A Bivalent Omicron-Containing Booster Vaccine against Covid-19

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

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Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · Nature Medicine · doi:10.1038/s41591-021-01377-8 · Cited by 3,742 · see citing works

Evolution of antibody immunity to SARS-CoV-2

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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

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Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

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Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa

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Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

El Sahly, H. M., Baden, L. R., Essink, B., Doblecki-Lewis, S., Martin, J. M., Anderson, E. J., Campbell, T. B., Clark, J., Jackson, L. A., Fichtenbaum, C. J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2113017 · Cited by 641 · see citing works

Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants

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Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

Pegu, A., O’Connell, S. E., Schmidt, S. D., O’Dell, S., Talana, C. A., Lai, L., Albert, J., Anderson, E., Bennett, H., Corbett, K. S., et al. (2021) · Science · doi:10.1126/science.abj4176 · Cited by 527 · see citing works

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

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Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

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Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

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Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

Thompson, M. G., Natarajan, K., Irving, S. A., Rowley, E. A., Griggs, E. P., Gaglani, M., Klein, N. P., Grannis, S. J., DeSilva, M. B., Stenehjem, E., et al. (2022) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7104e3 · Cited by 398 · see citing works

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Suryawanshi, R. K., Chen, I. P., Ma, T., Syed, A. M., Brazer, N., Saldhi, P., Simoneau, C. R., Ciling, A., Khalid, M. M., Sreekumar, B. K. N., et al. (2022) · Nature · doi:10.1038/s41586-022-04865-0 · Cited by 208 · see citing works

Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial

Chalkias, S., Eder, F. S., Essink, B. J., Khetan, S. K., Nestorova, B., Feng, J., Chen, X., Chang, Y., Zhou, H., Montefiori, D. C., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02031-7 · Cited by 130 · see citing works

Protection against omicron (B.1.1.529) BA.2 reinfection conferred by primary omicron BA.1 or pre-omicron SARS-CoV-2 infection among health-care workers with and without mRNA vaccination: a test-negative case-control study

Carazo, S., Skowronski, D. M., Brisson, M., Sauvageau, C., Brousseau, N., Gilca, R., Ouakki, M., Barkati, S., Fafard, J., Talbot, D. C., et al. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(22)00578-3 · Cited by 109 · see citing works

Immune Memory Response After a Booster Injection of mRNA-1273 for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)

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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infectionPreprint

Cao, Y., Yisimayi, A., Jian, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.30.489997 · Cited by 90 · see citing works

Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Tang, J., Novak, T., Hecker, J., Grubbs, G., Zahra, F. T., Bellusci, L., Pourhashemi, S., Chou, J. S., Moffitt, K. L., Halasa, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30649-1 · Cited by 55 · see citing works

Effectiveness of a COVID-19 Additional Primary or Booster Vaccine Dose in Preventing SARS-CoV-2 Infection Among Nursing Home Residents During Widespread Circulation of the Omicron Variant — United States, February 14–March 27, 2022

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Multiple Endpoints in Clinical Trials

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mRNA-1273 Vaccine-elicited Neutralization of SARS-CoV-2 Omicron in Adolescents and Children

Girard, B., Tomassini, J. E., Deng, W., Maglinao, M., Zhou, H., Figueroa, A., Ghamloush, S. S., Montefiori, D. C., Das, R., & Pajon, R. (2022) · doi:10.1101/2022.01.24.22269666 · Cited by 23 · see citing works

Safety, Immunogenicity and Antibody Persistence of a Bivalent Beta-Containing Booster VaccinePreprint

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Covid-19 in the Phase 3 Trial of mRNA-1273 During the Delta-variant SurgePreprint

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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

Wilson, E. M. P., Goswami, J., Baqui, A. H., Doreski, P. A., Marc, G. P., Zaman, K., Monroy, J., Duncan, C. J. A., Ujiie, M., Rämet, M., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2307079 · Cited by 517 · see citing works

Evolution of the SARS‐CoV‐2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission

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A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies

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Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-analysis

Menegale, F., Manica, M., Zardini, A., Guzzetta, G., Marziano, V., d'Andrea, V., Trentini, F., Ajelli, M., Poletti, P., & Merler, S. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.10650 · Cited by 280 · see citing works

Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster

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Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

Park, Y., Pinto, D., Walls, A. C., Liu, Z., Marco, A. D., Benigni, F., Zatta, F., Silacci-Fregni, C., Bassi, J., Sprouse, K. R., et al. (2022) · Science · doi:10.1126/science.adc9127 · Cited by 225 · see citing works

Strategies to reduce the risks of mRNA drug and vaccine toxicity

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Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters

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Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

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Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

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Mapping SARS-CoV-2 antigenic relationships and serological responses

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Effectiveness of a bivalent mRNA vaccine booster dose to prevent severe COVID-19 outcomes: a retrospective cohort study

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Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

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Durability of immune response after COVID-19 booster vaccination and association with COVID-19 omicron infection

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Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial

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Clinical delivery of circular RNA: Lessons learned from RNA drug development

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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans

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Bivalent Omicron BA.1–Adapted BNT162b2 Booster in Adults Older than 55 Years

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Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2

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Predicting the efficacy of variant-modified COVID-19 vaccine boosters

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Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults — VISION Network, Nine States, September–November 2022

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Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens

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Frameworks for transformational breakthroughs in RNA-based medicines

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In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms

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BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants

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mRNA Vaccines against SARS-CoV-2: Advantages and Caveats

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Comparative effectiveness of bivalent BA.4-5 and BA.1 mRNA booster vaccines among adults aged ≥50 years in Nordic countries: nationwide cohort study

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Global and regional genetic diversity of HIV-1 in 2010–21: systematic review and analysis of prevalence

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Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results

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Vaccine schedule recommendations and updates for patients with hematologic malignancy post‐hematopoietic cell transplant or CAR T‐cell therapy

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Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history

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Immune imprinting and next-generation coronavirus vaccines

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Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

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Safety and Immunogenicity of XBB.1.5-Containing mRNA VaccinesPreprint

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Defending against SARS-CoV-2: The T cell perspective

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Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines

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Duration of protection of ancestral-strain monovalent vaccines and effectiveness of bivalent BA.1 boosters against COVID-19 hospitalisation in England: a test-negative case-control study

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Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

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Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial

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Evolution of antibody immunity following Omicron BA.1 breakthrough infection

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Effectiveness of Monovalent mRNA Vaccines Against COVID-19–Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States — IVY Network, 18 States, December 26, 2021–August 31, 2022

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Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes

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T cell immune memory after covid-19 and vaccination

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Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

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Interim Report of the Reactogenicity and Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 XBB–Containing Vaccines

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School closures during COVID-19: an overview of systematic reviews

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Immunologic Effect of Bivalent mRNA Booster in Patients Undergoing Hemodialysis

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Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants

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