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Inflammatory Bowel Disease
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“The pathogenesis of IBD involves an abnormal immune response, likely to environmental factors, in genetically susceptible individuals62.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [62]
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“One of the proposed mechanisms for the development of IBD involves the interplay between microbes and the immune system, which may then lead to an abnormal inflammatory response in genetically susceptible individuals (Abraham 2009; Cleynen 2016).”
BackgroundInfluentialMycobiota in gastrointestinal diseases
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Intestinal Epithelium in Inflammatory Bowel Disease
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“When IBD occurs, it is often accompanied by the death of intestinal epithelial cells (Abraham and Cho, 2009).”
BackgroundCOVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies
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“It regularly occurs in the intestinal biopsies of patients with IBD and the milk of nursing mothers diagnosed with CD; the antibodies against Mycobacterium avium paratuberculosis spp. have been detected in more than 83% subjects with CD.17 Moreover, Mycobacterium is involved in the initiation of John’s disease occurri…”
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“While the inflammation in UC is normally restricted to the mucosal layer of the entire colon in an uninterrupted pattern, the inflammation in CD is typically confined to the mucosa layer of the colon (Abraham and Cho, 2009).”
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“Factors that contribute to the development of IBD are unclear, although the current paradigm of pathogenesis involves the interaction of disease-susceptibility genes, inappropriate immune response, gut microbiota, and environmental factors (Abraham 2009).”
BackgroundCharacterization of Microbial Dysbiosis and Metabolomic Changes in Dogs with Acute Diarrhea
Guard, B. C., Barr, J. W., Reddivari, L., Klemashevich, C. L., Jayaraman, A., Steiner, J. M., Vanamala, J., & Suchodolski, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127259 · Cited by 202
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“INTRODUCTION Inflammatory bowel diseases (IBD) are hypothesised to occur in genetically susceptible individuals as a result of dysregulated immune responses to gut flora after exposure to an as yet unidentified environmental stimulus.(1) 2 Investigation of diseases that present with intestinal inflammation that are si…”
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Metadata
- Authors
- Abraham, C., & Cho, J. H.
- Affiliations
- Yale University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-11-19
- Volume
- 361
- Issue
- 21
- Pages
- 2066-2078
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3491806
- OpenAlex
- W4244626580
- Cited by
- 2,712
- References
- 104
- Citations by year
- 2026: 94 · 2025: 137 · 2024: 169 · 2023: 151 · 2022: 171 · 2021: 184 · 2020: 237 · 2019: 189 · 2018: 193 · 2017: 182 · 2016: 171 · 2015: 217 · 2014: 174 · 2013: 142 · 2012: 120
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation of America (DK062422, R01DK077905)
- Crohn's and Colitis Foundation
- National Institutes of Health (DK P30-34989, U01 DK62429)
- Takeda Oncology
- National Institute of Diabetes and Digestive and Kidney Diseases (DK P30 34989, U01-DK62429, R01DK072373, R01DK077905, RC1DK086800, U01DK062429, P30DK034989, U01DK062422)
- National Center for Research Resources (UL1RR024139)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Dermatology › Autoimmune and Inflammatory Disorders
- Keywords
- inflammatory bowel disease
- MeSH terms
- Animals, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestinal Mucosa, T-Lymphocytes, Inflammatory Bowel Diseases, Interleukin-23, Metagenome
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