The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
Open accessAbstract
BACKGROUND: Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia. METHODS: In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 150 mg per day, or placebo from 11 to 14 weeks of gestation until 36 weeks of gestation. The primary outcome was delivery with preeclampsia before 37 weeks of gestation. The analysis was performed according to the intention-to-treat principle. RESULTS: A total of 152 women withdrew consent during the trial, and 4 were lost to follow up, which left 798 participants in the aspirin group and 822 in the placebo group. Preterm preeclampsia occurred in 13 participants (1.6%) in the aspirin group, as compared with 35 (4.3%) in the placebo group (odds ratio in the aspirin group, 0.38; 95% confidence interval, 0.20 to 0.74; P=0.004). Results were materially unchanged in a sensitivity analysis that took into account participants who had withdrawn or were lost to follow-up. Adherence was good, with a reported intake of 85% or more of the required number of tablets in 79.9% of the participants. There were no significant between-group differences in the incidence of neonatal adverse outcomes or other adverse events. CONCLUSIONS: Treatment with low-dose aspirin in women at high risk for preterm preeclampsia resulted in a lower incidence of this diagnosis than placebo. (Funded by the European Union Seventh Framework Program and the Fetal Medicine Foundation; EudraCT number, 2013-003778-29 ; Current Controlled Trials number, ISRCTN13633058 .).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, this finding was not confirmed in the Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial, which was primarily designed for preterm preeclampsia prevention.74,75”
From Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction (2020) · cites this paper as [74]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, a meta-analysis and an additional trial demonstrate that low-dose aspirin <100 mg is not effective in reducing preeclampsia.Low-dose aspirin >100 mg is required (117-119).”
From 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2024 (2024) · cites this paper as [118]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This is based on the ASPRE study, which showed that in women at high-risk of preeclampsia who received low-dose aspirin from 11 to 14 gestational weeks until 36 weeks, the risk of developing preeclampsia was significantly decreased (OR: 0.38; 95% CI: 0.20–0.74; p = 0.004) [78].”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [78]
Experimental — accuracy not yet measuredIn the citing paper
“The recent ASPRE trial demonstrated that administration of aspirin to a population identified as high risk using a first trimester screening test reduced the incidence of pre-eclampsia compared with placebo [17], but was underpowered to detect an effect on FGR/SGA and stillbirth.”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961
The Global Impact of Pre-eclampsia and Eclampsia
Duley, L. (2009) · Seminars in Perinatology · doi:10.1053/j.semperi.2009.02.010 · Cited by 2,866
Brown, M. A., Lindheimer, M. D., de Swiet, M., Assche, A. V., & Moutquin, J. (2001) · Hypertension in Pregnancy · doi:10.1081/prg-100104165 · Cited by 1,894
A CRITICAL EVALUATION OF SONAR “CROWN‐RUMP LENGTH” MEASUREMENTS
Robinson, H. P., & Fleming, J. E. E. (1975) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1975.tb00710.x · Cited by 1,413
Brown, M. A., Lindheimer, M. D., de SWIET, M., et al. (2001) · Hypertension in Pregnancy · doi:10.3109/10641950109152635 · Cited by 1,369
Bujold, E., Roberge, S., Lacasse, Y., Bureau, M., Audibert, F., Marcoux, S., Forest, J., & Giguère, Y. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e9322a · Cited by 1,112
Irgens, H. U., Roberts, J. M., Reisæter, L., Irgens, L. M., & Lie, R. T. (2001) · BMJ · doi:10.1136/bmj.323.7323.1213 · Cited by 1,040
Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data
Askie, L. M., Duley, L., Henderson-Smart, D. J., & Stewart, L. A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60712-0 · Cited by 1,025
Lisonkova, S., & Joseph, K. S. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.08.019 · Cited by 926
Roberge, S., Nicolaides, K., Demers, S., Hyett, J., Chaillet, N., & Bujold, E. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.09.076 · Cited by 679
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- National Collaborating Centre for Women’s and Children’s Health (UK). Hypertension in pregnancy: the management of hypertensive disorders during pregnancy. London: RCOG Press, 2010.
- Van Buuren S, 2011, J Stat Softw, 45, 1
Cited by
Sorted by citations
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
2020 International Society of Hypertension Global Hypertension Practice Guidelines
Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15026 · Cited by 4,132
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Gestational Hypertension and Preeclampsia
(2020) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000003891 · Cited by 2,949
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885
2024 ESC Guidelines for the management of elevated blood pressure and hypertension
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
Rana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095
Brown, M. A., Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C. E., Adoyi, G., & Ishaku, S. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10803 · Cited by 2,089
Practice Bulletin No. 183: postpartum hemorrhage
(2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002351 · Cited by 1,406
Poon, L. C., Shennan, A. H., Hyett, J. A., Kapur, A., Hadar, E., Divakar, H., McAuliffe, F. M., Costa, F. D. S., von Dadelszen, P., McIntyre, D. H., et al. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12802 · Cited by 1,430
Self-citationDiretrizes Brasileiras de Hipertensão Arterial – 2020
Barroso, W. K. S., Rodrigues, C. I. S., Bortolotto, L. A., Gomes, M. A. M., Brandão, A. A., Feitosa, A. D. M., Machado, C. A., Poli‐de‐Figueiredo, C. E., Amodeo, C., Mion, D., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20201238 · Cited by 1,389
2020 International Society of Hypertension global hypertension practice guidelines
Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002453 · Cited by 1,283
Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Phipps, E. A., Thadhani, R., Benzing, T. R., & Karumanchi, S. A. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0119-6 · Cited by 1,328
Pre-eclampsia: pathophysiology and clinical implications
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250
Magee, L. A., Brown, M. A., Hall, D. R., Gupte, S., Hennessy, A., Karumanchi, S. A., Kenny, L. C., McCarthy, F., Myers, J., Poon, L. C., et al. (2022) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.09.008 · Cited by 1,134
Self-citationBrown, M. A., Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C., Adoyi, G., & Ishaku, S. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.05.004 · Cited by 1,117
Dimitriadis, E., Rolnik, D. L., Zhou, W., Estrada‐Gutiérrez, G., Koga, K., Francisco, R. P. V., Whitehead, C. L., Hyett, J. A., Costa, F. D. S., Nicolaides, K. H., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00417-6 · Cited by 1,082
Self-citationChappell, L. C., Cluver, C. A., Kingdom, J. C., & Tong, S. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32335-7 · Cited by 1,013
(2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003018 · Cited by 944
ACOG Committee Opinion No. 743: Low-Dose Aspirin Use During Pregnancy
(2018) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002708 · Cited by 711
Oxidative Stress in Preeclampsia and Placental Diseases
Aouache, R., Biquard, L., Vaiman, D., & Miralles, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051496 · Cited by 645
Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis
Roberge, S., Bujold, E., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.561 · Cited by 628
Self-citationThe Impact of Sex and Gender on Stroke
Rexrode, K. M., Madsen, T. E., Yu, A., Carcel, C., Lichtman, J. H., & Miller, E. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319915 · Cited by 641
Jung, E., Romero, R. J., Yeo, L., Gomez‐Lopez, N., Chaemsaithong, P., Jaovisidha, A., Gotsch, F., & Erez, O. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.11.1356 · Cited by 648
Arterial hypertension in adults. Clinical guidelines 2020
Kobalava, Z. D., Конради, А. О., Nedogoda, S. V., Shlyakhto, E. V., Arutyunov, G. P., Баранова, Е. И., Барбараш, О. Л., Бойцов, С. А., Вавилова, Т. В., Вадимовна, В. С., et al. (2020) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2020-3-3786 · Cited by 609
Garovic, V. D., Dechend, R., Easterling, T., Karumanchi, S. A., McMurtry Baird, S., Magee, L. A., Rana, S., Vermunt, J. V., August, P., & on behalf of the American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, K. I. H. D. S. C. C. O. A. (2022) · Hypertension · doi:10.1161/hyp.0000000000000208 · Cited by 598
Melamed, N., Baschat, A., Yinon, Y., Athanasiadis, A. P., Mecacci, F., Figueras, F., Berghella, V., Nazareth, A., Tahlak, M., McIntyre, D. H., et al. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13522 · Cited by 629
Self-citationMagee, L. A., Nicolaides, K. H., & von Dadelszen, P. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2109523 · Cited by 613
Self-citationRabi, D. M., McBrien, K. A., Sapir-Pichhadze, R., Nakhla, M., Ahmed, S. B., Dumanski, S. M., Butalia, S., Leung, A. A., Harris, K. C., Cloutier, L., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.02.086 · Cited by 583
Martins, J. G., Biggio, J. R., & Abuhamad, A. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.05.010 · Cited by 584
15. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2022
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s015 · Cited by 504
ASPRE trial: performance of screening for preterm pre‐eclampsia
Rolnik, D. L., Wright, D. E., Poon, L. C., Syngelaki, A., O’Gorman, N., Matallana, C. D. P., Akolekar, R., Cicero, S., JANGA, D., Singh, M., et al. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18816 · Cited by 478
Self-citationScreening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation
Tan, M. Y., Syngelaki, A., Poon, L. C., Rolnik, D. L., O'Gorman, N., Delgado, J. L., Akolekar, R., Konstantinidou, L., Tsavdaridou, M., Galeva, S., et al. (2018) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.19112 · Cited by 438
Self-citationSchreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 445
Prevention of preeclampsia with aspirin
Rolnik, D. L., Nicolaides, K. H., & Poon, L. C. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.08.045 · Cited by 445
Self-citationUS Preventive Services Task Force, Davidson, K. W., Barry, M. J., Mangione, C. M., Cabana, M., Caughey, A. B., Davis, E. M., Donahue, K. E., Doubeni, C. A., Kubik, M., et al. (2021) · JAMA · doi:10.1001/jama.2021.14781 · Cited by 420
Tan, M. Y., Wright, D., Syngelaki, A., Akolekar, R., Cicero, S., JANGA, D., Singh, M., Greco, E., Wright, A., Maclagan, K., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19039 · Cited by 395
Self-citationFirst trimester preeclampsia screening and prediction
Chaemsaithong, P., Sahota, D. S., & Poon, L. C. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.07.020 · Cited by 412
Self-citationAntiplatelet agents for preventing pre-eclampsia and its complications
Duley, L., Meher, S., Hunter, K. E., Seidler, A. L., & Askie, L. M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004659.pub3 · Cited by 383
Tracking placental development in health and disease
Aplin, J., Myers, J., Timms, K., & Westwood, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0372-6 · Cited by 401
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy
Backer, J. F. A. D., Haugaa, K. H., Hasselberg, N. E., de Hosson, M., Brida, M., Castelletti, S., Cauldwell, M., Cerbai, E., Crotti, L., de Groot, N. M. S., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf193 · Cited by 380
Maas, A. H. E. M., Rosano, G. M. C., Cífková, R., Chieffo, A., van Dijken, D., Hamoda, H., Kunadian, V., Laan, E. T. M., Lambrinoudaki, I. V., Maclaran, K., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1044 · Cited by 382
Hoffman, M. K., Goudar, S. S., Kodkany, B. S., Metgud, M., Somannavar, M., Okitawutshu, J., Lokangaka, A., Tshefu, A., Bose, C. L., Mwapule, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(19)32973-3 · Cited by 360
Syngelaki, A., Hammami, A., Bower, S., Zidere, V., Akolekar, R., & Nicolaides, K. H. (2019) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.20844 · Cited by 350
Self-citationClinical tools and biomarkers to predict preeclampsia
MacDonald, T. M., Walker, S. P., Hannan, N. J., Tong, S., & Kaitu’u‐Lino, T. J. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103780 · Cited by 335
The first 3500 years of aspirin history from its roots – A concise summary
Montinari, M. R., Minelli, S., & Caterina, R. D. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.10.008 · Cited by 351
Advanced maternal age and adverse pregnancy outcomes
Frick, A. (2020) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2020.07.005 · Cited by 345
Preeclampsia beyond pregnancy: long-term consequences for mother and child
Turbeville, H. R., & Sasser, J. M. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00071.2020 · Cited by 340
Subtypes of Preeclampsia: Recognition and Determining Clinical Usefulness
Roberts, J. M., Rich-Edwards, J. W., McElrath, T. F., Garmire, L., Myatt, L., & for the Global Pregnancy Collaboration (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14781 · Cited by 311
Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssière, C., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101861 · Cited by 324
15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2023
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D. M., Johnson, E. L., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s015 · Cited by 341
The role of immune cells and mediators in preeclampsia
Deer, E. M., Herrock, O., Campbell, N., Cornelius, D. C., Fitzgerald, S. J., Amaral, L. M., & LaMarca, B. B. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00670-0 · Cited by 316
Pregnancy and cardiovascular disease
Ramlakhan, K. P., Johnson, M. R., & Roos‐Hesselink, J. W. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0390-z · Cited by 316
Magee, L. A., Smith, G. N., Bloch, C., Côté, A., Jain, V., Nerenberg, K. A., von Dadelszen, P., Helewa, M. E., & Rey, É. (2022) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2022.03.002 · Cited by 309
Clinical practice guideline on pregnancy and renal disease
Wiles, K., Chappell, L. C., Clark, K., Elman, L., Hall, M., Lightstone, L., Mohamed, G., Mukherjee, D., Nelson‐Piercy, C., Webster, P., et al. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1560-2 · Cited by 305
Hypertension in pregnancy: Pathophysiology and treatment
Braunthal, S., & Brateanu, A. (2019) · SAGE Open Medicine · doi:10.1177/2050312119843700 · Cited by 312
ISUOG Practice Guidelines (updated): performance of 11–14‐week ultrasound scan
International Society of Ultrasound in Obstetrics and Gynecology, Bilardo, C. M., Chaoui, R., Hyett, J. A., Kagan, K. O., Karim, J. N., Papageorghiou, A. T., Poon, L. C., Salomon, L. J., Syngelaki, A., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26106 · Cited by 283
Self-citationTomimatsu, T., Mimura, K., Matsuzaki, S., Endo, M., Kumasawa, K., & Kimura, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174246 · Cited by 290
Care of Women with Obesity in Pregnancy
Denison, F. C., Aedla, N., Keag, O. E., Hor, K., Reynolds, R. M., Milne, A., & Diamond, A. (2018) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15386 · Cited by 292
14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2021
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc21-s014 · Cited by 291
Long-Term Cardiovascular Risks Associated With Adverse Pregnancy Outcomes
Lane‐Cordova, A. D., Khan, S. S., Grobman, W. A., Greenland, P., & Shah, S. J. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.092 · Cited by 285
The competing risk approach for prediction of preeclampsia
Wright, D. E., Wright, A., & Nicolaides, K. H. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.11.1247 · Cited by 274
Self-citation2024 Clinical practice guidelines for Hypertension in adults
Кобалава, Ж. Д., Конради, А. О., Nedogoda, S. V., Shlyakhto, E. V., Arutyunov, G. P., Баранова, Е. И., Барбараш, О. Л., Bobkova, N. V., Boytsov, S. A., Bubnova, M. G., et al. (2024) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2024-6117 · Cited by 274
15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Ekhlaspour, L., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s015 · Cited by 252
Stepan, H., Galindo, A., Hund, M., Schlembach, D., Sillman, J., Surbek, D., & Vatish, M. (2023) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.26032 · Cited by 245
Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction
Mayrink, J., Costa, M. L., & Cecatti, J. G. (2018) · The Scientific World JOURNAL · doi:10.1155/2018/6268276 · Cited by 244
15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2024
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s015 · Cited by 232
Henderson, J. T., Vesco, K. K., Senger, C. A., Thomas, R. G., & Redmond, N. (2021) · JAMA · doi:10.1001/jama.2021.8551 · Cited by 227
Prediction of pre‐eclampsia: review of reviews
Townsend, R., Khalil, A. A., Premakumar, Y., Allotey, J., Snell, K. I. E., Chan, C., Chappell, L. C., Hooper, R., Green, M., Mol, B. W., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20117 · Cited by 232
Fetal Growth Restriction: Mechanisms, Epidemiology, and Management
Kamphof, H. D., Posthuma, S., Gordijn, S. J., & Ganzevoort, W. (2022) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000161 · Cited by 224
Aspirin for Prevention of Preeclampsia
Atallah, A., Lecarpentier, É., Goffinet, F., Doret-Dion, M., Gaucherand, P., & Tsatsaris, V. (2017) · Drugs · doi:10.1007/s40265-017-0823-0 · Cited by 217
ISUOG Practice Guidelines: role of ultrasound in screening for and follow‐up of pre‐eclampsia
Sotiriadis, A., Hernandez‐Andrade, E. A., Costa, F. D. S., Ghi, T., Glanc, P., Khalil, A. A., Martins, W. P., Odibo, A. O., Papageorghiou, A. T., Salomon, L. J., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20105 · Cited by 215
The Placental Basis of Fetal Growth Restriction
Zur, R. L., Kingdom, J. C., Parks, W. T., & Hobson, S. R. (2019) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2019.10.008 · Cited by 214
A Narrative Review on the Pathophysiology of Preeclampsia
Torres‐Torres, J., y Sosa, S. E., Martinez-Portilla, R. J., Borboa-Olivares, H. J., Estrada‐Gutiérrez, G., Acevedo‐Gallegos, S., Ruiz-Ramirez, E., Velasco-Espin, M., Cerda‐Flores, P., Ramirez-Gonzalez, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147569 · Cited by 213
Screening for fetal growth restriction and placental insufficiency
Audette, M. C., & Kingdom, J. C. (2017) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2017.11.004 · Cited by 219
Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches
Armaly, Z., Jadaon, J. E., Jabbour, A. R., & Abassi, Z. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00973 · Cited by 217
Predictive performance of the competing risk model in screening for preeclampsia
Wright, D. E., Tan, M. Y., O’Gorman, N., Poon, L. C., Syngelaki, A., Wright, A., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.11.1087 · Cited by 208
Self-citationPreeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function
Ridder, A., Giorgione, V., Khalil, A. A., & Thilaganathan, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133263 · Cited by 204
Poon, L. C., Wright, D. E., Rolnik, D. L., Syngelaki, A., Delgado⋈, J. L., Tsokaki, T., Leipold, G., Akolekar, R., Shearing, S., Stefani, L. F. B. D., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.07.038 · Cited by 200
Self-citationIntegrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia
Than, N. G., Romero, R. J., Tarca, A. L., Kékesi, K. A., Xu, Y., Xu, Z., Juhász, K., Bhatti, G., Leavitt, R., Gelencsér, Z., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01661 · Cited by 197
Self-citationNicolaides, K. H., Papastefanou, I., Syngelaki, A., Ashoor, G., & Akolekar, R. (2021) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17066 · Cited by 175
Self-citationChaemsaithong, P., Pooh, R. K., Zheng, M., Ma, R., Chaiyasit, N., Tokunaka, M., Shaw, S. W., Seshadri, S., Choolani, M. A., Wataganara, T., et al. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.09.041 · Cited by 178
Self-citationHastie, R. M., Tong, S., Wikström, A., Sandström, A., Hesselman, S., & Bergman, L. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.07.023 · Cited by 177
Wright, D. E., Poon, L. C., Rolnik, D. L., Syngelaki, A., Delgado⋈, J. L., Vojtassakova, D., de Alvarado, M., Kapeti, E., Rehal, A., Pazos, A., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.08.110 · Cited by 172
Self-citationMa’ayeh, M., & Costantine, M. M. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101123 · Cited by 197
Scott, G. M., Gillon, T. E. R., Pels, A., von Dadelszen, P., & Magee, L. A. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.08.018 · Cited by 177
Groom, K. M., & David, A. L. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.565 · Cited by 170
Chinese Guidelines for the Prevention and Treatment of Hypertension (2024 revision)
Wang, J. (2025) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2025.01.008 · Cited by 170
Hypertensive Disorders of Pregnancy
Wilkerson, R. G., & Ogunbodede, A. C. (2019) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2019.01.008 · Cited by 174
A placenta clinic approach to the diagnosis and management of fetal growth restriction
Kingdom, J. C., Audette, M. C., Hobson, S. R., Windrim, R. C., & Morgen, E. K. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.575 · Cited by 167
Agrawal, A., & WENGER, N. K. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01070-0 · Cited by 168
Morris, R. K., Johnstone, E., Lees, C., Morton, V. H., & Smith, G. C. S. (2024) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17814 · Cited by 169
Hamulyák, E. N., Scheres, L. J. J., Marijnen, M. C., Goddijn, M., & Middeldorp, S. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012852.pub2 · Cited by 158
Pusdekar, Y. V., Patel, A., Kurhe, K., Bhargav, S., Thorsten, V., Garcés, A., Goldenberg, R. L., Goudar, S. S., Saleem, S., Esamai, F., et al. (2020) · Reproductive Health · doi:10.1186/s12978-020-01029-z · Cited by 158
Hypertensive Disorders in Pregnancy
Sutton, A. L. M., Harper, L. M., & Tita, A. (2018) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2018.01.012 · Cited by 152
Cardiovascular origins of preeclampsia
Kalafat, E., & Thilaganathan, B. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000419 · Cited by 151
Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview
Cífková, R. (2023) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-023-00582-5 · Cited by 158
Colson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 149
Rychik, J. R., Goff, D. A., McKay, E. M., Mott, A. R., Tian, Z., Licht, D. J., & Gaynor, J. W. (2018) · Pediatric Cardiology · doi:10.1007/s00246-018-1876-x · Cited by 144
Metadata
- Authors
- Rolnik, D. L., Wright, D., Poon, L. C., O’Gorman, N., Syngelaki, A., de Paco Matallana, C., Akolekar, R., Cicero, S., Janga, D., Singh, M., Molina, F. S., Persico, N., Jani, J. C., Plasencia, W., Papaioannou, G., Tenenbaum-Gavish, K., Meiri, H., Gizurarson, S., Maclagan, K., & Nicolaides, K. H.
- Affiliations
- Université Libre de Bruxelles (BE)
- King's College Hospital (GB)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-08-17
- Volume
- 377
- Issue
- 7
- Pages
- 613-622
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2730504020
- Cited by
- 2,287
- References
- 24
- Citations by year
- 2026: 252 · 2025: 277 · 2024: 231 · 2023: 274 · 2022: 257 · 2021: 249 · 2020: 265 · 2019: 212 · 2018: 196 · 2017: 69
- FWCI
- 238.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Funders
- Imperial College London
- Imperial College Healthcare NHS Trust
- University College London
- European Commission (FP7-HEALTH-2013INNOVATION, 601852, HEALTH-2013)
- Fetal Medicine Foundation
- FP7 Health (601852)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- low-dose aspirin, preterm preeclampsia, high-risk pregnancy, preeclampsia prevention, singleton pregnancy, drug safety in pregnancy, adverse neonatal outcomes
- MeSH terms
- Adult, Aspirin, Double-Blind Method, Female, Humans, Infant, Newborn, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk, Incidence, Kaplan-Meier Estimate, Intention to Treat Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
