Cited by 257Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsDNA Repair Mechanisms

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis

Open access

Li, Min, Fang, Xiao, Baker, Darren J., Guo, Linjie, Gao, Xue, Wei, Zhubo, Han, Shuhua, van Deursen, Jan M., Zhang, Pumin·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1005960107PMC PMC2922543

Open this paper in CoChat — free account

Abstract

The spindle assembly checkpoint (SAC) is essential for proper sister chromatid segregation. Defects in this checkpoint can lead to chromosome missegregation and aneuploidy. An increasing body of evidence suggests that aneuploidy can play a causal role in tumorigenesis. However, mutant mice that are prone to aneuploidy have only mild tumor phenotypes, suggesting that there are limiting factors in the aneuploidy-induced tumorigenesis. Here we provide evidence that p53 is such a limiting factor. We show that aneuploidy activates p53 and that loss of p53 drastically accelerates tumor development in two independent aneuploidy models. The p53 activation depends on the ataxia-telangiectasia mutated (ATM) gene product and increased levels of reactive oxygen species. Thus, the ATM-p53 pathway safeguards not only DNA damage but also aneuploidy.

Integrity signals

Registry

Crossref · 10.1073/pnas.1005960107

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
How Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
Feedback control of mitosis in budding yeast
Li, R., & Murray, A. W. (1991) · Cell · doi:10.1016/0092-8674(81)90015-5 · Cited by 1,174
A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
King, R. W., Peters, J., Tugendreich, S., Rolfe, M., Hieter, P., & Kirschner, M. W. (1995) · Cell · doi:10.1016/0092-8674(95)90338-0 · Cited by 956
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science · doi:10.1126/science.1142210 · Cited by 935
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Identification of essential genes in cultured mammalian cells using small interfering RNAs
Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T., & Weber, K. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.24.4557 · Cited by 828
Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis
Zou, H., McGarry, T. J., Bernal, T. U., & Kirschner, M. W. (1999) · Science · doi:10.1126/science.285.5426.418 · Cited by 805

Show all 31 references

Sorted by citations

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
DNA breaks and chromosome pulverization from errors in mitosis
Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D., & Pellman, D. (2012) · Nature · doi:10.1038/nature10802 · Cited by 1,227
Causes and consequences of aneuploidy in cancer
Gordon, D. J., Resio, B. J., & Pellman, D. S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3123 · Cited by 845
Catastrophic nuclear envelope collapse in cancer cell micronuclei
Hatch, E. M., Fischer, A. H., Deerinck, T. J., & Hetzer, M. W. (2013) · Cell · doi:10.1016/j.cell.2013.06.007 · Cited by 741
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Holmfeldt, L., Wei, L., Díaz-Flores, E., Walsh, M. F., Zhang, J., Ding, L., Payne-Turner, D., Churchman, M. L., Andersson, A., Chen, S.-C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2532 · Cited by 738
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
Liu, Y., Sethi, N. S., Hinoue, T., Schneider, B., Cherniack, A. D., Sánchez-Vega, F., Seoane, J. A., Farshidfar, F., Bowlby, R., Islam, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.010 · Cited by 614
Ionizing Radiation-Induced DNA Damage, Response, and Repair
Santivasi, W. L., & Xia, F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 637
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
Janssen, A., van der Burg, M. J., Szuhai, K., Kops, G. J. P. L., & Medema, R. H. (2011) · Science · doi:10.1126/science.1210214 · Cited by 582
Short- and long-term effects of chromosome mis-segregation and aneuploidy
Santaguida, S., & Amon, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4025 · Cited by 550
Chromothripsis and cancer: causes and consequences of chromosome shattering
Forment, J. V., Kaidi, A., & Jackson, S. P. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3352 · Cited by 393
Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
Santaguida, S., Richardson, A., Iyer, D., M’Saad, O., Zasadil, L. M., Knouse, K. A., Wong, Y. L., Rhind, N., Desai, A. B., & Amon, A. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.022 · Cited by 367
Gene Copy-Number Alterations: A Cost-Benefit Analysis
Tang, Y.-C., & Amon, A. (2013) · Cell · doi:10.1016/j.cell.2012.11.043 · Cited by 348
Identification of Aneuploidy-Selective Antiproliferation Compounds
Tang, Y.-C., Williams, B. R., Siegel, J. J., & Amon, A. (2011) · Cell · doi:10.1016/j.cell.2011.01.017 · Cited by 328
Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells
Giladi, M., Schneiderman, R. S., Voloshin, T., Porat, Y., Munster, M., Blat, R., Sherbo, S., Bomzon, Z., Urman, N., Itzhaki, A., et al. (2015) · Scientific Reports · doi:10.1038/srep18046 · Cited by 327
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
Ditch, S., & Paull, T. T. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.10.002 · Cited by 333
Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer
Iyer, G., Al‐Ahmadie, H. A., Schultz, N. D., Hanrahan, A. J., Ostrovnaya, I., Balar, A. V., Kim, P. H., Lin, O., Weinhold, N., Sander, C., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.5740 · Cited by 309
Transcriptional consequences of aneuploidy
Sheltzer, J. M., Torres, E. M., Dunham, M. J., & Amon, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209227109 · Cited by 297
Losing balance: the origin and impact of aneuploidy in cancer
Holland, A. J., & Cleveland, D. W. (2012) · EMBO Reports · doi:10.1038/embor.2012.55 · Cited by 295
The aneuploidy paradox: costs and benefits of an incorrect karyotype
Sheltzer, J. M., & Amon, A. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.07.003 · Cited by 277
The impact of mitotic errors on cell proliferation and tumorigenesisPreprint
Levine, M. S., & Holland, A. J. (2018) · Genes & Development · doi:10.1101/gad.314351.118 · Cited by 274
Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast
Dephoure, N., Hwang, S., O'Sullivan, C., Dodgson, S. E., Gygi, S. P., Amon, A., & Torres, E. M. (2014) · eLife · doi:10.7554/elife.03023 · Cited by 266
Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
Liu, Z., Chen, P., Gao, H., Gu, Y., Yang, J., Peng, H., Xu, X., Wang, H., Yang, M., Liu, X., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.015 · Cited by 254
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors
Silk, A. D., Zasadil, L. M., Holland, A. J., Vitre, B., Cleveland, D. W., & Weaver, B. A. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317042110 · Cited by 258
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
Giam, M., & Rancati, G. I. (2015) · Cell Division · doi:10.1186/s13008-015-0009-7 · Cited by 253
Cellular Stress Associated with Aneuploidy
Zhu, J., Tsai, H.-J., Gordon, M. R., & Li, R. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.02.002 · Cited by 227
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
Tsuchida, C. A., Brandes, N., Bueno, R., Trinidad, M. I., Mazumder, T., Yu, B., Hwang, B., Chang, C. R., Liu, J., Sun, Y., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.041 · Cited by 220
ATM signalling and cancer
Cremona, C. A., & Behrens, A. (2013) · Oncogene · doi:10.1038/onc.2013.275 · Cited by 219
Chromosomal instability and aneuploidy in cancer: from yeast to man
Pfau, S. J., & Amon, A. (2012) · EMBO Reports · doi:10.1038/embor.2012.65 · Cited by 206
Single-chromosome Gains Commonly Function as Tumor Suppressors
Sheltzer, J. M., Ko, J. H., Replogle, J. M., Habibe Burgos, N. C., Chung, E. S., Meehl, C. M., Sayles, N. M., Passerini, V., Storchova, Z., & Amon, A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.004 · Cited by 201
New Insights into the Troubles of Aneuploidy
Siegel, J. J., & Amon, A. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155807 · Cited by 209
The two sides of chromosomal instability: drivers and brakes in cancer
Hosea, R., Hillary, S., Naqvi, S., Wu, S., & Kasim, V. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01767-7 · Cited by 226
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Kuznetsova, A. Y., Seget, K., Moeller, G. K., de Pagter, M. S., de Roos, J. A. D. M., Dürrbaum, M., Kuffer, C., Müller, S., Zaman, G. J. R., Kloosterman, W. P., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1068482 · Cited by 183
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
Singla, S., Iwamoto-Stohl, L. K., Zhu, M., & Zernicka‐Goetz, M. (2020) · Nature Communications · doi:10.1038/s41467-020-16796-3 · Cited by 184
ATM activation in the presence of oxidative stress
Guo, Z., Deshpande, R. A., & Paull, T. T. (2010) · Cell Cycle · doi:10.4161/cc.9.24.14323 · Cited by 191
Aneuploidy as a promoter and suppressor of malignant growth
Vasudevan, A., Schukken, K. M., Sausville, E. L., Girish, V., Adebambo, O. A., & Sheltzer, J. M. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00321-1 · Cited by 176
DNA damage associated with mitosis and cytokinesis failure
Hayashi, M., & Karlseder, J. (2013) · Oncogene · doi:10.1038/onc.2012.615 · Cited by 173
p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies
Soto, M., Raaijmakers, J. A., Bakker, B., Spierings, D. C. J., Lansdorp, P. M., Foijer, F., & Medema, R. H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.055 · Cited by 167
Genome Stability Requires p53
Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161
Aneuploidy: implications for protein homeostasis and disease
Oromendia, A. B., & Amon, A. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.013391 · Cited by 157
Chromosomes and cancer cells
Thompson, S. L., & Compton, D. A. (2010) · Chromosome Research · doi:10.1007/s10577-010-9179-y · Cited by 161
Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway
Durante, M., & Formenti, S. C. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00192 · Cited by 156
DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons
Wilhelm, T., Said, M., & Naim, V. (2020) · Genes · doi:10.3390/genes11060642 · Cited by 161
Whole Chromosome Instability induces senescence and promotes SASP
Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Tsai, W. L., Santambrogio, L., Maslov, A. Y., Gadina, M., Campisi, J., Vijg, J., et al. (2016) · Scientific Reports · doi:10.1038/srep35218 · Cited by 154
Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression
Hrycyniak, L., Zasadil, L. M., & Weaver, B. A. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.10.023 · Cited by 147
Effects of aneuploidy on cell behaviour and function
Li, R., & Zhu, J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00436-9 · Cited by 147
IDH Mutation and Neuroglial Developmental Features Define Clinically Distinct Subclasses of Lower Grade Diffuse Astrocytic Glioma
Gorovets, D. J., Kannan, K. S., Shen, R., Kastenhuber, E. R., Islamdoust, N., Campos, C., Pentsova, E. I., Heguy, A., Jhanwar, S. C., Mellinghoff, I. K., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2977 · Cited by 145
The cancer biology of whole-chromosome instability
Duijf, P. H. G., & Benezra, R. (2013) · Oncogene · doi:10.1038/onc.2012.616 · Cited by 125
Replication Stress in Mammalian Cells and Its Consequences for Mitosis
Gelot, C., Magdalou, I., & López, B. S. (2015) · Genes · doi:10.3390/genes6020267 · Cited by 140
Non-random Mis-segregation of Human Chromosomes
Worrall, J. T., Tamura, N., Mazzagatti, A., Shaikh, N., van Lingen, T., Bakker, B., Spierings, D. C. J., Vladimirou, E., Foijer, F., & McClelland, S. E. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.047 · Cited by 113
Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia
Dekanty, A., Barrio, L., Muzzopappa, M., Auer, H., & Milán, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206675109 · Cited by 122
Mitosis as an anti-cancer target
Janssen, A., & Medema, R. H. (2011) · Oncogene · doi:10.1038/onc.2011.30 · Cited by 116
Aneuploidy in health, disease, and aging
Ricke, R. M., & van Deursen, J. M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201301061 · Cited by 118
Unique features of the transcriptional response to model aneuploidy in human cells
Dürrbaum, M., Kuznetsova, A. Y., Passerini, V., Stingele, S., Stoehr, G., & Štorchová, Z. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-139 · Cited by 110
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability
Dorstyn, L., Puccini, J., Wilson, C. H., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2012.36 · Cited by 104
2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells
Zasadil, L. M., Britigan, E. M. C., & Weaver, B. A. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.02.001 · Cited by 106
Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivoPreprint
Pfau, S. J., Silberman, R. E., Knouse, K. A., & Amon, A. (2016) · Genes & Development · doi:10.1101/gad.278820.116 · Cited by 104
Engineering endogenous ABC transporter with improving ATP supply and membrane flexibility enhances the secretion of β-carotene in Saccharomyces cerevisiae
Bu, X., Lin, J.-B., Cheng, J., Yang, D. J., Duan, C., Koffas, M. A. G., & Yan, G. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01809-6 · Cited by 105
Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1
Tardif, K. D., Rogers, A., Cassiano, J., Roth, B. L., Cimbora, D. M., McKinnon, R. S., Peterson, A., Douce, T. B., Robinson, R., Dorweiler, I. J., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0453 · Cited by 105
A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
Sheltzer, J. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0749 · Cited by 102
Genetic instability: tipping the balance
Janssen, A., & Medema, R. H. (2012) · Oncogene · doi:10.1038/onc.2012.576 · Cited by 99
Impaired nuclear functions in micronuclei results in genome instability and chromothripsis
Terradas, M., Martı́n, M., & Genescà, A. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1818-4 · Cited by 98
How Many Ways Can a Podocyte Die?
Tharaux, P., & Huber, T. B. (2012) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.06.011 · Cited by 99
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer
López‐García, C., Sansregret, L., Domingo, E., McGranahan, N., Hobor, S., Birkbak, N. J., Horswell, S. D., Gronroos, E. C., Favero, F., Rowan, A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.11.001 · Cited by 94
Effects of aneuploidy on gene expression: implications for cancer
Dürrbaum, M., & Štorchová, Z. (2015) · FEBS Journal · doi:10.1111/febs.13591 · Cited by 95
Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells
Kaistha, B. P., Honstein, T., Müller, V., Bielak, S., Sauer, M., Kreider, R., Fassan, M., Scarpa, A., Schmees, C., Volkmer, H., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.460 · Cited by 91
The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo
Zhou, N., Singh, K., Mir, M. C., Parker, Y., Lindner, D. J., Dreicer, R., Ecsedy, J., Zhang, Z., Teh, B. T., Almasan, A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2383 · Cited by 90
Role of chromosomal instability in cancer progression
McClelland, S. E. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0187 · Cited by 90
Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion
Meena, J. K., Cerutti, A., Beichler, C., Morita, Y., Bruhn, C., Kumar, M., Kraus, J. M., Speicher, M. R., Wang, Z., Kestler, H. A., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490070 · Cited by 87
Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells
Wang, R. W., Viganò, S., Ben‐David, U., Amon, A., & Santaguida, S. (2021) · EMBO Reports · doi:10.15252/embr.202052032 · Cited by 84
WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy
Haarhuis, J. H. I., Elbatsh, A. M. O., van den Broek, B., Camps, D., Erkan, H., Jalink, K., Medema, R. H., & Rowland, B. D. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.003 · Cited by 84
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth
Rowald, K., Mantovan, M., Passos, J., Buccitelli, C., Mardin, B. R., Korbel, J. O., Jechlinger, M., & Sotillo, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.048 · Cited by 84
A p53-dependent response limits the viability of mammalian haploid cells
Olbrich, T., Mayor‐Ruiz, C., Vega-Sendino, M., Gomez, C., Ortega, S., Ruiz, S., & Fernández-Capetillo, Ó. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705133114 · Cited by 85
Chromosomal instability: A common feature and a therapeutic target of cancer
Tanaka, K., & Hirota, T. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.06.002 · Cited by 84
Aneuploidy and tumorigenesis
Fang, X., & Zhang, P. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.03.002 · Cited by 83
Self-citation
Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells
Kuffer, C., Kuznetsova, A. Y., & Štorchová, Z. (2013) · Chromosoma · doi:10.1007/s00412-013-0414-0 · Cited by 72
Ploidy variation as an adaptive mechanism in human pathogenic fungi
Morrow, C. A., & Fraser, J. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.01.008 · Cited by 74
Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues
Cosenza, M. R., & Krämer, A. (2015) · Chromosome Research · doi:10.1007/s10577-015-9505-5 · Cited by 72
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm -deficient mice
Puccini, J., Shalini, S., Voss, A. K., Gatei, M., Wilson, C. H., Hiwase, D. K., Lavin, M. F., Dorstyn, L., & Kumar, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311947110 · Cited by 69
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis
Jung, Y., Kraikivski, P., Shafiekhani, S., Terhune, S. S., & Dash, R. K. (2021) · npj Systems Biology and Applications · doi:10.1038/s41540-021-00203-8 · Cited by 68
Ethanol reduces mitochondrial membrane integrity and thereby impacts carbon metabolism of Saccharomyces cerevisiae
Yang, K.-M., Lee, N.-R., Woo, J.-M., Choi, W., Zimmermann, M., Blank, L. M., & Park, J. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2012.00818.x · Cited by 68
Aneuploidy in Cancer and Aging
Naylor, R. M., & van Deursen, J. M. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035303 · Cited by 66
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
Simonetti, G., Padella, A., do Valle, Í. F., Fontana, M. C., Fonzi, E., Bruno, S., Baldazzi, C., Guadagnuolo, V., Manfrini, M., Ferrari, A., et al. (2018) · Cancer · doi:10.1002/cncr.31837 · Cited by 64
High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation
Zasadil, L. M., Britigan, E. M. C., Ryan, S. D., Kaur, C., Guckenberger, D. J., Beebe, D. J., Moser, A. R., & Weaver, B. A. A. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0747 · Cited by 65
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
Joy, J., Barrio, L., Santos-Tapia, C., Romão, D., Giakoumakis, N. N., Clemente-Ruiz, M., & Milán, M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.009 · Cited by 63
Identification of Drivers of Aneuploidy in Breast Tumors
Pfister, K. E., Pipka, J. L., Chiang, C., Liu, Y., Clark, R. A., Keller, R. E., Skoglund, P., Guertin, M. J., Hall, I. M., & Stukenberg, P. T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.102 · Cited by 65
Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis
Xie, R., Wang, F., McKeehan, W. L., & Liu, L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2170 · Cited by 66
Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis
Clemente‐Ruiz, M., Murillo-Maldonado, J. M., Benhra, N., Barrio, L., Pérez, L., Quiroga-Artigas, G., Nebreda, Á. R., & Milán, M. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.008 · Cited by 62
Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets
Stratmann, S., Yones, S. A., Mayrhofer, M., Norgren, N., Skaftason, A., Sun, J., Smolińska, K., Komorowski, J., Herlin, M. K., Sundström, C., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003709 · Cited by 63
Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain
Andriani, G. A., Vijg, J., & Montagna, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.007 · Cited by 56
Anaphase: a fortune-teller of genomic instability
Bizard, A. H., & Hickson, I. D. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.02.012 · Cited by 57
Consequences of Centrosome Dysfunction During Brain Development
Nano, M., & Basto, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57127-0_2 · Cited by 54
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
Zerbib, J., Ippolito, M. R., Eliezer, Y., Feudis, G. D., Reuveni, E., Kadmon, A. S., Martin, S., Viganò, S., Leor, G., Berstler, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52176-x · Cited by 49
Immortalization and malignant transformation of Eukaryotic cells
Stepanenko, A. A., & KAVSAN, V. M. (2012) · Cytology and Genetics · doi:10.3103/s0095452712020041 · Cited by 52
Cancer in Drosophila
Herranz, H., Eichenlaub, T., & Cohen, S. M. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.11.037 · Cited by 52
Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation
Manning, A. L., Benes, C. H., & Dyson, N. J. (2013) · Oncogene · doi:10.1038/onc.2013.201 · Cited by 50
Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival
Xu, G., Jiang, Y., Xiao, Y., Liu, X.-D., Yue, F., Li, W., Li, X., He, Y., Jiang, X., Huang, H. W., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6669 · Cited by 50
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Tang, Y., Yuwen, H., Wang, K., Bruno, P. M., Bullock, K. H., Deik, A., Santaguida, S., Trakala, M., Pfau, S. J., Zhong, N., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0049 · Cited by 50
Tolerance of Chromosomal Instability in Cancer: Mechanisms and Therapeutic Opportunities
Gronroos, E. C., & López-García, C. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1958 · Cited by 51
Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients
Jiang, X., Zhong, W., Huang, H. W., He, H., Jiang, F., Chen, Y., Yue, F., Zou, J., Li, X., He, Y., et al. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22193 · Cited by 48
Ploidy variation in multinucleate cells changes under stress
Anderson, C. A., Roberts, S. E., Zhang, H., Kelly, C. M., Kendall, A., Lee, C., Gerstenberger, J. P., Koenig, A. B., Kabeche, R., & Gladfelter, A. S. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-09-1375 · Cited by 46

Authors: Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P.
Affiliations: Baylor College of Medicine (US)
Mayo Clinic (US)
The Mayo Clinic, Rochester, MN 55905
ORCID: Li, Min
Fang, Xiao
Baker, Darren J.
Guo, Linjie
Gao, Xue
Wei, Zhubo
Han, Shuhua
Zhang, Pumin
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-07-27
Volume: 107
Issue: 32
Pages: 14188-14193
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1005960107
PMC: PMC2922543
OpenAlex: W2123618943
Cited by: 257
References: 31
Citations by year: 2026: 6 · 2025: 7 · 2024: 17 · 2023: 14 · 2022: 20 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 20 · 2017: 21 · 2016: 15 · 2015: 21 · 2014: 16 · 2013: 25 · 2012: 25
FWCI: 10.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: National Institutes of Health (5r01ca116097-10)
National Cancer Institute (CA122623, R01-CA116097, R01CA126828, R01CA122623, CA116097)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: ATM, p53, aneuploidy, spindle assembly checkpoint, chromosome missegregation, sister chromatid segregation, reactive oxygen species, tumor suppression, DNA damage response
MeSH terms: Aneuploidy, Animals, DNA Damage, DNA-Binding Proteins, Mice, Transgenic, Neoplasms, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Reactive Oxygen Species, Cell Cycle Proteins, Tumor Suppressor Proteins, Mice, Ataxia Telangiectasia Mutated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks