Neuroprotective effect of Arthrospira(Spirulina)platensis against kainic acid-neuronal death
Open accessAbstract
Context Arthrospira (Spirulina) platensis (SP) is a cyanobacterium which has attracted attention because of its nutritional value and pharmacological properties. It was previously reported that SP reduces oxidative stress in the hippocampus and protects against damaging neurobehavioural effects of systemic kainic acid (KA). It is widely known that the systemic administration of KA induces neuronal damage, specifically in the CA3 hippocampal region. Objective The present study determines if the SP sub-chronic treatment has neuroprotective properties against KA. Materials and methods Male SW mice were treated with SP during 24 d, at doses of 0, 200, and 800 mg/kg, once daily, and with KA (35 mg/kg, ip) as a single dose on day 14. After the treatment, a histological analysis was performed and the number of atrophic neuronal cells in CA3 hippocampal region was quantified. Results Pretreatment with SP does not protect against seizures induced by KA. However, mortality in the SP 200 and the SP 800 groups was of 20%, while for the KA group, it was of 60%. A single KA ip administration produced a considerable neuronal damage, whereas both doses of SP sub-chronic treatment reduced the number of atrophic neurons in CA3 hippocampal region with respect to the KA group. Discussion The SP neurobehaviour improvement after KA systemic administration correlates with the capacity of SP to reduce KA-neuronal death in CA3 hippocampal cells. This neuroprotection may be related to the antioxidant properties of SP. Conclusion SP reduces KA-neuronal death in CA3 hippocampal cells.
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Pérez-Juárez et al. demonstrated that even a single intake of Arthrospira platensis reduced neuronal death in experimental animals.
“Pérez-Juárez et al. had demonstrated that even a single intake of Arthrospira platensis reduced neuronal death in experimental animals [88].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [88]
The Results report that Arthrospira (Spirulina) platensis partially reduced kainic-acid-induced neuronal cell death in mice. But Materials and methods specify that it was given once daily for 24 days; the single administration was of kainic acid, not Spirulina. The claim's “single intake” qualifier is therefore not supported. (LLM, conf=0.90)
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- Authors
- Pérez-Juárez, A., Chamorro, G., Alva-Sánchez, C., Paniagua-Castro, N., & Pacheco-Rosado, J.
- Affiliations
- Instituto Politécnico Nacional (MX)
- Corresponding author
- Pacheco-Rosado, Jorge
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2016-01-22
- Volume
- 54
- Issue
- 8
- Pages
- 1408-1412
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2250249613
- Cited by
- 33
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Spirulina platensis, Spirulina, neuroprotection, kainic acid, neuronal cell death, hippocampal CA3, seizures, cyanobacteria, antioxidant activity, oxidative stress
- MeSH terms
- Animals, Antioxidants, Atrophy, Dose-Response Relationship, Drug, Epilepsy, Tonic-Clonic, Kainic Acid, Male, Pyramidal Cells, Excitatory Amino Acid Agonists, Neuroprotective Agents, Cytoprotection, Mice, Spirulina, CA3 Region, Hippocampal
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