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Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning

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Volk, Lenora, Kim, Chong-Hyun, Takamiya, Kogo, Yu, Yilin, Huganir, Richard L.·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1016103107PMC PMC3003028
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Abstract

AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the mammalian central nervous system. Modulation of AMPAR trafficking supports several forms of synaptic plasticity thought to underlie learning and memory. Protein interacting with C kinase 1 (PICK1) is an AMPAR-binding protein shown to regulate both AMPAR trafficking and synaptic plasticity at many distinct synapses. However, studies examining the requirement for PICK1 in maintaining basal synaptic transmission and regulating synaptic plasticity at hippocampal Schaffer collateral–cornu ammonis 1 (SC–CA1) synapses have produced conflicting results. In addition, the effect of PICK1 manipulation on learning and memory has not been investigated. In the present study we analyzed the effect of genetic deletion of PICK1 on basal synaptic transmission and synaptic plasticity at hippocampal Schaffer collateral–CA1 synapses in adult and juvenile mice. Surprisingly, we find that loss of PICK1 has no significant effect on synaptic plasticity in juvenile mice but impairs some forms of long-term potentiation and multiple distinct forms of long-term depression in adult mice. Moreover, inhibitory avoidance learning is impaired only in adult KO mice. These results suggest that PICK1 is selectively required for hippocampal synaptic plasticity and learning in adult rodents.

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  • Mice lacking PICK1, KIBRA or Grasp1 all show reductions in hippocampal LTP as well as defects in hippocampus-dependent learning and memory tasks.

    “Mice lacking PICK1, KIBRA or Grasp1 all show reductions in hippocampal LTP as well as defects in hippocampus-dependent learning and memory tasks (Makuch et al., 2011, Volk et al., 2010, Chiu et al., 2017)”

    From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Volk et al., 2010

    The Discussion reports impaired hippocampal LTP with a pairing protocol in adult PICK1-KO mice, while other LTP protocols showed no difference. The Results report impaired inhibitory-avoidance learning in adults, but neither LTP nor learning was impaired in juvenile PICK1-KO mice. The source therefore supports the PICK1 portion of the sentence, but not its unqualified implication that these deficits occur across ages or LTP protocols; the other genes are outside this source's attribution. (LLM, conf=0.87)

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Authors
Volk, L., Kim, C.-H., Takamiya, K., Yu, Y., & Huganir, R. L.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Korea Institute of Science and Technology (KR)
  • University of Miyazaki (JP)
  • Johns Hopkins University (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2010-11-24
Volume
107
Issue
50
Pages
21784-21789
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1016103107
PMC
PMC3003028
OpenAlex
W1973827770
Cited by
85
References
8
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FWCI
2.98
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
PICK1, AMPA receptor trafficking, synaptic plasticity, hippocampus, Schaffer collateral-CA1 synapses, long-term potentiation, long-term depression, passive avoidance learning, learning and memory, developmental regulation, knockout mice, synaptic transmission
MeSH terms
Animals, Carrier Proteins, Hippocampus, Learning, Neuronal Plasticity, Nuclear Proteins, Synapses, Long-Term Potentiation, Receptors, AMPA, Patch-Clamp Techniques, Cell Cycle Proteins, Long-Term Synaptic Depression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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