ISSN-L)
DOI: 10.1054/tuld.1999.0220
OpenAlex: W2076379808
Cited by: 311
References: 59
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 13 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 17 · 2013: 15 · 2012: 18
FWCI: 11.60
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Tubercle and Lung Disease (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, proteome, gene duplication, domain shuffling, fatty acid metabolism, gene expression regulation, host-pathogen interaction, lipid transport, membrane transporters, intracellular lifestyle
MeSH terms: Bacterial Proteins, Fatty Acids, Genes, Bacterial, Mycobacterium tuberculosis, Operon, Computational Biology, Genes, Duplicate, Proteome, Amino Acid Motifs

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Analysis of the proteome of Mycobacterium tuberculosis in silico

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