Cited by 2,712Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeAutoimmune and Inflammatory Disorders

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Inflammatory Bowel Disease

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Abraham, Clara, Cho, Judy H.·2009·New England Journal of Medicine

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
Keane, J., Gershon, S. K., Wise, R. P., Mirabile‐Levens, E., Kasznica, J. M., Schwieterman, W. D., Siegel, J. N., & Braun, M. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011110 · Cited by 3,683
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554

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Musch MW, 2002, J Clin Invest, 110, 1739, 10.1172/JCI0215695 · DOI
Vijay-Kumar M, 2007, J Clin Invest, 117, 3909
10.1172/JCI19229 · DOI
Kamada N, 2008, J Clin Invest, 118, 2269
Watanabe T, 2008, J Clin Invest, 118, 545
Sugimoto K, 2008, J Clin Invest, 118, 534

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Dey, Y. N., Sharma, G., Wanjari, M., Kumar, D., Lomash, V., & Jadhav, A. D. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1226904 · Cited by 40
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Rodríguez–Lago, I., Merino, O., Azagra, I., Maíz, A., Zapata, E. M., Higuera, R., Montalvo, I., Fernández‐Calderón, M., Arreba, P., Carrascosa, J., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.11.006 · Cited by 40
Can IL-23 be a good target for ulcerative colitis?
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Effects of lactobacilli with different regulatory behaviours on tight junctions in mice with dextran sodium sulphate-induced colitis
Wang, G., Xu, Q., Jin, X., Hang, F., Liu, Z., Zhao, J., Zhang, H., & Chen, W. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.044 · Cited by 40
The state of the art on treatment of Crohn’s disease
Shi, H. Y., & Ng, S. C. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1479-6 · Cited by 39
Inflammation: a highly conserved, Janus-like phenomenon—a gastroenterologist’ perspective
Ribaldone, D. G., Pellicano, R., & Actis, G. C. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1668-z · Cited by 41
Alexithymia and Psychopathology in Patients Suffering From Inflammatory Bowel Disease: Arising Differences and Correlations to Tailoring Therapeutic Strategies
Viganò, C. A., Beltrami, M., Bosi, M. F., Zanello, R., Valtorta, M., & Maconi, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00324 · Cited by 42
“While inflammation in CD can involve the entire gastrointestinal tract (1), the inflammation in UC is localized at the colon and rectum level only.”
Background
Homoectoine Protects Against Colitis by Preventing a Claudin Switch in Epithelial Tight Junctions
Castro-Ochoa, K. F., Vargas‐Robles, H., Chánez-Paredes, S. D., Felipe‐López, A., Cabrera-Silva, R. I., Shibayama, M., Betanzos, A., Nava, P., Galinski, E. A., & Michael Schnoor, A. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5309-8 · Cited by 40
The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation
Giles, D. A., Zahner, S. P., Krause, P., van der Gracht, E. T. I., Riffelmacher, T., Morris, V., Tumanov, A. V., & Kronenberg, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02585 · Cited by 40
“Of interest, different mediators of the mucosal immune system can either protect from, or exacerbate disease (1).”
Background
Characterization of γδ T Cells in Intestinal Mucosa From Patients With Early-Onset or Long-Standing Inflammatory Bowel Disease and Their Correlation With Clinical Status
Presti, E. L., Mitri, R. D., Mocciaro, F., Stefano, A. B. D., Scibetta, N., Unti, E., Cicero, G., Pecoraro, G. M., Conte, E., Dieli, F., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz015 · Cited by 41
Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better
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3,3′-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway
Huang, Z. D., Zuo, L., Zhang, Z., Liu, J., Chen, J., Dong, L., & Zhang, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.703 · Cited by 40
“The inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract [5].”
Background
The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis
Robinson, A. M., Rahman, A. A., Miller, S., Stavely, R. G., Sakkal, S., & Nurgali, K. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0540-3 · Cited by 40
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Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response
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The coumaric acid and syringic acid ameliorate acetic acid-induced ulcerative colitis in rats via modulator of Nrf2/HO-1 and pro-inflammatory cytokines
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Revisiting the Role of Valeric Acid in Manipulating Ulcerative Colitis
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MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis
Dave, M., Dev, A., Somoza, R. A., Zhao, N., Viswanath, S. E., Mina, P. R., Chirra, P. V., Obmann, V. C., Mahabeleshwar, G. H., Menghini, P., et al. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00347-1 · Cited by 44
The Trend of Inflammatory Bowel Diseases in Taiwan: A Population-Based Study
Kuo, C., Yu, K., See, L., Chiu, C., Su, M., Hsu, C., Kuo, C., Chiou, M., Liu, J., & Wang, H. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3630-z · Cited by 39
T-Cell Trafficking and Anti-Adhesion Strategies in Inflammatory Bowel Disease: Current and Future Prospects
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“This newer preparation was evaluated in a phase II-b ‘bridging study’ that studied 46 adult patients with active UC (defined as a partial Mayo score [PMS] of[1).”
BackgroundMethod
TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages
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Pathway-based approaches to the treatment of inflammatory bowel disease
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Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy
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JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
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Overcoming Immune Dysregulation with Immunoengineered Nanobiomaterials
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Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study
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Prevalence and screening for anaemia in mild to moderate Crohn's disease and ulcerative colitis in the United States, 2010–2014
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Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis
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Anti-interleukin-12 and anti-interleukin-23 agents in Crohn’s disease
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Authors: Abraham, C., & Cho, J. H.
Affiliations: Yale University (US)
ORCID: Abraham, Clara
Cho, Judy H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-11-19
Volume: 361
Issue: 21
Pages: 2066-2078
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra0804647
PMC: PMC3491806
OpenAlex: W4244626580
Cited by: 2,712
References: 104
Citations by year: 2026: 94 · 2025: 137 · 2024: 169 · 2023: 151 · 2022: 171 · 2021: 184 · 2020: 237 · 2019: 189 · 2018: 193 · 2017: 182 · 2016: 171 · 2015: 217 · 2014: 174 · 2013: 142 · 2012: 120
FWCI: 9.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Crohn's and Colitis Foundation of America (DK062422, R01DK077905)
Crohn's and Colitis Foundation
National Institutes of Health (DK P30-34989, U01 DK62429)
Takeda Oncology
National Institute of Diabetes and Digestive and Kidney Diseases (DK P30 34989, U01-DK62429, R01DK072373, R01DK077905, RC1DK086800, U01DK062429, P30DK034989, U01DK062422)
National Center for Research Resources (UL1RR024139)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Dermatology › Autoimmune and Inflammatory Disorders
Keywords: inflammatory bowel disease
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestinal Mucosa, T-Lymphocytes, Inflammatory Bowel Diseases, Interleukin-23, Metagenome

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