Cited by 68Neuroendocrine regulation and behaviorObsessive-Compulsive Spectrum DisordersOlfactory and Sensory Function Studies

Intranasal oxytocin in obsessive-compulsive disorder

Open access
Ansseau, Marc, Legros, Jean-Jacques, Mormont, Chrsitian, Cerfontaine, Jean-Luc, Papart, Patrick, Geenen, Vincent, Adam, Francine, Franck, Georges·1987·Psychoneuroendocrinology

Abstract

A 55-year patient with obsessive-compulsive disorder showed clear improvement during 4 weeks of treatment with intranasal oxytocin compared to 4 weeks of intranasal placebo. This improvement was concurrent with the development of severe memory disturbances, supporting the amnestic properties of the peptide. However, the patient also developed psychotic symptoms and a marked decrease in plasma sodium and osmolality, which may have masked the obsessive symptomatology. This case highlights the need for careful monitoring in long-term oxytocin therapy.

Integrity signals

Registry

Crossref · 10.1016/0306-4530(87)90009-6

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Vranckx, Minne, Benghezal, Moeglen, Audibert (1979) Vasopressin and schizophrenia. Biological Psychiatry Today , J Obiols, C Baltus, E Gonzalez Monclus, J Pujol, Elsevier, Amsterdam; 753-758.

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Authors
Ansseau, M., Legros, J.-J., Mormont, C., Cerfontaine, J.-L., Papart, P., Geenen, V., Adam, F., & Franck, G.
Affiliations
University of Liège (BE)
Corresponding author
Ansseau, Marc
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1987-01
Volume
12
Issue
3
Pages
231-236
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2131646905
Cited by
68
References
26
Citations by year
2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 3
FWCI
4.04
Type
journal article
Language
en
Open access
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
intranasal oxytocin, obsessive-compulsive disorder, amnesia, memory impairment, psychosis, hyponatremia, plasma osmolality, adverse effects, treatment monitoring
MeSH terms
Administration, Intranasal, Humans, Hyponatremia, Male, Middle Aged, Obsessive-Compulsive Disorder, Osmolar Concentration, Oxytocin, Psychoses, Substance-Induced, Water-Electrolyte Imbalance

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