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miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely
Open accessAbstract
MicroRNAs (miRNAs) are a family of ≈22-nt noncoding RNAs that can posttranscriptionally regulate gene expression. Several miRNAs are specifically expressed in hematopoietic cells. Here we show that one such miRNA, miR-150, is mainly expressed in the lymph nodes and spleen and is highly up-regulated during the development of mature T and B cells; expression of miR-150 is sharply up-regulated at the immature B cell stage. Overexpression of miR-150 in hematopoietic stem cells, followed by bone marrow transplantation, had little effect on the formation of either mature CD8- and CD4-positive T cells or granulocytes or macrophages, but the formation of mature B cells was greatly impaired. Furthermore, premature expression of miR-150 blocked the transition from the pro-B to the pre-B stage. Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells.
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Metadata
- Authors
- Zhou, B., Wang, S., Mayr, C., Bartel, D. P., & Lodish, H. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-04-24
- Volume
- 104
- Issue
- 17
- Pages
- 7080-7085
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117472344
- Cited by
- 608
- References
- 1
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- green
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