Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats
Open accessAbstract
While reward-dependent facilitation of phasic dopamine signaling is well documented at both the cell bodies and terminals, little is known regarding fast dopamine transmission under aversive conditions. Exposure to aggressive confrontation is extremely aversive and stressful for many species including rats. The present study used fast-scan cyclic voltammetry and multiunit recording to determine if aggressive encounters and subsequent social defeat affect burst firing of ventral tegmental area (VTA) dopamine neurons and accumbal dopamine transients in defeated rats. Significant increases in the frequency of transient dopamine release were observed during interactions with an aggressive rat but not with a familiar cage mate. In agreement with voltammetric results, significant increases in burst frequency were detected in the VTA dopamine firing patterns during an aggressive confrontation; however, the number of spikes per burst remained unchanged. We found that neurons with lower burst rates under home cage conditions did not switch from nonbursting to bursting types, while neurons with higher burst levels showed amplified increases in bursting. This study demonstrates for the first time that aggressive confrontations in defeated rats are associated with increases in phasic dopamine transmission in the mesolimbic pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ventral tegmental area burst firing is increased in vivo during an encounter with an aggressive rat.
“burst firing is increased in vivo during an encounter with an aggressive rat [32].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · see citing works
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346 · see citing works
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · see citing works
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
Salamone, J. D., Correa, M., Farrar, A., & Mingote, S. M. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0668-9 · Cited by 1,000 · see citing works
The effects of predator odors in mammalian prey species: A review of field and laboratory studies
Apfelbach, R., Blanchard, C. D., Blanchard, R. J., Hayes, R. A., & McGregor, I. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.05.005 · Cited by 866 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli
Ungless, M. A., Magill, P. J., & Bolam, J. P. (2004) · Science · doi:10.1126/science.1093360 · Cited by 782 · see citing works
Dopamine operates as a subsecond modulator of food seeking
Roitman, M. F., Stuber, G. D., Phillips, P. E. M., Wightman, R. M., & Carelli, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3823-03.2004 · Cited by 718 · see citing works
Kelly, P. H., & Iversen, S. D. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90352-6 · Cited by 712 · see citing works
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M. (2007) · Nature Neuroscience · doi:10.1038/nn1923 · Cited by 710 · see citing works
Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo
Robinson, D. L., Venton, B. J., Heien, M. L., & Wightman, R. M. (2003) · Clinical Chemistry · doi:10.1373/49.10.1763 · Cited by 602 · see citing works
Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works
Is the short-latency dopamine response too short to signal reward error?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01373-3 · Cited by 506 · see citing works
Tidey, J. W., & Miczek, K. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00159-x · Cited by 496 · see citing works
Self-citationFiring modes of midbrain dopamine cells in the freely moving rat
Hyland, B. I., Reynolds, J. N. J., HAY, J. G., Perk, C. G., & Miller, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00267-1 · Cited by 487 · see citing works
Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats
Heien, M. L. A. V., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., Wassum, K. M., & Wightman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504657102 · Cited by 482 · see citing works
Role of brain dopamine in food reward and reinforcement
Wise, R. A. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1854 · Cited by 436 · see citing works
Grace, A. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.1.x · Cited by 433 · cited 1× · see citing works
“These changes may be the consequence of increased low-frequency tonic firing of dopamine neurons or glutamatergic actions at the level of dopamine terminals (Grace, 2000).”
BackgroundPan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1478-05.2005 · Cited by 429 · see citing works
Miczek, K. A. (1979) · Psychopharmacology · doi:10.1007/bf00426664 · Cited by 398 · see citing works
Self-citationElectrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area
Steffensen, S. C., Svingos, A. L., Pickel, V. M., & Henriksen, S. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08003.1998 · Cited by 388 · see citing works
Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L. A. V., Ariansen, J. L., Aragona, B. J., Phillips, P. E. M., & Wightman, R. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-06.2007 · Cited by 374 · see citing works
Book Review: Reward Signaling by Dopamine Neurons
Schultz, W. (2001) · The Neuroscientist · doi:10.1177/107385840100700406 · Cited by 343 · see citing works
Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake
MICZEK, K., YAP, J., & COVINGTONIII, H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.07.006 · Cited by 338 · see citing works
Self-citationDissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327 · see citing works
Repeated social-defeat stress, cocaine or morphine
Covington, H. E., & Miczek, K. A. (2001) · Psychopharmacology · doi:10.1007/s002130100858 · Cited by 326 · see citing works
Self-citationDiana, M., Pistis, M., Carboni, S., Gessa, G. L., & Rossetti, Z. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7966 · Cited by 309 · see citing works
Long-term impairment of autonomic circadian rhythms after brief intermittent social stress
Tornatzky, W., & Miczek, K. A. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90278-n · Cited by 306 · see citing works
Self-citationThe role of noradrenaline in tuning and dopamine in switching between signals in the CNS
Oades, R. D. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90050-8 · Cited by 306 · see citing works
Robinson, D. L., Heien, M. L. A. V., & Wightman, R. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10477.2002 · Cited by 290 · see citing works
THE BEHAVIOR OF THE LABORATORY RAT A Handbook with Tests
Wishaw, I. Q., & Kolb, B. E. (2004) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 290 · see citing works
Kuczenski, R. T., Segal, D., & Aizenstein, M. L. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02703.1991 · Cited by 285 · see citing works
Intraspecies aggression in rats: Effects of d-amphetamine and chlordiazepoxide
Miczek, K. A. (1974) · Psychopharmacology · doi:10.1007/bf00422968 · Cited by 268 · see citing works
Self-citationA role for mesencephalic dopamine in activation: commentary on Berridge (2006)
Robbins, T. W., & Everitt, B. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0528-7 · Cited by 265 · see citing works
Rebec, G. V., Christensen, J. R. C., Guerra, C., & Bardo, M. T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01004-4 · Cited by 235 · see citing works
Afferent modulation of dopamine neuron firing patterns
Kitai, S. T., Shepard, P. D., Callaway, J. C., & Scroggs, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00040-9 · Cited by 234 · see citing works
Richards, C. D., Shiroyama, T., & Kitai, S. T. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00093-6 · Cited by 233 · see citing works
Wichmann, T., & Soares, J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01013.2005 · Cited by 211 · see citing works
Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior
Cheer, J. F., Aragona, B. J., Heien, M. L., Seipel, A. T., Carelli, R. M., & Wightman, R. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.021 · Cited by 202 · see citing works
Hormonal Correlates of Agonistic Behavior in Adult Male Rats
Schuurman, T. (1980) · Progress in brain research · doi:10.1016/s0079-6123(08)60079-5 · Cited by 201 · see citing works
Restraint increases dopaminergic burst firing in awake rats
Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181 · see citing works
Self-citationMorrow, B. A., Redmond, A. J., Roth, R. H., & Elsworth, J. D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02174-0 · Cited by 180 · see citing works
Chang, J., Sawyer, S. F., Lee, R., & Woodward, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01224.1994 · Cited by 177 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Louilot, A., Moal, M. L., & Simon, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90646-3 · Cited by 168 · see citing works
Stuber, G. D., Wightman, R. M., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.036 · Cited by 168 · see citing works
Sub-second changes in accumbal dopamine during sexual behavior in male rats
Robinson, D. L., Phillips, P. E. M., Budygin, E. A., Trafton, B. J., Garris, P. A., & Wightman, R. M. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00051 · Cited by 147 · see citing works
Self-citationDual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes
Schilström, B., Rawal, N., Mameli-Engvall, M., Nomikos, G. G., & Svensson, T. H. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003188 · Cited by 143 · see citing works
Miczek, K. A., Covington, H. E., Nikulina, E. M., & Hammer, R. P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.005 · Cited by 136 · see citing works
Self-citationCovington, H. E., Kikusui, T., Goodhue, J., Nikulina, E. M., Hammer, R. P., & Miczek, K. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300587 · Cited by 127 · see citing works
Self-citationImpulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Marinelli, M., Cooper, D., Baker, L. K., & White, F. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1491-1 · Cited by 100 · see citing works
Behavioral associations of neuronal activity in the ventral tegmental area of the rat
Kosobud, A., Harris, G. C. M., & Chapin, J. K. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07117.1994 · Cited by 98 · see citing works
Budygin, E. A., Kilpatrick, M., Gainetdinov, R. R., & Wightman, R. M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00813-2 · Cited by 96 · see citing works
Self-citationCoizet, V., Dommett, E. J., Redgrave, P., & Overton, P. G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.030 · Cited by 92 · see citing works
Behavior-related activity of primate dopamine neurons.
Schultz, W. (1995) · PubMed · Cited by 74 · see citing works
Dual Role of Medial A10 Dopamine Neurons in Affective Encoding
Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73 · see citing works
Aldridge, J. W., & Gilman, S. (1991) · Brain Research · doi:10.1016/0006-8993(91)91055-6 · Cited by 72 · see citing works
Sabeti, J., Gerhardt, G. A., & Zahniser, N. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035816 · Cited by 71 · see citing works
In Vivo and in Vitro Intracellular Recordings from Rat Midbrain Dopamine Neuronsa
Grace, A. A. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42096.x · Cited by 67 · see citing works
Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration
Janak, P. H., Chang, J.-Y., & Woodward, D. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01245-1 · Cited by 65 · see citing works
Overton, P. G., Tong, Z.-Y., Brain, P. F., & Clark, D. (1996) · Brain Research · doi:10.1016/0006-8993(96)00722-6 · Cited by 55 · see citing works
Lee, C. R., Abercrombie, E. D., & Tepper, J. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.034 · Cited by 47 · see citing works
Specific effect on social stress and aggression on regional dopamine metabolism in rat brain
Mos, J., & van Valkenburg, C. F. (1979) · Neuroscience Letters · doi:10.1016/0304-3940(79)96134-2 · Cited by 38 · see citing works
Extrasynaptic dopamine and phasic neuronal activity
Phillips, P. E. M., & Wightman, R. M. (2004) · Nature Neuroscience · doi:10.1038/nn0304-199a · Cited by 25 · see citing works
Miczek, K. A. (1999) · Psychopharmacology · doi:10.1007/s002130051132 · Cited by 21 · see citing works
Self-citationEffects of restraint and haloperidol on sensory gating in the midbrain of awake rats
Anstrom, K. K., Cromwell, H. C., & Woodward, D. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.060 · Cited by 16 · see citing works
Self-citationDopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior
Budygin, E. A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.064 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418 · see citing works
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Schizophrenia: an integrated sociodevelopmental-cognitive model
Howes, O. D., & Murray, R. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62036-x · Cited by 864 · see citing works
Striatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382 · see citing works
Salamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350 · see citing works
The mesoaccumbens dopamine in coping with stress
Cabib, S., & Puglisi-Allegra, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.012 · Cited by 329 · see citing works
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works
Self-citationThe molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Mesolimbic Dopamine and the Regulation of Motivated Behavior
Salamone, J. D., Pardo, M., Yohn, S. E., López-Cruz, L., SanMiguel, N., & Correa, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_383 · Cited by 204 · see citing works
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Friedman, A. K., Juarez, B., Ku, S. M., Zhang, H., Calizo, R. C., Walsh, J. J., Chaudhury, D., Zhang, S., Hawkins, A., Dietz, D. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11671 · Cited by 172 · see citing works
Miczek, K. A., Nikulina, E. M., Shimamoto, A., & Covington, H. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0637-11.2011 · Cited by 162 · see citing works
Self-citationOrsini, C. A., Moorman, D. E., Young, J. W., Setlow, B., & Floresco, S. B. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.009 · Cited by 153 · see citing works
Aversive stimulus differentially triggers subsecond dopamine release in reward regions
Budygin, E. A., Park, J., Bass, C. E., Grinevich, V. P., Bonin, K. D., & Wightman, R. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.056 · Cited by 152 · see citing works
Self-citationStress responses and the mesolimbic dopamine system: Social contexts and sex differences
Trainor, B. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.013 · Cited by 138 · see citing works
Advances in understanding neural mechanisms of social dominance
Zhou, T., Sandi, C., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.01.006 · Cited by 133 · see citing works
Cook, T. B., Brenner, L. A., Cloninger, C. R., Langenberg, P., Igbide, A., Giegling, I., Hartmann, A. M., Konte, B., Friedl, M., Brundin, L., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.019 · Cited by 122 · see citing works
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works
Steinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works
Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults
McCutcheon, J. E., Conrad, K. L., Carr, S. B., Ford, K. A., McGehee, D. S., & Marinelli, M. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00077.2012 · Cited by 106 · see citing works
HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
Zhong, P., Vickstrom, C. R., Liu, X., Hu, Y., Yu, L., Yu, H.-G., & Liu, Q.-S. (2018) · eLife · doi:10.7554/elife.32420 · Cited by 99 · see citing works
“CSDS, in contrast to CMS, increases tonic and burst firing in mice susceptible to CSDS, but not in resilient mice (Anstrom et al., 2009; Cao et al., 2010; Chaudhury et al., 2013; Friedman et al., 2014; Krishnan et al., 2007).”
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat
Razzoli, M., Andreoli, M., Michielin, F., Quarta, D., & Sokal, D. M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.050 · Cited by 76 · see citing works
The neurobiology of offensive aggression: Revealing a modular view
de Boer, S. F., Olivier, B., Veening, J., & Koolhaas, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.040 · Cited by 70 · see citing works
Sex differences in effects of dopamine D1 receptors on social withdrawal
Campi, K. L., Greenberg, G. D., Kapoor, A., Ziegler, T. E., & Trainor, B. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.026 · Cited by 55 · see citing works
Yap, J. J., Chartoff, E. H., Holly, E. N., Potter, D. N., Carlezon, W. A., & Miczek, K. A. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3796-7 · Cited by 55 · see citing works
Self-citationRappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“Additionally, research has shown increased firing rates of VTA-DA neurons during aggressive confrontations in male Sprague-Dawley rats (Anstrom et al., 2009) and in C57BL/6 male mice susceptible to SDS (i.e., showing social avoidance) (Cao et al., 2010).”
BackgroundGreenberg, G. D., Steinman, M. Q., Doig, I. E., Hao, R., & Trainor, B. C. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13099 · Cited by 49 · see citing works
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test
Addy, N. A., Nunes, E. J., & Wickham, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.002 · Cited by 42 · see citing works
Montagud-Romero, S., Reguilon, M. D., Roger-Sanchez, C., Pascual, M., Aguilar, M. A., Guerri, C., Miñarro, J., & Rodríguez-Arias, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.008 · Cited by 31 · see citing works
- Authors
- Anstrom, K. K., Miczek, K. A., & Budygin, E. A.
- Affiliations
- Wake Forest University Health Sciences (US)
- Tufts University (US)
- Corresponding author
- Budygin, E.A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 161
- Issue
- 1
- Pages
- 3-12
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC4445890
- OpenAlex
- W2078550466
- Cited by
- 246
- References
- 71
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 13 · 2020: 9 · 2019: 16 · 2018: 19 · 2017: 15 · 2016: 18 · 2015: 28 · 2014: 24 · 2013: 14 · 2012: 20
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA013983, AA013983)
- National Institute on Drug Abuse (K01DA021634, DA021634)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- social defeat, mesolimbic system, ventral tegmental area, accumbens, burst firing, dopamine release, stress, dopaminergic neurons
- MeSH terms
- Action Potentials, Aggression, Animals, Dominance-Subordination, Dopamine, Electrophysiology, Male, Synaptic Transmission, Nucleus Accumbens, Stress, Psychological, Signal Transduction, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
