Cited by 93Pleistocene-Era Hominins and ArchaeologyForensic and Genetic ResearchGenetic diversity and population structure

Philippine Ayta possess the highest level of Denisovan ancestry in the world

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Larena, Maximilian, McKenna, James, Sanchez-Quinto, Federico, Bernhardsson, Carolina, Ebeo, Carlo, Reyes, Rebecca, Casel, Ophelia, Huang, Jin-Yuan +39 more·2021·Current Biology

Abstract

Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world-∼30%-40% greater than that of Australians and Papuans-consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.

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  • Papuans owe up to 5% of their genome to Denisovans.

    “Papuans, in particular, owe up to 5% of their genome to Denisovans”

    From Denisovan introgression has shaped the immune system of present-day Papuans (2022) · cites this paper as [5]

    The Results and discussion report Denisovan ancestry in Papuans, but do not give a figure of up to 5%. They state that an estimated 4.47% in ancestral Negritos is 46% higher than in Papuans, implying a Papuan estimate of about 3.1%. No page number is available in our copy. (LLM, conf=0.85)

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Authors
Larena, M., McKenna, J., Sanchez-Quinto, F., Bernhardsson, C., Ebeo, C., Reyes, R., Casel, O., Huang, J.-Y., Hagada, K. P., Guilay, D., Reyes, J., Allian, F. P., Mori, V., Azarcon, L. S., Manera, A., Terando, C., Jamero, L., Sireg, G., Manginsay-Tremedal, R., Labos, M. S., Vilar, R. D., Latiph, A., Saway, R. L., Marte, E., Magbanua, P., Morales, A., Java, I., Reveche, R., Barrios, B., Burton, E., Salon, J. C., Kels, M. J. T., Albano, A., Cruz-Angeles, R. B., Molanida, E., Granehäll, L., Vicente, M., Edlund, H., Loo, J.-H., Trejaut, J., Ho, S. Y. W., Reid, L., Lambeck, K., Malmström, H., Schlebusch, C., Endicott, P., & Jakobsson, M.
Affiliations
  • Uppsala University (SE)
  • National Museum of the Philippines (PH)
  • National Commission on Indigenous Peoples (PH)
  • Mackay Memorial Hospital (TW)
  • Quirino State University (PH)
  • Department of Education (PH)
  • Cagayan State University (PH)
  • Provincial Government of Sarangani (PH)
  • Museo Dabawenyo (PH)
  • Mindanao State University (PH)
  • The Negros Museum (PH)
  • Xavier University (PH)
  • Ifugao State University (PH)
  • The University of Sydney (AU)
  • University of Hawaiʻi at Mānoa (US)
  • Australian National University (AU)
  • Musée de l'Homme (FR)
Corresponding author
  • Larena, Maximilian
  • Jakobsson, Mattias
Venue
Current Biology
Publisher
Elsevier BV
Published
2021-10
Volume
31
Issue
19
Pages
4219-4230.e10
ISSN
0960-9822 (ISSN-L)
OpenAlex
W3187633170
Cited by
93
References
98
Citations by year
2026: 21 · 2025: 13 · 2024: 23 · 2023: 14 · 2022: 19 · 2021: 2 · 2020: 1
FWCI
55.97
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
  • Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
  • HAL (submittedVersion)
  • ANU Open Research (Australian National University) (submittedVersion, cc-by-nc-nd)
Funders
  • Knut och Alice Wallenbergs Stiftelse
  • Vetenskapsrådet (2020-04789, 642-2013-8019)
Topics
  • Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords
Denisovan admixture, archaic human admixture, Homo luzonensis, Island Southeast Asia
MeSH terms
Animals, Asia, Asia, Southeastern, Australia, Humans, Philippines, Hominidae, Racial Groups, Neanderthals

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