Photic memory for executive brain responses
Open accessAbstract
Light is a powerful stimulant for human alertness and cognition, presumably acting through a photoreception system that heavily relies on the photopigment melanopsin. In humans, evidence for melanopsin involvement in light-driven cognitive stimulation remains indirect, due to the difficulty to selectively isolate its contribution. Therefore, a role for melanopsin in human cognitive regulation remains to be established. Here, sixteen participants underwent consecutive and identical functional MRI recordings, during which they performed a simple auditory detection task and a more difficult auditory working memory task, while continuously exposed to the same test light (515 nm). We show that the impact of test light on executive brain responses depends on the wavelength of the light to which individuals were exposed prior to each recording. Test-light impact on executive responses in widespread prefrontal areas and in the pulvinar increased when the participants had been exposed to longer (589 nm), but not shorter (461 nm), wavelength light, more than 1 h before. This wavelength-dependent impact of prior light exposure is consistent with recent theories of the light-driven melanopsin dual states. Our results emphasize the critical role of light for cognitive brain responses and are, to date, the strongest evidence in favor of a cognitive role for melanopsin, which may confer a form of "photic memory" to human cognitive brain function.
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Light has a critical role for cognitive brain responses, emphasizing evidence of a cognitive role for melanopsin, which may confer a form of 'photic memory' to human cognitive brain function.
“Recently, another study showed the critical role of light for cognitive brain responses in emphasizing the evidence of a cognitive role for melanopsin, which may confer a form of 'photic memory' to human cognitive brain function [33].”
From Dawn simulation light impacts on different cognitive domains under sleep restriction (2015) · cites this paper as [33]
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Author response: Regional response to light illuminance across the human hypothalamus
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Selective activation of ipRGC modulates working memory performance
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Regional activity within the human amygdala varies with season, mood and illuminance
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Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health
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Effects of Sensory-Enhanced Acute Exercise on Affective Characteristics of Employees
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Regional response to light illuminance across the human hypothalamusPreprint
Campbell, I., Sharifpour, R., Aizpurua, J. F. B., Beckers, E., Paparella, I., Berger, A., Koshmanova, E., Mortazavi, N., Read, J., Zubkov, M. A., et al. (2024) · eLife · doi:10.7554/elife.96576.2 · Cited by 1 · see citing works
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Reviewer #3 (Public Review): Regional response to light illuminance across the human hypothalamus
Campbell, I., Sharifpour, R., Aizpurua, J. F. B., et al. (2024) · eLife · doi:10.7554/elife.96576.2.sa1
Reviewer #1 (Public Review): Regional response to light illuminance across the human hypothalamus
Campbell, I., Sharifpour, R., Aizpurua, J. F. B., et al. (2024) · eLife · doi:10.7554/elife.96576.2.sa3
eLife Assessment: Regional response to light illuminance across the human hypothalamus
Forstmann, B. U. (2024) · eLife · doi:10.7554/elife.96576.2.sa4
Reviewer #2 (Public Review): Regional response to light illuminance across the human hypothalamus
Campbell, I., Sharifpour, R., Aizpurua, J. F. B., et al. (2024) · eLife · doi:10.7554/elife.96576.2.sa2
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Potentialisation de la réponse antidépressive par la lumière : étude préclinique
Delcourte, S. (2019) · theses.fr (ABES) · doi:10.70675/7468b6d3zbf12z4888z88afzc63efcc91723
Left in the dark : wavelength-dependent post-illumination effects on human physiology and behavior
van der Meijden, W. P. (2018) · theses.fr (ABES) · doi:10.70675/1e8db86dzf465z4cefzbdcezd673c0fb1bfa
Lifetime changes in the biological effects of light on non-visual brain functions
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- Authors
- Chellappa, S. L., Ly, J. Q. M., Meyer, C., Balteau, E., Degueldre, C., Luxen, A., Phillips, C., Cooper, H. M., & Vandewalle, G.
- Affiliations
- University of Liège (BE)
- Inserm (FR)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-03-10
- Volume
- 111
- Issue
- 16
- Pages
- 6087-6091
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4000819
- OpenAlex
- W1980420659
- Cited by
- 92
- References
- 32
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 12 · 2023: 6 · 2022: 13 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 1
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-09-MNPS-0040)
- Science and Technology Facilities Council (ST/K001051/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- melanopsin, executive function, working memory, light exposure, wavelength dependence, prefrontal cortex, pulvinar, alertness, photoreception
- MeSH terms
- Adult, Brain, Female, Humans, Light, Male, Memory, Young Adult, Executive Function
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