Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase

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TopBP1 Activates the ATR-ATRIP Complex

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

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Initiating Cellular Stress Responses

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Mrc1 transduces signals of DNA replication stress to activate Rad53

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The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

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DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint

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A Central Role for DNA Replication Forks in Checkpoint Activation and Response

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

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Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

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The PCNA–RFC Families of DNA Clamps and Clamp Loaders

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Budding yeast Rad9 is an ATP-dependent Rad53 activating machine

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The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

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Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

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The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific fociPreprint

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Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint

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Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation

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BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response

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Replication Protein A Directs Loading of the DNA Damage Checkpoint Clamp to 5′-DNA Junctions

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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

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Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

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A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

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Lcd1p Recruits Mec1p to DNA Lesions In Vitro and In Vivo

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Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4 TOPBP1Preprint

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Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

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Checkpoint responses to replication fork barriers

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Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint

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The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint

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Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

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Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

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Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint

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Genetic and Physical Interactions Between <i>DPB11</i> and <i>DDC1</i> in the Yeast DNA Damage Response Pathway

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The S-phase checkpoint and its regulation in Saccharomyces cerevisiae

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A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

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Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.

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MEC1-dependent phosphorylation of yeast RPA1 in vitro

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DNA Stimulates Mec1-mediated Phosphorylation of Replication Protein A

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Modulation of the Protein Kinase Activity of mTOR

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Overproduction and Purification of RFC‐Related Clamp Loaders and PCNA‐Related Clamps from Saccharomyces cerevisiae

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Clamping the Mec1/ATR Checkpoint Kinase into Action

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DNA Damage Sensing by the ATM and ATR Kinases

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RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

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ATR signalling: more than meeting at the fork

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ATR: a master conductor of cellular responses to DNA replication stress

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ATR/Mec1: coordinating fork stability and repair

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Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

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Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

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A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

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Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae

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Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

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Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System

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Mind the gap: keeping UV lesions in check

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The human ATR-mediated DNA damage checkpoint in a reconstituted system

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Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

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Chapter 16 Chk1 and Chk2 as Checkpoint Targets

Zhang, H., Xiao, Z., & Sowin, T. (2009)

Chk1 and Chk2 as Checkpoint Targets

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Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

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Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways

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