Cited by 2,712Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeAutoimmune and Inflammatory Disorders

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Inflammatory Bowel Disease

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Abraham, Clara, Cho, Judy H.·2009·New England Journal of Medicine

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Biomaterial-based strategies for immunomodulation in IBD: current and future scenarios
Jori, C., Chaudhary, A. A., Rashid, S., Ali, M. A. M., Alawam, A. S., Haouala, F., & Khan, R. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00276d · Cited by 35
Gut Microbiota‐Derived 3‐Hydroxybutyrate Blocks GPR43‐Mediated IL6 Signaling to Ameliorate Radiation Proctopathy
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Viruses, Autophagy Genes, and Crohn’s Disease
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Circulating memory B cells and plasmablasts are associated with the levels of serum immunoglobulin in patients with ulcerative colitis
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Identification of Commensal Species Positively Correlated with Early Stress Responses to a Compromised Mucus Barrier
Sovran, B., Lu, P., Loonen, L. M. P., Hugenholtz, F., Belzer, C., Stolte, E. H., Boekschoten, M. V., van Baarlen, P., Smidt, H., Kleerebezem, M., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000688 · Cited by 34
CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn’s Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide
Marafini, I., Monteleone, I., Dinallo, V., Fusco, D. D., Simone, V. D., Laudisi, F., Fantini, M. C., Sabatino, A. D., Pallone, F., & Monteleone, G. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw191 · Cited by 35
IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis
Peng, L.-L., Wang, Y., Zhu, F.-L., Xu, W., Ji, X.-L., & Ni, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13607 · Cited by 35
“Ulcerative Colitis (UC) is a chronic relapsing and remitting intestinal inflammatory disorder that is confined to the mucosal and submucosal layers of rectum and colon, invading epithelial lining of the gut [1, 2].”
Background
Inflammatory Bowel Disease in Latin America: A Systematic Review
Calderón, M., Minckas, N., Núñez-González, S., & Ciapponi, A. (2018) · Value in Health Regional Issues · doi:10.1016/j.vhri.2018.03.010 · Cited by 35
Mimics of Inflammatory Bowel Disease
Shivashankar, R., & Lichtenstein, G. R. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy168 · Cited by 36
Colitis Alters Oxysterol Metabolism and is Affected by 4β-Hydroxycholesterol Administration
Guillemot‐Legris, O., Mutemberezi, V., Buisseret, B., Paquot, A., Palmieri, V., Bottemanne, P., Lemaire, J., Rahier, J., Alhouayek, M., & Muccioli, G. G. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy157 · Cited by 35
Immuno-PET of Innate Immune Markers CD11b and IL-1β Detects Inflammation in Murine Colitis
Dmochowska, N., Tieu, W., Keller, M., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P., & Hughes, P. A. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.219287 · Cited by 35
Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice
Sacco, A., Bruno, A., Contursi, A., Dovizio, M., Tacconelli, S., Ricciotti, E., Guillem‐Llobat, P., Salvatore, T., Francesco, L. D., Fullone, R., et al. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.259382 · Cited by 38
The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal epithelial cells injury
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Cadherin-11 Is a Regulator of Intestinal Fibrosis
Franzè, E., Monteleone, I., Laudisi, F., Rizzo, A., Dinallo, V., Fusco, D. D., Colantoni, A., Ortenzi, A., Giuffrida, P., Carlo, S. D., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz147 · Cited by 36
Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity
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Gerlach, K., Lechner, K., Popp, V., Offensperger, L., Zundler, S., Wiendl, M., Becker, E., Atreya, R. N., Räth, T., Neurath, M. F., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa162 · Cited by 35
Association Between Helicobacter pylori Colonization and Inflammatory Bowel Disease
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Distinct integrin activation pathways for effector and regulatory T cell trafficking and function
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Current therapy of pediatric Crohn’s disease
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Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients
Martini, M., Ferrara, A. M., Giachelia, M., Panieri, E., Siminovitch, K., Galeotti, T., Larocca, L. M., & Pani, G. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21814 · Cited by 35
Tanshinone IIA Protects against Dextran Sulfate Sodium‐ (DSS‐) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation
Liu, X., He, H., Huang, T., Lei, Z., Liu, F., An, G., & Wen, T. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7916763 · Cited by 35
Mucosa‐attached bacterial community in Crohn's disease coheres with the clinical disease activity index
Schäffler, H., Herlemann, D. P. R., Alberts, C., Kaschitzki, A., Bodammer, P., Bannert, K., Köller, T., Warnke, P., Kreikemeyer, B., & Lamprecht, G. (2016) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12411 · Cited by 35
The metabolomic physics of complex diseases
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Nanomedicine for colon-targeted drug delivery: strategies focusing on inflammatory bowel disease and colon cancer
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Metabolic and Immune System Dysregulation: Unraveling the Connections between Alzheimer’s Disease, Diabetes, Inflammatory Bowel Diseases, and Rheumatoid Arthritis
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“The exact etiology of inflammatory bowel disease is uncertain, although, in genetically predisposed individuals, the response of the mucosa to commensal gut flora appears to be dysregulated, leading to inflammation of the colon [95,96].”
Background
Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases
Ananthakrishnan, A. N., Cagan, A., Cai, T., Gainer, V. S., Shaw, S. Y., Churchill, S. E., Karlson, E. W., Murphy, S. N., Kohane, I. S., Liao, K. P., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000524 · Cited by 34
Anti-VEGF therapy reduces intestinal inflammation in Endoglin heterozygous mice subjected to experimental colitis
Ardelean, D. S., Yin, M., Jerkić, M., Peter, M. R., Ngan, B., Kerbel, R. S., Foster, F. S., & Letarte, M. (2014) · Angiogenesis · doi:10.1007/s10456-014-9421-x · Cited by 34
“Chronic inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are characterized by severe gut inflammation [1] and are accompanied by the formation of new, excessive and persistent abnormal blood vessels from pre-existing ones [2].”
The Role of Mucosal Healing in the Treatment of Patients With Inflammatory Bowel Disease
Vaughn, B. P., Shah, S., & Cheifetz, A. S. (2014) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-013-0008-1 · Cited by 34
“Classically, the goals of care when treating a patient with inflammatory bowel disease (IBD) were inducing and maintaining clinical remission and improving the patient’s quality of life [1, 2].”
Background
Pathogenic Microorganisms and Pancreatic Cancer
Wang, C., & Li, J. (2015) · Gastrointestinal Tumors · doi:10.1159/000380896 · Cited by 34
Lactobacillus plantarum LP-Onlly alters the gut flora and attenuates colitis by inducing microbiome alteration in interleukin-10 knockout mice
Chen, H., Xia, Y., Zhu, S., Yang, J., Yao, J., Di, J., Liang, Y., Gao, R., Wu, W., Yang, Y. P., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7351 · Cited by 34
The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models
Steinert, A., Linas, I., Kaya, B., Ibrahim, M. A., Schlitzer, A., Hruz, P. L., Radulovic, K., Terracciano, L., Macpherson, A. J., & Niess, J. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700350 · Cited by 33
Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease
Ihara, S., Hirata, Y., Hikiba, Y., Yamashita, A., Tsuboi, M., Hata, M., Konishi, M., Suzuki, N., Sakitani, K., Kinoshita, H., et al. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy088 · Cited by 34

Authors: Abraham, C., & Cho, J. H.
Affiliations: Yale University (US)
ORCID: Abraham, Clara
Cho, Judy H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-11-19
Volume: 361
Issue: 21
Pages: 2066-2078
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra0804647
PMC: PMC3491806
OpenAlex: W4244626580
Cited by: 2,712
References: 104
Citations by year: 2026: 94 · 2025: 137 · 2024: 169 · 2023: 151 · 2022: 171 · 2021: 184 · 2020: 237 · 2019: 189 · 2018: 193 · 2017: 182 · 2016: 171 · 2015: 217 · 2014: 174 · 2013: 142 · 2012: 120
FWCI: 9.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Crohn's and Colitis Foundation of America (DK062422, R01DK077905)
Crohn's and Colitis Foundation
National Institutes of Health (DK P30-34989, U01 DK62429)
Takeda Oncology
National Institute of Diabetes and Digestive and Kidney Diseases (DK P30 34989, U01-DK62429, R01DK072373, R01DK077905, RC1DK086800, U01DK062429, P30DK034989, U01DK062422)
National Center for Research Resources (UL1RR024139)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Dermatology › Autoimmune and Inflammatory Disorders
Keywords: inflammatory bowel disease
MeSH terms: Animals, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestinal Mucosa, T-Lymphocytes, Inflammatory Bowel Diseases, Interleukin-23, Metagenome

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