Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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The amazing osteocyte

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Osteocytes, mechanosensing and Wnt signaling

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The Osteocyte: An Endocrine Cell … and More

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Mechanical regulation of bone remodeling

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Mechanisms of Tooth Eruption and Orthodontic Tooth Movement

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Biomechanics and Mechanobiology of Trabecular Bone: A Review

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Mechanosensation and transduction in osteocytes

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Osteocytes: master orchestrators of bone

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Molecular mechanosensors in osteocytes

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Bone remodeling: an operational process ensuring survival and bone mechanical competence

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Mechanobiology and Developmental Control

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Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone

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Mechanical regulation of signaling pathways in bone

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Investigating cell mechanics with atomic force microscopy

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Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction

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The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth

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Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton

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Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

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Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

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In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation

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Osteocyte: the unrecognized side of bone tissue

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Stimulation of bone repair with ultrasound: A review of the possible mechanic effects

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Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development

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Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells

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Biomechanics and mechanobiology of the bone matrix

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Primary cilia mediate mechanotransduction through control of ATP‐induced Ca 2+ signaling in compressed chondrocytes

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Osteocyte Mechanobiology and Pericellular Mechanics

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Primary Cilia‐Mediated Mechanotransduction in Human Mesenchymal Stem Cells

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Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization

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Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network

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From mechanical stimulus to bone formation: A review

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Disuse Osteoporosis: Clinical and Mechanistic Insights

Rolvien, T., & Amling, M. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00836-1 · Cited by 176

Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

Yuan, K., Frolova, N., Xie, Y., Wang, D., Cook, L. M., Kwon, Y.-J., Steg, A. D., Serra, R. A., & Frost, A. R. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955856 · Cited by 165

Mechanotransduction in the renal tubule

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Gap junctions and hemichannels in signal transmission, function and development of bone

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From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction

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Osteocyte primary cilium and its role in bone mechanotransduction

Temiyasathit, S., & Jacobs, C. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05243.x · Cited by 154

Mesenchymal stem cell responses to mechanical stimuli.

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Cell cycle progression by the repression of primary cilia formation in proliferating cells

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Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis

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Muscle-bone interactions: From experimental models to the clinic? A critical update

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Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

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Mechanically induced osteogenic lineage commitment of stem cells

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The primary cilium functions as a mechanical and calcium signaling nexus

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Chapter 5 Targeting Proteins to the Ciliary Membrane

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Primary cilia signaling mediates intraocular pressure sensation

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Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins

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Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

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The role of hedgehog signalling in skeletal health and disease

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Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials

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TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

Ryskamp, D. A., Frye, A. M., Phuong, T. T. T., Yarishkin, O., Jo, A. O., Xu, Y., Lakk, M., Iuso, A., Redmon, S. N., Ambati, B., et al. (2016) · Scientific Reports · doi:10.1038/srep30583 · Cited by 139

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

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Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

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Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia

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From Central to Rudimentary to Primary: The History of an Underappreciated Organelle Whose Time Has Come.The Primary Cilium

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Mechanosensing by the Primary Cilium: Deletion of Kif3A Reduces Bone Formation Due to Loading

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The mechanics of the primary cilium: An intricate structure with complex function

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Osteoimmunology in Periodontitis and Orthodontic Tooth Movement

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The extracellular matrix and ciliary signaling

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Primary cilia: Cell and molecular mechanosensors directing whole tissue function

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A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

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Emerging role of primary cilia as mechanosensors in osteocytes

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The role of osteocytes in bone mechanotransduction

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Odontoblast: a mechano‐sensory cell

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Evidence for pleiotropic factors in genetics of the musculoskeletal system

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Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells

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Developmental and regenerative paradigms of cilia regulated hedgehog signaling

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Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

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The molecular basis of bone mechanotransduction.

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Cellular and Molecular Mechanisms of Dental Nociception

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Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

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Bone targeting for the treatment of osteoporosis

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Lengthening primary cilia enhances cellular mechanosensitivity

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Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

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Activation of Hedgehog Signaling Inhibits Osteoblast Differentiation of Human Mesenchymal Stem Cells

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Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia

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Physiology of Bone

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Primary cilia respond to fluid shear stress and mediate flow‐induced calcium deposition in osteoblasts

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Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis

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Osteocytes and Estrogen Deficiency

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Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice

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Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation

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Chapter 11 Cilia Involvement in Patterning and Maintenance of the Skeleton

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The cilium as a force sensor−myth versus reality

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Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

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The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

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Mechanistic Insight into Orthodontic Tooth Movement Based on Animal Studies: A Critical Review

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Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice

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Ciliary diffusion barrier: The gatekeeper for the primary cilium compartment

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Effects of cyclic hydraulic pressure on osteocytes

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A bioreactor test system to mimic the biological and mechanical environment of oral soft tissues and to evaluate substitutes for connective tissue grafts

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Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium

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Emerging principles of primary cilia dynamics in controlling tissue organization and function

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