The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
Open accessAbstract
Adipocyte precursor cells give raise to two major cell populations with different physiological roles: white and brown adipocytes. Here we demonstrate that the retinoblastoma protein (pRB) regulates white vs. brown adipocyte differentiation. Functional inactivation of pRB in wild-type mouse embryo fibroblasts (MEFs) and white preadipocytes by expression of simian virus 40 large T antigen results in the expression of the brown fat-specific uncoupling protein 1 (UCP-1) in the adipose state. Retinoblastoma gene-deficient ( Rb – / – ) MEFs and stem cells, but not the corresponding wild-type cells, differentiate into adipocytes with a gene expression pattern and mitochondria content resembling brown adipose tissue. pRB-deficient MEFs exhibit an increased expression of the Forkhead transcription factor Foxc2 and its target gene cAMP-dependent protein kinase regulatory subunit RIα, resulting in increased cAMP sensitivity. Suppression of cAMP-dependent protein kinase activity in Rb –/– MEFs blocked the brown adipocyte-like gene expression pattern without affecting differentiation per se . Immunohistochemical studies revealed that pRB is present in the nuclei of white but not brown adipocyte precursor cells at a developmental stage where both cell types begin to accumulate lipid and brown adipocytes express UCP-1. Furthermore, pRB rapidly undergoes phosphorylation upon cold-induced neodifferentiation and up-regulation of UCP-1 expression in brown adipose tissue. Finally, down-regulation of pRB expression accompanies transdifferentiation of white into brown adipocytes in response to β3-adrenergic receptor agonist treatment. We propose that pRB acts as a molecular switch determining white vs. brown adipogenesis, suggesting a previously uncharacterized function of this key cell cycle regulator in adipocyte lineage commitment and differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among the known inhibitors of preadipocyte-adipocyte transition, proteins of the retinoblastoma (Rb) family, and necdin, a growth repressor functionally resembling Rb, selectively inhibit brown preadipocyte differentiation 132,133,168”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
Transcriptional regulation of adipogenesisPreprint
Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,908
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440
The Rb/E2F pathway: expanding roles and emerging paradigms
Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075
Research works printed but not linked: 2
- Lipinski, M. M. & Jacks, T. (2000) Oncogene 18, 7873–7882.
- Kozak, U. C., Held, W., Kreutter, D. & Kozak, L. P. (1992) Mol. Endocrinol. 6, 763–772.1603085
Cited by
Sorted by citations
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170
Transcriptional control of adipocyte formation
Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478
Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263
Self-citationPrdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,272
Self-citationAdipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Transcriptional Control of Brown Fat Determination by PRDM16
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174
Transcriptional Regulation of Metabolism
Desvergne, B., Michalik, L., & Wahli, W. (2006) · Physiological Reviews · doi:10.1152/physrev.00025.2005 · Cited by 921
New developments in adipogenesis
Lefterova, M. I., & Lazar, M. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.11.005 · Cited by 888
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828
PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 770
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3760 · Cited by 738
Timmons, J. A., Wennmalm, K., Larsson, O., Walden, T. B., Lassmann, T., Petrovic, N., Hamilton, D. L., Gimeno, R. E., Wahlestedt, C., Baar, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610615104 · Cited by 732
Self-citationInitiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703
Ali, A. T., Hochfeld, W. E., Myburgh, R., & Pepper, M. S. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.06.001 · Cited by 631
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468
Kajimura, S., & Saito, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170252 · Cited by 438
Transcriptional Control of Brown Fat Development
Kajimura, S., Seale, P., & Spiegelman, B. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.005 · Cited by 430
Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 390
Brown fat as a therapy for obesity and diabetes
Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376
Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 365
Self-citationTailoring to RB: tumour suppressor status and therapeutic response
Knudsen, E. S., & Knudsen, K. E. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2401 · Cited by 354
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
Inagaki, T., Sakai, J., & Kajimura, S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.62 · Cited by 344
Transcriptional coregulators in the control of energy homeostasis
Feige, J. N., & Auwerx, J. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.04.001 · Cited by 325
Rb regulates fate choice and lineage commitment in vivo
Calo, E., Quintero-Estades, J. A., Danielian, P. S., Nedelcu, S., Berman, S. D., & Lees, J. A. (2010) · Nature · doi:10.1038/nature09264 · Cited by 312
Transcriptional control of brown adipocyte development and physiological function—of mice and menPreprint
Seale, P., Kajimura, S., & Spiegelman, B. M. (2009) · Genes & Development · doi:10.1101/gad.1779209 · Cited by 295
Role of A-type lamins in signaling, transcription, and chromatin organization
Andrés, V., & González, J. M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904124 · Cited by 298
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
Kleiner, S., Mepani, R. J., Laznik, D., Li, Y., Jurczak, M. J., Jornayvaz, F. R., Estall, J. L., Bhowmick, D. C., Shulman, G. I., & Spiegelman, B. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207287109 · Cited by 291
Pharmacological and nutritional agents promoting browning of white adipose tissue
Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 285
Hedgehog signaling plays a conserved role in inhibiting fat formation
Suh, J. M., Gao, X., McKay, J., McKay, R. M., Salo, Z., & Graff, J. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.012 · Cited by 279
Subcutaneous fat in normal and diseased states
Avram, M. M., Avram, A. S., & James, W. D. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.022 · Cited by 269
Chen, B. J., Mariño‐Enríquez, A., Fletcher, C. D. �., & Hornick, J. L. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31825d532d · Cited by 254
Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice
Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244
Self-citationBrown fat biology and thermogenesis
Richard, D. (2010) · Frontiers in bioscience · doi:10.2741/3786 · Cited by 251
Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase
Ahmad, B., Serpell, C. J., Fong, I. L., & Wong, E. H. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00076 · Cited by 258
Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240
Shao, M., Ishibashi, J., Kusminski, C. M., Wang, Q. A., Hepler, C., Vishvanath, L., MacPherson, K. A., Spurgin, S. B., Sun, K., Holland, W. L., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.023 · Cited by 223
Lipid metabolism in mammalian tissues and its control by retinoic acid
Bonet, M. L., Ribot, J., & Palou, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.001 · Cited by 218
Berry, D. C., Jiang, Y., Arpke, R. W., Close, E. L., Uchida, A., Reading, D., Berglund, E. D., Kyba, M., & Graff, J. M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.023 · Cited by 214
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
Kiefer, F. W., Vernochet, C., O’Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.2757 · Cited by 210
Giralt, A., Hondares, E., Villena, J. A., Ribas, F., Díaz-Delfín, J., Giralt, M., Iglesias, R., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202390 · Cited by 210
E2F1, a Novel Regulator of Metabolism
Denechaud, P., Fajas, L., & Giralt, A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00311 · Cited by 207
A-type lamins: Guardians of the soma?
Hutchison, C., & Worman, H. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1062 · Cited by 208
Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 203
Self-citationScimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199
UCP1: its involvement and utility in obesity
Kozak, L. P., & Anunciado‐Koza, R. P. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.236 · Cited by 200
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194
Fat-specific Protein 27 Regulates Storage of Triacylglycerol
Keller, P., Petrie, J. T., Rose, P. D., Gerin, I., Hahn, W. S., Chiang, S.-H., Nielsen, A. R., Fischer, C. P., Pedersen, B. K., & MacDougald, O. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708323200 · Cited by 187
The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation
Smorlesi, A., Frontini, A., Giordano, A., & Cinti, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01039.x · Cited by 189
Self-citationRIP140-Targeted Repression of Gene Expression in Adipocytes
Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., & Parker, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9383-9391.2005 · Cited by 184
Collins, S., Cao, W., & Robidoux, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0193 · Cited by 179
Xue, B., Coulter, A. A., Rim, J. S., Koza, R. A., & Kozak, L. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8311-8322.2005 · Cited by 179
Dorner, D., Vlcek, S., Foeger, N., Gajewski, A., Makolm, C., Gotzmann, J., Hutchison, C. J., & Foisner, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511149 · Cited by 186
Regulatory circuits controlling white versus brown adipocyte differentiation
Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178
Self-citationTownsend, K. L., & Tseng, Y. (2012) · Adipocyte · doi:10.4161/adip.18951 · Cited by 182
Subcutaneous fat in normal and diseased states
Avram, A. S., Avram, M. M., & James, W. D. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.015 · Cited by 169
Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells
Calder, A. N., Roth-Albin, I., Bhatia, S., Pilquil, C., Lee, J., Bhatia, M., Levadoux‐Martin, M., McNicol, J. D., Russell, J., Collins, T., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0168 · Cited by 160
The retinoblastoma tumor-suppressor gene, the exception that proves the rule
Goodrich, D. W. (2006) · Oncogene · doi:10.1038/sj.onc.1209616 · Cited by 170
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Self-citationFree radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
A Genome Scan for Positive Selection in Thoroughbred Horses
Gu, J., Orr, N., Park, S. D., Katz, L. M., Сулимова, Г. Е., MacHugh, D. E., & Hill, E. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005767 · Cited by 160
Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
Schulz, T. J., & Tseng, Y.-H. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.019 · Cited by 154
Zhang, X., Zhang, Q.-X., Wang, X., Zhang, L., Qu, W., Bao, B., Liu, C.-A., & Liu, J. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.108 · Cited by 143
Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α
Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, J. B., Kristiansen, K., & MacDougald, O. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1272-1282.2005 · Cited by 136
Self-citationAblation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
Wang, J., Liu, R., Wang, F., Hong, J., Li, X., Chen, M., Ke, Y., Zhang, X., Ma, Q., Wang, R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2867 · Cited by 141
RB, the conductor that orchestrates life, death and differentiation
Khidr, L., & Chen, P.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209612 · Cited by 123
The retinoblastoma tumor suppressor and stem cell biologyPreprint
Sage, J. (2012) · Genes & Development · doi:10.1101/gad.193730.112 · Cited by 123
Dali‐Youcef, N., Mataki, C., Coste, A., Messaddeq, N., Giroud, S., Blanc, S., Koehl, C., Champy, M., Chambon, P., Fajas, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611568104 · Cited by 119
Developmental and functional heterogeneity of white adipocytes within a single fat depot
Lee, K. Y., Luong, Q. V., Sharma, R., Dreyfuss, J. M., Ussar, S., & Kahn, C. R. (2018) · The EMBO Journal · doi:10.15252/embj.201899291 · Cited by 118
Rahman, S. M., Janssen, R. C., Choudhury, M., Baquero, K. C., Aikens, R. M., de la Houssaye, B. A., & Friedman, J. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410613 · Cited by 115
Fatty acids and expression of adipokines
Drevon, C. A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.019 · Cited by 113
Gotzmann, J., & Foisner, R. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0050-8 · Cited by 109
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRαPreprint
Yan, M., Audet‐Walsh, É., Manteghi, S., Dufour, C. R., Walker, B., Baba, M., St‐Pierre, J., Giguère, V., & Pause, A. (2016) · Genes & Development · doi:10.1101/gad.281410.116 · Cited by 111
Anunciado‐Koza, R. P., Ukropec, J., Koza, R. A., & Kozak, L. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804268200 · Cited by 108
Retinoblastoma Tumor Suppressor: Where Cancer Meets the Cell Cycle
Knudsen, E. S., & Knudsen, K. E. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100713 · Cited by 106
Egerod, K. L., Holst, B., Petersen, P. S., Hansen, J. B., Mulder, J., Hökfelt, T. G. M., & Schwartz, T. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0055 · Cited by 101
Self-citationEmerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development
Gutzat, R., Borghi, L., & Gruissem, W. (2012) · Trends in Plant Science · doi:10.1016/j.tplants.2011.12.001 · Cited by 100
Aguilar, V. M., & Fajas, L. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000089 · Cited by 107
Mercader, J., Palou, A., & Bonet, M. L. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.007 · Cited by 95
Hormone‐sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL
Ström, K., Gundersen, T. E., Hansson, O., Lucas, S., Fernandez, C., Blomhoff, R., & Holm, C. (2009) · The FASEB Journal · doi:10.1096/fj.08-120923 · Cited by 91
Reversible physiological transdifferentiation in the adipose organ
Cinti, S. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990140 · Cited by 88
Self-citationThe tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting
Elattar, S., Dimri, M., & Ande, S. (2018) · The FASEB Journal · doi:10.1096/fj.201701465rr · Cited by 89
Metabolic regulation and the anti-obesity perspectives of human brown fat
Schéele, C., & Nielsen, S. J. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.011 · Cited by 91
Nicolay, B., Danielian, P. S., Kottakis, F., Lapek, J. D., Sanidas, I., Miles, W. O., Dehnad, M., Tschöp, K., Gierut, J. J., Manning, A. L., et al. (2015) · Genes & Development · doi:10.1101/gad.264127.115 · Cited by 84
Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis
Park, Y.-K., & Ge, K. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00260-16 · Cited by 84
All-Trans Retinoic Acid Increases Oxidative Metabolism in Mature Adipocytes
Mercader, J., Madsen, L., Felipe, F., Palou, A., Kristiansen, K., & Bonet, M. L. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110717 · Cited by 84
Self-citationVáraljai, R., Islam, A. B. M. M. K., Beshiri, M. L., Rehman, J., López-Bigas, N., & Benevolenskaya, E. V. (2015) · Genes & Development · doi:10.1101/gad.264036.115 · Cited by 83
Auffret, J., Viengchareun, S., Carré, N., Denis, R., Magnan, C., Marie, P., Muscat, A., Fève, B., Lombès, M., & Binart, N. (2012) · The FASEB Journal · doi:10.1096/fj.12-204958 · Cited by 81
Xie, X., Yu, H., Wang, Y., Zhou, Y., Li, G., Ruan, Z., Li, F., Wang, X., Liu, H., & Zhang, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.08.017 · Cited by 77
CDK6 inhibits white to beige fat transition by suppressing RUNX1
Hou, X. S., Zhang, Y., Li, W., Hu, A. J., Luo, C., Zhou, W., Hu, J. K., Daniele, S. G., Wang, J., Sheng, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03451-1 · Cited by 74
Liu, P., Huang, S., Ling, S., Xu, S., Wang, F., Zhang, W., Zhou, R., He, L., Xia, X., Yao, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12988-8 · Cited by 75
The multiple connections between pRB and cell metabolism
Nicolay, B., & Dyson, N. J. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.07.012 · Cited by 76
Adipose tissue-derived cells: from physiology to regenerative medicine
Casteilla, L., & Dani, C. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70297-5 · Cited by 75
Lipodystrophy in HIV 1-infected patients: lessons for obesity research
Villarroya, F., Domingo, P., & Giralt, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803698 · Cited by 76
Burgos, P. V., Klattenhoff, C., de la Fuente-Ortega, E., Rigotti, A., & González, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400295101 · Cited by 73
Metadata
- Authors
- Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., Riele, H. T., & Kristiansen, K.
- Affiliations
- Stockholm University (SE)
- Departments of Biochemistry and Molecular Biology and Anatomy and Neurobiology, University of Southern Denmark, DK-5230 Odense M, Denmark; The Netherlands Cancer Institute, Division of Molecular Biology, NL-1066 CX Amsterdam, The Netherlands; Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Ancona 60020, Italy; The Wenner-Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden; and Medical Genetics, Department of Medical Biochemistry, Göteborg University, SE...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-03-15
- Volume
- 101
- Issue
- 12
- Pages
- 4112-4117
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC384703
- OpenAlex
- W2145157621
- Cited by
- 287
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 15 · 2017: 12 · 2016: 11 · 2015: 14 · 2014: 16 · 2013: 23 · 2012: 23
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Update notices
- correction (2004-04-27)
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- retinoblastoma protein, white adipocyte differentiation, brown adipocyte differentiation, UCP1, FOXC2, protein kinase A, protein phosphorylation, beta3-adrenergic agonists, adipocyte transdifferentiation, adipose tissue
- MeSH terms
- Uncoupling Protein 1, Cyclic AMP, Animals, Antigens, Polyomavirus Transforming, Adipose Tissue, Brown, Carrier Proteins, Cell Differentiation, Fibroblasts, Ion Channels, Membrane Proteins, Mice, Inbred C57BL, Simian virus 40, Retinoblastoma Protein, Rats, Sprague-Dawley, Adipocytes, Mitochondrial Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
