The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ribosomal protein–Mdm2–p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation
Abstract
Significance: Although progress has been made in the characterization of p53 in regulating metabolism, very little is known about the signaling pathways involved in this regulation in response to stress in vivo. Here we show that p53 controls hepatic fatty acid oxidation in mice in response to fasting. Disruption of ribosome protein (RP)-mouse double minute (Mdm)2 binding in Mdm2 C305F mice results in fasting-induced hepatosteatosis. A full-dosage of p53 and an intact RP-Mdm2-p53 pathway are required for the induction of malonyl coA decarboxylase (MCD), a critical regulator of fatty acid oxidation. Thus, the RP-Mdm2-p53 pathway functions as a key regulator of hepatic lipid homeostasis in response to nutrient deprivation stress, a function that has implications in organismal survival and tumor suppression.
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“p53 also activates malonyl-CoA decarboxylase (MCD), PANK1, and CPT1C to accelerate fatty acid oxidation.93–95”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [93]
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Cites
p53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650
Regulation of hepatic fatty acid oxidation and ketone body production
McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460 · cited 2×
“Ketogenesis, a process that produces β-HB during FAO (13), was fully induced in fasted WT mice as indicated by high levels of serum β-HB (Fig.”
BackgroundVousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959
Glycolytic Enzymes Can Modulate Cellular Life Span
Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647
Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells
Saggerson, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155434 · Cited by 301
p53 ancestry: gazing through an evolutionary lens
Lu, W.-J., Amatruda, J. F., & Abrams, J. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2732 · Cited by 112
Research works printed but not linked: 25
- 10.1126/science.123.3191.309 · DOI · Paper page
- 10.1016/j.ccr.2009.09.024 · DOI · Paper page
- 10.1002/(SICI)1096-9896(199705)182:1<54::AID-PATH815>3.0.CO;2-I · DOI
- 10.1002/ijc.1271 · DOI
- 10.1128/MCB.01307-06 · DOI
- 10.1016/j.ccr.2010.08.007 · DOI · Paper page
- 10.1016/j.physbeh.2004.04.025 · DOI
- 10.1073/pnas.96.13.7473 · DOI · Paper page
- 10.1007/s00360-004-0452-2 · DOI
- 10.1097/01.mco.0000241677.40170.17 · DOI
- 10.1016/B978-1-4831-9943-6.50007-4 · DOI
- 10.1038/sj.emboj.7600247 · DOI · Paper page
- 10.1016/S0021-9258(18)96360-X · DOI · Paper page
- 10.1074/jbc.M608372200 · DOI · Paper page
- 10.1038/ijo.2008.123 · DOI
- 10.1152/ajpendo.2000.279.2.E259 · DOI
- 10.1007/s00109-011-0735-5 · DOI · Paper page
- 10.1158/0008-5472.CAN-03-0846 · DOI · Paper page
- 10.1016/j.cell.2006.05.036 · DOI · Paper page
- 10.1016/j.molcel.2011.08.038 · DOI · Paper page
- 10.1073/pnas.1001006107 · DOI · Paper page
- 10.1073/pnas.1002459107 · DOI · Paper page
- 10.1158/0008-5472.CAN-06-4447 · DOI · Paper page
- 10.1016/j.jhep.2012.11.042 · DOI · Paper page
- 10.1128/MCB.01284-09 · DOI
Cited by
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 30
Metadata
- Authors
- Liu, Y., He, Y., Jin, A., Tikunov, A. P., Zhou, L., Tollini, L. A., Leslie, P., Kim, T.-H., Li, L. O., Coleman, R. A., Gu, Z., Chen, Y. Q., Macdonald, J. M., Graves, L. M., & Zhang, Y.
- Affiliations
- Department of Radiation Oncology,
- Departments of eBiomedical Engineering and
- Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
- Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157; and
- Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-05-28
- Volume
- 111
- Issue
- 23
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 80
- References
- 6
- Language
- en
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- Liu, Y., He, Y., Jin, A., Tikunov, A. P., Zhou, L., Tollini, L. A., Leslie, P., Kim, T.-H., Li, L. O., Coleman, R. A., Gu, Z., Chen, Y. Q., Macdonald, J. M., Graves, L. M., & Zhang, Y. (2014). Ribosomal protein–Mdm2–p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315605111
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