Intranasal oxytocin in obsessive-compulsive disorder
Open accessAbstract
A 55-year patient with obsessive-compulsive disorder showed clear improvement during 4 weeks of treatment with intranasal oxytocin compared to 4 weeks of intranasal placebo. This improvement was concurrent with the development of severe memory disturbances, supporting the amnestic properties of the peptide. However, the patient also developed psychotic symptoms and a marked decrease in plasma sodium and osmolality, which may have masked the obsessive symptomatology. This case highlights the need for careful monitoring in long-term oxytocin therapy.
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- Authors
- Ansseau, M., Legros, J.-J., Mormont, C., Cerfontaine, J.-L., Papart, P., Geenen, V., Adam, F., & Franck, G.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Ansseau, Marc
- ORCID
- Geenen, Vincent
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 12
- Issue
- 3
- Pages
- 231-236
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2131646905
- Cited by
- 68
- References
- 26
- Citations by year
- 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- orbi.uliege.be
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- intranasal oxytocin, obsessive-compulsive disorder, amnesia, memory impairment, psychosis, hyponatremia, plasma osmolality, adverse effects, treatment monitoring
- MeSH terms
- Administration, Intranasal, Humans, Hyponatremia, Male, Middle Aged, Obsessive-Compulsive Disorder, Osmolar Concentration, Oxytocin, Psychoses, Substance-Induced, Water-Electrolyte Imbalance
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