Cited by 119Plant biochemistry and biosynthesisSesquiterpenes and Asteraceae StudiesPlant tissue culture and regeneration

The DOI matches its Crossref record.

Trichome Dynamics and Artemisinin Accumulation during Development and Senescence of Artemisia annua Leaves

Open access

Lommen, W. J., Schenk, E., Bouwmeester, H. J., Verstappen, F. W.·2006·Planta Medica

DOI 10.1055/s-2005-916202

Open this paper in CoChat — free account

Abstract

Artemisinin is a sesquiterpene lactone endoperoxide and an important antimalarial drug produced in Artemisia annua. To unravel the diverse processes determining artemisinin yield in A. annua crops, artemisinin accumulation during the development of individual leaves was studied in two field experiments. During the life cycle of a leaf, artemisinin was always present. Quantities were low at leaf appearance and increased steadily. In leaves studied until after senescence, maximum quantities and concentrations were achieved after the leaf had turned brown. The total quantity of possible artemisinin precursors per leaf (dihydroartemisinic acid and other upstream precursors) was highest early in the leaf cycle when the leaf was still expanding. Dihydroartemisinic acid was more abundant than the other compounds and its quantity declined during leaf development whereas that of artemisinin increased. Dihydroartemisinic acid was not converted directly into artemisinin, because on a per leaf basis the decline in molar quantity of precursors in the earliest formed leaves was not compensated for by a simultaneous increase in artemisinin. Our results suggest that a (putative) intermediate such as dihydroartemisinic acid hydroperoxide temporarily may have accumulated in considerable quantities. The number of mature, capitate trichomes on the adaxial leaf side increased after leaf appearance until the end of leaf expansion, and then decreased, probably due to collapse of trichomes. Artemisinin production thus (also) occurred when trichomes were collapsing. Later formed leaves achieved higher concentrations of artemisinin than earlier formed leaves, because of a higher trichome density and a higher capacity per trichome.

Integrity signals

Registry

Crossref · 10.1055/s-2005-916202

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Sorted by citations

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Glandular trichomes: micro‐organs with model status?
Schuurink, R. C., & Tissier, A. F. (2019) · New Phytologist · doi:10.1111/nph.16283 · Cited by 253
Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants
Maes, L., Van Nieuwerburgh, F. C. W., Zhang, Y., Reed, D. W., Pollier, J., Vande Casteele, S. R. F., Inzé, D., Covello, P. S., Deforce, D. L. D., & Goossens, A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03466.x · Cited by 240
Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases
Weathers, P. J., Arsenault, P. R., Covello, P. S., McMickle, A., Teoh, K. H., & Reed, D. W. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9166-0 · Cited by 202
Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Ivanescu, B., Miron, A., & Corciova, A. (2015) · Journal of Analytical Methods in Chemistry · doi:10.1155/2015/247685 · Cited by 201
“Detection methods applied in sesquiterpene lactones analysis include GC-MS [141], GCECD, and GC-FID [139].”
Method
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.
Pu, G., Ma, D., Chen, J.-L., Ma, L., Wang, H., Li, G., Ye, H., & Liu, B. (2009) · Plant Cell Reports · doi:10.1007/s00299-009-0713-3 · Cited by 172
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study
Schramek, N., Wang, H., Römisch-Margl, W., Keil, B., Radykewicz, T., Winzenhörlein, B., Beerhues, L., Bacher, A., Rohdich, F., Gershenzon, J., et al. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2009.10.015 · Cited by 150
A Review of Biotechnological Artemisinin Production in Plants
Ikram, N. K. K., & Simonsen, H. T. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01966 · Cited by 131
Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants
Gandhi, S. G., Mahajan, V., & Bedi, Y. S. (2014) · Planta · doi:10.1007/s00425-014-2232-x · Cited by 126
Biology, Genome Evolution, Biotechnological Issues and Research Including Applied Perspectives in Artemisia (Asteraceae)
Vallès, J., Garcia, S., Hidalgo, O., Martín, J., Pellicer, J., Sanz, M., & Garnatje, T. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-385851-1.00015-9 · Cited by 122
Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.)
Majdi, M., Liu, Q., Karimzadeh, G., Malboobi, M. A., Beekwilder, J., Cankar, K., de Vos, R. C. H., Todorović, S., Simonović, A. D., & Bouwmeester, H. J. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.04.021 · Cited by 113
Self-citation
Regulation of cell fate determination by single-repeat R3 MYB transcription factors in Arabidopsis
Wang, S., & Chen, J. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00133 · Cited by 112
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
Alam, P., & Abdin, M. Z. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1099-6 · Cited by 108
Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography–mass spectrometry
Ma, C., Wang, H., Lu, X., Xu, G., & Liu, B. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.09.023 · Cited by 103
Transgenic approach to increase artemisinin content in Artemisia annua L.
Tang, K., Shen, Q., Yan, T., & Fu, X. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1566-y · Cited by 96
Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism
Czechowski, T., Larson, T. R., Catania, T. M., Harvey, D., Brown, G. D., & Graham, I. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611567113 · Cited by 94
Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco
Shangguan, X., Xu, B., Yu, Z.-X., Wang, L.-J., & Chen, X. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern204 · Cited by 93
Production of artemisinin by genetically-modified microbes
Zeng, Q.-P., Qiu, F., & Yuan, L. (2007) · Biotechnology Letters · doi:10.1007/s10529-007-9596-y · Cited by 87
Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua
Arsenault, P. R., Vail, D. R., Wobbe, K. K., Erickson, K., & Weathers, P. J. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.162552 · Cited by 85
A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua
Ma, D.-M., Wang, Z., Wang, L., Alejos-Gonzales, F., Sun, M.-A., & Xie, D.-Y. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.07.004 · Cited by 83
Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua
Lv, Z., Guo, Z., Zhang, L., Zhang, F., Jiang, W., Shen, Q., Fu, X., Yan, T., Shi, P., Hao, X., et al. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz166 · Cited by 79
Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion
Wang, H., Han, J., Kanagarajan, S., Lundgren, A., & Brodelius, P. E. (2012) · Plant Molecular Biology · doi:10.1007/s11103-012-9986-y · Cited by 76
Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua
Judd, R., Bagley, M. C., Li, M., Zhu, Y., Lei, C., Yuzuak, S., Ekelöf, M., Pu, G., Zhao, X., Muddiman, D. C., et al. (2019) · Molecular Plant · doi:10.1016/j.molp.2019.02.011 · Cited by 75
Impact of plant growth promoting Pseudomonas monteilii PsF84 and Pseudomonas plecoglossicid a PsF610 on metal uptake and production of secondary metabolite (monoterpenes) by rose-scented geranium ( Pelargonium graveolens cv. bourbon) grown on tannery sludge amended soil
Dharni, S., Srivastava, A. K., Samad, A., et al. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.08.001 · Cited by 70
Expression of β‐glucosidase increases trichome density and artemisinin content in transgenic Artemisia annua plants
Singh, N. D., Kumar, S., & Daniell, H. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12476 · Cited by 67
Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.
Nguyen, K. T., Arsenault, P. R., & Weathers, P. J. (2011) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-011-9343-x · Cited by 66
Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives
Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9480-2 · Cited by 63
Antibacterial and Phytochemical Screening of Artemisia Species
BORDEAN, M.-E., Ungur, R. A., Țoc, D. A., et al. (2023) · Antioxidants · doi:10.3390/antiox12030596 · Cited by 60
Natural sesquiterpenoids
Fraga, B. M. (2007) · Natural Product Reports · doi:10.1039/b706427f · Cited by 60
RNAi down-regulation of cinnamate-4-hydroxylase increases artemisinin biosynthesis in Artemisia annua
Kumar, R., Vashisth, D., Misra, A., Akhtar, M. Q., Jalil, S. U., Shanker, K., Gupta, M. M., Rout, P. K., Gupta, A. K., & Shasany, A. K. (2016) · Scientific Reports · doi:10.1038/srep26458 · Cited by 56
Strategies to Modulate Specialized Metabolism in Mediterranean Crops: From Molecular Aspects to Field
Balestrini, R., Brunetti, C., Cammareri, M., Caretto, S., Cavallaro, V., Cominelli, E., Palma, M. D., Docimo, T., Giovinazzo, G., Grandillo, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062887 · Cited by 62
The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua
Lv, Z., Li, J., Qiu, S., Qi, F., Su, H., Bu, Q., Jiang, R. J., Tang, K., Zhang, L., & Chen, W. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13258 · Cited by 55
Variations in key artemisinic and other metabolites throughout plant development in Artemisia annua L. for potential therapeutic use
Towler, M. J., & Weathers, P. J. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.01.007 · Cited by 51
Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment
Xiang, L., Zhu, S., Zhao, T., Zhang, M., Liu, W., Chen, M., Lan, X., & Liao, Z. (2015) · Plant Growth Regulation · doi:10.1007/s10725-014-0004-z · Cited by 52
Phytochemistry of the Carnivorous Sundew Genus Drosera (Droseraceae) – Future Perspectives and Ethnopharmacological Relevance
Egan, P. A., & van der Kooy, F. (2013) · Chemistry & Biodiversity · doi:10.1002/cbdv.201200359 · Cited by 52
Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annua
Czechowski, T., Larson, T. R., Catania, T. M., Harvey, D., Wei, C., Essome, M., Brown, G. D., & Graham, I. A. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00641 · Cited by 47
Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin
Kjær, A., Grevsen, K., & Jensen, M. (2012) · AoB Plants · doi:10.1093/aobpla/pls018 · Cited by 45
The evolutionary advantage of artemisinin production by Artemisia annua
Yin, Q., Li, X., Han, X., Zhang, Y., Lyu, R., Yuan, L., & Chen, S. (2024) · Trends in Plant Science · doi:10.1016/j.tplants.2024.09.006 · Cited by 46
Senescent Leaves of Artemisia annua are One of the Most Active Organs for Overexpression of Artemisinin Biosynthesis Responsible Genes upon Burst of Singlet Oxygen
Yang, R.-Y., Zeng, X.-M., Lu, Y.-Y., Lu, W.-J., Feng, L.-L., Yang, X.-Q., & Zeng, Q.-P. (2010) · Planta Medica · doi:10.1055/s-0029-1240620 · Cited by 40
Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content
Nair, P., Misra, A., Singh, A., Shukla, A. K., Gupta, M. M., Gupta, A. K., Gupta, V., Khanuja, S. P. S., & Shasany, A. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060375 · Cited by 38
Biotechnological approaches for artemisinin production in Artemisia
Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37
Cloning of artemisinin biosynthetic cDNAs and novel ESTs and quantification of low temperature-induced gene overexpression
Zeng, Q.-P., Chang, Z., Yin, L., Yang, R., Zeng, X.-M., Huang, Y., Feng, L.-L., & Yang, X. (2008) · Science in China Series C Life Sciences · doi:10.1007/s11427-008-0032-x · Cited by 34
Molecular Cloning and Characterization of a Trichome-Specific Promoter of Artemisinic Aldehyde Δ11(13) Reductase (DBR2) in Artemisia annua
Jiang, W., Lu, X., Qiu, B., Zhang, F., Shen, Q., Lv, Z., Fu, X., Yan, T., Gao, E., Zhu, M., et al. (2013) · Plant Molecular Biology Reporter · doi:10.1007/s11105-013-0603-2 · Cited by 34
Montanoa tomentosa glandular trichomes containing kaurenoic acids chemical profile and distribution
Robles‐Zepeda, R. E., Lozoya‐Gloria, E., López, M. G., et al. (2008) · Fitoterapia · doi:10.1016/j.fitote.2008.09.002 · Cited by 34
Overexpression of a type‐I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase
Ma, D., Li, G., Alejos-González, F., Zhu, Y., Xue, Z. H., Wang, A., Zhang, H., Li, X., Ye, H., Wang, H., et al. (2017) · The Plant Journal · doi:10.1111/tpj.13583 · Cited by 32
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31
Affordable and sensitive determination of artemisinin in Artemisia annua L. by gas chromatography with electron-capture detection
Liu, S., Tian, N., Liu, Z., Huang, J., Li, J., & Ferreira, J. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.089 · Cited by 29
The dual role of GoPGF reveals that the pigment glands are synthetic sites of gossypol in aerial parts of cotton
Zhang, Z., Long, L., Zhao, X., et al. (2023) · New Phytologist · doi:10.1111/nph.19331 · Cited by 28
The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.
Nguyen, K. T., Towler, M. J., & Weathers, P. J. (2013) · Plant Cell Reports · doi:10.1007/s00299-012-1355-4 · Cited by 27
A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L.
Larson, T. R., Branigan, C., Harvey, D., Penfield, T., Bowles, D., & Graham, I. A. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.12.004 · Cited by 27
Studies on the Expression of Sesquiterpene Synthases Using Promoter-β-Glucuronidase Fusions in Transgenic Artemisia annua L
Wang, H., Han, J., Kanagarajan, S., Lundgren, A., & Brodelius, P. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080643 · Cited by 25
Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin
Kiani, B. H., Suberu, J., & Mirza, B. (2016) · Malaria Journal · doi:10.1186/s12936-016-1312-8 · Cited by 27
Overexpression of the gibberellin 20-oxidase gene from Torenia fournieri resulted in modified trichome formation and terpenoid metabolities of Artemisia annua L.
Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26
Artemisia annua L. and photoresponse: from artemisinin accumulation, volatile profile and anatomical modifications to gene expression
Lopes, E. M., Guimarães-Dias, F., Gama, T. D. S. S., Macedo, A. L., Valverde, A. L., de Moraes, M. C., de Aguiar-Dias, A. C. A., Bizzo, H. R., Alves‐Ferreira, M., Tavares, E. S., et al. (2019) · Plant Cell Reports · doi:10.1007/s00299-019-02476-0 · Cited by 26
AaHY5 ChIP-seq based on transient expression system reveals the role of AaWRKY14 in artemisinin biosynthetic gene regulation
Zhou, L., Huang, Y., Wang, Q., et al. (2021) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2021.10.010 · Cited by 24
Artemisinin production and precursor ratio in full grown Artemisia annua L. plants subjected to external stress
Kjær, A., Verstappen, F. W. A., Bouwmeester, H. J., Ivarsen, E., Fretté, X. C., Christensen, L. P., Grevsen, K., & Jensen, M. (2012) · Planta · doi:10.1007/s00425-012-1811-y · Cited by 23
Self-citation
High performance liquid chromatographic evaluation of artemisinin, raw material in the synthesis of artesunate and artemether
Stringham, R. W., Lynam, K. G., Mrozinski, P., Kilby, G. W., Pelczer, I., & Kraml, C. M. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.10.056 · Cited by 23
Genetic elaborations of glandular and non-glandular trichomes in Mentha arvensis genotypes: assessing genotypic and phenotypic correlations along with gene expressions
Mishra, A., Lal, R. K., Chanotiya, C. S., et al. (2016) · PROTOPLASMA · doi:10.1007/s00709-016-1011-x · Cited by 23
Identification of Putative Artemisia annua ABCG Transporter Unigenes Related to Artemisinin Yield Following Expression Analysis in Different Plant Tissues and in Response to Methyl Jasmonate and Abscisic Acid Treatments
Zhang, L., Lu, X., Shen, Q., Chen, Y., Wang, T., Zhang, F., Wu, S., Jiang, W., Liu, P., Zhang, L., et al. (2011) · Plant Molecular Biology Reporter · doi:10.1007/s11105-011-0400-8 · Cited by 22
Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies
Majdi, M., Ashengroph, M., & Abdollahi, M. R. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7128-6 · Cited by 22
Morphology and mass spectrometry-based chemical profiling of peltate glandular trichomes on Mentha haplocalyx Briq leaves
Liu, R., Wang, Y., Liang, C., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.112323 · Cited by 21
Characterization of a trichome-specific promoter of the aldehyde dehydrogenase 1 (ALDH1) gene in Artemisia annua
Liu, M., Shi, P., Fu, X., Brodelius, P. E., Shen, Q., Jiang, W., He, Q., & Tang, K. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-1015-4 · Cited by 22
Simple and rapid micro‐scale quantification of artemisinin in living Artemisia annua L. by improved gas chromatography with electron‐capture detection
Liu, S., Tian, N., Li, J., et al. (2009) · Biomedical Chromatography · doi:10.1002/bmc.1230 · Cited by 18
MODELLING PROCESSES DETERMINING AND LIMITING THE PRODUCTION OF SECONDARY METABOLITES DURING CROP GROWTH: THE EXAMPLE OF THE ANTIMALARIAL ARTEMISININ PRODUCED IN ARTEMISIA ANNUA
Lommen, W. J. M., Bouwmeester, H. J., Schenk, E., et al. (2008) · Acta Horticulturae · doi:10.17660/actahortic.2008.765.10 · Cited by 18
Self-citation
New cultivation approaches of Artemisia annua L. for a sustainable production of the antimalarial drug artemisinin
Nadali, B. J., Arvind, B., Kamaruzaman, M., & Keng, C. L. (2014) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.1053 · Cited by 18
Chemistry, biosynthesis and biological activity of artemisinin and related natural peroxides
Rydén, A.-M., & Kayser, O. (2007) · Topics in Heterocyclic Chemistry · doi:10.1007/7081_2007_085 · Cited by 16
Morphoanatomy, histochemistry, essential oil, and other secondary metabolites ofArtemisia copa(Asteraceae)
Mercado, M. I., Marcial, G., Catalán, J. V., Grau, A., Catalán, C. A. N., & Ponessa, G. I. (2021) · Botany Letters · doi:10.1080/23818107.2021.1956585 · Cited by 14
In vitro conservation, phytochemistry, and medicinal activity of Artemisia tridentata Nutt.: metabolomics as a hypothesis-generating tool for plant tissue culture
Turi, C. E., Axwik, K. E., & Murch, S. J. (2014) · Plant Growth Regulation · doi:10.1007/s10725-014-9915-y · Cited by 14
Synergistic interaction of two bHLH transcription factors positively regulates artemisinin biosynthetic pathway in Artemisia annua L.
Mohammad, Hurrah, I. M., Kumar, A., & Abbas, N. (2023) · Physiologia Plantarum · doi:10.1111/ppl.13849 · Cited by 12
Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) under stressed environments
Tripathi, A., Pandey, P., Tripathi, S. N., & Kalra, A. (2025) · Plant Stress · doi:10.1016/j.stress.2025.100757 · Cited by 14
Expression and Localization of Amorpha-4,11-diene Synthase in Artemisia annua L.
Pu, G., Ma, D., Wang, H., Ye, H., & Liu, B. (2012) · Plant Molecular Biology Reporter · doi:10.1007/s11105-012-0472-0 · Cited by 11
Evaluation of the Effect of Leaf Development in Plectranthus amboinicus L. on Antimicrobial Activity and Virulence Factors of Pseudomonas aeruginosa PAO1 and Staphylococcus aureus NCTC8325
Sawant, S., Baldwin, T. C., Khan, H., & Rahman, A. (2022) · Current Microbiology · doi:10.1007/s00284-022-03126-7 · Cited by 16
The truncated AaActin1 promoter is a candidate tool for metabolic engineering of artemisinin biosynthesis in Artemisia annua L.
Li, Y., Chen, T., Liu, H., Qin, W. D., Yan, X., Wu-Zhang, K., Peng, B., Zhang, Y., Yao, X., Fu, X., et al. (2022) · Journal of Plant Physiology · doi:10.1016/j.jplph.2022.153712 · Cited by 11
Effects of N fertilization on trichome density, leaf size and artemisinin production in Artemisia annua leaves
Bilkova, I., Kjær, A., van der Kooy, F., et al. (2016) · Acta Horticulturae · doi:10.17660/actahortic.2016.1125.48 · Cited by 10
Self-citation
AaABCG20 transporter involved in cutin and wax secretion affects the initiation and development of glandular trichomes in Artemisia annua
Fu, X., Zheng, H., Wang, Y., Liu, H., Pin, L., Li, L., Zhao, J., Sun, X., & Tang, K. (2023) · Plant Science · doi:10.1016/j.plantsci.2023.111959 · Cited by 10
Molecular Cloning and Characterization of a Broad Substrate Terpenoid Oxidoreductase from Artemisia annua
Rydén, A., Ruyter-Spira, C. P., Litjens, R. H. M. G., Takahashi, S., Quax, W. J., Osada, H., Bouwmeester, H. J., & Kayser, O. (2010) · Plant and Cell Physiology · doi:10.1093/pcp/pcq073 · Cited by 10
Self-citation
Secretory Structures in Flourensia campestris and F. oolepis: Ultrastructure, Distribution, and (-)-Hamanasic Acid A Secretion
Silva, M. P., Tourn, G. M., López, D., Galati, B. G., Piazza, L. A., Zarlavsky, G., Cantero, J. J., & Scopel, A. L. (2015) · American Journal of Plant Sciences · doi:10.4236/ajps.2015.67100 · Cited by 8
Herbgenomics meets Papaveraceae: a promising -omics perspective on medicinal plant research
Kielich, N., Mazur, O., Musidlak, O., et al. (2023) · Briefings in Functional Genomics · doi:10.1093/bfgp/elad050 · Cited by 7
The Plasmodesmata-Located β-1,3-Glucanase Enzyme PdBG4 Regulates Trichomes Growth in Arabidopsis thaliana
Fan, Y., Lin, S., Li, T., Shi, F., Shan, G., & Zeng, F. (2022) · Cells · doi:10.3390/cells11182856 · Cited by 7
Simultaneous Nonchiral Determination of Artemisinin and Arteannuin B in Artemisia annua Using Circular Dichroism Detection
Chen, J., Gu, J., Zhao, R., et al. (2008) · Chromatographia · doi:10.1365/s10337-008-0880-3 · Cited by 7
Breeding triple‐advantage cottonseed with higher yield, enhanced nutrition, and reduced toxicity by redirecting terpenoid metabolism to astaxanthin
Long, L., Tang, Y., Zhang, Z., et al. (2025) · Plant Biotechnology Journal · doi:10.1111/pbi.70116 · Cited by 6
Furofuran lignans of Artemisia genus: Isolation, biosynthesis and biological activity
Ickovski, J. D., Pavlović, J., Mitić, M., Palić, I. R., Kostić, D. A., Petrović, G. M., & Stojanović, G. (2020) · Journal of the Serbian Chemical Society · doi:10.2298/jsc191210009i · Cited by 6
From leaf explants to rooted plantlets in a mist reactor
Fei, L., & Weathers, P. J. (2015) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-015-9727-4 · Cited by 6
Artemisinin the Nobel Molecule
Weathers, P. J., Cambra, H. M., Desrosiers, M. R., Rassias, D., & Towler, M. J. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63931-8.00005-9 · Cited by 6
Accumulation of Secondary Metabolites and Improved Size of Glandular Trichomes in Artemisia annua
Pandey, N., Tiwari, A., Rai, S. K., & Rai, S. P. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_31 · Cited by 6
Expression of Two Key Enzymes of Artemisinin Biosynthesis FPS and ADS genes in Saccharomyces cerevisiae
Elfahmi, E., Hapsari, R. A., Chrysanthy, T., Synthiarini, V., Masduki, F. F., Setiawan, A., & Muranaka, T. (2020) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2021.019 · Cited by 5
Eradication of malaria through genetic engineering: the current situation
Chong, W. C., Basir, R., & Fei, Y. M. (2013) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(13)60001-2 · Cited by 6
Molecular Farming Approach Towards Bioactive Compounds
Khatri, S., Saini, R. V., & Chhillar, A. K. (2017) · Springer eBooks · doi:10.1007/978-981-10-5511-9_3 · Cited by 4
Effect of Chemical and Physical Stress Conditions on the Concentration and Composition of Essential Oil Components in Leaves of Full‐Grown A rtemisia annua L.
Ivarsen, E., Kjær, A., Jensen, M., Grevsen, K., Christensen, L. P., & Fretté, X. C. (2013) · Journal of Agronomy and Crop Science · doi:10.1111/jac.12030 · Cited by 5
Influence of planting density and development stage on photosynthetically absorbed radiation, biomass and artemisinin yield of Artemisia annua L. ‘Apollon’
Carlen, C., Koch, S., Christ, B., & Simonnet, X. (2023) · Acta Horticulturae · doi:10.17660/actahortic.2023.1358.13 · Cited by 3
CpSPL10-CpELF4 module involves in the negative regulation of flower bud differentiation in Chinese cherry
Shang, C., Hou, Q., Qiao, G., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135964 · Cited by 3
Transfer Of Rol Genes And Evaluation Of Artemisinin Synthesis In Transgenic Artemisia Annua L. And Artemisia Dubia Wall
Kiani, B. H. (2012) · HEC National Digital Library · Cited by 3
Morphology of glandular trichome and lignin-based structure for its function
Hao, N., Kamiya, T., & Wu, T. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.02.014 · Cited by 2
AaSPATULA synergistically coordinates glandular trichome initiation and vegetative growth to maximize whole-plant artemisinin yield in Artemisia annua
Yuan, M., & Zhou, F. (2026) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2026.111316 · Cited by 2
Extraction, Purification, and Quantification of Artemisinin and its Analogs from Artemisia annua L.
Liu, S., Tian, N., & Liu, Z. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_9 · Cited by 2
Identification of R2R3-MYB members in Lonicera japonica: Insights into the positive role of Lj5.MYB61 and Lj4.MYB16 in glandular trichome density
Yuan, Y., Wang, Q., Tong, B., et al. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118738 · Cited by 2
Trichomes in Artemisia annua: Initiation, Development, Maturation and the Possibilities to Influence these Factors
Kjær, A., Grevsen, K., & Jensen, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_7 · Cited by 2
Accumulation of Secondary Metabolites and Improved Size of Glandular Trichomes in Artemisia annua
Pandey, N., Tiwari, A., Kumar, S., & Rai, S. P. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-030-11253-0_31-1 · Cited by 2
An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygenPreprint
He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827v1 · Cited by 2
An Overview of Heterologous Organisms Used to Produce Artemisinin and Its Precursors
Li, X., He, H., Jianting, C., Wang, H., & Ye, H. (2012) · Chinese Bulletin of Botany · doi:10.3724/sp.j.1259.2012.00571 · Cited by 1

Authors: Lommen, W. J., Schenk, E., Bouwmeester, H. J., & Verstappen, F. W.
Affiliations: Wageningen University & Research (NL)
ORCID: Lommen, W. J.
Bouwmeester, H. J.
Verstappen, F. W.
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 2006-12
Volume: 72
Issue: 4
Pages: 336-345
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2005-916202
OpenAlex: W2014837193
Cited by: 119
References: 0
Citations by year: 2026: 5 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 8
FWCI: 2.30
Type: journal article
Language: de
Open access: green
research.wur.nl
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Keywords: artemisinin, Artemisia annua, trichomes, leaf senescence, leaf development, dihydroartemisinic acid, sesquiterpene lactone biosynthesis
MeSH terms: Antimalarials, Humans, Phytotherapy, Sesquiterpenes, Plant Leaves, Artemisia annua, Artemisinins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Trichome Dynamics and Artemisinin Accumulation during Development and Senescence of Artemisia annua Leaves

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cited by

Related

Metadata

Record

About these checks