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Cited by 502

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study

Mahncke, Henry W., Connor, Bonnie B., Appelman, Jed, Ahsanuddin, Omar N., Hardy, Joseph L., Wood, Richard A., Joyce, Nicholas M., Boniske, Tania, Atkins, Sharona M., Merzenich, Michael M.·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0605194103
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Abstract

Normal aging is associated with progressive functional losses in perception, cognition, and memory. Although the root causes of age-related cognitive decline are incompletely understood, psychophysical and neuropsychological evidence suggests that a significant contribution stems from poorer signal-to-noise conditions and down-regulated neuromodulatory system function in older brains. Because the brain retains a lifelong capacity for plasticity and adaptive reorganization, dimensions of negative reorganization should be at least partially reversible through the use of an appropriately designed training program. We report here results from such a training program targeting age-related cognitive decline. Data from a randomized, controlled trial using standardized measures of neuropsychological function as outcomes are presented. Significant improvements in assessments directly related to the training tasks and significant generalization of improvements to nonrelated standardized neuropsychological measures of memory (effect size of 0.25) were documented in the group using the training program. Memory enhancement appeared to be sustained after a 3-month no-contact follow-up period. Matched active control and no-contact control groups showed no significant change in memory function after training or at the 3-month follow-up. This study demonstrates that intensive, plasticity-engaging training can result in an enhancement of cognitive function in normal mature adults.

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Research works printed but not linked: 35

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Metadata

Authors
Mahncke, H. W., Connor, B. B., Appelman, J., Ahsanuddin, O. N., Hardy, J. L., Wood, R. A., Joyce, N. M., Boniske, T., Atkins, S. M., & Merzenich, M. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2006-08-15
Volume
103
Issue
33
Pages
12523-12528
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.0605194103
Cited by
502
References
11
Language
en

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CoChat. (2026). Citation check: Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study. https://app.cochat.ai/papers/10.1073/pnas.0605194103
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Mahncke, H. W., Connor, B. B., Appelman, J., Ahsanuddin, O. N., Hardy, J. L., Wood, R. A., Joyce, N. M., Boniske, T., Atkins, S. M., & Merzenich, M. M. (2006). Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0605194103

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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