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Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
Open accessAbstract
PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinase, whereas Parkin functions as an E3 ubiquitin ligase. Under steady-state conditions, Parkin localizes to the cytoplasm where its E3 activity is repressed. A decrease in mitochondrial membrane potential triggers Parkin E3 activity and recruits it to depolarized mitochondria for ubiquitylation of mitochondrial substrates. The molecular basis for how the E3 activity of Parkin is re-established by mitochondrial damage has yet to be determined. Here we provide in vitro biochemical evidence for ubiquitin-thioester formation on Cys-431 of recombinant Parkin. We also report that Parkin forms a ubiquitin-ester following a decrease in mitochondrial membrane potential in cells, and that this event is essential for substrate ubiquitylation. Importantly, the Parkin RING2 domain acts as a transthiolation or acyl-transferring domain rather than an E2-recruiting domain. Furthermore, formation of the ubiquitin-ester depends on PINK1 phosphorylation of Parkin Ser-65. A phosphorylation-deficient mutation completely inhibited formation of the Parkin ubiquitin-ester intermediate, whereas phosphorylation mimics, such as Ser to Glu substitution, enabled partial formation of the intermediate irrespective of Ser-65 phosphorylation. We propose that PINK1-dependent phosphorylation of Parkin leads to the ubiquitin-ester transfer reaction of the RING2 domain, and that this is an essential step in Parkin activation. Background: Parkin is a ubiquitin ligase activated by a decrease in the mitochondrial membrane potential (ΔΨm). However, details regarding its mechanism remain limited. Results: PINK1-dependent phosphorylation of Parkin at Ser-65 following dissipation of ΔΨm triggers ubiquitin-ester transfer by the RING2 domain of Parkin to Cys-431. Conclusion: Parkin catalyzes trans- (ubiquitin-thioester)ification upon PINK1-dependent phosphorylation. Significance: The molecular process of Parkin-catalyzed ubiquitylation has been determined.
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“Both events are required for the activation of the pathway.”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [10]
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“Upon mitochondrial depolarization, PINK1 stabilizes on the outer mitochondrial membrane, where it phosphorylates ubiquitin (Ub) and PRKN at Ser65 [5–10].”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [10]
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Specificity and disease in the ubiquitin system
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Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation
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Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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Metadata
- Authors
- Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., & Matsuda, N.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- Keio University (JP)
- Tokushima University (JP)
- Tokyo Women's Medical University (JP)
- Corresponding author
- Tanaka, Keiji
- Matsuda, Noriyuki
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 288
- Issue
- 30
- Pages
- 22019-22032
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3724655
- OpenAlex
- W2015758704
- Cited by
- 209
- References
- 75
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 8 · 2016: 18 · 2015: 36 · 2014: 25 · 2013: 5
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (publishedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (23570231, 25860721)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- Parkin, PINK1, mitochondrial membrane potential, mitochondrial depolarization, familial parkinsonism
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Binding Sites, Carbonyl Cyanide m-Chlorophenyl Hydrazone, Cells, Cultured, Cysteine, Embryo, Mammalian, Esters, Fibroblasts, HeLa Cells, Humans, Models, Biological, Phosphorylation, Protein Kinases, Serine, Substrate Specificity, Immunoblotting, Mice, Knockout, Ubiquitin, Ubiquitin-Protein Ligases, Mice, Membrane Potential, Mitochondrial, Ubiquitination, Biocatalysis, HEK293 Cells, Proton Ionophores
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