Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine
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Variant SARS-CoV-2 and the mRNA-1273 Vaccine How well do serum samples from persons vaccinated with the mRNA-1273 vaccine neutralize the P.1 lineage, the B.1.1.7 lineage, the B.1.1.7 lineage plus t...
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Neutralizing antibody titres against certain SARS-CoV-2 variants, such as B.1.351 (Beta) and B.1.617.2 (Delta), were lower than those against the parental strain WA1/2020.
“As previously reported for other vaccines29–33, the neutralizing antibody titres against certain SARS-CoV-2 variants, such as the B.1.351 (Beta) and B.1.617.2 (Delta) variants, were lower than those against the parental strain WA1/2020.”
From Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine (2022) · cites this paper as [31]
In the main text (page not specified), the paper reports lower neutralizing titers against B.1.351 in serum from mRNA-1273 recipients, using the original Wuhan-Hu-1 isolate as a reference. It does not report results for B.1.617.2 (Delta) or name WA1/2020 as the comparator. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe impact of B.1.1.7 mutations on neutralizing antibody titers is moderate.
“In general, the impact of B.1.1.7 mutations on neutralizing antibody titers is moderate.15, 16, 17, 18,20,24”
From Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals (2021) · cites this paper as [16]
Mutations in B.1.351 and P.1 variants are associated with the more pronounced loss of neutralizing capacity.
“In contrast, mutations in B.1.351 and P.1 variants are associated with the more pronounced loss of neutralizing capacity.15,16,22,23,25”
From Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals (2021) · cites this paper as [16]
Reduced sensitivity to vaccine-elicited nAbs has been reported for other B.1.351 variants.
“Reduced sensitivity to vaccine-elicited nAbs has been reported for other B.1.351 variants (66, 83, 84).”
From mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection (2021) · cites this paper as [84]
B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the WA1 strain.
“In multiple studies, B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the virus strain first described in January 2020 (Wuhan-Hu-1, spike also called WA1) (2–9).”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [7]
Most prior studies evaluated sera from vaccinated individuals soon after the first or second dose and had limited data on the durability of such responses.
“Most of these prior studies have evaluated sera from vaccinated individuals at time points soon after the first or second dose and have had limited data on the durability of such responses.”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [7]
Cross-neutralization efficacies against SARS-CoV-2 variants are significantly lower than against the ancestral variant.
“However, cross-neutralization efficacies have been significantly lower compared with the ancestral variant208–211.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [210]
The FDA-approved mRNA vaccines BNT162b2 and mRNA-1273 produce cross-neutralizing antibodies against B.1.351, P.1 and other SARS-CoV-2 variants.
“Fortunately, the FDA-approved mRNA vaccines BNT162b2 and mRNA-1273 produce cross-neutralizing antibodies against B.1.351 and P.1, as well as against other variants, suggesting that they can provide protection against them.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [210]
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- Authors
- Wu, K., Werner, A. P., Koch, M., Choi, A., Narayanan, E., Stewart-Jones, G. B. E., Colpitts, T., Bennett, H., Boyoglu-Barnum, S., Shi, W., Moliva, J. I., Sullivan, N. J., Graham, B. S., Carfi, A., Corbett, K. S., Seder, R. A., & Edwards, D. K.
- Affiliations
- Moderna, Cambridge, MA
- National Institute of Allergy and Infectious Diseases (US)
- Moderna Therapeutics (United States) (US)
- Corresponding author
- Edwards, Darin K.
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-04-15
- Volume
- 384
- Issue
- 15
- Pages
- 1468-1470
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8008744
- OpenAlex
- W3132479927
- Cited by
- 409
- References
- 3
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 11 · 2023: 30 · 2022: 144 · 2021: 215 · 2020: 3
- FWCI
- 31.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH Office of the Director (Undergraduate Scholarship Program)
- National Institute of Allergy and Infectious Diseases (Intramural Research Program of the Vaccine Researc)
- Office of Public Health Preparedness and Response (75A50120C00034)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- mRNA-1273 vaccine, SARS-CoV-2, neutralizing antibodies, P.1 lineage, B.1.1.7 lineage, Omicron variant, SARS-CoV-2 variants, vaccine efficacy
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, mRNA Vaccines, 2019-nCoV Vaccine mRNA-1273, Antibodies, Viral, Humans, Mutation, Vaccines, Synthetic, Statistics, Nonparametric, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus
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