Cited by 2,712Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeAutoimmune and Inflammatory Disorders

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Inflammatory Bowel Disease

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Abraham, Clara, Cho, Judy H.·2009·New England Journal of Medicine

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
Keane, J., Gershon, S. K., Wise, R. P., Mirabile‐Levens, E., Kasznica, J. M., Schwieterman, W. D., Siegel, J. N., & Braun, M. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011110 · Cited by 3,683
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554

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Musch MW, 2002, J Clin Invest, 110, 1739, 10.1172/JCI0215695 · DOI
Vijay-Kumar M, 2007, J Clin Invest, 117, 3909
10.1172/JCI19229 · DOI
Kamada N, 2008, J Clin Invest, 118, 2269
Watanabe T, 2008, J Clin Invest, 118, 545
Sugimoto K, 2008, J Clin Invest, 118, 534

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BackgroundMethodInfluential
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Authors: Abraham, C., & Cho, J. H.
Affiliations: Yale University (US)
ORCID: Abraham, Clara
Cho, Judy H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-11-19
Volume: 361
Issue: 21
Pages: 2066-2078
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra0804647
PMC: PMC3491806
OpenAlex: W4244626580
Cited by: 2,712
References: 104
Citations by year: 2026: 94 · 2025: 137 · 2024: 169 · 2023: 151 · 2022: 171 · 2021: 184 · 2020: 237 · 2019: 189 · 2018: 193 · 2017: 182 · 2016: 171 · 2015: 217 · 2014: 174 · 2013: 142 · 2012: 120
FWCI: 9.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Crohn's and Colitis Foundation of America (DK062422, R01DK077905)
Crohn's and Colitis Foundation
National Institutes of Health (DK P30-34989, U01 DK62429)
Takeda Oncology
National Institute of Diabetes and Digestive and Kidney Diseases (DK P30 34989, U01-DK62429, R01DK072373, R01DK077905, RC1DK086800, U01DK062429, P30DK034989, U01DK062422)
National Center for Research Resources (UL1RR024139)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Dermatology › Autoimmune and Inflammatory Disorders
Keywords: inflammatory bowel disease
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestinal Mucosa, T-Lymphocytes, Inflammatory Bowel Diseases, Interleukin-23, Metagenome

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