Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus

Venables, Michelle C.; Jeukendrup, Asker E.

doi:10.1002/dmrr.983

Cited by 137Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and HealthAdipokines, Inflammation, and Metabolic Diseases

Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus

Open access

Venables, Michelle C., Jeukendrup, Asker E.·2009·Diabetes/Metabolism Research and Reviews

DOI 10.1002/dmrr.983

Open this paper in CoChat — free account Open PDF

Abstract

Data from the health survey for England 2006 1, showed that the prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In the USA certain States have a prevalence of T2DM of greater than 10% 2. Globally it has been reported that this increase is by no means slowing down and that the number of individuals with the disease is expected to rise from 171 million cases reported in 2000 to 366 million by the year 2030 3. Physical inactivity and obesity are two major risk factors for the development of T2DM. In this review we will discuss evidence of an association between physical inactivity, obesity and T2DM from prospective cohort studies and clinical trials. We will also discuss some of the potential mechanisms that are thought to link obesity and physical inactivity with the major pathophysiological precursor of T2DM, insulin resistance. Copyright © 2009 John Wiley & Sons, Ltd.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/dmrr.983

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Global Prevalence of Diabetes
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866 · see citing works
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320 · see citing works
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
Physical activity and reduced occurrence of non–insulin-dependent diabetes mellitus
Helmrich, S. P., Ragland, D. R., Leung, R. W., & Paffenbarger, R. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107183250302 · Cited by 1,634 · see citing works
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311 · see citing works
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167 · see citing works
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works
Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
Goodpaster, B. H., Leland Thaete, F., Simoneau, J.-A., & Kelley, D. E. (1997) · Diabetes · doi:10.2337/diacare.46.10.1579 · Cited by 1,012 · see citing works
Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action
Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010 · see citing works
Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967 · see citing works
Walking Compared With Vigorous Physical Activity and Risk of Type 2 Diabetes in Women: A Prospective Study
Hu, F. B., Sigal, R. J., Rich-Edwards, J. W., Colditz, G. A., Solomon, C. G., Willett, W. C., Speizer, F. E., & Manson, J. E. (1999) · JAMA · doi:10.1001/jama.282.15.1433 · Cited by 914 · see citing works
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.
Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.
Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A., & Thaete, F. L. (1999) · Diabetes · doi:10.2337/diabetes.48.4.839 · Cited by 608 · see citing works
Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works
Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men
Perry, I. J., Wannamethee, S. G., Walker, M. K., Thomson, A. G., Whincup, P. H., & Shaper, A. G. (1995) · BMJ · doi:10.1136/bmj.310.6979.560 · Cited by 532 · see citing works
Intramuscular lipid content is increased in obesity and decreased by weight loss
Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80010-4 · Cited by 526 · see citing works
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works
Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss.
Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491 · see citing works
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487 · see citing works
Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
Santomauro, A. T., Boden, G., Silva, M. E., Rocha, D. M., Santos, R. F., Ursich, M. J., Strassmann, P. G., & Wajchenberg, B. L. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1836 · Cited by 431 · see citing works
Relationship of Physical Activity vs Body Mass Index With Type 2 Diabetes in Women
Weinstein, A. R. (2004) · JAMA · doi:10.1001/jama.292.10.1188 · Cited by 420 · see citing works
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410 · see citing works
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1640 · Cited by 404 · see citing works
Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
Phillips, D. I. W., Caddy, S., Ilic, V., Fielding, B. A., Frayn, K. N., Borthwick, A. C., & Taylor, R. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90260-7 · Cited by 390 · see citing works
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781930 · Cited by 362 · see citing works
Physical Activity, Body Mass Index, and Risk of Type 2 Diabetes in Patients With Normal or Impaired Glucose Regulation
Hu, G., Lindström, J., Valle, T. T., Eriksson, J. G., Jousilahti, P., Silventoinen, K., Qiao, Q., & Tuomilehto, J. O. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.8.892 · Cited by 340 · see citing works
Skeletal muscle lipid metabolism with obesity
Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339 · see citing works
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117864 · Cited by 320 · see citing works
Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., & McGarry, J. D. (2001) · Diabetes · doi:10.2337/diabetes.50.1.123 · Cited by 315 · see citing works
Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats
Luiken, J. J. F. P., Arumugam, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M. L., Turcotte, L. P., Tandon, N. N., Glatz, J. F. C., & Bonen, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100052200 · Cited by 282 · see citing works
Protein Kinase C Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation Requires Serine 612
Fea, K. D., & Roth, R. A. (1997) · Biochemistry · doi:10.1021/bi971157f · Cited by 246 · see citing works
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18917 · Cited by 244 · see citing works
Intramyocellular Lipids: Anthropometric Determinants and Relationships with Maximal Aerobic Capacity and Insulin Sensitivity
Thamer, C., Machann, J., Bachmann, O. P., Haap, M. M., Dahl, D. B., Wietek, B., Tschritter, O., Niess, A. M., Brechtel, K., Fritsche, A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021674 · Cited by 228 · see citing works
Fat content in individual muscle fibers of lean and obese subjects.
Malenfant, P., Joanisse, D., Thériault, R., Goodpaster, B., Kelley, D., & Simoneau, J.-A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801733 · Cited by 227 · see citing works
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker‐Krongrad, A., Hirsch, D. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418917 · Cited by 212 · see citing works
Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population: The MONICA/KORA Augsburg Cohort Study
Meisinger, C., L�wel, H., Thorand, B., & D�ring, A. (2005) · Diabetologia · doi:10.1007/s00125-004-1604-3 · Cited by 209 · see citing works
Exercise training increases intramyocellular lipid and oxidative capacity in older adults
Pruchnic, R., Katsiaras, A., He, J., Kelley, D. E., Winters, C., & Goodpaster, B. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00459.2003 · Cited by 177 · see citing works
Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.
Chin, J. E., Dickens, M., Tavaré, J. M., & Roth, R. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53258-0 · Cited by 164 · see citing works
Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation
Perdomo, G., Commerford, S. R., Richard, A.-M. T., Adams, S. H., Corkey, B. E., O'Doherty, R. M., & Brown, N. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403566200 · Cited by 158 · see citing works
Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy.
Baron, A., Laakso, M., Brechtel, G., & Edelman, S. V. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115117 · Cited by 127 · see citing works
Impaired plasma fatty acid oxidation in extremely obese women
Thyfault, J. P., Kraus, R. M., Hickner, R. C., Howell, A. W., Wolfe, R. R., & Dohm, G. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00177.2004 · Cited by 122 · see citing works
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Berti, L., Mosthaf, L., Kroder, G., Kellerer, M., Tippmer, S., Mushack, J., Seffer, E., Seedorf, K., & Häring, H.-U. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41873-4 · Cited by 114 · see citing works
Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes
Cusi, K. J., Kashyap, S., Gastaldelli, A., Bajaj, M. S., & Cersósimo, E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00624.2006 · Cited by 107 · see citing works
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes
Kashyap, S. R., Belfort, R., Berria, R., Suraamornkul, S., Pratipranawatr, T., Finlayson, J., Barrentine, A., Bajaj, M., Mandarino, L., DeFronzo, R., et al. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00541.2003 · Cited by 103 · see citing works
Protein kinase C modulates insulin action in human skeletal muscle
Cortright, R. N., Azevedo, J. L., Zhou, Q., Sinha, M. K., Pories, W. J., Itani, S. I., & Dohm, G. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.3.e553 · Cited by 100 · see citing works
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta
Greene, M. W., MORRICE, N. A., Garofalo, R. S., & Roth, R. A. (2004) · Biochemical Journal · doi:10.1042/bj20031493 · Cited by 89 · see citing works
Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism
Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00311.2006 · Cited by 87 · see citing works
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.
Chin, J. E., Liu, F., & Roth, R. A. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.1.7512195 · Cited by 85 · see citing works
Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids
Hoeks, J., Hesselink, M. K. C., Russell, A. P., Mensink, M., Saris, W. H. M., Mensink, R. P., & Schrauwen, P. (2006) · Diabetologia · doi:10.1007/s00125-006-0369-2 · Cited by 74 · see citing works
Daily life activity and risk of developing impaired fasting glucose or Type 2 diabetes in middle-aged Japanese men
Nakanishi, N., Takatorige, T., & Suzuki, K. (2004) · Diabetologia · doi:10.1007/s00125-004-1528-y · Cited by 44 · see citing works
Substrate utilization during exercise in formerly morbidly obese women
Guesbeck, N. R., Hickey, M. S., MacDonald, K. G., Pories, W. J., Harper, I., Ravussin, É., Dohm, G. L., & Houmard, J. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.3.1007 · Cited by 44 · see citing works
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1
Chin, J. E. (1994) · Molecular Endocrinology · doi:10.1210/me.8.1.51 · Cited by 28 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Copyright  2009 John Wiley & Sons, Ltd. Diabetes Metab Res Rev 2009; 25: 18-23. DOI: 10.1002/dmrr · DOI

Sorted by citations

Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
Chronic disease and the link to physical activity
Durstine, J. L., Gordon, B., Wang, Z., & Luo, X. (2013) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2012.07.009 · Cited by 460 · see citing works
Current views on type 2 diabetes
Lin, Y., & Sun, Z. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0260 · Cited by 457 · see citing works
Physical activity and incident type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of prospective cohort studies.
Smith, A. D., Crippa, A., Woodcock, J., & Brage, S. (2016) · Diabetologia · doi:10.1007/s00125-016-4079-0 · Cited by 430 · see citing works
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia
Hordern, M. D., Dunstan, D. W., Prins, J. B., Baker, M. K., Singh, M. A. F., & Coombes, J. S. (2012) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2011.04.005 · Cited by 273 · see citing works
Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men
Saremi, A., Asghari, M., & Ghorbani, A. (2010) · Journal of Sports Sciences · doi:10.1080/02640414.2010.484070 · Cited by 103 · see citing works
Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7796727 · Cited by 91 · see citing works
Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance
Dubé, J. J., Coen, P. M., DiStefano, G., Chacon, A. C., Helbling, N. L., Desimone, M. E., Stafanovic-Racic, M., Hames, K. C., Despines, A. A., Toledo, F. G. S., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2014 · Cited by 83 · see citing works
Measurement and Physiological Relevance of the Maximal Lipid Oxidation Rate During Exercise (LIPOXmax)
Brun, J.-F., Varlet-Marie, E., Jrme, A., & Mercier, J. (2012) · An International Perspective on Topics in Sports Medicine and Sports Injury · doi:10.5772/25451 · Cited by 19 · see citing works

Insulin Resistance in Type 2 Diabetes
Yki‐Järvinen, H. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch11 · Cited by 25 · see citing works
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585 · see citing works
The occurrence of insulin resistance and metabolic syndrome in polycystic ovary syndrome
Dong-z, Y. (2011) · Chinese Journal of Clinical Obstetrics and Gynecology
How much insulin resistance in polycystic ovary syndrome? Comparison of HOMA-IR and insulin resistance (Belfiore) index models
Lewandowski, K. C., Skowrońska‐Jóźwiak, E., Łukasiak, K., Gałuszko, K., Dukowicz, A., Cedro, M., & Lewiñski, A. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.82672 · Cited by 55 · see citing works
The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals
Reaven, G. M. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.002 · Cited by 506 · see citing works

Authors: Venables, M. C., & Jeukendrup, A. E.
Affiliations: University of Birmingham (GB)
Corresponding author: Venables, Michelle C.
ORCID: Venables, Michelle C.
Venue: Diabetes/Metabolism Research and Reviews
Publisher: Wiley
Published: 2009-08-06
Volume: 25
Issue: S1
Pages: S18-23
ISSN: 1520-7552 (ISSN-L)
1520-7560
DOI: 10.1002/dmrr.983
OpenAlex: W2114614939
Cited by: 137
References: 66
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 9 · 2018: 1 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 12
FWCI: 1.71
Type: journal article
Language: en
Open access: green
radar.brookes.ac.uk
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes/Metabolism Research and Reviews (publishedVersion)
PubMed (publishedVersion)
Radar (Oxford Brookes University) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: physical inactivity, obesity, type 2 diabetes, insulin resistance, diabetes prevalence, diabetes risk factors
MeSH terms: Adipose Tissue, Energy Intake, Clinical Trials as Topic, Diabetes Mellitus, Diabetes Mellitus, Type 2, Dietary Fats, Fatty Acids, Female, Humans, Insulin, Male, Myocardium, Obesity, Risk, Reproducibility of Results, Exercise, Muscle, Skeletal, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks