Cited by 221Neuroscience and Neural EngineeringEEG and Brain-Computer InterfacesStroke Rehabilitation and Recovery

Restoration of function after brain damage using a neural prosthesis

Open access
Guggenmos, David J., Azin, Meysam, Barbay, Scott, Mahnken, Jonathan D., Dunham, Caleb, Mohseni, Pedram, Nudo, Randolph J.·2013·Proceedings of the National Academy of Sciences

Abstract

Significance: Closed-loop systems, or brain–machine–brain interfaces (BMBIs), have not been widely developed for brain repair. In this study, we targeted spared motor and somatosensory regions of the rat brain after traumatic brain injury for establishment of a functional bridge using a battery-powered microdevice. The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated. This study provides strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Although this study is restricted to a rodent model of TBI, it is likely that the approach will also be applicable to other types of acquired brain injuries.

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Crossref · 10.1073/pnas.1316885110

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  • Establishing a continuous link between the brain and spinal cord promotes the reorganization of residual neuronal pathways that link these two regions under normal physiological conditions.

    “This cooperation probably plays an essential role in the reorganization of neuronal pathways that mediate neurological recovery in response to neurorehabilitation with the BSI.”

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Authors
Guggenmos, D. J., Azin, M., Barbay, S., Mahnken, J. D., Dunham, C., Mohseni, P., & Nudo, R. J.
Affiliations
  • University of Kansas Medical Center (US)
  • Case Western Reserve University (US)
  • Biostatistics, and
Venue
Proceedings of the National Academy of Sciences
Published
2013-12-09
Volume
110
Issue
52
Pages
21177-21182
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2147851954
Cited by
221
References
50
Citations by year
2026: 14 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 21 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 27 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 14 · 2012: 1
FWCI
8.34
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
neural prosthesis, neural interfaces, brain injury recovery, focal brain lesions, premotor cortex, somatosensory cortex, microelectrodes, reach-to-grasp, functional connectivity, rat model
MeSH terms
Action Potentials, Animals, Brain Injuries, Male, Motor Cortex, Motor Skills, Neural Pathways, Linear Models, Rats, Long-Evans, Rats, Neural Prostheses, Brain-Computer Interfaces

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