Restoration of function after brain damage using a neural prosthesis
Open accessAbstract
Significance: Closed-loop systems, or brain–machine–brain interfaces (BMBIs), have not been widely developed for brain repair. In this study, we targeted spared motor and somatosensory regions of the rat brain after traumatic brain injury for establishment of a functional bridge using a battery-powered microdevice. The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated. This study provides strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Although this study is restricted to a rodent model of TBI, it is likely that the approach will also be applicable to other types of acquired brain injuries.
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Establishing a continuous link between the brain and spinal cord promotes the reorganization of residual neuronal pathways that link these two regions under normal physiological conditions.
“This cooperation probably plays an essential role in the reorganization of neuronal pathways that mediate neurological recovery in response to neurorehabilitation with the BSI.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [40]
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- Authors
- Guggenmos, D. J., Azin, M., Barbay, S., Mahnken, J. D., Dunham, C., Mohseni, P., & Nudo, R. J.
- Affiliations
- University of Kansas Medical Center (US)
- Case Western Reserve University (US)
- Biostatistics, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-12-09
- Volume
- 110
- Issue
- 52
- Pages
- 21177-21182
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3876197
- OpenAlex
- W2147851954
- Cited by
- 221
- References
- 50
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 21 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 27 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 14 · 2012: 1
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- other-oa
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- neural prosthesis, neural interfaces, brain injury recovery, focal brain lesions, premotor cortex, somatosensory cortex, microelectrodes, reach-to-grasp, functional connectivity, rat model
- MeSH terms
- Action Potentials, Animals, Brain Injuries, Male, Motor Cortex, Motor Skills, Neural Pathways, Linear Models, Rats, Long-Evans, Rats, Neural Prostheses, Brain-Computer Interfaces
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