Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels
Abstract
Objective: Fibroblast growth factor 21 (FGF21) levels have been linked with beneficial effects on glucose and lipid metabolism in animals. It is elevated in humans with the metabolic syndrome. This study investigates independent factors associated with serum FGF21 levels. Design: Cross-sectional study done in healthy blue-collar workers. Methods: A medical history was taken, and FGF21 (measured using an ELISA commercial kit), glucose, uric acid, plasma lipids, total/high-molecular weight (HMW) adiponectin, and retinal-binding protein 4 (RBP4) were measured in 210 individuals with (n=81) and without (n=129) metabolic syndrome. Results: The median of serum FGF21 levels were higher in subjects with metabolic syndrome (339.5 vs 276.4 ng/l,P=0.01). Serum FGF21 levels correlated positively with body mass index (BMI;r=0.23,P=0.001) and age (r=0.17,P=0.01). After adjusting for age and BMI, a significant positive correlation persisted for fasting glucose, uric acid, and physical activity in both males (r=0.21,r=0.11, and r=0.19, all P<0.05) and females (r=0.20,r=0.19, and r=0.14, all P<0.05). In addition, FGF21 also correlates negatively with RBP4 (r=−0.27,P=0.02), total (r=−0.26,P=0.03), and HMW adiponectin (r=−0.30,P=0.01) in women. A multiple linear regression model analysis identified that BMI (standardized β (SB)=0.247;P=0.008), glucose (SB=0.226;P=0.003), uric acid (SB=0.191;P=0.04), and physical activity (SB=0.223;P=0.004) are independent factors influencing serum FGF21 levels (F=10.05,r2=0.19,P<0.001). In addition, fasting hyperglycemia ≥100 mg/dl, excess body weight with BMI ≥25 kg/m 2, and uric acid ≥5.5 mg/dl predicted higher serum FGF21 levels. Conclusion: Serum FGF21 levels are influenced by BMI, fasting glycemia, uric acid, and physical activity.
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Circulating levels of FGF21 are significantly elevated in humans during type 2 diabetes, obesity, hepatosteatosis, pancreatitis, and mitochondrial dysfunction.
“Circulating levels of FGF21 are significantly elevated in humans during pathophysiological states, including type 2 diabetes (16, 18), obesity (22, 30, 93), hepatosteatosis (30, 79, 146), pancreatitis (117, 137), and mitochondrial dysfunction (78).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [22]
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- Authors
- Cuevas-Ramos, D., Almeda-Valdes, P., Gómez-Pérez, F. J., Meza-Arana, C. E., Cruz-Bautista, I., Arellano-Campos, O., Navarrete-López, M., & Aguilar-Salinas, C. A.
- Affiliations
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09
- Volume
- 163
- Issue
- 3
- Pages
- 469-477
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2146313282
- Cited by
- 58
- References
- 39
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Keywords
- FGF21, physical activity, fasting blood glucose, uric acid, body mass index, metabolic syndrome, adiponectin, retinol-binding protein 4, plasma lipids, blue-collar workers, obesity, insulin resistance, adipokines, sex differences, age, healthy adults
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Fasting, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, Motor Activity, Time Factors, Uric Acid, Cohort Studies, Body Mass Index, Metabolic Syndrome
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