Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

Shimano, Hitoshi; Yahagi, Naoya; Amemiya-Kudo, Michiyo; Hasty, Alyssa H.; Osuga, Jun-ichi; Tamura, Yoshiaki; Shionoiri, Futoshi; Iizuka, Yoko; Ohashi, Ken; Harada, Kenji; Gotoda, Takanari; Ishibashi, Shun; Yamada, Nobuhiro

doi:10.1074/jbc.274.50.35832

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Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

Shimano, Hitoshi, Yahagi, Naoya, Amemiya-Kudo, Michiyo, Hasty, Alyssa H., Osuga, Jun-ichi, Tamura, Yoshiaki, Shionoiri, Futoshi, Iizuka, Yoko, Ohashi, Ken, Harada, Kenji, Gotoda, Takanari, Ishibashi, Shun, Yamada, Nobuhiro·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.50.35832

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Global- and hepatocyte-specific loss of MARCHF6 in mice results in elevated abundance of G6PD.
“In line with this heightened NADPH demand, global- and hepatocyte-specific loss of MARCHF6 in mice resulted in elevated abundance of G6PD, the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway, and an SREBP1-sensitive gene [58,59].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [59]
G6PD is the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway and an SREBP1-sensitive gene.
“In line with this heightened NADPH demand, global- and hepatocyte-specific loss of MARCHF6 in mice resulted in elevated abundance of G6PD, the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway, and an SREBP1-sensitive gene [58,59].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [59]

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“…to hormones (e.g., insulin) and fatty acids, (e.g., polyunsaturated fatty acids) (Ntambi et al., 2004) and regulated by multiple transcription factors (e.g., sterol regulatory element-binding protein 1c [SREBP-1c]), as part of a coordinated fatty acid synthetic effort (Shimano et al., 1999).”
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Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis
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Authors: Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J.-I., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S., & Yamada, N.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-12
Volume: 274
Issue: 50
Pages: 35832-35839
ISSN: 0021-9258
DOI: 10.1074/jbc.274.50.35832
Cited by: 607
References: 1
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7617 d)

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Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

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