Negative and competitive social interactions are related to heightened proinflammatory cytokine activity
Open accessAbstract
Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.
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Negative social interactions involving friends, peers, teachers, or family members in daily life are associated with elevations in several markers of inflammatory activity, including CRP, IL-6, and a soluble receptor for TNFα.
“negative social interactions involving friends, peers, teachers, or family members in daily life are associated with elevations in several markers of inflammatory activity, including CRP, IL-6, and a soluble receptor for TNFα”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Chiang, Eisenberger, Seeman, & Taylor, 2012
The Results report that daily negative interactions were associated with higher sTNFαRII at baseline and higher IL-6 and sTNFαRII after a laboratory stressor. The Methods describe conflicts with family or friends as typical negative interactions, but do not establish the association separately for peers or teachers. The study did not measure CRP; its mentions of CRP concern earlier research. (LLM, conf=0.90)
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- Authors
- Chiang, J. J., Eisenberger, N. I., Seeman, T. E., & Taylor, S. E.
- Affiliations
- University of California, Los Angeles (US)
- Department of Psychology, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-01-23
- Volume
- 109
- Issue
- 6
- Pages
- 1878-1882
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3277534
- OpenAlex
- W2115552364
- Cited by
- 114
- References
- 71
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 15 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 6 · 2012: 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 030309, R01AG030309)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- social interaction, negative social interactions, inflammatory cytokines, interleukin-6, soluble TNF receptor 2, systemic inflammation, social stress
- MeSH terms
- Adult, Competitive Behavior, Female, Humans, Interpersonal Relations, Male, Stress, Psychological, Cytokines, Inflammation Mediators, Racial Groups
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