Cited by 301Forensic and Genetic ResearchGenetic diversity and population structureRace, Genetics, and Society

Ancient west Eurasian ancestry in southern and eastern Africa

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Pickrell, Joseph K., Patterson, Nick, Loh, Po-Ru, Lipson, Mark, Berger, Bonnie, Stoneking, Mark, Pakendorf, Brigitte, Reich, David·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: The hunter–gatherer and pastoralist populations of southern Africa are among the culturally, linguistically, and genetically most diverse human populations. However, little is known about their history. We show that all of these populations have some ancestry most closely related to Europeans and Middle Easterners and use this to reconstruct the history of population movements between Eurasia, eastern Africa, and southern Africa.

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Crossref · 10.1073/pnas.1313787111

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29 of 29 references verified0 citation errors · 0 not checkable

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  • These Neanderthal haplotype blocks may have originated in ancient European migrants to eastern Africa and spread beyond eastern Africa through gene flow, which is known to have affected even the basal Africa-MBK lineages.

    “These Neanderthal haplotype blocks may have originated in ancient European migrants to eastern Africa (26) and spread beyond eastern Africa through gene flow, which is known to have affected even the basal Africa-MBK lineages (27).”
  • These observations suggest that the population-specific haplotype blocks may be the result of more recent population-specific Neanderthal admixture.

    “These observations suggest that the population-specific haplotype blocks may be the result of more recent population-specific Neanderthal admixture, as has recently been suggested (26–28, 30).”
  • Migrations from the Near East occurred towards the southwest into East African populations which experienced West Eurasian admixture ~1,000 BCE.

    “Migrations from the Near East also occurred towards the southwest into East African populations which experienced West Eurasian admixture ~1,000 BCE31,32.”

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Authors
Pickrell, J. K., Patterson, N., Loh, P.-R., Lipson, M., Berger, B., Stoneking, M., Pakendorf, B., & Reich, D.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Broad Institute (US)
  • Massachusetts Institute of Technology (US)
  • Max Planck Society (DE)
  • Centre National de la Recherche Scientifique (FR)
Venue
Proceedings of the National Academy of Sciences
Published
2014-02-03
Volume
111
Issue
7
Pages
2632-2637
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2109211295
Cited by
300
References
29
Citations by year
2026: 10 · 2025: 49 · 2024: 5 · 2023: 16 · 2022: 25 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 27 · 2017: 21 · 2016: 26 · 2015: 23 · 2014: 21 · 2013: 1
FWCI
19.92
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • HAL (submittedVersion, other-oa)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • arXiv (Cornell University)
Funders
  • National Science Foundation (1032255)
  • Howard Hughes Medical Institute
  • Simons Foundation
  • European Science Foundation
  • Deutsche Forschungsgemeinschaft
  • Agence Nationale de la Recherche (ANR-11-IDEX-0007)
  • Max-Planck-Gesellschaft
  • National Institutes of Health (GM100233)
  • National Human Genome Research Institute (T32HG004947)
  • National Institute of General Medical Sciences (GM108348, F32GM103098, GM103098, GM100233, R01GM108348, R01GM100233)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
Keywords
Southern Africa, East Africa, hunter-gatherers, pastoralists, demographic history, migration routes
MeSH terms
Africa, Eastern, Africa, Southern, Computer Simulation, Demography, Emigration and Immigration, Ethnicity, Europe, Gene Frequency, Genetics, Population, Genotype, Humans, Models, Genetic, Linkage Disequilibrium, White People, Gene Flow

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