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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
Open accessAbstract
The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.
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Metadata
- Authors
- Cantley, L. C., & Neel, B. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-13
- Volume
- 96
- Issue
- 8
- Pages
- 4240-4245
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1984418041
- Cited by
- 2,006
- References
- 6
- FWCI
- 34.69
- Type
- journal article
- Language
- en
- Open access
- green
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