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High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice
Open accessAbstract
To permit rapid optical control of brain activity, we have engineered multiple lines of transgenic mice that express the light-activated cation channel Channelrhodopsin-2 (ChR2) in subsets of neurons. Illumination of ChR2-positive neurons in brain slices produced photocurrents that generated action potentials within milliseconds and with precisely timed latencies. The number of light-evoked action potentials could be controlled by varying either the amplitude or duration of illumination. Furthermore, the frequency of light-evoked action potentials could be precisely controlled up to 30 Hz. Photostimulation also could evoke synaptic transmission between neurons, and, by scanning with a small laser light spot, we were able to map the spatial distribution of synaptic circuits connecting neurons within living cerebral cortex. We conclude that ChR2 is a genetically based photostimulation technology that permits analysis of neural circuits with high spatial and temporal resolution in transgenic mammals.
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Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
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Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
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Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
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Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341
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Arenkiel, B. R., Peca, J., Davison, I. G., Feliciano, C., Deisseroth, K., Augustine, G. J., Ehlers, M. D., & Feng, G. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.005 · Cited by 755
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Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. (2010) · Nature Protocols · doi:10.1038/nprot.2009.226 · Cited by 692
Self-citationZhao, S., Ting, J. T., Atallah, H. E., Qiu, L., Tan, J., Gloss, B., Augustine, G. J., Deisseroth, K., Luo, M., Graybiel, A. M., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1668 · Cited by 653
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Huber, D., Petreanu, L., Ghitani, N., Ranade, S., Hromádka, T., Mainen, Z., & Svoboda, K. (2008) · Nature · doi:10.1038/nature06445 · Cited by 539
Cruikshank, S. J., Urabe, H., Nurmikko, A. V., & Connors, B. W. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.025 · Cited by 459
Functional maps of neocortical local circuitry.
Thomson, A. M. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.002.2007 · Cited by 434
Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324
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Mateo, C., Knutsen, P. M., Tsai, P. S., Shih, A. Y., & Kleinfeld, D. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.012 · Cited by 303
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Llewellyn, M. E., Thompson, K. R., Deisseroth, K., & Delp, S. L. (2010) · Nature Medicine · doi:10.1038/nm.2228 · Cited by 217
Self-citationThunemann, M., Lu, Y., Liu, X., Kılıç, K., Desjardins, M., Vandenberghe, M., Sadegh, S., Saisan, P. A., Cheng, Q., Weldy, K. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04457-5 · Cited by 178
Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice
Young, P., Qiu, L., Wang, D., Zhao, S., Gross, J., & Feng, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2118 · Cited by 152
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Zhang, J., Ackman, J. B., Xu, H.-P., & Crair, M. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3007 · Cited by 136
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics
Samineni, V. K., Yoon, J., Crawford, K. E., Jeong, Y. R., McKenzie, K. C., Shin, G., Xie, Z., Sundaram, S. S., Li, Y., Yang, M. Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000968 · Cited by 119
Shining light on wakefulness and arousal
de Lecea, L., Carter, M. E., & Adamantidis, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.032 · Cited by 103
Temporal interactions during paired-electrode stimulation in two retinal prosthesis subjects
Horsager, A., Boynton, G. M., Greenberg, R. J., & Fine, I. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5282 · Cited by 48
Transdermal optogenetic peripheral nerve stimulation
Maimon, B. E., Zorzos, A. N., Bendell, R., Harding, A., Fahmi, M., Srinivasan, S., Calvaresi, P., & Herr, H. M. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa5e20 · Cited by 42
Shifting the paradigm: new approaches for characterizing and classifying neurons
Bernard, A., Sorensen, S. A., & Lein, E. S. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.010 · Cited by 26
Metadata
- Authors
- Wang, H., Peca, J., Matsuzaki, M., Matsuzaki, K., Noguchi, J., Qiu, L., Wang, D., Zhang, F., Boyden, E., Deisseroth, K., Kasai, H., Hall, W. C., Feng, G., & Augustine, G. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-05-08
- Volume
- 104
- Issue
- 19
- Pages
- 8143-8148
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2119070939
- Cited by
- 390
- References
- 1
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- green
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