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Essential Role of Hrs in Endocytic Recycling of Full-length TrkB Receptor but Not Its Isoform TrkB.T1
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TrkB-FL and TrkB.T1 receptors traverse divergent recycling pathways after endocytosis.
“We previously found that TrkB-FL and TrkB.T1 receptors traverse divergent recycling pathways after endocytosis (Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
TrkB receptors are degraded via lysosomes in a BDNF-dependent manner in cell lines such as PC12 cells and in primary neuronal cultures.
“It has been established that TrkB receptors are degraded via lysosomes in a BDNF-dependent manner in cell lines such as PC12 cells and in primary neuronal cultures (Chen et al., 2005;Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
BDNF can efficiently drive TrkB receptor internalization, and endocytosed TrkB receptors can either traffic to lysosomes for degradation or recycle back to the plasma membrane.
“BDNF can efficiently drive TrkB receptor internalization and endocytosed TrkB receptors could either traffic to lysosomes for degradation or recycle back to the plasma membrane (Chen et al., 2005;Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
Recycling of endocytic TrkB-FL receptors occurs in a sequence-directed regulated recycling pathway that relies on its tyrosine kinase activity and hepatocyte growth factor-regulated tyrosine kinase substrate.
“We have previously found that recycling of endocytic TrkB-FL receptors occurs in a sequence-directed regulated recycling pathway that relies on its tyrosine kinase activity and hepatocyte growth factor-regulated tyrosine kinase substrate (Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
TrkB-FL and TrkB.T1 receptors are both efficiently endocytosed by BDNF treatment.
“It has been established that TrkB-FL and TrkB.T1 receptors are both efficiently endocytosed by BDNF treatment (Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
TrkB.T1 receptors recycle more efficiently after internalization via the default pathway.
“In contrast, TrkB.T1 receptors recycle more efficiently after internalization via the default pathway (Huang et al., 2009).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Huang et al., 2009
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Self-citation
Metadata
- Authors
- Huang, S.-H., Zhao, L., Sun, Z.-P., Li, X.-Z., Geng, Z., Zhang, K.-D., Chao, M. V., & Chen, Z.-Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 284
- Issue
- 22
- Pages
- 15126-15136
- ISSN
- 0021-9258
- Cited by
- 54
- References
- 4
- Language
- en
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