A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders
Open accessAbstract
Fecal and blood samples of infants with autism spectrum disorders (ASD) and healthy infants were analyzed to investigate the association of altered gut microbiota and ASD development. 16S rRNA gene-based sequencing found that, unlike those of healthy infants, feces of ASD infants had significantly higher and lower abundance of genera Faecalibacterium and Blautia, respectively. Moreover, DNA microarray analysis of peripheral blood mononuclear cells (PBMC) detected more highly than low expressed genes in ASD infants than in healthy infants. Gene Ontology analysis revealed that differentially expressed genes between ASD and healthy infants were involved in interferon (IFN)-γ and type-I IFN signaling pathways. Finally, strong positive correlations between expression of IFN signaling-associated genes in PBMC and fecal abundance of Faecalibacterium were found. Our results strongly suggested that altered gut microbiota in infants resulted from ASD development and was associated with systemic immunity dysregulation, especially chronic inflammation.
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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366 · see citing works
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114 · see citing works
Mechanisms of type-I- and type-II-interferon-mediated signalling
Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,480 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works
Simon, J., McGoldrick, M., Pearce, J. K., & Giordano, J. (1983) · Family Relations · doi:10.2307/583699 · Cited by 1,727 · see citing works
Fadrosh, D. W., Ma, B., Gajer, P., Sengamalay, N., Ott, S., Brotman, R. M., & Ravel, J. (2014) · Microbiome · doi:10.1186/2049-2618-2-6 · Cited by 1,698 · see citing works
Robins, D. L., Fein, D., Barton, M. L., & Green, J. A. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010738829569 · Cited by 1,563 · see citing works
Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works
Faecalibacterium prausnitzii and human intestinal health
Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,239 · see citing works
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977 · see citing works
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949 · see citing works
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works
De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D. I., Cristofori, F., Guerzoni, M. E., Gobbetti, M., & Francavilla, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076993 · Cited by 887 · see citing works
Quévrain, E., Maubert, M.-A., Michon, C., Chain, F., Marquant, R., Tailhades, J., Miquel, S., Carlier, L., Bermúdez‐Humarán, L. G., Pigneur, B., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307649 · Cited by 861 · see citing works
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works
Gut microbiota–generated metabolites in animal health and disease
Lee, W.-J., & Hase, K. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1535 · Cited by 756 · see citing works
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742 · see citing works
Duncan, S. H., Hold, G. L., Harmsen, H. J. M., Stewart, C. S., & Flint, H. J. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-6-2141 · Cited by 735 · see citing works
Disentangling the heterogeneity of autism spectrum disorder through genetic findings
Jeste, S. S., & Geschwind, D. H. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.278 · Cited by 644 · see citing works
Alterations in intestinal permeability
Arrieta, M., Bistritz, L., & Meddings, J. B. (2006) · Gut · doi:10.1136/gut.2005.085373 · Cited by 634 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556 · see citing works
A comparison of eating behaviors between children with and without autism
Schreck, K. A., Williams, K., & Smith, A. F. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000037419.78531.86 · Cited by 536 · see citing works
The immune response in autism: a new frontier for autism research
Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works
Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works
Ashwal, S., Bale, J. F., Coulter, D. L., Eiben, R., & Garg, B. P. (2006) · Annals of Neurology · doi:10.1002/(issn)1531-8249 · Cited by 514 · see citing works
Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024585 · Cited by 492 · see citing works
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05212-11 · Cited by 432 · see citing works
Song, H., Yoo, Y., Hwang, J., Na, Y.-C., & Kim, H. S. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.021 · Cited by 416 · see citing works
Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012) · mBio · doi:10.1128/mbio.00261-11 · Cited by 378 · see citing works
Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65208-0 · Cited by 359 · see citing works
Müller, M., Carter, S., Hofer, M. J., & Campbell, I. L. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01089.x · Cited by 293 · see citing works
Hansen, R., Russell, R. K., Reiff, C., Louis, P., McIntosh, F. M., Berry, S. H., Mukhopadhya, I., Bisset, W. M., Barclay, A. R., Bishop, J., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.335 · Cited by 288 · see citing works
Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders
Paakki, J.-J., Rahko, J., Long, X., Moilanen, I., Tervonen, O., Nikkinen, J., Starck, T., Remes, J., Hurtig, T., Haapsamo, H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.081 · Cited by 286 · see citing works
Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders
Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020470 · Cited by 252 · see citing works
Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children
Ramadass, B., George, G., Kabeerdoss, J., Hepsiba, J., Chandragunasekaran, A. M. S., & Ramakrishna, B. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992182 · Cited by 209 · see citing works
de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 203 · see citing works
Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism
Singh, V. K. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00014-8 · Cited by 199 · see citing works
Essential fatty acids and phospholipase A2 in autistic spectrum disorders
Bell, J. G., Mackinlay, E. E., Dick, J. R., MacDonald, D. J., Boyle, R. M., & Glen, A. C. A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.008 · Cited by 199 · see citing works
Perceptions of Dementia, Caregiving, and Help Seeking among Asian and Pacific Islander Americans
Braun, K. L., & Browne, C. V. (1998) · Health & Social Work · doi:10.1093/hsw/23.4.262 · Cited by 189 · see citing works
Duncan, S. H. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.02241-0 · Cited by 184 · see citing works
Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation
Lee, P. Y., Li, Y., Kumagai, Y., Xu, Y., Weinstein, J. S., Kellner, E. S., Nacionales, D. C., Butfiloski, E. J., van Rooijen, N., Akira, S., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090328 · Cited by 182 · see citing works
Environmental risk factors for autism
Dietert, R. R., Dietert, J. M., & DeWitt, J. C. (2011) · Emerging Health Threats Journal · doi:10.3402/ehtj.v4i0.7111 · Cited by 139 · see citing works
IFN-α and IFN-β: a link between immune memory and chronic inflammation
Akbar, A. N., Lord, J. M., & Salmon, M. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01652-2 · Cited by 137 · see citing works
Yoshikawa, T., Inoüe, R., Matsumoto, M., Yajima, T., Ushida, K., & Iwanaga, T. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0779-1 · Cited by 129 · see citing works
Mueller, A., Oertli, M., & Arnold, I. C. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-25 · Cited by 89 · see citing works
Does the Human Gut Microbiota Contribute to the Etiology of Autism Spectrum Disorders?
Louis, P. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2286-1 · Cited by 81 · see citing works
Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis
Lepej, S. Ž., Misić-Majerus, L., Jeren, T., Rode, O. Đ., Remenar, A., Šporec, V., & Vince, A. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00726.x · Cited by 70 · see citing works
Innate immune responses in central nervous system inflammation
Finsen, B., & Owens, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.030 · Cited by 50 · see citing works
Quévrain, E., Maubert, M.-A., Sokol, H., Devreese, B. V., & Seksik, P. (2015) · Gut · doi:10.1136/gutjnl-2015-311094 · Cited by 31 · see citing works
Stubbs, G. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02178169 · Cited by 27 · see citing works
Nishibayashi, R., Inoüe, R., Harada, Y., Watanabe, T., Makioka‐Itaya, Y., & Ushida, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129806 · Cited by 25 · see citing works
Moniuszko-Malinowska, A. M., Czupryna, P., Pancewicz, S. A., Rutkowski, K., Zajkowska, O., Świerzbińska, R., Grygorczuk, S., Kondrusik, M., Owłasiuk, P., & Zajkowska, J. M. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.11.002 · Cited by 23 · see citing works
Matsumoto, M., Inoue, R., Tsuruta, T., Hara, H., & Yajima, T. (2009) · British Journal of Nutrition · doi:10.1017/s0007114509990365 · Cited by 16 · see citing works
Self-citationChemokine Deregulation in HIV Infection: Role of Interferon Gamma Induced Th1-Chemokine Signaling
Mehla, R. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s7-004 · Cited by 9 · see citing works
Comparison of gene expression profiles of T cells in porcine colostrum and peripheral blood
Ogawa, S., Okutani, M., Tsukahara, T., Nakanishi, N., Kato, Y., Fukuta, K., Romero‐Pérez, G. A., USHIDA, K., & Inoüe, R. (2016) · American Journal of Veterinary Research · doi:10.2460/ajvr.77.9.961 · Cited by 9 · see citing works
Self-citationAll interferons are not equal: Specific mechanisms of interfering with osteoclastogenesis
Takayanagi, H. (2005) · BoneKEy-Osteovision · doi:10.1138/20050183 · Cited by 1 · see citing works
Flagged first, then by citations
4 of the 69 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nishino, K., Nishida, A., Inoüe, R., Kawada, Y., Ohno, M., Sakai, S., Inatomi, O., Bamba, S., Sugimoto, M., Kawahara, M., et al. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1384-4 · Cited by 463 · see citing works
The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder
Srikantha, P., & Mohajeri, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092115 · Cited by 400 · see citing works
Iglesias-Vázquez, L., Van Ginkel Riba, G., Arija, V., & Canals, J. (2020) · Nutrients · doi:10.3390/nu12030792 · Cited by 352 · see citing works
Liu, F., Li, J., Wu, F., Zheng, H., Peng, Q., & Zhou, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0389-6 · Cited by 336 · see citing works
Xu, M., Xu, X., Li, J., & Li, F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00473 · Cited by 309 · see citing works
Microbiota-gut-brain axis and the central nervous system
Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W. (2017) · Oncotarget · doi:10.18632/oncotarget.17754 · Cited by 308 · see citing works
Gut microbiome composition and diversity are related to human personality traits
Johnson, K. V. ‐. (2019) · Human Microbiome Journal · doi:10.1016/j.humic.2019.100069 · Cited by 241 · see citing works
Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development
Indrio, F., Martini, S., Francavilla, R., Corvaglia, L., Cristofori, F., Mastrolia, S. A., Neu, J., Rautava, S., Spena, G. R., Raimondi, F., et al. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00178 · Cited by 232 · see citing works
Aging, Frailty, and the Microbiome—How Dysbiosis Influences Human Aging and Disease
Haran, J. P., & McCormick, B. A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.060 · Cited by 220 · see citing works
Steroids, stress and the gut microbiome-brain axis
Tetel, M. J., de Vries, G. J., Melcangi, R. C., Panzica, G., & O'Mahony, S. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12548 · Cited by 187 · see citing works
Kong, X.-J., Liu, J., Liu, K., Koh, M., Sherman, H., Liu, S., Tian, R., Sukijthamapan, P., Wang, J., Fong, M., et al. (2021) · Nutrients · doi:10.3390/nu13051552 · Cited by 150 · see citing works
Gut microbiota changes in children with autism spectrum disorder: a systematic review
Ho, L. K. H., Tong, V. J. W., Syn, N., Nagarajan, N., Tham, E. H., Tay, S. K., Shorey, S., Tambyah, P. A., & Law, E. C. N. (2020) · Gut Pathogens · doi:10.1186/s13099-020-0346-1 · Cited by 149 · see citing works
Wan, Y., Zuo, T., Xu, Z., Zhang, F., Zhan, H., Dorothy, C. H. A. N., Leung, T.-F., Yeoh, Y. K., Chan, F. K. L., Chan, R., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-324015 · Cited by 148 · see citing works
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127 · see citing works
Inoüe, R., Ohue‐Kitano, R., Tsukahara, T., Tanaka, M., Masuda, S., Inoue, T., Yamakage, H., Kusakabe, T., Hasegawa, K., Shimatsu, A., et al. (2017) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-44 · Cited by 117 · see citing works
Self-citationGarcía-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 115 · see citing works
Restoration of dysbiotic human gut microbiome for homeostasis
Dixit, K. K., Chaudhari, D. S., Dhotre, D. P., Shouche, Y. S., & Saroj, S. D. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119622 · Cited by 112 · see citing works
The gut microbiota as a key regulator of visceral pain
O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2016) · Pain · doi:10.1097/j.pain.0000000000000779 · Cited by 98 · see citing works
Eltokhi, A., Janmaat, I. E., Genedi, M., Haarman, B. C. M., & Sommer, I. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24616 · Cited by 100 · see citing works
Autism Spectrum Disorder and the Gut Microbiota in Children: A Systematic Review
Bezawada, N., Phang, T. H., Hold, G., & Hansen, R. (2020) · Annals of Nutrition and Metabolism · doi:10.1159/000505363 · Cited by 93 · see citing works
A Meta-analysis of Gut Microbiota in Children with Autism
Andreo-Martínez, P., Rubio-Aparicio, M., Sánchez-Meca, J., Veas, A., & Martínez-González, A. E. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05002-y · Cited by 96 · see citing works
Xu, R., Zhang, Y., Chen, S., Zeng, Y., Fu, X., Chen, T., Luo, S., & Zhang, X. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2044286 · Cited by 95 · see citing works
Gut microbiota dysbiosis enhances migraine-like pain via TNFα upregulation
Tang, Y., Liu, S., Shu, H., Yanagisawa, L., & Tao, F. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01721-7 · Cited by 88 · see citing works
Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease
Imai, T., Inoüe, R., Kawada, Y., Morita, Y., Inatomi, O., Nishida, A., Bamba, S., Kawahara, M., & Andoh, A. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1530-7 · Cited by 82 · see citing works
Inoüe, R., Sakaue, Y., Kawada, Y., Tamaki, R., Yasukawa, Z., Ozeki, M., Ueba, S., Sawai, C., Nonomura, K., Tsukahara, T., et al. (2019) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-105 · Cited by 76 · see citing works
Self-citationAn approach to gut microbiota profile in children with autism spectrum disorder
Andreo‐Martínez, P., García-Martínez, N., Sánchez‐Samper, E. P., & Martínez‐González, A. E. (2019) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12810 · Cited by 76 · see citing works
Irritable Bowel Syndrome and Stress-Related Psychiatric Co-morbidities: Focus on Early Life Stress
O’Mahony, S. M., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_128 · Cited by 75 · see citing works
The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00247 · Cited by 71 · see citing works
Air Pollution, Early Life Microbiome, and Development
Vallès, Y., & Francino, M. P. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0215-y · Cited by 65 · see citing works
Lasheras, I., Seral, P., Latorre, E., Barroso, E., Gracia‐García, P., & Santabárbara, J. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.101874 · Cited by 64 · see citing works
Lee, Y., Park, J. Y., Lee, E. H., Yang, J., Jeong, B.-R., Kim, Y., Seoh, J., Lee, S., Han, P., & Kim, E. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.5.307 · Cited by 64 · see citing works
Roussin, L., Prince, N., Perez‐Pardo, P., Kraneveld, A. D., Rabot, S., & Naudon, L. (2020) · Microorganisms · doi:10.3390/microorganisms8091369 · Cited by 64 · see citing works
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Ding, H., Yi, X., Zhang, X., Wang, H., Liu, H., & Mou, W.-W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.572752 · Cited by 61 · see citing works
Duque, A. L. R. F., Demarqui, F. M., Santoni, M. M., Zanelli, C. F., Adorno, M. Â. T., Milenković, D., Mesa, V., & Sivieri, K. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110657 · Cited by 59 · see citing works
Ye, F., Gao, X., Wang, Z., Cao, S., Liang, G., He, D., Lv, Z., Wang, L., Xu, P., & Zhang, Q. (2021) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.03.003 · Cited by 56 · see citing works
Gut Microbiota in Psychiatric Disorders: A Systematic Review
Chen, L. L., Abbaspour, A., Mkoma, G. F., Bulik, C. M., Rück, C., & Djurfeldt, D. R. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000959 · Cited by 54 · see citing works
Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes
Laue, H. E., Karagas, M. R., Coker, M. O., Bellinger, D. C., Baker, E., Korrick, S., & Madan, J. C. (2021) · Pediatric Research · doi:10.1038/s41390-021-01785-z · Cited by 48 · see citing works
A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder
Azhari, A., Azizan, F., & Esposito, G. (2018) · Developmental Psychobiology · doi:10.1002/dev.21803 · Cited by 47 · see citing works
Comparison of the fecal microbiota of two monogastric herbivorous and five omnivorous mammals
Kobayashi, R., Nagaoka, K., Nishimura, N., Koike, S., Takahashi, E., Niimi, K., MURASE, H., Kinjo, T., Tsukahara, T., & Inoüe, R. (2020) · Animal Science Journal · doi:10.1111/asj.13366 · Cited by 45 · see citing works
Self-citationLiyanage, G. I. M., Inoüe, R., Fujitani, M., Ishijima, T., Shibutani, T., Abe, K., Kishida, T., & Okada, S. (2021) · Nutrients · doi:10.3390/nu13113759 · Cited by 42 · see citing works
The link between autism spectrum disorder and gut microbiota: A scoping review
Nitschke, A. S., Deonandan, R., & Konkle, A. T. M. (2020) · Autism · doi:10.1177/1362361320913364 · Cited by 45 · see citing works
Aoi, W., Inoüe, R., Mizushima, K., Honda, A., Björnholm, M., Takagi, T., & Naito, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106251 · Cited by 40 · see citing works
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Pauer, H., Hardoim, C. C. P., Teixeira, F. L., Miranda, K. R., Barbirato, D. D. S., de Carvalho, D. P., Antunes, L. C. M., Leitão, Á. C., Lobo, L. A., & Domingues, R. M. C. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203748 · Cited by 37 · see citing works
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Sugitani, Y., Inoüe, R., Inatomi, O., Nishida, A., Morishima, S., Imai, T., Kawahara, M., Naito, Y., & Andoh, A. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-93 · Cited by 37 · see citing works
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Fuess, L. E., den Haan, S., Ling, F., Weber, J. N., Steinel, N. C., & Bolnick, D. I. (2021) · mBio · doi:10.1128/mbio.00145-21 · Cited by 35 · see citing works
Alteration of the fecal microbiota in Chinese children with autism spectrum disorder
Xie, X., Li, L., Wu, X., Hou, F., Chen, Y., Shi, L., Liu, Q., Zhu, K., Jiang, Q., Feng, Y., et al. (2022) · Autism Research · doi:10.1002/aur.2718 · Cited by 36 · see citing works
Dental Caries Status in Autistic Children: A Meta-analysis
Zhang, Y., Lin, L., Liu, J., Shi, L., & Lu, J. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04256-x · Cited by 34 · see citing works
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Kashiwagi, S., Naito, Y., Inoüe, R., Takagi, T., Nakano, T., Inada, Y., Fukui, A., Katada, K., Mizushima, K., Kamada, K., et al. (2019) · Digestion · doi:10.1159/000496102 · Cited by 31 · see citing works
Zhang, X., Yoshihara, K., Miyata, N., Hata, T., Altaisaikhan, A., Takakura, S., Asano, Y., Izuno, S., & Sudo, N. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113653 · Cited by 28 · see citing works
Effect of storage and DNA extraction method on 16S rRNA-profiled fecal microbiota in Japanese adults
Kawada, Y., Naito, Y., Andoh, A., Ozeki, M., & Inoüe, R. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-84 · Cited by 29 · see citing works
Self-citationYang, C.-J., Xiao, H., Zhu, H., Du, Y., & Wang, L. (2024) · BioScience Trends · doi:10.5582/bst.2024.01123 · Cited by 28 · see citing works
Wang, M., Monaco, M. H., Hauser, J., Yan, J., Dilger, R. N., & Donovan, S. M. (2021) · Microorganisms · doi:10.3390/microorganisms9050884 · Cited by 28 · see citing works
Kappéter, Á., Sipos, D., Varga, A., Vigvári, S., Halda-Kiss, B., & Péterfi, Z. (2023) · Microorganisms · doi:10.3390/microorganisms11082083 · Cited by 29 · see citing works
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Uryu, H., Tsukahara, T., Ishikawa, H., Munetaka, O. I., Otake, S., YAMANE, I., & Inoüe, R. (2020) · Microorganisms · doi:10.3390/microorganisms8101469 · Cited by 27 · see citing works
Self-citationWong, O. W. H., Lam, A. M. W., Or, B. P. N., Mo, F. Y. M., Shea, C. K., Lai, K. Y. C., Ma, S. L., Hung, S. F., Chan, S. S. M., Kwong, T. N. Y., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14785-8 · Cited by 28 · see citing works
Yu, R., Hafeez, R., Ibrahim, M. K., Alonazi, W. B., & Li, B. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115177 · Cited by 30 · see citing works
IFNG/IFNG-AS1 expression level balance: implications for autism spectrum disorder
Fallah, H., Sayad, A., Ranjbaran, F., Talebian, F., Ghafouri‐Fard, S., & Taheri, M. N. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00510-4 · Cited by 25 · see citing works
Tang, Y., Zhang, H., Yan, J., Luo, N., Fu, X., Wu, X., Wu, J., Liu, C., & Zhang, D. (2023) · Water Research · doi:10.1016/j.watres.2023.120136 · Cited by 24 · see citing works
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Shigeta, M., Aoi, W., Morita, C., Soga, K., Inoüe, R., Fukushima, Y., Kobayashi, Y., & Kuwahata, M. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00859-4 · Cited by 31 · see citing works
Olaguez-Gonzalez, J. M., Chaírez, I., Bretón‐Deval, L., & Alfaro-Ponce, M. (2023) · Biomedicines · doi:10.3390/biomedicines11102633 · Cited by 23 · see citing works
Makioka‐Itaya, Y., Tsukahara, T., 伊地知哲生, & Inoüe, R. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1451738 · Cited by 23 · see citing works
Self-citationShigeno, Y., Zhang, H., Banno, T., Usuda, K., Nochi, T., Inoüe, R., Watanabe, G., Jin, W., Benno, Y., & Nagaoka, K. (2018) · The FASEB Journal · doi:10.1096/fj.201801462r · Cited by 22 · see citing works
Cupertino, M. D. C., Resende, M. B., Veloso, I. D. F., de Carvalho, C. A., Duarte, V. F., & Ramos, G. A. (2019) · ABCS Health Sciences · doi:10.7322/abcshs.v44i2.1167 · Cited by 22 · see citing works
Zhang, F., & Wang, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1191445 · Cited by 23 · see citing works
Kimura-Todani, T., Hata, T., Miyata, N., Takakura, S., Yoshihara, K., Zhang, X., Asano, Y., Altaisaikhan, A., Tsukahara, T., & Sudo, N. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113004 · Cited by 22 · see citing works
Self-citationHawkins, B., Montgomery, M., Bokota, G., Santoyo, M., Giron, E., & Eltokhi, A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2574934 · Cited by 22 · see citing works
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Imai, T., Inoüe, R., Nishida, A., Yokota, Y., Morishima, S., Kawahara, M., Kusada, H., Tamaki, H., & Andoh, A. (2022) · Journal of Gastroenterology · doi:10.1007/s00535-022-01882-8 · Cited by 20 · see citing works
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Liu, L., Wang, H., Yu, Y., Zeng, B., Rao, X., Chen, J., Zhou, C., Zheng, P., Pu, J., Yang, L., et al. (2020) · Epigenomics · doi:10.2217/epi-2019-0307 · Cited by 20 · see citing works
Tochitani, S., Maehara, Y., Kawase, T., Tsukahara, T., Shimizu, R., Watanabe, T., Maehara, K., Asaoka, K., & Matsuzaki, H. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-96 · Cited by 19 · see citing works
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Morishima, S., Oda, N., Ikeda, H., Segawa, T., Oda, M., Tsukahara, T., Kawase, Y., Takagi, T., Naito, Y., Fujibayashi, M., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9081687 · Cited by 15 · see citing works
Self-citationXiao, L., Wang, M., Zhang, W., Song, Y., Zeng, J., Li, H., Yu, H. Y., Li, L., Gao, P., & Yao, P. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00693-0 · Cited by 16 · see citing works
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Ogawa, C., Inoüe, R., Yonejima, Y., Hisa, K., Yamamoto, Y., & Suzuki, T. (2021) · Journal of Applied Microbiology · doi:10.1111/jam.15161 · Cited by 15 · see citing works
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Morimoto, C., Matsumoto, H., Nomura, N., Sunadome, H., Nagasaki, T., Satô, S., Sato, A., Oguma, T., Ito, I., Kogo, M., et al. (2023) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2023.100194 · Cited by 14 · see citing works
Self-citationHong, R., Hou, Y.-Y., Xu, X., Lang, J., Jin, Y., Zeng, X.-F., Zhang, X., Tian, G., & You, X. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.886196 · Cited by 13 · see citing works
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Levkova, M., Chervenkov, T., & Pancheva, R. (2023) · Children · doi:10.3390/children10071103 · Cited by 12 · see citing works
Tuplin, E. W. N., Fernandes, T. S., Lowry, D. E., Cho, N. A., Sales, K. M., Patterson, R. A., & Reimer, R. A. (2023) · Obesity · doi:10.1002/oby.23731 · Cited by 12 · see citing works
Wei, Y., Shen, D., Ramzan, M. N., Emmanuel, A., Zhu, J., Yang, W., Wang, Y., & Zheng, Z. (2024) · International Biodeterioration & Biodegradation · doi:10.1016/j.ibiod.2024.105792 · Cited by 11 · see citing works
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Andoh, A., Inoüe, R., Kawada, Y., Morishima, S., Inatomi, O., Ohno, M., Bamba, S., Nishida, A., Kawahara, M., & Naito, Y. (2019) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.19-8 · Cited by 11 · see citing works
Xu, X., Lang, J., Yang, J., Long, B., Liu, X., Zeng, X.-F., Tian, G., & You, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1100816 · Cited by 11 · see citing works
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Yamashita, T., Tai, S., Tsukahara, T., & Inoüe, R. (2021) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbab029 · Cited by 10 · see citing works
Self-citationZarezadeh, M., Mahmoudinezhad, M., Hosseini, B., Khorraminezhad, L., Razaghi, M., Alvandi, E., & Saedisomeolia, A. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.014 · Cited by 11 · see citing works
Widjaja, F., & Rietjens, I. M. C. M. (2023) · Biomedicines · doi:10.3390/biomedicines11102658 · Cited by 10 · see citing works
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Interino, N., Vitagliano, R., D’Amico, F., Lodi, R., Porru, E., Turroni, S., & Fiori, J. (2025) · Biomolecules · doi:10.3390/biom15020243 · Cited by 10 · see citing works
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Prasanthan, A. T., Damodaran, A., Kumar, N. S., & Viswanad, V. (2022) · Indian Journal of Microbiology · doi:10.1007/s12088-022-01051-8 · Cited by 9 · see citing works
The Microbiome in Child and Adolescent Psychiatry
Zimmermann-Rösner, A., & Prehn‐Kristensen, A. (2024) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000965 · Cited by 8 · see citing works
Miura, H., Oda, M., Abe, K., Ikeda, H., Fujibayashi, M., Oda, N., Segawa, T., Abe, A., Ueta, N., Tsukahara, T., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13071561 · Cited by 8 · see citing works
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Xue, Y., An, S., Qiu, W., Zhang, W., Li-min, F., & Zhen, Z. (2023) · International Journal of Sports Medicine · doi:10.1055/a-2018-2477 · Cited by 9 · see citing works
Li, Y., Gao, S., & Meng, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1136154 · Cited by 8 · see citing works
Metagenomics revealed a correlation of gut phageome with autism spectrum disorder
Shahin, K., Soleimani-Delfan, A., He, Z., Sansonetti, P. J., & Collard, J. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00561-0 · Cited by 8 · see citing works
Nakano, T., Dohi, O., Takagi, T., Naito, Y., Fukui, H., Miyazaki, H., Yasuda, T., Yoshida, T., Azuma, Y., Ishida, T., et al. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08154-2 · Cited by 8 · see citing works
Kambe, J., Usuda, K., Inoüe, R., Hirayama, K., Ito, M., Suenaga, K., Masukado, S., Liu, H., Miyata, S., Li, C., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359729 · Cited by 8 · see citing works
Midori, Y., Nosaka, T., Hiramatsu, K., Akazawa, Y., Tanaka, T., Takahashi, K., Naito, T., Matsuda, H., Ohtani, M., & Nakamoto, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1371429 · Cited by 7 · see citing works
Tochitani, S., Kisohara, H., Nakamura, K., Hiramoto, K., Terasawa, M., & Suzuki, K. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106192 · Cited by 7 · see citing works
Gong, X.-R., You, X.-R., Guo, M.-R., Ding, X., & Ma, B. (2023) · Medicine · doi:10.1097/md.0000000000036794 · Cited by 8 · see citing works
Katsumata, S., Hayashi, Y., Oishi, K., Tsukahara, T., Inoüe, R., Obata, A., Hirooka, H., & Kumagai, H. (2023) · animal · doi:10.1016/j.animal.2023.100873 · Cited by 6 · see citing works
Self-citationZheng, Y.-M., Ye, M.-M., Zhang, H., Luo, D.-P., Liu, T., He, X., Chen, X.-Y., & Wu, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1606417 · Cited by 5 · see citing works
Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice
Tochitani, S., Tsukahara, T., & Inoüe, R. (2024) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.100.020 · Cited by 6 · see citing works
Self-citation
- Authors
- Inoue, R., Sakaue, Y., Sawai, C., Sawai, T., Ozeki, M., Romero-Pérez, G. A., & Tsukahara, T.
- Affiliations
- Laboratory of Animal Science, Department of Agricultural and Life Sciences, Kyoto Prefectural University, Kyoto, Japan
- Shiga University of Medical Science (JP)
- Mukogawa Women's University (JP)
- Kyoto Institute of Nutrition and Pathology, Kyoto, Japan
- Kyoto Prefectural University (JP)
- ORCID
- Tsukahara, Takamitsu
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2016-12-01
- Volume
- 80
- Issue
- 12
- Pages
- 2450-2458
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2516846297
- Cited by
- 148
- References
- 69
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 23 · 2023: 25 · 2022: 11 · 2021: 26 · 2020: 14 · 2019: 13 · 2018: 7 · 2017: 7 · 2016: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Morinaga Foundation for Health & Nutrition
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, gut microbiota, infants, peripheral blood mononuclear cells, gene expression, Faecalibacterium, Blautia, interferon-gamma signaling, type I interferon signaling, chronic inflammation, fecal microbiota
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Child, Preschool, Feces, Humans, Infant, Leukocytes, Mononuclear, Case-Control Studies, Transcriptome
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