Cited by 273Stress Responses and CortisolMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress

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McKlveen, J. M., Myers, B., Herman, J. P.·2015·Journal of Neuroendocrinology

Abstract

Responding to real or potential threats in the environment requires the coordination of autonomic, neuroendocrine and behavioural processes to promote adaptation and survival. These diverging systems necessitate input from the limbic forebrain to integrate and modulate functional output in accordance with contextual demand. In the present review, we discuss the potential role of the medial prefrontal cortex (m PFC ) as a coordinator of behavioural and physiological stress responses across multiple temporal and contextual domains. Furthermore, we highlight converging evidence from rodent and human research indicating the necessity of the m PFC for modulating physiological energetic systems to mobilise or limit energetic resources as needed to ultimately promote behavioural adaptation in the face of stress. We review the literature indicating that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the m PFC , as well as shaping how the m PFC acts within a network of brain structures to modulate responses to stress. Finally, we discuss how both rodent and human studies point toward a critical role of the m PFC in the coordination of anticipatory responses to stress and why this distinction is an important one to make in stress neurobiology.

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  1. [83]Harlow JM Passage of an Iron Road Through the Head Bost Med Surg J 1868 39 389 393 PMC9904626 37319500

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Authors
McKlveen, J. M., Myers, B., & Herman, J. P.
Affiliations
University of Cincinnati (US)
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2015-05-26
Volume
27
Issue
6
Pages
446-456
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W2092831348
Cited by
273
References
120
Citations by year
2026: 27 · 2025: 29 · 2024: 24 · 2023: 26 · 2022: 21 · 2021: 26 · 2020: 25 · 2019: 36 · 2018: 27 · 2017: 18 · 2016: 12 · 2015: 2
FWCI
1.53
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (MH097430, MH069860, MH049698.B, HL122454)
  • American Heart Association (17070152)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
medial prefrontal cortex, stress response, glucocorticoids, autonomic responses, neuroendocrine response, behavioral adaptation, anticipatory stress, limbic forebrain, contextual modulation
MeSH terms
Adaptation, Psychological, Animals, Autonomic Nervous System, Behavior, Humans, Neurosecretory Systems, Stress, Psychological, Prefrontal Cortex

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